Results

Transcript	Gene symbol	Prediction	Tree vote	Model	Splice site change	Amino acid changes	Variant type	Protein length	Features at a glance
ENST00000360870	TTN	Deleterious	10\|0	complex_aae	No	E5506*	Single base exchange	Slightly truncated protein, might cause NMD (-99 AA / less than 10% missing)	Amino acid sequence changed Protein features (might be) affected Truncated protein (might cause NMD)
ENST00000426232	TTN	Deleterious	110\|90	without_aae	No		Single base exchange	N/A
ENST00000436599	TTN	Deleterious	122\|78	without_aae	No		Single base exchange	N/A
ENST00000446966	TTN	Deleterious	125\|75	without_aae	No		Single base exchange	N/A
ENST00000425332	TTN	Deleterious	133\|67	without_aae	No		Single base exchange	N/A
ENST00000412264	TTN	Deleterious	136\|64	without_aae	No		Single base exchange	N/A
ENST00000460472	TTN	Deleterious	138\|62	without_aae	No		Single base exchange	N/A
ENST00000342175	TTN	Deleterious	140\|60	without_aae	No		Single base exchange	N/A
ENST00000359218	TTN	Deleterious	141\|59	without_aae	No		Single base exchange	N/A
ENST00000715174	TTN	Benign	10\|190	without_aae	No		Single base exchange	N/A
ENST00000589042(MANE Select)	TTN	Benign	74\|126	without_aae	No		Single base exchange	N/A
ENST00000591111	TTN	Benign	90\|110	without_aae	No		Single base exchange	N/A
ENST00000342992	TTN	Benign	96\|104	without_aae	No		Single base exchange	N/A

Variant:

2:178745884C>A_12_ENST00000360870

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Amino acid sequence changed
Protein features (might be) affected
Truncated protein (might cause NMD)

Model: complex_aae
Tree vote: 10|0 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.52, LOF (oe): 0.46, misssense (oe): 0.96, synonymous (oe): 0.94 ? (gnomAD)

Ensembl transcript ID

ENST00000360870.10

Genbank transcript ID

NM_133379 (by similarity)

UniProt / AlphaMissense peptide

TITIN_HUMAN | AlphaMissense: transcript, gene

Variant type

Single base exchange

Gene region

CDS

DNA changes

c.16516G>T
g.84919G>T

AA changes

AAE:

E5506*

F5507-

Q5508-

V5509-

V5510-

E5511-

G5512-

P5513-

P5514-

R5515-

F5516-

I5517-

K5518-

G5519-

I5520-

S5521-

D5522-

C5523-

Y5524-

A5525-

P5526-

I5527-

G5528-

T5529-

A5530-

A5531-

Y5532-

F5533-

Q5534-

C5535-

L5536-

V5537-

R5538-

G5539-

S5540-

P5541-

R5542-

P5543-

T5544-

V5545-

Y5546-

W5547-

Y5548-

K5549-

D5550-

G5551-

K5552-

L5553-

V5554-

Q5555-

G5556-

R5557-

R5558-

F5559-

T5560-

V5561-

E5562-

E5563-

S5564-

G5565-

T5566-

G5567-

F5568-

H5569-

N5570-

L5571-

F5572-

I5573-

T5574-

S5575-

L5576-

V5577-

K5578-

S5579-

D5580-

E5581-

G5582-

E5583-

Y5584-

R5585-

C5586-

V5587-

A5588-

T5589-

N5590-

K5591-

S5592-

G5593-

M5594-

A5595-

E5596-

S5597-

F5598-

A5599-

A5600-

L5601-

T5602-

L5603-

T5604-

*5605-

Score:

Frameshift

Length of protein

Slightly truncated protein, might cause NMD (-99 AA / less than 10% missing)

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

Species	Match	AA	Alignment
Human		5506	V	L	K	S	N	Y	T	D	S	F	F	E	F	Q	V	V	E	G	P	P	R	F	I	K	G	I	S	D	C	Y	A	P	I	G	T	A	A	Y	F	Q	C	L	V	R	G	S	P	R	P	T	V	Y	W	Y	K	D	G	K	L	V	Q	G	R	R	F	T	V	E	E	S	G	T	G	F	H	N	L	F	I	T	S	L	V	K	S	D	E	G	E	Y	R	C	V	A	T	N	K	S	G	M	A	E	S	F	A	A	L
mutated	partly conserved	1423	V	S	R	S	P	I	R	M	S	P	A	R	M	S	P	A	RMSPARM	S	P	A	R	M	S	P	GRRLEE	T	D	E	S	Q	L	E	R	L	Y	K	P	V	F	V	L	K	P	V	S	F	K	C	L	E	G	Q	T	A	R	F	D	L	K	V	V	G	R	P	M	P	E	T	F	W	F	H	D	G	Q	Q	I	V	N	D	Y	T	H	K	V
Ptroglodytes	no homologue
Mmulatta	no homologue
Fcatus	no homologue
Mmusculus	no homologue
Ggallus	no homologue
Trubripes	no homologue
Drerio	no homologue
Dmelanogaster	no homologue
Celegans	no homologue
Xtropicalis	no homologue

