[{"type":"protein-coding","gene_no":351,"end_pos":"26171128","reactome_pathways":[{"name":"NFkB complex is transported from cytosol to nucleus","id":168166},{"id":379048,"name":"Liganded Gq/11-activating GPCRs act as GEFs for Gq/11"},{"id":380073,"name":"Liganded Gi-activating GPCR acts as a GEF for Gi"},{"id":391913,"name":"FPR2 binds FPR2 ligands"},{"id":481007,"name":"Exocytosis of platelet alpha granule contents"},{"name":"Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq","id":749448},{"id":749452,"name":"The Ligand:GPCR:Gq complex dissociates"},{"name":"The Ligand:GPCR:Gi complex dissociates","id":749454},{"name":"Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi","id":749456},{"id":844440,"name":"NLRP3 activation by elicitor proteins"},{"name":"NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction","id":844610},{"id":844612,"name":"PYCARD recruits procaspase-1 via CARD"},{"name":"AGER binds ERK1/2","id":879362},{"id":879411,"name":"Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor"},{"id":976734,"name":"Amyloid fibrils have additional components"},{"id":977136,"name":"Amyloid precursor proteins form ordered fibrils"},{"name":"AGER binds rat ERK1/2","id":997411},{"name":"NLRP3 oligomerizes via NACHT domains","id":1296421},{"id":2467665,"name":"AGRN binds Beta amyloid fibril via GAG chains"},{"name":"AP4 transports APP from trans-Golgi network to endosome lumen","id":5229111},{"id":5229132,"name":"AP4 binds APP"},{"name":"BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)","id":5692495},{"id":6783332,"name":"APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region"},{"id":8863009,"name":"Influx of extracellular calcium"},{"id":8870710,"name":"APP gene expression"},{"name":"SORL1 binds APP(18-770)","id":8871494},{"id":8871506,"name":"SORL1 transports APP(18-770) from endosome lumen to Golgi lumen"},{"id":8952289,"name":"FAM20C phosphorylates FAM20C substrates"},{"id":9010034,"name":"ADAM10:Zn2+:TSPANs cleaves APP(18-770)"},{"id":9010091,"name":"APP translocates from plasma membrane to endosome lumen"},{"name":"Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)","id":9010096},{"id":9617595,"name":"SGTA binds mislocalized membrane protein"},{"name":"BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP","id":9617596}],"description":"amyloid beta precursor protein","discontinued":null,"clinvar_pathogenic":26,"geneconstraints_synonymous":0.388,"ensembl_gene_stable_id":["ENSG00000142192"],"geneconstraint":1,"start_pos":"25880550","genesymbol":"APP","chromosome":21,"geneconstraints_missense":2.252,"geneconstraints_lof":0.999,"changed_to":null}]