Protein features

Start (aa)	End (aa)	Feature	Details
1	34350	CHAIN		lost
5505	5594	DOMAIN	Ig-like	lost
5602	5690	DOMAIN	Ig-like	lost
5623	5623	DISULFID		lost
5695	5783	DOMAIN	Ig-like	lost
5788	5877	DOMAIN	Ig-like	lost
5810	5810	DISULFID		lost
5882	5970	DOMAIN	Ig-like	lost
5903	5903	DISULFID		lost
5975	6063	DOMAIN	Ig-like	lost
6067	6156	DOMAIN	Ig-like	lost
6164	6252	DOMAIN	Ig-like	lost
6185	6185	DISULFID		lost
6257	6347	DOMAIN	Ig-like	lost
6350	6440	DOMAIN	Ig-like	lost
6372	6372	DISULFID		lost
6444	6534	DOMAIN	Ig-like	lost
6465	6465	DISULFID		lost
6537	6626	DOMAIN	Ig-like	lost
6630	6721	DOMAIN	Ig-like	lost
6727	6815	DOMAIN	Ig-like	lost
6748	6748	DISULFID		lost
6820	6908	DOMAIN	Ig-like	lost
6912	7001	DOMAIN	Ig-like	lost
6920	6920	MOD_RES	Phosphoserine	lost
7005	7093	DOMAIN	Ig-like	lost
7027	7027	DISULFID		lost
7102	7190	DOMAIN	Ig-like	lost
7123	7123	DISULFID		lost
7198	7286	DOMAIN	Ig-like	lost
7219	7219	DISULFID		lost
7291	7380	DOMAIN	Ig-like	lost
7313	7313	DISULFID		lost
7385	7473	DOMAIN	Ig-like	lost
7406	7406	DISULFID		lost
7478	7567	DOMAIN	Ig-like	lost
7571	7662	DOMAIN	Ig-like	lost
7668	7756	DOMAIN	Ig-like	lost
7689	7689	DISULFID		lost
7761	7849	DOMAIN	Ig-like	lost
7853	7942	DOMAIN	Ig-like	lost
7946	8035	DOMAIN	Ig-like	lost
7968	7968	DISULFID		lost
8042	8133	DOMAIN	Ig-like	lost
8064	8064	DISULFID		lost
8138	8229	DOMAIN	Ig-like	lost
8160	8160	DISULFID		lost
8232	8321	DOMAIN	Ig-like	lost
8254	8254	DISULFID		lost
8326	8414	DOMAIN	Ig-like	lost
8347	8347	DISULFID		lost
8419	8508	DOMAIN	Ig-like	lost
8512	8603	DOMAIN	Ig-like	lost
8609	8697	DOMAIN	Ig-like	lost
8630	8630	DISULFID		lost
8702	8790	DOMAIN	Ig-like	lost
8794	8883	DOMAIN	Ig-like	lost
8888	8976	DOMAIN	Ig-like	lost
8909	8909	DISULFID		lost
8984	9074	DOMAIN	Ig-like	lost
9005	9005	DISULFID		lost
9079	9168	DOMAIN	Ig-like	lost
9101	9101	DISULFID		lost
9122	9122	MOD_RES	Phosphoserine	lost
9176	9265	DOMAIN	Ig-like	lost
9272	9361	DOMAIN	Ig-like	lost
9294	9294	DISULFID		lost
9366	9470	DOMAIN	Ig-like	lost
9506	9510	HELIX		lost
9518	9525	HELIX		lost
9530	9543	HELIX		lost
9534	9577	COILED		lost
9582	9587	STRAND		lost
9592	9595	STRAND		lost
9600	9608	STRAND		lost
9616	9619	STRAND		lost
9628	9635	STRAND		lost
9638	9643	STRAND		lost
9648	9650	HELIX		lost
9652	9658	STRAND		lost
9660	9755	DOMAIN	Ig-like	lost
9661	9670	STRAND		lost
9674	9676	STRAND		lost
9681	9684	STRAND		lost
9689	9697	STRAND		lost
9693	9693	DISULFID		lost
9703	9706	STRAND		lost
9717	9722	STRAND		lost
9725	9732	STRAND		lost
9735	9737	HELIX		lost
9739	9745	STRAND		lost
9748	9757	STRAND		lost
9760	9851	DOMAIN	Ig-like	lost
9763	9765	STRAND		lost
9770	9772	STRAND		lost
9778	9786	STRAND		lost
9790	9795	STRAND		lost
9803	9811	STRAND		lost
9814	9819	STRAND		lost
9824	9826	HELIX		lost
9828	9835	STRAND		lost
9841	9850	STRAND		lost
9920	9936	COMPBIAS	Basic and acidic residues	lost
9920	9945	REGION		lost
10039	10070	REGION		lost
10044	10070	COMPBIAS	Acidic residues	lost
10087	10109	REGION		lost
10207	10221	COMPBIAS	Basic and acidic residues	lost
10207	10280	REGION		lost
10216	10242	REPEAT	PEVK	lost
10222	10246	COMPBIAS	Pro residues	lost
10244	10270	REPEAT	PEVK	lost
10247	10261	COMPBIAS	Basic and acidic residues	lost
10272	10298	REPEAT	PEVK	lost
10300	10326	REPEAT	PEVK	lost
10314	10361	REGION		lost
10327	10353	REPEAT	PEVK	lost
10330	10350	COMPBIAS	Basic and acidic residues	lost
10355	10381	REPEAT	PEVK	lost
10412	10457	REGION		lost
10439	10457	COMPBIAS	Acidic residues	lost
10499	10566	REGION		lost
10505	10566	COMPBIAS	Basic and acidic residues	lost
10508	10534	REPEAT	PEVK	lost
10536	10562	REPEAT	PEVK	lost
10583	10617	REGION		lost
10592	10618	REPEAT	PEVK	lost
10661	10743	REGION		lost
10666	10704	COMPBIAS	Acidic residues	lost
10719	10736	COMPBIAS	Pro residues	lost
10878	10904	REPEAT	PEVK	lost
10882	10948	COMPBIAS	Basic and acidic residues	lost
10882	11102	REGION		lost
10906	10930	REPEAT	PEVK	lost
10932	10958	REPEAT	PEVK	lost
10960	10986	REPEAT	PEVK	lost
10987	11014	REPEAT	PEVK	lost
10991	11016	COMPBIAS	Basic and acidic residues	lost
11032	11098	COMPBIAS	Acidic residues	lost
11158	11193	REGION		lost
11162	11187	COMPBIAS	Acidic residues	lost
11362	11636	REGION		lost
11363	11396	REPEAT	PEVK	lost
11384	11417	COMPBIAS	Basic and acidic residues	lost
11397	11421	REPEAT	PEVK	lost
11453	11479	REPEAT	PEVK	lost
11481	11507	REPEAT	PEVK	lost
11503	11503	MOD_RES	Phosphoserine	lost
11509	11535	REPEAT	PEVK	lost
11537	11563	REPEAT	PEVK	lost
11565	11591	REPEAT	PEVK	lost
11592	11609	COMPBIAS	Acidic residues	lost
11610	11630	COMPBIAS	Pro residues	lost
11657	11683	REPEAT	PEVK	lost
11666	12032	REGION		lost
11680	11694	COMPBIAS	Basic and acidic residues	lost
11703	11729	REPEAT	PEVK	lost
11745	11771	REPEAT	PEVK	lost
11770	11804	COMPBIAS	Basic and acidic residues	lost
11775	11801	REPEAT	PEVK	lost
11816	11841	COMPBIAS	Basic and acidic residues	lost
11836	11862	REPEAT	PEVK	lost
11850	11904	COMPBIAS	Basic and acidic residues	lost
11864	11890	REPEAT	PEVK	lost
11893	11919	REPEAT	PEVK	lost
11917	11933	COMPBIAS	Basic and acidic residues	lost
11929	11955	REPEAT	PEVK	lost
11935	11949	COMPBIAS	Pro residues	lost
11966	11992	REPEAT	PEVK	lost
11984	11999	COMPBIAS	Basic and acidic residues	lost
11996	12022	REPEAT	PEVK	lost
12007	12007	MOD_RES	Phosphothreonine	lost
12008	12024	COMPBIAS	Basic and acidic residues	lost
12009	12009	MOD_RES	Phosphoserine	lost
12022	12022	MOD_RES	Phosphoserine	lost
12041	12133	DOMAIN	Ig-like	lost
12067	12067	DISULFID		lost
12138	12222	DOMAIN	Ig-like	lost
12233	12318	DOMAIN	Ig-like	lost
12499	12584	DOMAIN	Ig-like	lost
12590	12672	DOMAIN	Ig-like	lost
12611	12611	DISULFID		lost
12680	12682	STRAND		lost
12687	12690	STRAND		lost
12691	12693	STRAND		lost
12695	12705	STRAND		lost
12709	12712	STRAND		lost
12719	12722	STRAND		lost
12723	12728	STRAND		lost
12731	12736	STRAND		lost
12741	12743	HELIX		lost
12745	12751	STRAND		lost
12754	12763	STRAND		lost
12766	12850	DOMAIN	Ig-like	lost
12945	13032	DOMAIN	Ig-like	lost
12966	12966	DISULFID		lost
13120	13206	DOMAIN	Ig-like	lost
13210	13295	DOMAIN	Ig-like	lost
13233	13233	DISULFID		lost
13299	13384	DOMAIN	Ig-like	lost
13322	13322	DISULFID		lost
13388	13478	DOMAIN	Ig-like	lost
13411	13411	DISULFID		lost
13479	13562	DOMAIN	Ig-like	lost
13565	13655	DOMAIN	Ig-like	lost
13659	13748	DOMAIN	Ig-like	lost
13749	13833	DOMAIN	Ig-like	lost
13771	13771	DISULFID		lost
13927	14012	DOMAIN	Ig-like	lost
14019	14114	DOMAIN	Fibronectin type-III	lost
14120	14215	DOMAIN	Fibronectin type-III	lost
14216	14236	REGION		lost
14221	14236	COMPBIAS	Polar residues	lost
14221	14316	DOMAIN	Fibronectin type-III	lost
14223	14228	STRAND		lost
14232	14240	STRAND		lost
14252	14259	STRAND		lost
14275	14281	STRAND		lost
14288	14296	STRAND		lost
14308	14314	STRAND		lost
14319	14322	STRAND		lost
14325	14327	HELIX		lost
14331	14334	STRAND		lost
14339	14349	STRAND		lost
14352	14357	STRAND		lost
14368	14372	STRAND		lost
14374	14381	STRAND		lost
14386	14388	HELIX		lost
14390	14397	STRAND		lost
14402	14412	STRAND		lost
14417	14513	DOMAIN	Fibronectin type-III	lost
14419	14424	STRAND		lost
14431	14436	STRAND		lost
14446	14455	STRAND		lost
14462	14468	STRAND		lost
14470	14475	STRAND		lost
14484	14492	STRAND		lost
14506	14509	STRAND		lost
14517	14614	DOMAIN	Fibronectin type-III	lost
14522	14524	STRAND		lost
14528	14534	STRAND		lost
14549	14555	STRAND		lost
14568	14576	STRAND		lost
14584	14592	STRAND		lost
14615	14708	DOMAIN	Ig-like	lost
14713	14806	DOMAIN	Fibronectin type-III	lost
14812	14907	DOMAIN	Fibronectin type-III	lost
14891	14921	REGION		lost
14913	15007	DOMAIN	Fibronectin type-III	lost
15010	15107	DOMAIN	Fibronectin type-III	lost
15113	15207	DOMAIN	Fibronectin type-III	lost
15214	15310	DOMAIN	Fibronectin type-III	lost
15216	15224	STRAND		lost
15227	15233	STRAND		lost
15245	15252	STRAND		lost
15268	15273	STRAND		lost
15282	15290	STRAND		lost
15305	15307	STRAND		lost
15314	15402	DOMAIN	Ig-like	lost
15409	15503	DOMAIN	Fibronectin type-III	lost
15509	15604	DOMAIN	Fibronectin type-III	lost
15608	15724	DOMAIN	Ig-like	lost
15731	15826	DOMAIN	Fibronectin type-III	lost
15832	15926	DOMAIN	Fibronectin type-III	lost
15911	15939	REGION		lost
15922	15936	COMPBIAS	Pro residues	lost
15929	16025	DOMAIN	Fibronectin type-III	lost
16029	16119	DOMAIN	Ig-like	lost
16126	16218	DOMAIN	Fibronectin type-III	lost
16224	16318	DOMAIN	Fibronectin type-III	lost
16322	16420	DOMAIN	Ig-like	lost
16427	16522	DOMAIN	Fibronectin type-III	lost
16528	16628	DOMAIN	Fibronectin type-III	lost
16533	16538	STRAND		lost
16541	16546	STRAND		lost
16559	16566	STRAND		lost
16585	16592	STRAND		lost
16600	16609	STRAND		lost
16614	16654	REGION		lost
16621	16638	COMPBIAS	Pro residues	lost
16623	16626	STRAND		lost
16634	16734	DOMAIN	Fibronectin type-III	lost
16727	16834	DOMAIN	Ig-like	lost
16841	16934	DOMAIN	Fibronectin type-III	lost
16941	17041	DOMAIN	Fibronectin type-III	lost
17044	17139	DOMAIN	Ig-like	lost
17147	17240	DOMAIN	Fibronectin type-III	lost
17246	17345	DOMAIN	Fibronectin type-III	lost
17348	17445	DOMAIN	Fibronectin type-III	lost
17449	17536	DOMAIN	Ig-like	lost
17545	17640	DOMAIN	Fibronectin type-III	lost
17646	17741	DOMAIN	Fibronectin type-III	lost
17745	17834	DOMAIN	Ig-like	lost
17842	17935	DOMAIN	Fibronectin type-III	lost
17941	18036	DOMAIN	Fibronectin type-III	lost
18042	18139	DOMAIN	Fibronectin type-III	lost
18143	18228	DOMAIN	Ig-like	lost
18239	18333	DOMAIN	Fibronectin type-III	lost
18339	18431	DOMAIN	Fibronectin type-III	lost
18435	18526	DOMAIN	Ig-like	lost
18533	18632	DOMAIN	Fibronectin type-III	lost
18614	18637	REGION		lost
18633	18727	DOMAIN	Fibronectin type-III	lost
18716	18743	REGION		lost
18733	18829	DOMAIN	Fibronectin type-III	lost
18833	18924	DOMAIN	Ig-like	lost
18931	19025	DOMAIN	Fibronectin type-III	lost
19030	19124	DOMAIN	Fibronectin type-III	lost
19128	19219	DOMAIN	Ig-like	lost
19226	19321	DOMAIN	Fibronectin type-III	lost
19304	19331	REGION		lost
19315	19331	COMPBIAS	Basic and acidic residues	lost
19325	19420	DOMAIN	Fibronectin type-III	lost
19426	19527	DOMAIN	Fibronectin type-III	lost
19531	19617	DOMAIN	Ig-like	lost
19628	19722	DOMAIN	Fibronectin type-III	lost
19728	19823	DOMAIN	Fibronectin type-III	lost
19826	19914	DOMAIN	Ig-like	lost
19921	20017	DOMAIN	Fibronectin type-III	lost
20018	20116	DOMAIN	Fibronectin type-III	lost
20119	20217	DOMAIN	Fibronectin type-III	lost
20220	20311	DOMAIN	Ig-like	lost
20318	20411	DOMAIN	Fibronectin type-III	lost
20417	20512	DOMAIN	Fibronectin type-III	lost
20518	20613	DOMAIN	Fibronectin type-III	lost
20520	20528	STRAND		lost
20531	20537	STRAND		lost
20549	20556	STRAND		lost
20568	20570	HELIX		lost
20573	20580	STRAND		lost
20587	20594	STRAND		lost
20716	20813	DOMAIN	Fibronectin type-III	lost
20814	20908	DOMAIN	Fibronectin type-III	lost
20893	20996	DOMAIN	Ig-like	lost
21006	21101	DOMAIN	Fibronectin type-III	lost
21105	21200	DOMAIN	Fibronectin type-III	lost
21203	21299	DOMAIN	Fibronectin type-III	lost
21303	21395	DOMAIN	Ig-like	lost
21402	21495	DOMAIN	Fibronectin type-III	lost
21501	21596	DOMAIN	Fibronectin type-III	lost
21506	21509	STRAND		lost
21515	21518	STRAND		lost
21532	21539	STRAND		lost
21546	21551	STRAND		lost
21553	21560	STRAND		lost
21568	21577	STRAND		lost
21602	21697	DOMAIN	Fibronectin type-III	lost
21701	21793	DOMAIN	Ig-like	lost
21797	21891	DOMAIN	Fibronectin type-III	lost
21894	21986	DOMAIN	Fibronectin type-III	lost
21990	22083	DOMAIN	Ig-like	lost
22088	22182	DOMAIN	Fibronectin type-III	lost
22188	22283	DOMAIN	Fibronectin type-III	lost
22286	22382	DOMAIN	Fibronectin type-III	lost
22291	22296	STRAND		lost
22299	22303	STRAND		lost
22319	22324	STRAND		lost
22340	22345	STRAND		lost
22354	22361	STRAND		lost
22367	22377	STRAND		lost
22381	22384	HELIX		lost
22386	22477	DOMAIN	Ig-like	lost
22484	22578	DOMAIN	Fibronectin type-III	lost
22584	22679	DOMAIN	Fibronectin type-III	lost
22685	22781	DOMAIN	Fibronectin type-III	lost
22785	22874	DOMAIN	Ig-like	lost
22881	22976	DOMAIN	Fibronectin type-III	lost
22883	22890	STRAND		lost
22895	22900	STRAND		lost
22912	22919	STRAND		lost
22926	22932	STRAND		lost
22934	22939	STRAND		lost
22947	22956	STRAND		lost
22970	22972	STRAND		lost
22978	23071	DOMAIN	Fibronectin type-III	lost
22982	22987	STRAND		lost
22992	22996	STRAND		lost
23009	23016	STRAND		lost
23023	23035	STRAND		lost
23043	23052	STRAND		lost
23075	23163	DOMAIN	Ig-like	lost
23170	23264	DOMAIN	Fibronectin type-III	lost
23270	23364	DOMAIN	Fibronectin type-III	lost
23368	23463	DOMAIN	Fibronectin type-III	lost
23468	23555	DOMAIN	Ig-like	lost
23566	23660	DOMAIN	Fibronectin type-III	lost
23568	23575	STRAND		lost
23581	23586	STRAND		lost
23596	23605	STRAND		lost
23612	23618	STRAND		lost
23620	23625	STRAND		lost
23633	23642	STRAND		lost
23666	23761	DOMAIN	Fibronectin type-III	lost
23671	23676	STRAND		lost
23679	23683	STRAND		lost
23697	23704	STRAND		lost
23711	23716	STRAND		lost
23720	23725	STRAND		lost
23733	23742	STRAND		lost
23767	23863	DOMAIN	Fibronectin type-III	lost
23769	23776	STRAND		lost
23781	23786	STRAND		lost
23798	23805	STRAND		lost
23806	23808	TURN		lost
23811	23815	STRAND		lost
23820	23827	STRAND		lost
23835	23843	STRAND		lost
23867	23954	DOMAIN	Ig-like	lost
23963	24057	DOMAIN	Fibronectin type-III	lost
24060	24153	DOMAIN	Fibronectin type-III	lost
24157	24241	DOMAIN	Ig-like	lost
24252	24346	DOMAIN	Fibronectin type-III	lost
24352	24446	DOMAIN	Fibronectin type-III	lost
24450	24546	DOMAIN	Fibronectin type-III	lost
24550	24641	DOMAIN	Ig-like	lost
24648	24742	DOMAIN	Fibronectin type-III	lost
24748	24843	DOMAIN	Fibronectin type-III	lost
24849	24945	DOMAIN	Fibronectin type-III	lost
24949	25038	DOMAIN	Ig-like	lost
25045	25139	DOMAIN	Fibronectin type-III	lost
25142	25235	DOMAIN	Fibronectin type-III	lost
25239	25325	DOMAIN	Ig-like	lost
25335	25428	DOMAIN	Fibronectin type-III	lost
25434	25529	DOMAIN	Fibronectin type-III	lost
25439	25443	STRAND		lost
25448	25451	STRAND		lost
25465	25472	STRAND		lost
25479	25481	STRAND		lost
25486	25493	STRAND		lost
25501	25509	STRAND		lost
25514	25517	STRAND		lost
25532	25627	DOMAIN	Fibronectin type-III	lost
25632	25722	DOMAIN	Ig-like	lost
25731	25825	DOMAIN	Fibronectin type-III	lost
25831	25926	DOMAIN	Fibronectin type-III	lost
25932	26028	DOMAIN	Fibronectin type-III	lost
26032	26121	DOMAIN	Ig-like	lost
26128	26222	DOMAIN	Fibronectin type-III	lost
26130	26137	STRAND		lost
26142	26147	STRAND		lost
26157	26166	STRAND		lost
26173	26179	STRAND		lost
26181	26186	STRAND		lost
26194	26203	STRAND		lost
26206	26212	STRAND		lost
26225	26318	DOMAIN	Fibronectin type-III	lost
26322	26410	DOMAIN	Ig-like	lost
26417	26510	DOMAIN	Fibronectin type-III	lost
26516	26611	DOMAIN	Fibronectin type-III	lost
26614	26710	DOMAIN	Fibronectin type-III	lost
26714	26801	DOMAIN	Ig-like	lost
26812	26906	DOMAIN	Fibronectin type-III	lost
26912	27007	DOMAIN	Fibronectin type-III	lost
27013	27107	DOMAIN	Fibronectin type-III	lost
27090	27110	REGION		lost
27101	27196	DOMAIN	Ig-like	lost
27205	27296	DOMAIN	Fibronectin type-III	lost
27302	27392	DOMAIN	Fibronectin type-III	lost
27499	27593	DOMAIN	Fibronectin type-III	lost
27599	27694	DOMAIN	Fibronectin type-III	lost
27697	27793	DOMAIN	Fibronectin type-III	lost
27797	27888	DOMAIN	Ig-like	lost
27895	27989	DOMAIN	Fibronectin type-III	lost
27995	28090	DOMAIN	Fibronectin type-III	lost
28096	28192	DOMAIN	Fibronectin type-III	lost
28196	28286	DOMAIN	Ig-like	lost
28295	28389	DOMAIN	Fibronectin type-III	lost
28392	28484	DOMAIN	Fibronectin type-III	lost
28488	28577	DOMAIN	Ig-like	lost
28583	28680	DOMAIN	Fibronectin type-III	lost
28686	28781	DOMAIN	Fibronectin type-III	lost
28784	28879	DOMAIN	Fibronectin type-III	lost
28882	28974	DOMAIN	Ig-like	lost
28979	29071	DOMAIN	Fibronectin type-III	lost
29081	29177	DOMAIN	Fibronectin type-III	lost
29180	29278	DOMAIN	Fibronectin type-III	lost
29282	29367	DOMAIN	Ig-like	lost
29378	29473	DOMAIN	Fibronectin type-III	lost
29475	29568	DOMAIN	Fibronectin type-III	lost
29568	29663	DOMAIN	Ig-like	lost
29670	29764	DOMAIN	Fibronectin type-III	lost
29770	29865	DOMAIN	Fibronectin type-III	lost
29868	29967	DOMAIN	Fibronectin type-III	lost
29971	30059	DOMAIN	Ig-like	lost
30070	30163	DOMAIN	Fibronectin type-III	lost
30169	30265	DOMAIN	Fibronectin type-III	lost
30271	30367	DOMAIN	Fibronectin type-III	lost
30371	30460	DOMAIN	Ig-like	lost
30443	30443	MOD_RES	Phosphothreonine	lost
30467	30561	DOMAIN	Fibronectin type-III	lost
30564	30658	DOMAIN	Fibronectin type-III	lost
30663	30754	DOMAIN	Ig-like	lost
30761	30855	DOMAIN	Fibronectin type-III	lost
30861	30956	DOMAIN	Fibronectin type-III	lost
30962	31058	DOMAIN	Fibronectin type-III	lost
31061	31150	DOMAIN	Ig-like	lost
31158	31254	DOMAIN	Fibronectin type-III	lost
31238	31267	REGION		lost
31249	31263	COMPBIAS	Pro residues	lost
31258	31354	DOMAIN	Fibronectin type-III	lost
31360	31455	DOMAIN	Fibronectin type-III	lost
31458	31464	STRAND		lost
31460	31548	DOMAIN	Ig-like	lost
31469	31472	STRAND		lost
31475	31487	STRAND		lost
31481	31481	DISULFID		lost
31490	31495	STRAND		lost
31498	31500	STRAND		lost
31504	31520	STRAND		lost
31524	31526	HELIX		lost
31528	31535	STRAND		lost
31540	31555	STRAND		lost
31563	31568	STRAND		lost
31573	31583	STRAND		lost
31586	31591	STRAND		lost
31600	31606	STRAND		lost
31608	31617	STRAND		lost
31620	31623	HELIX		lost
31625	31632	STRAND		lost
31637	31647	STRAND		lost
31653	31748	DOMAIN	Fibronectin type-III	lost
31754	31849	DOMAIN	Fibronectin type-III	lost
31855	31945	DOMAIN	Ig-like	lost
31856	31859	STRAND		lost
31864	31867	STRAND		lost
31872	31879	STRAND		lost
31885	31890	STRAND		lost
31893	31895	STRAND		lost
31899	31907	STRAND		lost
31908	31910	TURN		lost
31911	31916	STRAND		lost
31921	31923	HELIX		lost
31925	31933	STRAND		lost
31936	31952	STRAND		lost
31955	32046	DOMAIN	Ig-like	lost
31956	31959	HELIX		lost
31961	31967	STRAND		lost
31973	31982	STRAND		lost
31985	31992	STRAND		lost
31997	32000	STRAND		lost
32002	32005	STRAND		lost
32007	32013	STRAND		lost
32020	32022	HELIX		lost
32024	32032	STRAND		lost
32035	32046	STRAND		lost
32051	32144	DOMAIN	Fibronectin type-III	lost
32053	32061	STRAND		lost
32063	32070	STRAND		lost
32076	32078	STRAND		lost
32082	32089	STRAND		lost
32095	32111	STRAND		lost
32117	32125	STRAND		lost
32142	32154	HELIX		lost
32167	32170	STRAND		lost
32175	32177	TURN		lost
32178	32186	STRAND		lost
32178	32432	DOMAIN	Protein kinase	lost
32184	32192	BINDING	ATP	lost
32188	32197	STRAND		lost
32198	32201	TURN		lost
32202	32209	STRAND		lost
32207	32207	BINDING	ATP	lost
32214	32228	HELIX		lost
32237	32243	STRAND		lost
32246	32251	STRAND		lost
32259	32263	HELIX		lost
32265	32267	STRAND		lost
32272	32291	HELIX		lost
32298	32298	ACT_SITE		lost
32301	32303	HELIX		lost
32304	32310	STRAND		lost
32314	32316	STRAND		lost
32330	32336	STRAND		lost
32338	32340	HELIX		lost
32341	32341	MOD_RES	Phosphotyrosine	lost
32343	32346	HELIX		lost
32353	32369	HELIX		lost
32379	32388	HELIX		lost
32395	32398	HELIX		lost
32403	32410	HELIX		lost
32417	32419	HELIX		lost
32423	32428	HELIX		lost
32430	32433	HELIX		lost
32436	32438	HELIX		lost
32447	32457	HELIX		lost
32466	32472	HELIX		lost
32474	32476	STRAND		lost
32483	32489	STRAND		lost
32496	32584	DOMAIN	Ig-like	lost
32504	32506	STRAND		lost
32512	32520	STRAND		lost
32516	32516	DISULFID		lost
32526	32531	STRAND		lost
32538	32547	STRAND		lost
32550	32555	STRAND		lost
32560	32562	HELIX		lost
32564	32571	STRAND		lost
32576	32585	STRAND		lost
32586	32588	TURN		lost
32617	32710	DOMAIN	Ig-like	lost
32720	32726	STRAND		lost
32722	32811	DOMAIN	Ig-like	lost
32731	32734	STRAND		lost
32739	32749	STRAND		lost
32752	32757	STRAND		lost
32765	32767	TURN		lost
32768	32773	STRAND		lost
32774	32776	TURN		lost
32777	32784	STRAND		lost
32787	32789	HELIX		lost
32791	32799	STRAND		lost
32802	32813	STRAND		lost
33213	33256	REGION		lost
33221	33240	COMPBIAS	Basic and acidic residues	lost
33245	33245	MOD_RES	Phosphoserine	lost
33247	33247	MOD_RES	Phosphoserine	lost
33294	33297	TURN		lost
33299	33305	STRAND		lost
33301	33391	DOMAIN	Ig-like	lost
33310	33313	STRAND		lost
33318	33328	STRAND		lost
33331	33336	STRAND		lost
33345	33352	STRAND		lost
33355	33360	STRAND		lost
33365	33367	HELIX		lost
33369	33377	STRAND		lost
33380	33391	STRAND		lost
33432	33460	COMPBIAS	Polar residues	lost
33432	33463	REGION		lost
33488	33576	DOMAIN	Ig-like	lost
33489	33492	STRAND		lost
33497	33503	STRAND		lost
33509	33512	STRAND		lost
33514	33516	STRAND		lost
33523	33526	STRAND		lost
33532	33538	STRAND		lost
33540	33547	STRAND		lost
33556	33560	STRAND		lost
33571	33577	STRAND		lost
33584	33638	REGION		lost
33597	33617	COMPBIAS	Basic and acidic residues	lost
33602	33602	MOD_RES	Phosphoserine	lost
33614	33614	MOD_RES	Phosphoserine	lost
33645	33732	DOMAIN	Ig-like	lost
33664	33664	DISULFID		lost
33749	33767	COMPBIAS	Basic and acidic residues	lost
33749	33777	REGION		lost
33777	33783	STRAND		lost
33779	33867	DOMAIN	Ig-like	lost
33788	33794	STRAND		lost
33796	33806	STRAND		lost
33809	33814	STRAND		lost
33821	33830	STRAND		lost
33833	33838	STRAND		lost
33843	33845	HELIX		lost
33847	33855	STRAND		lost
33858	33869	STRAND		lost
33963	34052	DOMAIN	Ig-like	lost
34060	34071	STRAND		lost
34061	34149	DOMAIN	Ig-like	lost
34078	34088	STRAND		lost
34091	34096	STRAND		lost
34104	34106	TURN		lost
34107	34112	STRAND		lost
34115	34122	STRAND		lost
34125	34127	HELIX		lost
34129	34136	STRAND		lost
34138	34148	STRAND		lost
34254	34258	STRAND		lost
34256	34344	DOMAIN	Ig-like	lost
34263	34268	STRAND		lost
34271	34283	STRAND		lost
34286	34291	STRAND		lost
34300	34302	HELIX		lost
34304	34308	STRAND		lost
34310	34319	STRAND		lost
34322	34324	HELIX		lost
34326	34334	STRAND		lost
34337	34348	STRAND		lost

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

poly(A) signal

N/A

AA sequence altered

Yes

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered cDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Wildtype AA sequence

Mutated AA sequence

Position of stopcodon in wt / mu CDS

16815 / 16518

Position (AA) of stopcodon in wt / mu AA sequence

5605 / 5506

Position of stopcodon in wt / mu cDNA

17040 / 16743

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

10585

Theoretical NMD boundary in CDS

10309

Length of CDS

16815

Coding sequence (CDS) position

16516

cDNA position

16741

gDNA position

84919

Chromosomal position

178745884

Speed

0.10 s

All positions are in basepairs (bp) if not explicitly stated differently. cDNA/gDNA/chromosomal position: Ins/del are shown as 'last normal base / first normal base'.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project

Back to summary table

Variant:

2:178745884C>A_6_ENST00000426232

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 110|90 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 1.06, LOF (oe): 0.71, misssense (oe): 1.17, synonymous (oe): 0.93 ? (gnomAD)

Ensembl transcript ID

ENST00000426232.6

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11312-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV
IPEGETPIVK RRKTPSPTVP ESPREIVPVK ETPMAAPLEI EIPPTKAPEA MKEVVPEMKI
FEDVPEEPET PRMKTPEAPQ EIIPAKTVPS KKREPPSVKV PEALQEIVPE KKTLVVPLRK
PEVLPDEVPE ALREVVPEKK VHPPQRAEVV PVKVHEAPKE IIPEKKVSVV PPKKPEVPPV
KVPEASKEVI REEKVPLAPP KEPEVPPVKV PEPPKEVVPE KKAPVAPPKE PEVPPVKVPE
APKEVVPEKK VPVPPPKKPE VPPTKVPEVP KAAVPEKKLP EAIPPKPESP PPEVPEVLPP
KEVVPEKKVP VPPAKKPEAP PPKVPEAPKE VVLEKKASVA VPKKPEAPRA KVPEAAQEVV
PEKKIPKAPI KKPEAPAVTV PEVPQEATEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP
KAPPTKPEAP PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPSAPPK
KPEVPPVKVP EAPKEVVPEK KVPVPPPKKP EVPPTKVPEV PKAAVPEKKV PEAIPPKPES
PPPEVPEVLP PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVLEKKASV AVPKKPEAPR
AKVPEAAQEV VPEKKIPKAP IKKPEAPAVT VPEVPQEAAE KEIPVAPPKK PEAPIVPVPE
AQEVVPEKKV PKAPPTKPEA PPATVPEVPQ EIVPEKKTLV LPKKPEVPPV TVPEAPKEVV
LEKKVPSTPP KKPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK
VPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP KEVVLEKKVS
VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAA EKEIPVAPPK
KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL VLPKKPEVPP
VTVPEAPKEV VLEKKVPLAP PKKPEVPPVK VPEAPKEVVP EKKVPVTPPK KPEVPPVKVP
EAPIEVVPEK KMPLAPPKKP EVPPVKVPEA PKEVVPEKKV PSAPPKKPEV PPVKVPEAPK
EVVPEKKVPA APPKKPEVTP VKVPEAPKEV VPEKKVPVPP PKKPEVPPTK VPEVPKVAVP
EKKVPEAIPP KPESPPPEVF EEPEEVALEE PPAEVVEEPE PAAPPQVTVP PKKPVPEKKA
PAVVAKKPEL PPVKVPEVPK EVVPEKKVPL VVPKKPEAPP AKVPEVPKEV VPEKKVAVPK
KPEVPPAKVP EVPKKPVLEE KPAVPVPERA ESPPPEVYEE PEEIAPEEEI APEEEKPVPV
AEEEEPEVPP PAVPEEPKKI IPEKKVPVIK KPEAPPPKEP EPEKVIEKPK LKPRPPPPPP
APPKEDVKEK IFQLKAIPKK KVPEKPQVPE KVELTPLKVP EPPPPKPVEE VEVPTVTKRE
RKIPEPTKVP EIKPAIPLPA PEPKPKPEAE VKTIKPPPVE PEPTPIAAPV TVPVVGKKAE
AKAPKEEAAK PKGPIKGVPK KTPSPIEAER RKLRPGSGGE KPPDEAPFTY QLKAVPLKFV
KEIKDIILTE SEFVGSSAIF ECLVSPSTAI TTWMKDGSNI RESPKHRFIA DGKDRKLHII
DVQLSDAGEY TCVLRLGNKE KTSTAKLVVE ELPVRFVKTL EEEVTVVKGQ PLYLSCELNK
ERDVVWRKDG KIVVEKPGRI VPGVIGLMRA LTINDADDTD AGTYTVTVEN ANNLECSSCV
KVVEVIRDWL VKPIRDQHVK PKGTAIFACD IAKDTPNIKW FKGYDEIPAE PNDKTEILRD
GNHLYLKIKN AMPEDIAEYA VEIEGKRYPA KLTLGEREVE LLKPIEDVTI YEKESASFDA
EISEADIPGQ WKLKGELLRP SPTCEIKAEG GKRFLTLHKV KLDQAGEVLY QALNAITTAI
LTVKEIELDF AVPLKDVTVP ERRQARFECV LTREANVIWS KGPDIIKSSD KFDIIADGKK
HILVINDSQF DDEGVYTAEV EGKKTSARLF VTGIRLKFMS PLEDQTVKEG ETATFVCELS
HEKMHVVWFK NDAKLHTSRT VLISSEGKTH KLEMKEVTLD DISQIKAQVK ELSSTAQLKV
LEADPYFTVK LHDKTAVEKD EITLKCEVSK DVPVKWFKDG EEIVPSPKYS IKADGLRRIL
KIKKADLKDK GEYVCDCGTD KTKANVTVEA RLIKVEKPLY GVEVFVGETA HFEIELSEPD
VHGQWKLKGQ PLTASPDCEI IEDGKKHILI LHNCQLGMTG EVSFQAANAK SAANLKVKEL
PLIFITPLSD VKVFEKDEAK FECEVSREPK TFRWLKGTQE ITGDDRFELI KDGTKHSMVI
KSAAFEDEAK YMFEAEDKHT SGKLIIEGIR LKFLTPLKDV TAKEKESAVF TVELSHDNIR
VKWFKNDQRL HTTRSVSMQD EGKTHSITFK DLSIDDTSQI RVEAMGMSSE AKLTVLEGDP
YFTGKLQDYT GVEKDEVILQ CEISKADAPV KWFKDGKEIK PSKNAVIKAD GKKRMLILKK
ALKSDIGQYT CDCGTDKTSG KLDIEDREIK LVRPLHSVEV METETARFET EISEDDIHAN
WKLKGEALLQ TPDCEIKEEG KIHSLVLHNC RLDQTGGVDF QAANVKSSAH LRVKPRVIGL
LRPLKDVTVT AGETATFDCE LSYEDIPVEW YLKGKKLEPS DKVVPRSEGK VHTLTLRDVK
LEDAGEVQLT AKDFKTHANL FVKEPPVEFT KPLEDQTVEE GATAVLECEV SRENAKVKWF
KNGTEILKSK KYEIVADGRV RKLVIHDCTP EDIKTYTCDA KDFKTSCNLN VVPPHVEFLR
PLTDLQVREK EMARFECELS RENAKVKWFK DGAEIKKGKK YDIISKGAVR ILVINKCLLD
DEAEYSCEVR TARTSGMLTV LEEEAVFTKN LANIEVSETD TIKLVCEVSK PGAEVIWYKG
DEEIIETGRY EILTEGRKRI LVIQNAHLED AGNYNCRLPS SRTDGKVKVH ELAAEFISKP
QNLEILEGEK AEFVCSISKE SFPVQWKRDD KTLESGDKYD VIADGKKRVL VVKDATLQDM
GTYVVMVGAA RAAAHLTVIE KLRIVVPLKD TRVKEQQEVV FNCEVNTEGA KAKWFRNEEA
IFDSSKYIIL QKDLVYTLRI RDAHLDDQAN YNVSLTNHRG ENVKSAANLI VEEEDLRIVE
PLKDIETMEK KSVTFWCKVN RLNVTLKWTK NGEEVPFDNR VSYRVDKYKH MLTIKDCGFP
DEGEYIVTAG QDKSVAELLI IEAPTEFVEH LEDQTVTEFD DAVFSCQLSR EKANVKWYRN
GREIKEGKKY KFEKDGSIHR LIIKDCRLDD ECEYACGVED RKSRARLFVE EIPVEIIRPP
QDILEAPGAD VVFLAELNKD KVEVQWLRNN MVVVQGDKHQ MMSEGKIHRL QICDIKPRDQ
GEYRFIAKDK EARAKLELAA APKIKTADQD LVVDVGKPLT MVVPYDAYPK AEAEWFKENE
PLSTKTIDTT AEQTSFRILE AKKGDKGRYK IVLQNKHGKA EGFINLKVID VPGPVRNLEV
TETFDGEVSL AWEEPLTDGG SKIIGYVVER RDIKRKTWVL ATDRAESCEF TVTGLQKGGV
EYLFRVSARN RVGTGEPVET DNPVEARSKY DVPGPPLNVT ITDVNRFGVS LTWEPPEYDG
GAEITNYVIE LRDKTSIRWD TAMTVRAEDL SATVTDVVEG QEYSFRVRAQ NRIGVGKPSA
ATPFVKVADP IERPSPPVNL TSSDQTQSSV QLKWEPPLKD GGSPILGYII ERCEEGKDNW
IRCNMKLVPE LTYKVTGLEK GNKYLYRVSA ENKAGVSDPS EILGPLTADD AFVEPTMDLS
AFKDGLEVIV PNPITILVPS TGYPRPTATW CFGDKVLETG DRVKMKTLSA YAELVISPSE
RSDKGIYTLK LENRVKTISG EIDVNVIARP SAPKELKFGD ITKDSVHLTW EPPDDDGGSP
LTGYVVEKRE VSRKTWTKVM DFVTDLEFTV PDLVQGKEYL FKVCARNKCG PGEPAYVDEP
VNMSTPATVP DPPENVKWRD RTANSIFLTW DPPKNDGGSR IKGYIVERCP RGSDKWVACG
EPVAETKMEV TGLEEGKWYA YRVKALNRQG ASKPSRPTEE IQAVDTQEAP EIFLDVKLLA
GLTVKAGTKI ELPATVTGKP EPKITWTKAD MILKQDKRIT IENVPKKSTV TIVDSKRSDT
GTYIIEAVNV CGRATAVVEV NVLDKPGPPA AFDITDVTNE SCLLTWNPPR DDGGSKITNY
VVERRATDSE VWHKLSSTVK DTNFKATKLI PNKEYIFRVA AENMYGVGEP VQASPITAKY
QFDPPGPPTR LEPSDITKDA VTLTWCEPDD DGGSPITGYW VERLDPDTDK WVRCNKMPVK
DTTYRVKGLT NKKKYRFRVL AENLAGPGKP SKSTEPILIK DPIDPPWPPG KPTVKDVGKT
SVRLNWTKPE HDGGAKIESY VIEMLKTGTD EWVRVAEGVP TTQHLLPGLM EGQEYSFRVR
AVNKAGESEP SEPSDPVLCR EKLYPPSPPR WLEVINITKN TADLKWTVPE KDGGSPITNY
IVEKRDVRRK GWQTVDTTVK DTKCTVTPLT EGSLYVFRVA AENAIGQSDY TEIEDSVLAK
DTFTTPGPPY ALAVVDVTKR HVDLKWEPPK NDGGRPIQRY VIEKKERLGT RWVKAGKTAG
PDCNFRVTDV IEGTEVQFQV RAENEAGVGH PSEPTEILSI EDPTSPPSPP LDLHVTDAGR
KHIAIAWKPP EKNGGSPIIG YHVEMCPVGT EKWMRVNSRP IKDLKFKVEE GVVPDKEYVL
RVRAVNAIGV SEPSEISENV VAKDPDCKPT IDLETHDIIV IEGEKLSIPV PFRAVPVPTV
SWHKDGKEVK ASDRLTMKND HISAHLEVPK SVRADAGIYT ITLENKLGSA TASINVKVIG
LPGPCKDIKA SDITKSSCKL TWEPPEFDGG TPILHYVLER REAGRRTYIP VMSGENKLSW
TVKDLIPNGE YFFRVKAVNK VGGGEYIELK NPVIAQDPKQ PPDPPVDVEV HNPTAEAMTI
TWKPPLYDGG SKIMGYIIEK IAKGEERWKR CNEHLVPILT YTAKGLEEGK EYQFRVRAEN
AAGISEPSRA TPPTKAVDPI DAPKVILRTS LEVKRGDEIA LDASISGSPY PTITWIKDEN
VIVPEEIKKR AAPLVRRRKG EVQEEEPFVL PLTQRLSIDN SKKGESQLRV RDSLRPDHGL
YMIKVENDHG IAKAPCTVSV LDTPGPPINF VFEDIRKTSV LCKWEPPLDD GGSEIINYTL
EKKDKTKPDS EWIVVTSTLR HCKYSVTKLI EGKEYLFRVR AENRFGPGPP CVSKPLVAKD
PFGPPDAPDK PIVEDVTSNS MLVKWNEPKD NGSPILGYWL EKREVNSTHW SRVNKSLLNA
LKANVDGLLE GLTYVFRVCA ENAAGPGKFS PPSDPKTAHD PISPPGPPIP RVTDTSSTTI
ELEWEPPAFN GGGEIVGYFV DKQLVGTNEW SRCTEKMIKV RQYTVKEIRE GADYKLRVSA
VNAAGEGPPG ETQPVTVAEP QEPPAVELDV SVKGGIQIMA GKTLRIPAVV TGRPVPTKVW
TKEEGELDKD RVVIDNVGTK SELIIKDALR KDHGRYVITA TNSCGSKFAA ARVEVFDVPG
PVLDLKPVVT NRKMCLLNWS DPEDDGGSEI TGFIIERKDA KMHTWRQPIE TERSKCDITG
LLEGQEYKFR VIAKNKFGCG PPVEIGPILA VDPLGPPTSP ERLTYTERTK STITLDWKEP
RSNGGSPIQG YIIEKRRHDK PDFERVNKRL CPTTSFLVEN LDEHQMYEFR VKAVNEIGES
EPSLPLNVVI QDDEVPPTIK LRLSVRGDTI KVKAGEPVHI PADVTGLPMP KIEWSKNETV
IEKPTDALQI TKEEVSRSEA KTELSIPKAV REDKGTYTVT ASNRLGSVFR NVHVEVYDRP
SPPRNLAVTD IKAESCYLTW DAPLDNGGSE ITHYVIDKRD ASRKKAEWEE VTNTAVEKRY
GIWKLIPNGQ YEFRVRAVNK YGISDECKSD KVVIQDPYRL PGPPGKPKVL ARTKGSMLVS
WTPPLDNGGS PITGYWLEKR EEGSPYWSRV SRAPITKVGL KGVEFNVPRL LEGVKYQFRA
MAINAAGIGP PSEPSDPEVA GDPIFPPGPP SCPEVKDKTK SSISLGWKPP AKDGGSPIKG
YIVEMQEEGT TDWKRVNEPD KLITTCECVV PNLKELRKYR FRVKAVNEAG ESEPSDTTGE
IPATDIQEEP EVFIDIGAQD CLVCKAGSQI RIPAVIKGRP TPKSSWEFDG KAKKAMKDGV
HDIPEDAQLE TAENSSVIII PECKRSHTGK YSITAKNKAG QKTANCRVKV MDVPGPPKDL
KVSDITRGSC RLSWKMPDDD GGDRIKGYVI EKRTIDGKAW TKVNPDCGST TFVVPDLLSE
QQYFFRVRAE NRFGIGPPVE TIQRTTARDP IYPPDPPIKL KIGLITKNTV HLSWKPPKND
GGSPVTHYIV ECLAWDPTGT KKEAWRQCNK RDVEELQFTV EDLVEGGEYE FRVKAVNAAG
VSKPSATVGP VTVKDQTCPP SIDLKEFMEV EEGTNVNIVA KIKGVPFPTL TWFKAPPKKP
DNKEPVLYDT HVNKLVVDDT CTLVIPQSRR SDTGLYTITA VNNLGTASKE MRLNVLGRPG
PPVGPIKFES VSADQMTLSW FPPKDDGGSK ITNYVIEKRE ANRKTWVHVS SEPKECTYTI
PKLLEGHEYV FRIMAQNKYG IGEPLDSEPE TARNLFSVPG APDKPTVSSV TRNSMTVNWE
EPEYDGGSPV TGYWLEMKDT TSKRWKRVNR DPIKAMTLGV SYKVTGLIEG SDYQFRVYAI
NAAGVGPASL PSDPATARDP IAPPGPPFPK VTDWTKSSAD LEWSPPLKDG GSKVTGYIVE
YKEEGKEEWE KGKDKEVRGT KLVVTGLKEG AFYKFRVRAV NIAGIGEPGE VTDVIEMKDR
LVSPDLQLDA SVRDRIVVHA GGVIRIIAYV SGKPPPTVTW NMNERTLPQE ATIETTAISS
SMVIKNCQRS HQGVYSLLAK NEAGERKKTI IVDVLDVPGP VGTPFLAHNL TNESCKLTWF
SPEDDGGSPI TNYVIEKRES DRRAWTPVTY TVTRQNATVQ GLIQGKAYFF RIAAENSIGM
GPFVETSEAL VIREPITVPE RPEDLEVKEV TKNTVTLTWN PPKYDGGSEI INYVLESRLI
GTEKFHKVTN DNLLSRKYTV KGLKEGDTYE YRVSAVNIVG QGKPSFCTKP ITCKDELAPP
TLHLDFRDKL TIRVGEAFAL TGRYSGKPKP KVSWFKDEAD VLEDDRTHIK TTPATLALEK
IKAKRSDSGK YCVVVENSTG SRKGFCQVNV VDRPGPPVGP VSFDEVTKDY MVISWKPPLD
DGGSKITNYI IEKKEVGKDV WMPVTSASAK TTCKVSKLLE GKDYIFRIHA ENLYGISDPL
VSDSMKAKDR FRVPDAPDQP IVTEVTKDSA LVTWNKPHDG GKPITNYILE KRETMSKRWA
RVTKDPIHPY TKFRVPDLLE GCQYEFRVSA ENEIGIGDPS PPSKPVFAKD PIAKPSPPVN
PEAIDTTCNS VDLTWQPPRH DGGSKILGYI VEYQKVGDEE WRRANHTPES CPETKYKVTG
LRDGQTYKFR VLAVNAAGES DPAHVPEPVL VKDRLEPPEL ILDANMAREQ HIKVGDTLRL
SAIIKGVPFP KVTWKKEDRD APTKARIDVT PVGSKLEIRN AAHEDGGIYS LTVENPAGSK
TVSVKVLVLD KPGPPRDLEV SEIRKDSCYL TWKEPLDDGG SVITNYVVER RDVASAQWSP
LSATSKKKSH FAKHLNEGNQ YLFRVAAENQ YGRGPFVETP KPIKALDPLH PPGPPKDLHH
VDVDKTEVSL VWNKPDRDGG SPITGYLVEY QEEGTQDWIK FKTVTNLECV VTGLQQGKTY
RFRVKAENIV GLGLPDTTIP IECQEKLVPP SVELDVKLIE GLVVKAGTTV RFPAIIRGVP
VPTAKWTTDG SEIKTDEHYT VETDNFSSVL TIKNCLRRDT GEYQITVSNA AGSKTVAVHL
TVLDVPGPPT GPINILDVTP EHMTISWQPP KDDGGSPVIN YIVEKQDTRK DTWGVVSSGS
SKTKLKIPHL QKGCEYVFRV RAENKIGVGP PLDSTPTVAK HKFSPPSPPG KPVVTDITEN
AATVSWTLPK SDGGSPITGY YMERREVTGK WVRVNKTPIA DLKFRVTGLY EGNTYEFRVF
AENLAGLSKP SPSSDPIKAC RPIKPPGPPI NPKLKDKSRE TADLVWTKPL SDGGSPILGY
VVECQKPGTA QWNRINKDEL IRQCAFRVPG LIEGNEYRFR IKAANIVGEG EPRELAESVI
AKDILHPPEV ELDVTCRDVI TVRVGQTIRI LARVKGRPEP DITWTKEGKV LVREKRVDLI
QDLPRVELQI KEAVRADHGK YIISAKNSSG HAQGSAIVNV LDRPGPCQNL KVTNVTKENC
TISWENPLDN GGSEITNFIV EYRKPNQKGW SIVASDVTKR LIKANLLANN EYYFRVCAEN
KVGVGPTIET KTPILAINPI DRPGEPENLH IADKGKTFVY LKWRRPDYDG GSPNLSYHVE
RRLKGSDDWE RVHKGSIKET HYMVDRCVEN QIYEFRVQTK NEGGESDWVK TEEVVVKEDL
QKPVLDLKLS GVLTVKAGDT IRLEAGVRGK PFPEVAWTKD KDATDLTRSP RVKIDTRADS
SKFSLTKAKR SDGGKYVVTA TNTAGSFVAY ATVNVLDKPG PVRNLKIVDV SSDRCTVCWD
PPEDDGGCEI QNYILEKCET KRMVWSTYSA TVLTPGTTVT RLIEGNEYIF RVRAENKIGT
GPPTESKPVI AKTKYDKPGR PDPPEVTKVS KEEMTVVWNP PEYDGGKSIT GYFLEKKEKH
STRWVPVNKS AIPERRMKVQ NLLPDHEYQF RVKAENEIGI GEPSLPSRPV VAKDPIEPPG
PPTNFRVVDT TKHSITLGWG KPVYDGGAPI IGYVVEMRPK IADASPDEGW KRCNAAAQLV
RKEFTVTSLD ENQEYEFRVC AQNQVGIGRP AELKEAIKPK EILEPPEIDL DASMRKLVIV
RAGCPIRLFA IVRGRPAPKV TWRKVGIDNV VRKGQVDLVD TMAFLVIPNS TRDDSGKYSL
TLVNPAGEKA VFVNVRVLDT PGPVSDLKVS DVTKTSCHVS WAPPENDGGS QVTHYIVEKR
EADRKTWSTV TPEVKKTSFH VTNLVPGNEY YFRVTAVNEY GPGVPTDVPK PVLASDPLSE
PDPPRKLEVT EMTKNSATLA WLPPLRDGGA KIDGYITSYR EEEQPADRWT EYSVVKDLSL
VVTGLKEGKK YKFRVAARNA VGVSLPREAE GVYEAKEQLL PPKILMPEQI TIKAGKKLRI
EAHVYGKPHP TCKWKKGEDE VVTSSHLAVH KADSSSILII KDVTRKDSGY YSLTAENSSG
TDTQKIKVVV MDAPGPPQPP FDISDIDADA CSLSWHIPLE DGGSNITNYI VEKCDVSRGD
WVTALASVTK TSCRVGKLIP GQEYIFRVRA ENRFGISEPL TSPKMVAQFP FGVPSEPKNA
RVTKVNKDCI FVAWDRPDSD GGSPIIGYLI ERKERNSLLW VKANDTLVRS TEYPCAGLVE
GLEYSFRIYA LNKAGSSPPS KPTEYVTARM PVDPPGKPEV IDVTKSTVSL IWARPKHDGG
SKIIGYFVEA CKLPGDKWVR CNTAPHQIPQ EEYTATGLEE KAQYQFRAIA RTAVNISPPS
EPSDPVTILA ENVPPRIDLS VAMKSLLTVK AGTNVCLDAT VFGKPMPTVS WKKDGTLLKP
AEGIKMAMQR NLCTLELFSV NRKDSGDYTI TAENSSGSKS ATIKLKVLDK PGPPASVKIN
KMYSDRAMLS WEPPLEDGGS EITNYIVDKR ETSRPNWAQV SATVPITSCS VEKLIEGHEY
QFRICAENKY GVGDPVFTEP AIAKNPYDPP GRCDPPVISN ITKDHMTVSW KPPADDGGSP
ITGYLLEKRE TQAVNWTKVN RKPIIERTLK ATGLQEGTEY EFRVTAINKA GPGKPSDASK
AAYARDPQYP PGPPAFPKVY DTTRSSVSLS WGKPAYDGGS PIIGYLVEVK RADSDNWVRC
NLPQNLQKTR FEVTGLMEDT QYQFRVYAVN KIGYSDPSDV PDKHYPKDIL IPPEGELDAD
LRKTLILRAG VTMRLYVPVK GRPPPKITWS KPNVNLRDRI GLDIKSTDFD TFLRCENVNK
YDAGKYILTL ENSCGKKEYT IVVKVLDTPG PPVNVTVKEI SKDSAYVTWE PPIIDGGSPI
INYVVQKRDA ERKSWSTVTT ECSKTSFRVA NLEEGKSYFF RVFAENEYGI GDPGETRDAV
KASQTPGPVV DLKVRSVSKS SCSIGWKKPH SDGGSRIIGY VVDFLTEENK WQRVMKSLSL
QYSAKDLTEG KEYTFRVSAE NENGEGTPSE ITVVARDDVV APDLDLKGLP DLCYLAKENS
NFRLKIPIKG KPAPSVSWKK GEDPLATDTR VSVESSAVNT TLIVYDCQKS DAGKYTITLK
NVAGTKEGTI SIKVVGKPGI PTGPIKFDEV TAEAMTLKWA PPKDDGGSEI TNYILEKRDS
VNNKWVTCAS AVQKTTFRVT RLHEGMEYTF RVSAENKYGV GEGLKSEPIV ARHPFDVPDA
PPPPNIVDVR HDSVSLTWTD PKKTGGSPIT GYHLEFKERN SLLWKRANKT PIRMRDFKVT
GLTEGLEYEF RVMAINLAGV GKPSLPSEPV VALDPIDPPG KPEVINITRN SVTLIWTEPK
YDGGHKLTGY IVEKRDLPSK SWMKANHVNV PECAFTVTDL VEGGKYEFRI RAKNTAGAIS
APSESTETII CKDEYEAPTI VLDPTIKDGL TIKAGDTIVL NAISILGKPL PKSSWSKAGK
DIRPSDITQI TSTPTSSMLT IKYATRKDAG EYTITATNPF GTKVEHVKVT VLDVPGPPGP
VEISNVSAEK ATLTWTPPLE DGGSPIKSYI LEKRETSRLL WTVVSEDIQS CRHVATKLIQ
GNEYIFRVSA VNHYGKGEPV QSEPVKMVDR FGPPGPPEKP EVSNVTKNTA TVSWKRPVDD
GGSEITGYHV ERREKKSLRW VRAIKTPVSD LRCKVTGLQE GSTYEFRVSA ENRAGIGPPS
EASDSVLMKD AAYPPGPPSN PHVTDTTKKS ASLAWGKPHY DGGLEITGYV VEHQKVGDEA
WIKDTTGTAL RITQFVVPDL QTKEKYNFRI SAINDAGVGE PAVIPDVEIV EREMAPDFEL
DAELRRTLVV RAGLSIRIFV PIKGRPAPEV TWTKDNINLK NRANIENTES FTLLIIPECN
RYDTGKFVMT IENPAGKKSG FVNVRVLDTP GPVLNLRPTD ITKDSVTLHW DLPLIDGGSR
ITNYIVEKRE ATRKSYSTAT TKCHKCTYKV TGLSEGCEYF FRVMAENEYG IGEPTETTEP
VKASEAPSPP DSLNIMDITK STVSLAWPKP KHDGGSKITG YVIEAQRKGS DQWTHITTVK
GLECVVRNLT EGEEYTFQVM AVNSAGRSAP RESRPVIVKE QTMLPELDLR GIYQKLVIAK
AGDNIKVEIP VLGRPKPTVT WKKGDQILKQ TQRVNFETTA TSTILNINEC VRSDSGPYPL
TARNIVGEVG DVITIQVHDI PGPPTGPIKF DEVSSDFVTF SWDPPENDGG VPISNYVVEM
RQTDSTTWVE LATTVIRTTY KATRLTTGLE YQFRVKAQNR YGVGPGITSA CIVANYPFKV
PGPPGTPQVT AVTKDSMTIS WHEPLSDGGS PILGYHVERK ERNGILWQTV SKALVPGNIF
KSSGLTDGIA YEFRVIAENM AGKSKPSKPS EPMLALDPID PPGKPVPLNI TRHTVTLKWA
KPEYTGGFKI TSYIVEKRDL PNGRWLKANF SNILENEFTV SGLTEDAAYE FRVIAKNAAG
AISPPSEPSD AITCRDDVEA PKIKVDVKFK DTVILKAGEA FRLEADVSGR PPPTMEWSKD
GKELEGTAKL EIKIADFSTN LVNKDSTRRD SGAYTLTATN PGGFAKHIFN VKVLDRPGPP
EGPLAVTEVT SEKCVLSWFP PLDDGGAKID HYIVQKRETS RLAWTNVASE VQVTKLKVTK
LLKGNEYIFR VMAVNKYGVG EPLESEPVLA VNPYGPPDPP KNPEVTTITK DSMVVCWGHP
DSDGGSEIIN YIVERRDKAG QRWIKCNKKT LTDLRYKVSG LTEGHEYEFR IMAENAAGIS
APSPTSPFYK ACDTVFKPGP PGNPRVLDTS RSSISIAWNK PIYDGGSEIT GYMVEIALPE
EDEWQIVTPP AGLKATSYTI TGLTENQEYK IRIYAMNSEG LGEPALVPGT PKAEDRMLPP
EIELDADLRK VVTIRACCTL RLFVPIKGRP APEVKWARDH GESLDKASIE STSSYTLLIV
GNVNRFDSGK YILTVENSSG SKSAFVNVRV LDTPGPPQDL KVKEVTKTSV TLTWDPPLLD
GGSKIKNYIV EKRESTRKAY STVATNCHKT SWKVDQLQEG CSYYFRVLAE NEYGIGLPAE
TAESVKASER PLPPGKITLM DVTRNSVSLS WEKPEHDGGS RILGYIVEMQ TKGSDKWATC
ATVKVTEATI TGLIQGEEYS FRVSAQNEKG ISDPRQLSVP VIAKDLVIPP AFKLLFNTFT
VLAGEDLKVD VPFIGRPTPA VTWHKDNVPL KQTTRVNAES TENNSLLTIK DACREDVGHY
VVKLTNSAGE AIETLNVIVL DKPGPPTGPV KMDEVTADSI TLSWGPPKYD GGSSINNYIV
EKRDTSTTTW QIVSATVART TIKACRLKTG CEYQFRIAAE NRYGKSTYLN SEPTVAQYPF
KVPGPPGTPV VTLSSRDSME VQWNEPISDG GSRVIGYHLE RKERNSILWV KLNKTPIPQT
KFKTTGLEEG VEYEFRVSAE NIVGIGKPSK VSECYVARDP CDPPGRPEAI IVTRNSVTLQ
WKKPTYDGGS KITGYIVEKK ELPEGRWMKA SFTNIIDTHF EVTGLVEDHR YEFRVIARNA
AGVFSEPSES TGAITARDEV DPPRISMDPK YKDTIVVHAG ESFKVDADIY GKPIPTIQWI
KGDQELSNTA RLEIKSTDFA TSLSVKDAVR VDSGNYILKA KNVAGERSVT VNVKVLDRPG
PPEGPVVISG VTAEKCTLAW KPPLQDGGSD IINYIVERRE TSRLVWTVVD ANVQTLSCKV
TKLLEGNEYT FRIMAVNKYG VGEPLESEPV VAKNPFVVPD APKAPEVTTV TKDSMIVVWE
RPASDGGSEI LGYVLEKRDK EGIRWTRCHK RLIGELRLRV TGLIENHDYE FRVSAENAAG
LSEPSPPSAY QKACDPIYKP GPPNNPKVID ITRSSVFLSW SKPIYDGGCE IQGYIVEKCD
VSVGEWTMCT PPTGINKTNI EVEKLLEKHE YNFRICAINK AGVGEHADVP GPIIVEEKLE
APDIDLDLEL RKIINIRAGG SLRLFVPIKG RPTPEVKWGK VDGEIRDAAI IDVTSSFTSL
VLDNVNRYDS GKYTLTLENS SGTKSAFVTV RVLDTPSPPV NLKVTEITKD SVSITWEPPL
LDGGSKIKNY IVEKREATRK SYAAVVTNCH KNSWKIDQLQ EGCSYYFRVT AENEYGIGLP
AQTADPIKVA EVPQPPGKIT VDDVTRNSVS LSWTKPEHDG GSKIIQYIVE MQAKHSEKWS
ECARVKSLQA VITNLTQGEE YLFRVVAVNE KGRSDPRSLA VPIVAKDLVI EPDVKPAFSS
YSVQVGQDLK IEVPISGRPK PTITWTKDGL PLKQTTRINV TDSLDLTTLS IKETHKDDGG
QYGITVANVV GQKTASIEIV TLDKPDPPKG PVKFDDVSAE SITLSWNPPL YTGGCQITNY
IVQKRDTTTT VWDVVSATVA RTTLKVTKLK TGTEYQFRIF AENRYGQSFA LESDPIVAQY
PYKEPGPPGT PFATAISKDS MVIQWHEPVN NGGSPVIGYH LERKERNSIL WTKVNKTIIH
DTQFKAQNLE EGIEYEFRVY AENIVGVGKA SKNSECYVAR DPCDPPGTPE PIMVKRNEIT
LQWTKPVYDG GSMITGYIVE KRDLPDGRWM KASFTNVIET QFTVSGLTED QRYEFRVIAK
NAAGAISKPS DSTGPITAKD EVELPRISMD PKFRDTIVVN AGETFRLEAD VHGKPLPTIE
WLRGDKEIEE SARCEIKNTD FKALLIVKDA IRIDGGQYIL RASNVAGSKS FPVNVKVLDR
PGPPEGPVQV TGVTSEKCSL TWSPPLQDGG SDISHYVVEK RETSRLAWTV VASEVVTNSL
KVTKLLEGNE YVFRIMAVNK YGVGEPLESA PVLMKNPFVL PGPPKSLEVT NIAKDSMTVC
WNRPDSDGGS EIIGYIVEKR DRSGIRWIKC NKRRITDLRL RVTGLTEDHE YEFRVSAENA
AGVGEPSPAT VYYKACDPVF KPGPPTNAHI VDTTKNSITL AWGKPIYDGG SEILGYVVEI
CKADEEEWQI VTPQTGLRVT RFEISKLTEH QEYKIRVCAL NKVGLGEATS VPGTVKPEDK
LEAPELDLDS ELRKGIVVRA GGSARIHIPF KGRPTPEITW SREEGEFTDK VQIEKGVNYT
QLSIDNCDRN DAGKYILKLE NSSGSKSAFV TVKVLDTPGP PQNLAVKEVR KDSAFLVWEP
PIIDGGAKVK NYVIDKREST RKAYANVSSK CSKTSFKVEN LTEGAIYYFR VMAENEFGVG
VPVETVDAVK AAEPPSPPGK VTLTDVSQTS ASLMWEKPEH DGGSRVLGYV VEMQPKGTEK
WSIVAESKVC NAVVTGLSSG QEYQFRVKAY NEKGKSDPRV LGVPVIAKDL TIQPSLKLPF
NTYSIQAGED LKIEIPVIGR PRPNISWVKD GEPLKQTTRV NVEETATSTV LHIKEGNKDD
FGKYTVTATN SAGTATENLS VIVLEKPGPP VGPVRFDEVS ADFVVISWEP PAYTGGCQIS
NYIVEKRDTT TTTWHMVSAT VARTTIKITK LKTGTEYQFR IFAENRYGKS APLDSKAVIV
QYPFKEPGPP GTPFVTSISK DQMLVQWHEP VNDGGTKIIG YHLEQKEKNS ILWVKLNKTP
IQDTKFKTTG LDEGLEYEFK VSAENIVGIG KPSKVSECFV ARDPCDPPGR PEAIVITRNN
VTLKWKKPAY DGGSKITGYI VEKKDLPDGR WMKASFTNVL ETEFTVSGLV EDQRYEFRVI
ARNAAGNFSE PSDSSGAITA RDEIDAPNAS LDPKYKDVIV VHAGETFVLE ADIRGKPIPD
VVWSKDGKEL EETAARMEIK STIQKTTLVV KDCIRTDGGQ YILKLSNVGG TKSIPITVKV
LDRPGPPEGP LKVTGVTAEK CYLAWNPPLQ DGGANISHYI IEKRETSRLS WTQVSTEVQA
LNYKVTKLLP GNEYIFRVMA VNKYGIGEPL ESGPVTACNP YKPPGPPSTP EVSAITKDSM
VVTWARPVDD GGTEIEGYIL EKRDKEGVRW TKCNKKTLTD LRLRVTGLTE GHSYEFRVAA
ENAAGVGEPS EPSVFYRACD ALYPPGPPSN PKVTDTSRSS VSLAWSKPIY DGGAPVKGYV
VEVKEAAADE WTTCTPPTGL QGKQFTVTKL KENTEYNFRI CAINSEGVGE PATLPGSVVA
QERIEPPEIE LDADLRKVVV LRASATLRLF VTIKGRPEPE VKWEKAEGIL TDRAQIEVTS
SFTMLVIDNV TRFDSGRYNL TLENNSGSKT AFVNVRVLDS PSAPVNLTIR EVKKDSVTLS
WEPPLIDGGA KITNYIVEKR ETTRKAYATI TNNCTKTTFR IENLQEGCSY YFRVLASNEY
GIGLPAETTE PVKVSEPPLP PGRVTLVDVT RNTATIKWEK PESDGGSKIT GYVVEMQTKG
SEKWSTCTQV KTLEATISGL TAGEEYVFRV AAVNEKGRSD PRQLGVPVIA RDIEIKPSVE
LPFHTFNVKA REQLKIDVPF KGRPQATVNW RKDGQTLKET TRVNVSSSKT VTSLSIKEAS
KEDVGTYELC VSNSAGSITV PITIIVLDRP GPPGPIRIDE VSCDSITISW NPPEYDGGCQ
ISNYIVEKKE TTSTTWHIVS QAVARTSIKI VRLTTGSEYQ FRVCAENRYG KSSYSESSAV
VAEYPFSPPG PPGTPKVVHA TKSTMLVTWQ VPVNDGGSRV IGYHLEYKER SSILWSKANK
ILIADTQMKV SGLDEGLMYE YRVYAENIAG IGKCSKSCEP VPARDPCDPP GQPEVTNITR
KSVSLKWSKP HYDGGAKITG YIVERRELPD GRWLKCNYTN IQETYFEVTE LTEDQRYEFR
VFARNAADSV SEPSESTGPI IVKDDVEPPR VMMDVKFRDV IVVKAGEVLK INADIAGRPL
PVISWAKDGI EIEERARTEI ISTDNHTLLT VKDCIRRDTG QYVLTLKNVA GTRSVAVNCK
VLDKPGPPAG PLEINGLTAE KCSLSWGRPQ EDGGADIDYY IVEKRETSHL AWTICEGELQ
MTSCKVTKLL KGNEYIFRVT GVNKYGVGEP LESVAIKALD PFTVPSPPTS LEITSVTKES
MTLCWSRPES DGGSEISGYI IERREKNSLR WVRVNKKPVY DLRVKSTGLR EGCEYEYRVY
AENAAGLSLP SETSPLIRAE DPVFLPSPPS KPKIVDSGKT TITIAWVKPL FDGGAPITGY
TVEYKKSDDT DWKTSIQSLR GTEYTISGLT TGAEYVFRVK SVNKVGASDP SDSSDPQIAK
EREEEPLFDI DSEMRKTLIV KAGASFTMTV PFRGRPVPNV LWSKPDTDLR TRAYVDTTDS
RTSLTIENAN RNDSGKYTLT IQNVLSAASL TLVVKVLDTP GPPTNITVQD VTKESAVLSW
DVPENDGGAP VKNYHIEKRE ASKKAWVSVT NNCNRLSYKV TNLQEGAIYY FRVSGENEFG
VGIPAETKEG VKITEKPSPP EKLGVTSISK DSVSLTWLKP EHDGGSRIVH YVVEALEKGQ
KNWVKCAVAK STHHVVSGLR ENSEYFFRVF AENQAGLSDP RELLLPVLIK EQLEPPEIDM
KNFPSHTVYV RAGSNLKVDI PISGKPLPKV TLSRDGVPLK ATMRFNTEIT AENLTINLKE
SVTADAGRYE ITAANSSGTT KAFINIVVLD RPGPPTGPVV ISDITEESVT LKWEPPKYDG
GSQVTNYILL KRETSTAVWT EVSATVARTM MKVMKLTTGE EYQFRIKAEN RFGISDHIDS
ACVTVKLPYT TPGPPSTPWV TNVTRESITV GWHEPVSNGG SAVVGYHLEM KDRNSILWQK
ANKLVIRTTH FKVTTISAGL IYEFRVYAEN AAGVGKPSHP SEPVLAIDAC EPPRNVRITD
ISKNSVSLSW QQPAFDGGSK ITGYIVERRD LPDGRWTKAS FTNVTETQFI ISGLTQNSQY
EFRVFARNAV GSISNPSEVV GPITCIDSYG GPVIDLPLEY TEVVKYRAGT SVKLRAGISG
KPAPTIEWYK DDKELQTNAL VCVENTTDLA SILIKDADRL NSGCYELKLR NAMGSASATI
RVQILDKPGP PGGPIEFKTV TAEKITLLWR PPADDGGAKI THYIVEKRET SRVVWSMVSE
HLEECIITTT KIIKGNEYIF RVRAVNKYGI GEPLESDSVV AKNAFVTPGP PGIPEVTKIT
KNSMTVVWSR PIADGGSDIS GYFLEKRDKK SLGWFKVLKE TIRDTRQKVT GLTENSDYQY
RVCAVNAAGQ GPFSEPSEFY KAADPIDPPG PPAKIRIADS TKSSITLGWS KPVYDGGSAV
TGYVVEIRQG EEEEWTTVST KGEVRTTEYV VSNLKPGVNY YFRVSAVNCA GQGEPIEMNE
PVQAKDILEA PEIDLDVALR TSVIAKAGED VQVLIPFKGR PPPTVTWRKD EKNLGSDARY
SIENTDSSSL LTIPQVTRND TGKYILTIEN GVGEPKSSTV SVKVLDTPAA CQKLQVKHVS
RGTVTLLWDP PLIDGGSPII NYVIEKRDAT KRTWSVVSHK CSSTSFKLID LSEKTPFFFR
VLAENEIGIG EPCETTEPVK AAEVPAPIRD LSMKDSTKTS VILSWTKPDF DGGSVITEYV
VERKGKGEQT WSHAGISKTC EIEVSQLKEQ SVLEFRVFAK NEKGLSDPVT IGPITVKELI
ITPEVDLSDI PGAQVTVRIG HNVHLELPYK GKPKPSISWL KDGLPLKESE FVRFSKTENK
ITLSIKNAKK EHGGKYTVIL DNAVCRIAVP ITVITLGPPS KPKGPIRFDE IKADSVILSW
DVPEDNGGGE ITCYSIEKRE TSQTNWKMVC SSVARTTFKV PNLVKDAEYQ FRVRAENRYG
VSQPLVSSII VAKHQFRIPG PPGKPVIYNV TSDGMSLTWD APVYDGGSEV TGFHVEKKER
NSILWQKVNT SPISGREYRA TGLVEGLDYQ FRVYAENSAG LSSPSDPSKF TLAVSPVDPP
GTPDYIDVTR ETITLKWNPP LRDGGSKIVG YSIEKRQGNE RWVRCNFTDV SECQYTVTGL
SPGDRYEFRI IARNAVGTIS PPSQSSGIIM TRDENVPPIV EFGPEYFDGL IIKSGESLRI
KALVQGRPVP RVTWFKDGVE IEKRMNMEIT DVLGSTSLFV RDATRDHRGV YTVEAKNASG
SAKAEIKVKV QDTPGKVVGP IRFTNITGEK MTLWWDAPLN DGCAPITHYI IEKRETSRLA
WALIEDKCEA QSYTAIKLIN GNEYQFRVSA VNKFGVGRPL DSDPVVAQIQ YTVPDAPGIP
EPSNITGNSI TLTWARPESD GGSEIQQYIL ERREKKSTRW VKVISKRPIS ETRFKVTGLT
EGNEYEFHVM AENAAGVGPA SGISRLIKCR EPVNPPGPPT VVKVTDTSKT TVSLEWSKPV
FDGGMEIIGY IIEMCKADLG DWHKVNAEAC VKTRYTVTDL QAGEEYKFRV SAINGAGKGD
SCEVTGTIKA VDRLTAPELD IDANFKQTHV VRAGASIRLF IAYQGRPTPT AVWSKPDSNL
SLRADIHTTD SFSTLTVENC NRNDAGKYTL TVENNSGSKS ITFTVKVLDT PGPPGPITFK
DVTRGSATLM WDAPLLDGGA RIHHYVVEKR EASRRSWQVI SEKCTRQIFK VNDLAEGVPY
YFRVSAVNEY GVGEPYEMPE PIVATEQPAP PRRLDVVDTS KSSAVLAWLK PDHDGGSRIT
GYLLEMRQKG SDFWVEAGHT KQLTFTVERL VEKTEYEFRV KAKNDAGYSE PREAFSSVII
KEPQIEPTAD LTGITNQLIT CKAGSPFTID VPISGRPAPK VTWKLEEMRL KETDRVSITT
TKDRTTLTVK DSMRGDSGRY FLTLENTAGV KTFSVTVVVI GRPGPVTGPI EVSSVSAESC
VLSWGEPKDG GGTEITNYIV EKRESGTTAW QLVNSSVKRT QIKVTHLTKY MEYSFRVSSE
NRFGVSKPLE SAPIIAEHPF VPPSAPTRPE VYHVSANAMS IRWEEPYHDG GSKIIGYWVE
KKERNTILWV KENKVPCLEC NYKVTGLVEG LEYQFRTYAL NAAGVSKASE ASRPIMAQNP
VDAPGRPEVT DVTRSTVSLI WSAPAYDGGS KVVGYIIERK PVSEVGDGRW LKCNYTIVSD
NFFTVTALSE GDTYEFRVLA KNAAGVISKG SESTGPVTCR DEYAPPKAEL DARLHGDLVT
IRAGSDLVLD AAVGGKPEPK IIWTKGDKEL DLCEKVSLQY TGKRATAVIK FCDRSDSGKY
TLTVKNASGT KAVSVMVKVL DSPGPCGKLT VSRVTQEKCT LAWSLPQEDG GAEITHYIVE
RRETSRLNWV IVEGECPTLS YVVTRLIKNN EYIFRVRAVN KYGPGVPVES EPIVARNSFT
IPSPPGIPEE VGTGKEHIII QWTKPESDGG NEISNYLVDK REKKSLRWTR VNKDYVVYDT
RLKVTSLMEG CDYQFRVTAV NAAGNSEPSE ASNFISCREP SYTPGPPSAP RVVDTTKHSI
SLAWTKPMYD GGTDIVGYVL EMQEKDTDQW YRVHTNATIR NTEFTVPDLK MGQKYSFRVA
AVNVKGMSEY SESIAEIEPV ERIEIPDLEL ADDLKKTVTI RAGASLRLMV SVSGRPPPVI
TWSKQGIDLA SRAIIDTTES YSLLIVDKVN RYDAGKYTIE AENQSGKKSA TVLVKVYDTP
GPCPSVKVKE VSRDSVTITW EIPTIDGGAP VNNYIVEKRE AAMRAFKTVT TKCSKTLYRI
SGLVEGTMYY FRVLPENIYG IGEPCETSDA VLVSEVPLVP AKLEVVDVTK STVTLAWEKP
LYDGGSRLTG YVLEACKAGT ERWMKVVTLK PTVLEHTVTS LNEGEQYLFR IRAQNEKGVS
EPRETVTAVT VQDLRVLPTI DLSTMPQKTI HVPAGRPVEL VIPIAGRPPP AASWFFAGSK
LRESERVTVE THTKVAKLTI RETTIRDTGE YTLELKNVTG TTSETIKVII LDKPGPPTGP
IKIDEIDATS ITISWEPPEL DGGAPLSGYV VEQRDAHRPG WLPVSESVTR STFKFTRLTE
GNEYVFRVAA TNRFGIGSYL QSEVIECRSS IRIPGPPETL QIFDVSRDGM TLTWYPPEDD
GGSQVTGYIV ERKEVRADRW VRVNKVPVTM TRYRSTGLTE GLEYEHRVTA INARGSGKPS
RPSKPIVAMD PIAPPGKPQN PRVTDTTRTS VSLAWSVPED EGGSKVTGYL IEMQKVDQHE
WTKCNTTPTK IREYTLTHLP QGAEYRFRVL ACNAGGPGEP AEVPGTVKVT EMLEYPDYEL
DERYQEGIFV RQGGVIRLTI PIKGKPFPIC KWTKEGQDIS KRAMIATSET HTELVIKEAD
RGDSGTYDLV LENKCGKKAV YIKVRVIGSP NSPEGPLEYD DIQVRSVRVS WRPPADDGGA
DILGYILERR EVPKAAWYTI DSRVRGTSLV VKGLKENVEY HFRVSAENQF GISKPLKSEE
PVTPKTPLNP PEPPSNPPEV LDVTKSSVSL SWSRPKDDGG SRVTGYYIER KETSTDKWVR
HNKTQITTTM YTVTGLVPDA EYQFRIIAQN DVGLSETSPA SEPVVCKDPF DKPSQPGELE
ILSISKDSVT LQWEKPECDG GKEILGYWVE YRQSGDSAWK KSNKERIKDK QFTIGGLLEA
TEYEFRVFAE NETGLSRPRR TAMSIKTKLT SGEAPGIRKE MKDVTTKLGE AAQLSCQIVG
RPLPDIKWYR FGKELIQSRK YKMSSDGRTH TLTVMTEEQE DEGVYTCIAT NEVGEVETSS
KLLLQATPQF HPGYPLKEKY YGAVGSTLRL HVMYIGRPVP AMTWFHGQKL LQNSENITIE
NTEHYTHLVM KNVQRKTHAG KYKVQLSNVF GTVDAILDVE IQDKPDKPTG PIVIEALLKN
SAVISWKPPA DDGGSWITNY VVEKCEAKEG AEWQLVSSAI SVTTCRIVNL TENAGYYFRV
SAQNTFGISD PLEVSSVVII KSPFEKPGAP GKPTITAVTK DSCVVAWKPP ASDGGAKIRN
YYLEKREKKQ NKWISVTTEE IRETVFSVKN LIEGLEYEFR VKCENLGGES EWSEISEPIT
PKSDVPIQAP HFKEELRNLN VRYQSNATLV CKVTGHPKPI VKWYRQGKEI IADGLKYRIQ
EFKGGYHQLI IASVTDDDAT VYQVRATNQG GSVSGTASLE VEVPAKIHLP KTLEGMGAVH
ALRGEVVSIK IPFSGKPDPV ITWQKGQDLI DNNGHYQVIV TRSFTSLVFP NGVERKDAGF
YVVCAKNRFG IDQKTVELDV ADVPDPPRGV KVSDVSRDSV NLTWTEPASD GGSKITNYIV
EKCATTAERW LRVGQARETR YTVINLFGKT SYQFRVIAEN KFGLSKPSEP SEPTITKEDK
TRAMNYDEEV DETREVSMTK ASHSSTKELY EKYMIAEDLG RGEFGIVHRC VETSSKKTYM
AKFVKVKGTD QVLVKKEISI LNIARHRNIL HLHESFESME ELVMIFEFIS GLDIFERINT
SAFELNEREI VSYVHQVCEA LQFLHSHNIG HFDIRPENII YQTRRSSTIK IIEFGQARQL
KPGDNFRLLF TAPEYYAPEV HQHDVVSTAT DMWSLGTLVY VLLSGINPFL AETNQQIIEN
IMNAEYTFDE EAFKEISIEA MDFVDRLLVK ERKSRMTASE ALQHPWLKQK IERVSTKVIR
TLKHRRYYHT LIKKDLNMVV SAARISCGGA IRSQKGVSVA KVKVASIEIG PVSGQIMHAV
GEEGGHVKYV CKIENYDQST QVTWYFGVRQ LENSEKYEIT YEDGVAILYV KDITKLDDGT
YRCKVVNDYG EDSSYAELFV KGVREVYDYY CRRTMKKIKR RTDTMRLLER PPEFTLPLYN
KTAYVGENVR FGVTITVHPE PHVTWYKSGQ KIKPGDNDKK YTFESDKGLY QLTINSVTTD
DDAEYTVVAR NKYGEDSCKA KLTVTLHPPP TDSTLRPMFK RLLANAECQE GQSVCFEIRV
SGIPPPTLKW EKDGQPLSLG PNIEIIHEGL DYYALHIRDT LPEDTGYYRV TATNTAGSTS
CQAHLQVERL RYKKQEFKSK EEHERHVQKQ IDKTLRMAEI LSGTESVPLT QVAKEALREA
AVLYKPAVST KTVKGEFRLE IEEKKEERKL RMPYDVPEPR KYKQTTIEED QRIKQFVPMS
DMKWYKKIRD QYEMPGKLDR VVQKRPKRIR LSRWEQFYVM PLPRITDQYR PKWRIPKLSQ
DDLEIVRPAR RRTPSPDYDF YYRPRRRSLG DISDEELLLP IDDYLAMKRT EEERLRLEEE
LELGFSASPP SRSPPHFELS SLRYSSPQAH VKVEETRKDF RYSTYHIPTK AEASTSYAEL
RERHAQAAYR QPKQRQRIMA EREDEELLRP VTTTQHLSEY KSELDFMSKE EKSRKKSRRQ
REVTEITEIE EEYEISKHAQ RESSSSASRL LRRRRSLSPT YIELMRPVSE LIRSRPQPAE
EYEDDTERRS PTPERTRPRS PSPVSSERSL SRFERSARFD IFSRYESMKA ALKTQKTSER
KYEVLSQQPF TLDHAPRITL RMRSHRVPCG QNTRFILNVQ SKPTAEVKWY HNGVELQESS
KIHYTNTSGV LTLEILDCHT DDSGTYRAVC TNYKGEASDY ATLDVTGGDY TTYASQRRDE
EVPRSVFPEL TRTEAYAVSS FKKTSEMEAS SSVREVKSQM TETRESLSSY EHSASAEMKS
AALEEKSLEE KSTTRKIKTT LAARILTKPR SMTVYEGESA RFSCDTDGEP VPTVTWLRKG
QVLSTSARHQ VTTTKYKSTF EISSVQASDE GNYSVVVENS EGKQEAEFTL TIQKARVTEK
AVTSPPRVKS PEPRVKSPEA VKSPKRVKSP EPSHPKAVSP TETKPTPTEK VQHLPVSAPP
KITQFLKAEA SKEIAKLTCV VESSVLRAKE VTWYKDGKKL KENGHFQFHY SADGTYELKI
NNLTESDQGE YVCEISGEGG TSKTNLQFMG QAFKSIHEKV SKISETKKSD QKTTESTVTR
KTEPKAPEPI SSKPVIVTGL QDTTVSSDSV AKFAVKATGE PRPTAIWTKD GKAITQGGKY
KLSEDKGGFF LEIHKTDTSD SGLYTCTVKN SAGSVSSSCK LTIKAIKDTE AQKVSTQKTS
EITPQKKAVV QEEISQKALR SEEIKMSEAK SQEKLALKEE ASKVLISEEV KKSAATSLEK
SIVHEEITKT SQASEEVRTH AEIKAFSTQM SINEGQRLVL KANIAGATDV KWVLNGVELT
NSEEYRYGVS GSDQTLTIKQ ASHRDEGILT CISKTKEGIV KCQYDLTLSK ELSDAPAFIS
QPRSQNINEG QNVLFTCEIS GEPSPEIEWF KNNLPISISS NVSISRSRNV YSLEIRNASV
SDSGKYTIKA KNFRGQCSAT ASLMVLPLVE EPSREVVLRT SGDTSLQGSF SSQSVQMSAS
KQEASFSSFS SSSASSMTEM KFASMSAQSM SSMQESFVEM SSSSFMGISN MTQLESSTSK
MLKAGIRGIP PKIEALPSDI SIDEGKVLTV ACAFTGEPTP EVTWSCGGRK IHSQEQGRFH
IENTDDLTTL IIMDVQKQDG GLYTLSLGNE FGSDSATVNI HIRSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107347

Theoretical NMD boundary in CDS

107071

Length of CDS

107418

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_7_ENST00000436599

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 122|78 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.95, LOF (oe): 0.64, misssense (oe): 0.96, synonymous (oe): 0.99 ? (gnomAD)

Ensembl transcript ID

ENST00000436599.2

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11036-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAMRKEAE KTALSTIAVA TAKAKEQETI LRTRETMATR QEQIQVTHGK
VDVGKKAEAV ATVVAAVDQA RVREPREPGH LEESYAQQTT LEYGYKERIS AAKVAEPPQR
PASEPHVVPK AVKPRVIQAP SETHIKTTDQ KGMHISSQIK KTTDLTTERL VHVDKRPRTA
SPHFTVSKIS VPKTEHGYEA SIAGSAIATL QKELSATSSA QKITKSVKAP TVKPSETRVR
AEPTPLPQFP FADTPDTYKS EAGVEVKKEV GVSITGTTVR EERFEVLHGR EAKVTETARV
PAPVEIPVTP PTLVSGLKNV TVIEGESVTL ECHISGYPSP TVTWYREDYQ IESSIDFQIT
FQSGIARLMI REAFAEDSGR FTCSAVNEAG TVSTSCYLAV QVSEEFEKET TAVTEKFTTE
EKRFVESRDV VMTDTSLTEE QAGPGEPAAP YFITKPVVQK LVEGGSVVFG CQVGGNPKPH
VYWKKSGVPL TTGYRYKVSY NKQTGECKLV ISMTFADDAG EYTIVVRNKH GETSASASLL
EEADYELLMK SQQEMLYQTQ VTAFVQEPKV GETAPGFVYS EYEKEYEKEQ ALIRKKMAKD
TVVVRTYVED QEFHISSFEE RLIKEIEYRI IKTTLEELLE EDGEEKMAVD ISESEAVESG
FDSRIKNYRI LEGMGVTFHC KMSGYPLPKI AWYKDGKRIK HGERYQMDFL QDGRASLRIP
VVLPEDEGIY TAFASNIKGN AICSGKLYVE PAAPLGAPTY IPTLEPVSRI RSLSPRSVSR
SPIRMSPARM SPARMSPARM SPARMSPGRR LEETDESQLE RLYKPVFVLK PVSFKCLEGQ
TARFDLKVVG RPMPETFWFH DGQQIVNDYT HKVVIKEDGT QSLIIVPATP SDSGEWTVVA
QNRAGRSSIS VILTVEAVEH QVKPMFVEKL KNVNIKEGSR LEMKVRATGN PNPDIVWLKN
SDIIVPHKYP KIRIEGTKGE AALKIDSTVS QDSAWYTATA INKAGRDTTR CKVNVEVEFA
EPEPERKLII PRGTYRAKEI AAPELEPLHL RYGQEQWEEG DLYDKEKQQK PFFKKKLTSL
RLKRFGPAHF ECRLTPIGDP TMVVEWLHDG KPLEAANRLR MINEFGYCSL DYGVAYSRDS
GIITCRATNK YGTDHTSATL IVKDEKSLVE ESQLPEGRKG LQRIEELERM AHEGALTGVT
TDQKEKQKPD IVLYPEPVRV LEGETARFRC RVTGYPQPKV NWYLNGQLIR KSKRFRVRYD
GIHYLDIVDC KSYDTGEVKV TAENPEGVIE HKVKLEIQQR EDFRSVLRRA PEPRPEFHVH
EPGKLQFEVQ KVDRPVDTTE TKEVVKLKRA ERITHEKVPE ESEELRSKFK RRTEEGYYEA
ITAVELKSRK KDESYEELLR KTKDELLHWT KELTEEEKKA LAEEGKITIP TFKPDKIELS
PSMEAPKIFE RIQSQTVGQG SDAHFRVRVV GKPDPECEWY KNGVKIERSD RIYWYWPEDN
VCELVIRDVT AEDSASIMVK AINIAGETSS HAFLLVQAKQ LITFTQELQD VVAKEKDTMA
TFECETSEPF VKVKWYKDGM EVHEGDKYRM HSDRKVHFLS ILTIDTSDAE DYSCVLVEDE
NVKTTAKLIV EGAVVEFVKE LQDIEVPESY SGELECIVSP ENIEGKWYHN DVELKSNGKY
TITSRRGRQN LTVKDVTKED QGEYSFVIDG KKTTCKLKMK PRPIAILQGL SDQKVCEGDI
VQLEVKVSLE SVEGVWMKDG QEVQPSDRVH IVIDKQSHML LIEDMTKEDA GNYSFTIPAL
GLSTSGRVSV YSVDVITPLK DVNVIEGTKA VLECKVSVPD VTSVKWYLND EQIKPDDRVQ
AIVKGTKQRL VINRTHASDE GPYKLIVGRV ETNCNLSVEK IKIIRGLRDL TCTETQNVVF
EVELSHSGID VLWNFKDKEI KPSSKYKIEA HGKIYKLTVL NMMKDDEGKY TFYAGENMTS
GKLTVAGGAI SKPLTDQTVA ESQEAVFECE VANPDSKGEW LRDGKHLPLT NNIRSESDGH
KRRLIIAATK LDDIGEYTYK VATSKTSAKL KVEAVKIKKT LKNLTVTETQ DAVFTVELTH
PNVKGVQWIK NGVVLESNEK YAISVKGTIY SLRIKNCAIV DESVYGFRLG RLGASARLHV
ETVKIIKKPK DVTALENATV AFEVSVSHDT VPVKWFHKSV EIKPSDKHRL VSERKVHKLM
LQNISPSDAG EYTAVVGQLE CKAKLFVETL HITKTMKNIE VPETKTASFE CEVSHFNVPS
MWLKNGVEIE MSEKFKIVVQ GKLHQLIIMN TSTEDSAEYT FVCGNDQVSA TLTVTPIMIT
SMLKDINAEE KDTITFEVTV NYEGISYKWL KNGVEIKSTD KCQMRTKKLT HSLNIRNVHF
GDAADYTFVA GKATSTATLY VEARHIEFRK HIKDIKVLEK KRAMFECEVS EPDITVQWMK
DDQELQITDR IKIQKEKYVH RLLIPSTRMS DAGKYTVVAG GNVSTAKLFV EGRDVRIRSI
KKEVQVIEKQ RAVVEFEVNE DDVDAHWYKD GIEINFQVQE RHKYVVERRI HRMFISETRQ
SDAGEYTFVA GRNRSSVTLY VNAPEPPQVL QELQPVTVQS GKPARFCAVI SGRPQPKISW
YKEEQLLSTG FKCKFLHDGQ EYTLLLIEAF PEDAAVYTCE AKNDYGVATT SASLSVEVPE
VVSPDQEMPV YPPAIITPLQ DTVTSEGQPA RFQCRVSGTD LKVSWYSKDK KIKPSRFFRM
TQFEDTYQLE IAEAYPEDEG TYTFVASNAV GQVSSTANLS LEGFSKFEEN TSNSQWHVSL
SVSFKKEPLG QKPSFIQPLS SLRVHNGETV RFHARVSGIP KPEIQWFHNQ QLILPTKDVV
FHFEESTGMA LMLIVDAYSE HAGQYSCKAA NSAGEATCAA TLTVTPKVQA LDRQSSGKDV
RESTKSQAVA DSSFTKEESK ISQKEIKSFQ GSSYEYEVQV FESVSQSSIH TAASVQDTQL
CHTASLSQIA ESTELSKECA KESTGEAPKI FLHLQDVTVK CGDTAQFLCV LKDDSFIDVT
WTHEGAKIEE SERLKQSQNG NIQFLTICNV QLVDQGLYSC IVHNDCGERT TSAVLSVEGA
PESILHERIE QEIEMEMKEF SSSFLSAEEE GLHSAELQLS KINETLELLS ESPVYPTKFD
SEKEGTGPIF IKEVSNADIS MGDVATLSVT VIGIPKPKIQ WFFNGVLLTP SADYKFVFDG
DDHSLIILFT KLEDEGEYTC MASNDYGKTI CSAYLKINSK GEGHKDTETE SAVAKSLEKL
GGPCPPHFLK ELKPIRCAQG LPAIFEYTVV GEPAPTVTWF KENKQLCTSV YYTIIHNPNG
SGTFIVNDPQ REDSGLYICK AENMLGESTC AAELLVLLED TDMTDTPCKA KSTPEAPEDF
PQTPLKGPAV EALDSEQEIA TFVKDTILKA ALITEENQQL SYEHIAKANE LSSQLPLGAQ
ELQSILEQDK LTPESTREFL CINGSIHFQP LKEPSPNLQL QIVQSQKTFS KEGILMPEEP
ETQAVLSDTE KIFPSAMSIE QINSLTVEPL KTLLAEPEGN YPQSSIEPPM HSYLTSVAEE
VLSPKEKTVS DTNREQRVTL QKQEAQSALI LSQSLAEGHV ESLQSPDVMI SQVNYEPLVP
SEHSCTEGGK ILIESANPLE NAGQDSAVRI EEGKSLRFPL ALEEKQVLLK EEHSDNVVMP
PDQIIESKRE PVAIKKVQEV QGRDLLSKES LLSGIPEEQR LNLKIQICRA LQAAVASEQP
GLFSEWLRNI EKVEVEAVNI TQEPRHIMCM YLVTSAKSVT EEVTIIIEDV DPQMANLKME
LRDALCAIIY EEIDILTAEG PRIQQGAKTS LQEEMDSFSG SQKVEPITEP EVESKYLIST
EEVSYFNVQS RVKYLDATPV TKGVASAVVS DEKQDESLKP SEEKEESSSE SGTEEVATVK
IQEAEGGLIK EDGPMIHTPL VDTVSEEGDI VHLTTSITNA KEVNWYFENK LVPSDEKFKC
LQDQNTYTLV IDKVNTEDHQ GEYVCEALND SGKTATSAKL TVVKRAAPVI KRKIEPLEVA
LGHLAKFTCE IQSAPNVRFQ WFKAGREIYE SDKCSIRSSK YISSLEILRT QVVDCGEYTC
KASNEYGSVS CTATLTVTEA YPPTFLSRPK SLTTFVGKAA KFICTVTGTP VIETIWQKDG
AALSPSPNWR ISDAENKHIL ELSNLTIQDR GVYSCKASNK FGADICQAEL IIIDKPHFIK
ELEPVQSAIN KKVHLECQVD EDRKVTVTWS KDGQKLPPGK DYKICFEDKI ATLEIPLAKL
KDSGTYVCTA SNEAGSSSCS ATVTVREPPS FVKKVDPSYL MLPGESARLH CKLKGSPVIQ
VTWFKNNKEL SESNTVRMYF VNSEAILDIT DVKVEDSGSY SCEAVNDVGS DSCSTEIVIK
EPPSFIKTLE PADIVRGTNA LLQCEVSGTG PFEISWFKDK KQIRSSKKYR LFSQKSLVCL
EIFSFNSADV GEYECVVANE VGKCGCMATH LLKEPPTFVK KVDDLIALGG QTVTLQAAVR
GSEPISVTWM KGQEVIREDG KIKMSFSNGV AVLIIPDVQI SFGGKYTCLA ENEAGSQTSV
GELIVKEPAK IIERAELIQV TAGDPATLEY TVAGTPELKP KWYKDGRPLV ASKKYRISFK
NNVAQLKFYS AELHDSGQYT FEISNEVGSS SCETTFTVLD RDIAPFFTKP LRNVDSVVNG
TCRLDCKIAG SLPMRVSWFK DGKEIAASDR YRIAFVEGTA SLEIIRVDMN DAGNFTCRAT
NSVGSKDSSG ALIVQEPPSF VTKPGSKDVL PGSAVCLKST FQGSTPLTIR WFKGNKELVS
GGSCYITKEA LESSLELYLV KTSDSGTYTC KVSNVAGGVE CSANLFVKEP ATFVEKLEPS
QLLKKGDATQ LACKVTGTPP IKITWFANDR EIKESSKHRM SFVESTAVLR LTDVGIEDSG
EYMCEAQNEA GSDHCSSIVI VKESPYFTKE FKPIEVLKEY DVMLLAEVAG TPPFEITWFK
DNTILRSGRK YKTFIQDHLV SLQILKFVAA DAGEYQCRVT NEVGSSICSA RVTLREPPSF
IKKIESTSSL RGGTAAFQAT LKGSLPITVT WLKDSDEITE DDNIRMTFEN NVASLYLSGI
EVKHDGKYVC QAKNDAGIQR CSALLSVKEP ATITEEAVSI DVTQGDPATL QVKFSGTKEI
TAKWFKDGQE LTLGSKYKIS VTDTVSILKI ISTEKKDSGE YTFEVQNDVG RSSCKARINV
LDLIIPPSFT KKLKKMDSIK GSFIDLECIV AGSHPISIQW FKDDQEISAS EKYKFSFHDN
TAFLEISQLE GTDSGTYTCS ATNKAGHNQC SGHLTVKEPP YFVEKPQSQD VNPNTRVQLK
ALVGGTAPMT IKWFKDNKEL HSGAARSVWK DDTSTSLELF AAKATDSGTY ICQLSNDVGT
ATSKATLFVK EPPQFIKKPS PVLVLRNGQS TTFECQITGT PKIRVSWYLD GNEITAIQKH
GISFIDGLAT FQISGARVEN SGTYVCEARN DAGTASCSIE LKVKEPPTFI RELKPVEVVK
YSDVELECEV TGTPPFEVTW LKNNREIRSS KKYTLTDRVS VFNLHITKCD PSDTGEYQCI
VSNEGGSCSC STRVALKEPP SFIKKIENTT TVLKSSATFQ STVAGSPPIS ITWLKDDQIL
DEDDNVYISF VDSVATLQIR SVDNGHSGRY TCQAKNESGV ERCYAFLLVQ EPAQIVEKAK
SVDVTEKDPM TLECVVAGTP ELKVKWLKDG KQIVPSRYFS MSFENNVASF RIQSVMKQDS
GQYTFKVEND FGSSSCDAYL RVLDQNIPPS FTKKLTKMDK VLGSSIHMEC KVSGSLPISA
QWFKDGKEIS TSAKYRLVCH ERSVSLEVNN LELEDTANYT CKVSNVAGDD ACSGILTVKE
PPSFLVKPGR QQAIPDSTVE FKAILKGTPP FKIKWFKDDV ELVSGPKCFI GLEGSTSFLN
LYSVDASKTG QYTCHVTNDV GSDSCTTMLL VTEPPKFVKK LEASKIVKAG DSSRLECKIA
GSPEIRVVWF RNEHELPASD KYRMTFIDSV AVIQMNNLST EDSGDFICEA QNPAGSTSCS
TKVIVKEPPV FSSFPPIVET LKNAEVSLEC ELSGTPPFEV VWYKDKRQLR SSKKYKIASK
NFHTSIHILN VDTSDIGEYH CKAQNEVGSD TCVCTVKLKE PPRFVSKLNS LTVVAGEPAE
LQASIEGAQP IFVQWLKEKE EVIRESENIR ITFVENVATL QFAKAEPANA GKYICQIKND
GGMRENMATL MVLEPAVIVE KAGPMTVTVG ETCTLECKVA GTPELSVEWY KDGKLLTSSQ
KHKFSFYNKI SSLRILSVER QDAGTYTFQV QNNVGKSSCT AVVDVSDRAV PPSFTRRLKN
TGGVLGASCI LECKVAGSSP ISVAWFHEKT KIVSGAKYQT TFSDNVCTLQ LNSLDSSDMG
NYTCVAANVA GSDECRAVLT VQEPPSFVKE PEPLEVLPGK NVTFTSVIRG TPPFKVNWFR
GARELVKGDR CNIYFEDTVA ELELFNIDIS QSGEYTCVVS NNAGQASCTT RLFVKEPAAF
LKRLSDHSVE PGKSIILEST YTGTLPISVT WKKDGFNITT SEKCNIVTTE KTCILEILNS
TKRDAGQYSC EIENEAGRDV CGALVSTLEP PYFVTELEPL EAAVGDSVSL QCQVAGTPEI
TVSWYKGDTK LRPTPEYRTY FTNNVATLVF NKVNINDSGE YTCKAENSIG TASSKTVFRI
QERQLPPSFA RQLKDIEQTV GLPVTLTCRL NGSAPIQVCW YRDGVLLRDD ENLQTSFVDN
VATLKILQTD LSHSGQYSCS ASNPLGTASS SARLTAREPK KSPFFDIKPV SIDVIAGESA
DFECHVTGAQ PMRITWSKDN KEIRPGGNYT ITCVGNTPHL RILKVGKGDS GQYTCQATND
VGKDMCSAQL SVKEPPKFVK KLEASKVAKQ GESIQLECKI SGSPEIKVSW FRNDSELHES
WKYNMSFINS VALLTINEAS AEDSGDYICE AHNGVGDASC STALTVKAPP VFTQKPSPVG
ALKGSDVILQ CEISGTPPFE VVWVKDRKQV RNSKKFKITS KHFDTSLHIL NLEASDVGEY
HCKATNEVGS DTCSCSVKFK EPPRFVKKLS DTSTLIGDAV ELRAIVEGFQ PISVVWLKDR
GEVIRESENT RISFIDNIAT LQLGSPEASN SGKYICQIKN DAGMRECSAV LTVLEPARII
EKPEPMTVTT GNPFALECVV TGTPELSAKW FKDGRELSAD SKHHITFINK VASLKIPCAE
MSDKGLYSFE VKNSVGKSNC TVSVHVSDRI VPPSFIRKLK DVNAILGASV VLECRVSGSA
PISVGWFQDG NEIVSGPKCQ SSFSENVCTL NLSLLEPSDT GIYTCVAANV AGSDECSAVL
TVQEPPSFEQ TPDSVEVLPG MSLTFTSVIR GTPPFKVKWF KGSRELVPGE SCNISLEDFV
TELELFEVQP LESGDYSCLV TNDAGSASCT THLFVKEPAT FVKRLADFSV ETGSPIVLEA
TYTGTPPISV SWIKDEYLIS QSERCSITMT EKSTILEILE STIEDYAQYS CLIENEAGQD
ICEALVSVLE PPYFIEPLEH VEAVIGEPAT LQCKVDGTPE IRISWYKEHT KLRSAPAYKM
QFKNNVASLV INKVDHSDVG EYSCKADNSV GAVASSAVLV IKARKLPPFF ARKLKDVHET
LGFPVAFECR INGSEPLQVS WYKDGVLLKD DANLQTSFVH NVATLQILQT DQSHIGQYNC
SASNPLGTAS SSAKLILSEH EVPPFFDLKP VSVDLALGES GTFKCHVTGT APIKITWAKD
NREIRPGGNY KMTLVENTAT LTVLKVGKGD AGQYTCYASN IAGKDSCSAQ LGVQEPPRFI
KKLEPSRIVK QDEFTRYECK IGGSPEIKVL WYKDETEIQE SSKFRMSFVD SVAVLEMHNL
SVEDSGDYTC EAHNAAGSAS SSTSLKVKEP PIFRKKPHPI ETLKGADVHL ECELQGTPPF
HVSWYKDKRE LRSGKKYKIM SENFLTSIHI LNVDAADIGE YQCKATNDVG SDTCVGSIAL
KAPPRFVKKL SDISTVVGKE VQLQTTIEGA EPISVVWFKD KGEIVRESDN IWISYSENIA
TLQFSRVEPA NAGKYTCQIK NDAGMQECFA TLSVLEPATI VEKPESIKVT TGDTCTLECT
VAGTPELSTK WFKDGKELTS DNKYKISFFN KVSGLKIINV APSDSGVYSF EVQNPVGKDS
CTASLQVSDR TVPPSFTRKL KETNGLSGSS VVMECKVYGS PPISVSWFHE GNEISSGRKY
QTTLTDNTCA LTVNMLEESD SGDYTCIATN MAGSDECSAP LTVREPPSFV QKPDPMDVLT
GTNVTFTSIV KGTPPFSVSW FKGSSELVPG DRCNVSLEDS VAELELFDVD TSQSGEYTCI
VSNEAGKASC TTHLYIKAPA KFVKRLNDYS IEKGKPLILE GTFTGTPPIS VTWKKNGINV
TPSQRCNITT TEKSAILEIP SSTVEDAGQY NCYIENASGK DSCSAQILIL EPPYFVKQLE
PVKVSVGDSA SLQCQLAGTP EIGVSWYKGD TKLRPTTTYK MHFRNNVATL VFNQVDINDS
GEYICKAENS VGEVSASTFL TVQEQKLPPS FSRQLRDVQE TVGLPVVFDC AISGSEPISV
SWYKDGKPLK DSPNVQTSFL DNTATLNIFK TDRSLAGQYS CTATNPIGSA SSSARLILTE
GKNPPFFDIR LAPVDAVVGE SADFECHVTG TQPIKVSWAK DSREIRSGGK YQISYLENSA
HLTVLKVDKG DSGQYTCYAV NEVGKDSCTA QLNIKERLIP PSFTKRLSET VEETEGNSFK
LEGRVAGSQP ITVAWYKNNI EIQPTSNCEI TFKNNTLVLQ VRKAGMNDAG LYTCKVSNDA
GSALCTSSIV IKEPKKPPVF DQHLTPVTVS EGEYVQLSCH VQGSEPIRIQ WLKAGREIKP
SDRCSFSFAS GTAVLELRDV AKADSGDYVC KASNVAGSDT TKSKVTIKDK PAVAPATKKA
AVDGRLFFVS EPQSIRVVEK TTATFIAKVG GDPIPNVKWT KGKWRQLNQG GRVFIHQKGD
EAKLEIRDTT KTDSGLYRCV AFNEHGEIES NVNLQVDERK KQEKIEGDLR AMLKKTPILK
KGAGEEEEID IMELLKNVDP KEYEKYARMY GITDFRGLLQ AFELLKQSQE EETHRLEIEE
IERSERDEKE FEELVSFIQQ RLSQTEPVTL IKDIENQTVL KDNDAVFEID IKINYPEIKL
SWYKGTEKLE PSDKFEISID GDRHTLRVKN CQLKDQGNYR LVCGPHIASA KLTVIEPAWE
RHLQDVTLKE GQTCTMTCQF SVPNVKSEWF RNGRILKPQG RHKTEVEHKV HKLTIADVRA
EDQGQYTCKY EDLETSAELR IEAEPIQFTK RIQNIVVSEH QSATFECEVS FDDAIVTWYK
GPTELTESQK YNFRNDGRCH YMTIHNVTPD DEGVYSVIAR LEPRGEARST AELYLTTKEI
KLELKPPDIP DSRVPIPTMP IRAVPPEEIP PVVAPPIPLL LPTPEEKKPP PKRIEVTKKA
VKKDAKKVVA KPKEMTPREE IVKKPPPPTT LIPAKAPEII DVSSKAEEVK IMTITRKKEV
QKEKEAVYEK KQAVHKEKRV FIESFEEPYD ELEVEPYTEP FEQPYYEEPD EDYEEIKVEA
KKEVHEEWEE DFEEGQEYYE REEGYDEGEE EWEEAYQERE VIQVQKEVYE ESHERKVPAK
VPEKKAPPPP KVIKKPVIEK IEKTSRRMEE EKVQVTKVPE VSKKIVPQKP SRTPVQEEVI
EVKVPAVHTK KMVISEEKMF FASHTEEEVS VTVPEVQKEI VTEEKIHVAI SKRVEPPPKV
PELPEKPAPE EVAPVPIPKK VEPPAPKVPE VPKKPVPEEK KPVPVPKKEP AAPPKVPEVP
KKPVPEEKIP VPVAKKKEAP PAKVPEVQKG VVTEEKITIV TQREESPPPA VPEIPKKKVP
EERKPVPRKE EEVPPPPKVP ALPKKPVPEE KVAVPVPVAK KAPPPRAEVS KKTVVEEKRF
VAEEKLSFAV PQRVEVTRHE VSAEEEWSYS EEEEGVSISV YREEEREEEE EAEVTEYEVM
EEPEEYVVEE KLHIISKRVE AEPAEVTERQ EKKIVLKPKI PAKIEEPPPA KVPEAPKKIV
PEKKVPAPVP KKEKVPPPKV PEEPKKPVPE KKVPPKVIKM EEPLPAKVTE RHMQITQEEK
VLVAVTKKEA PPKARVPEEP KRAVPEEKVL KLKPKREEEP PAKVTEFRKR VVKEEKVSIE
APKREPQPIK EVTIMEEKER AYTLEEEAVS VQREEEYEEY EEYDYKEFEE YEPTEEYDQY
EEYEEREYER YEEHEEYITE PEKPIPVKPV PEEPVPTKPK APPAKVLKKA VPEEKVPVPI
PKKLKPPPPK VPEEPKKVFE EKIRISITKR EKEQVTEPAA KVPMKPKRVV AEEKVPVPRK
EVAPPVRVPE VPKELEPEEV AFEEEVVTHV EEYLVEEEEE YIHEEEEFIT EEEVVPVIPV
KVPEVPRKPV PEEKKPVPVP KKKEAPPAKV PEVPKKPEEK VPVLIPKKEK PPPAKVPEVP
KKPVPEEKVP VPVPKKVEAP PAKVPEVPKK PVPEKKVPVP APKKVEAPPA KVPEVPKKLI
PEEKKPTPVP KKVEAPPPKV PKKREPVPVP VALPQEEEVL FEEEIVPEEE VLPEEEEVLP
EEEEVLPEEE EVLPEEEEIP PEEEEVPPEE EYVPEEEEFV PEEEVLPEVK PKVPVPAPVP
EVPKKPVPEK KVPVPAPKKV EPPPPPKVPE IKKKVTEKKV VIPKKEEAPP AKVSVVPKKP
EPEKKVPPPG LKKAVAPPAK VPEVPKKVEE KRIILPKEEE VLPVEVTEEP EEEPISEEEI
PEEPPSIEEV EEVAPPRVPE VIKKAVPEAP TPVPKKVEAP PAKVSKKIPE EKVPVPVQKK
EAPPAKVPEV PKKVPEKKVL VPKKEAVPPA KGRTVLEEKV SVAFRQEVVV KERLELEVVE
AEVEEIPEEE EFHEVEEYFE EGEFHEVEEF IKLEQHRVEE EHRVEKVHRV IEVFEAEEVE
VFEKPKAPPK GPEISEKIIP PKKPPTKVVP RKEPPAKVPE VPKKIVVEEK VRVPEEPRVP
PTKAPEVPKK IVPEEKVREA VLKKPEVPPA KVPGMPKKSV QEEKSPIVIS EDTEMYIYEA
SEEAVLEEKV LVTQPQKTKP KLAKVPEPPK KVVPEDKIYV TIPKKRETPA TKEPDTTRGI
FPEVEPPEAI PEIPEHPPTE EFEVFKEVIP EGETPIVKRR KTPSPTVPES PREIVPVKET
PMAAPLEIEI PPTKAPEAMK EVVPEMKIFE DVPEEPETPR MKTPEAPQEI IPAKTVPSKK
REPPSVKVPE ALQEIVPEKK TLVVPLRKPE VLPDEVPEAL REVVPEKKVH PPQRAEVVPV
KVHEAPKEII PEKKVSVVPP KKPEVPPVKV PEASKEVIRE EKVPLAPPKE PEVPPVKVPE
PPKEVVPEKK APVAPPKEPE VPPVKVPEAP KEVVPEKKVP VPPPKKPEVP PTKVPEVPKA
AVPEKKLPEA IPPKPESPPP EVPEVLPPKE VVPEKKVPVP PAKKPEAPPP KVPEAPKEVV
LEKKASVAVP KKPEAPRAKV PEAAQEVVPE KKIPKAPIKK PEAPAVTVPE VPQEATEKEI
PVAPPKKPEA PIVPVPEAQE VVPEKKVPKA PPTKPEAPPA TVPEVPQEIV PEKKTLVLPK
KPEVPPVTVP EAPKEVVLEK KVPSAPPKKP EVPPVKVPEA PKEVVPEKKV PVPPPKKPEV
PPTKVPEVPK AAVPEKKVPE AIPPKPESPP PEVPEVLPPK EVVPEKKVPV PPAKKPEAPP
PKVPEAPKEV VLEKKASVAV PKKPEAPRAK VPEAAQEVVP EKKIPKAPIK KPEAPAVTVP
EVPQEAAEKE IPVAPPKKPE APIVPVPEAQ EVVPEKKVPK APPTKPEAPP ATVPEVPQEI
VPEKKTLVLP KKPEVPPVTV PEAPKEVVLE KKVPSTPPKK PEVPPVKVPE APKEVVPEKK
VPVPPPKKPE VPPTKVPEVP KAAVPEKKVP EAIPPKPESP PPEVPEVLPP KEVVPEKKVP
VPPAKKPEAP PPKVPEAPKE VVLEKKVSVA VPKKPEAPRA KVPEAAQEVV PEKKIPKAPI
KKPEAPAVTV PEVPQEAAEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP KAPPTKPEAP
PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPLAPPK KPEVPPVKVP
EAPKEVVPEK KVPVTPPKKP EVPPVKVPEA PIEVVPEKKM PLAPPKKPEV PPVKVPEAPK
EVVPEKKVPS APPKKPEVPP VKVPEAPKEV VPEKKVPAAP PKKPEVTPVK VPEAPKEVVP
EKKVPVPPPK KPEVPPTKVP EVPKVAVPEK KVPEAIPPKP ESPPPEVFEE PEEVALEEPP
AEVVEEPEPA APPQVTVPPK KPVPEKKAPA VVAKKPELPP VKVPEVPKEV VPEKKVPLVV
PKKPEAPPAK VPEVPKEVVP EKKVAVPKKP EVPPAKVPEV PKKPVLEEKP AVPVPERAES
PPPEVYEEPE EIAPEEEIAP EEEKPVPVAE EEEPEVPPPA VPEEPKKIIP EKKVPVIKKP
EAPPPKEPEM PKKVVPVKKV PTVKKPETPA AKVPEVPKKL VPVKKEPVPV TKKPEVLPEK
VPKVPEKIIP EKEVSVPIPA EPEVPPAEVE ETPEEIIYEE KASITIGRKE TPPVEEREIE
KYIKPEEPEP EPQPEEIPVK EPEPEKVIEK PKLKPRPPPP PPAPPKEDVK EKIFQLKAIP
KKKVPEKPQV PEKVELTPLK VPGGEKKVRK LLPERKPEPK EEVVLKSVLR KRPEEEEPKV
EPKKLEKVKK PAVPEPPPPK PVEEVEVPTV TKRERKIPEP TKVPEIKPAI PLPAPEPKPK
PEAEVKTIKP PPVEPEPTPI AAPVTVPVVG KKAEAKAPKE EAAKPKGPIK GVPKKTPSPI
EAERRKLRPG SGGEKPPDEA PFTYQLKAVP LKFVKEIKDI ILTESEFVGS SAIFECLVSP
STAITTWMKD GSNIRESPKH RFIADGKDRK LHIIDVQLSD AGEYTCVLRL GNKEKTSTAK
LVVEELPVRF VKTLEEEVTV VKGQPLYLSC ELNKERDVVW RKDGKIVVEK PGRIVPGVIG
LMRALTINDA DDTDAGTYTV TVENANNLEC SSCVKVVEVI RDWLVKPIRD QHVKPKGTAI
FACDIAKDTP NIKWFKGYDE IPAEPNDKTE ILRDGNHLYL KIKNAMPEDI AEYAVEIEGK
RYPAKLTLGE REVELLKPIE DVTIYEKESA SFDAEISEAD IPGQWKLKGE LLRPSPTCEI
KAEGGKRFLT LHKVKLDQAG EVLYQALNAI TTAILTVKEI ELDFAVPLKD VTVPERRQAR
FECVLTREAN VIWSKGPDII KSSDKFDIIA DGKKHILVIN DSQFDDEGVY TAEVEGKKTS
ARLFVTGIRL KFMSPLEDQT VKEGETATFV CELSHEKMHV VWFKNDAKLH TSRTVLISSE
GKTHKLEMKE VTLDDISQIK AQVKELSSTA QLKVLEADPY FTVKLHDKTA VEKDEITLKC
EVSKDVPVKW FKDGEEIVPS PKYSIKADGL RRILKIKKAD LKDKGEYVCD CGTDKTKANV
TVEARLIKVE KPLYGVEVFV GETAHFEIEL SEPDVHGQWK LKGQPLTASP DCEIIEDGKK
HILILHNCQL GMTGEVSFQA ANAKSAANLK VKELPLIFIT PLSDVKVFEK DEAKFECEVS
REPKTFRWLK GTQEITGDDR FELIKDGTKH SMVIKSAAFE DEAKYMFEAE DKHTSGKLII
EGIRLKFLTP LKDVTAKEKE SAVFTVELSH DNIRVKWFKN DQRLHTTRSV SMQDEGKTHS
ITFKDLSIDD TSQIRVEAMG MSSEAKLTVL EGDPYFTGKL QDYTGVEKDE VILQCEISKA
DAPVKWFKDG KEIKPSKNAV IKADGKKRML ILKKALKSDI GQYTCDCGTD KTSGKLDIED
REIKLVRPLH SVEVMETETA RFETEISEDD IHANWKLKGE ALLQTPDCEI KEEGKIHSLV
LHNCRLDQTG GVDFQAANVK SSAHLRVKPR VIGLLRPLKD VTVTAGETAT FDCELSYEDI
PVEWYLKGKK LEPSDKVVPR SEGKVHTLTL RDVKLEDAGE VQLTAKDFKT HANLFVKEPP
VEFTKPLEDQ TVEEGATAVL ECEVSRENAK VKWFKNGTEI LKSKKYEIVA DGRVRKLVIH
DCTPEDIKTY TCDAKDFKTS CNLNVVPPHV EFLRPLTDLQ VREKEMARFE CELSRENAKV
KWFKDGAEIK KGKKYDIISK GAVRILVINK CLLDDEAEYS CEVRTARTSG MLTVLEEEAV
FTKNLANIEV SETDTIKLVC EVSKPGAEVI WYKGDEEIIE TGRYEILTEG RKRILVIQNA
HLEDAGNYNC RLPSSRTDGK VKVHELAAEF ISKPQNLEIL EGEKAEFVCS ISKESFPVQW
KRDDKTLESG DKYDVIADGK KRVLVVKDAT LQDMGTYVVM VGAARAAAHL TVIEKLRIVV
PLKDTRVKEQ QEVVFNCEVN TEGAKAKWFR NEEAIFDSSK YIILQKDLVY TLRIRDAHLD
DQANYNVSLT NHRGENVKSA ANLIVEEEDL RIVEPLKDIE TMEKKSVTFW CKVNRLNVTL
KWTKNGEEVP FDNRVSYRVD KYKHMLTIKD CGFPDEGEYI VTAGQDKSVA ELLIIEAPTE
FVEHLEDQTV TEFDDAVFSC QLSREKANVK WYRNGREIKE GKKYKFEKDG SIHRLIIKDC
RLDDECEYAC GVEDRKSRAR LFVEEIPVEI IRPPQDILEA PGADVVFLAE LNKDKVEVQW
LRNNMVVVQG DKHQMMSEGK IHRLQICDIK PRDQGEYRFI AKDKEARAKL ELAAAPKIKT
ADQDLVVDVG KPLTMVVPYD AYPKAEAEWF KENEPLSTKT IDTTAEQTSF RILEAKKGDK
GRYKIVLQNK HGKAEGFINL KVIDVPGPVR NLEVTETFDG EVSLAWEEPL TDGGSKIIGY
VVERRDIKRK TWVLATDRAE SCEFTVTGLQ KGGVEYLFRV SARNRVGTGE PVETDNPVEA
RSKYDVPGPP LNVTITDVNR FGVSLTWEPP EYDGGAEITN YVIELRDKTS IRWDTAMTVR
AEDLSATVTD VVEGQEYSFR VRAQNRIGVG KPSAATPFVK VADPIERPSP PVNLTSSDQT
QSSVQLKWEP PLKDGGSPIL GYIIERCEEG KDNWIRCNMK LVPELTYKVT GLEKGNKYLY
RVSAENKAGV SDPSEILGPL TADDAFVEPT MDLSAFKDGL EVIVPNPITI LVPSTGYPRP
TATWCFGDKV LETGDRVKMK TLSAYAELVI SPSERSDKGI YTLKLENRVK TISGEIDVNV
IARPSAPKEL KFGDITKDSV HLTWEPPDDD GGSPLTGYVV EKREVSRKTW TKVMDFVTDL
EFTVPDLVQG KEYLFKVCAR NKCGPGEPAY VDEPVNMSTP ATVPDPPENV KWRDRTANSI
FLTWDPPKND GGSRIKGYIV ERCPRGSDKW VACGEPVAET KMEVTGLEEG KWYAYRVKAL
NRQGASKPSR PTEEIQAVDT QEAPEIFLDV KLLAGLTVKA GTKIELPATV TGKPEPKITW
TKADMILKQD KRITIENVPK KSTVTIVDSK RSDTGTYIIE AVNVCGRATA VVEVNVLDKP
GPPAAFDITD VTNESCLLTW NPPRDDGGSK ITNYVVERRA TDSEVWHKLS STVKDTNFKA
TKLIPNKEYI FRVAAENMYG VGEPVQASPI TAKYQFDPPG PPTRLEPSDI TKDAVTLTWC
EPDDDGGSPI TGYWVERLDP DTDKWVRCNK MPVKDTTYRV KGLTNKKKYR FRVLAENLAG
PGKPSKSTEP ILIKDPIDPP WPPGKPTVKD VGKTSVRLNW TKPEHDGGAK IESYVIEMLK
TGTDEWVRVA EGVPTTQHLL PGLMEGQEYS FRVRAVNKAG ESEPSEPSDP VLCREKLYPP
SPPRWLEVIN ITKNTADLKW TVPEKDGGSP ITNYIVEKRD VRRKGWQTVD TTVKDTKCTV
TPLTEGSLYV FRVAAENAIG QSDYTEIEDS VLAKDTFTTP GPPYALAVVD VTKRHVDLKW
EPPKNDGGRP IQRYVIEKKE RLGTRWVKAG KTAGPDCNFR VTDVIEGTEV QFQVRAENEA
GVGHPSEPTE ILSIEDPTSP PSPPLDLHVT DAGRKHIAIA WKPPEKNGGS PIIGYHVEMC
PVGTEKWMRV NSRPIKDLKF KVEEGVVPDK EYVLRVRAVN AIGVSEPSEI SENVVAKDPD
CKPTIDLETH DIIVIEGEKL SIPVPFRAVP VPTVSWHKDG KEVKASDRLT MKNDHISAHL
EVPKSVRADA GIYTITLENK LGSATASINV KVIGLPGPCK DIKASDITKS SCKLTWEPPE
FDGGTPILHY VLERREAGRR TYIPVMSGEN KLSWTVKDLI PNGEYFFRVK AVNKVGGGEY
IELKNPVIAQ DPKQPPDPPV DVEVHNPTAE AMTITWKPPL YDGGSKIMGY IIEKIAKGEE
RWKRCNEHLV PILTYTAKGL EEGKEYQFRV RAENAAGISE PSRATPPTKA VDPIDAPKVI
LRTSLEVKRG DEIALDASIS GSPYPTITWI KDENVIVPEE IKKRAAPLVR RRKGEVQEEE
PFVLPLTQRL SIDNSKKGES QLRVRDSLRP DHGLYMIKVE NDHGIAKAPC TVSVLDTPGP
PINFVFEDIR KTSVLCKWEP PLDDGGSEII NYTLEKKDKT KPDSEWIVVT STLRHCKYSV
TKLIEGKEYL FRVRAENRFG PGPPCVSKPL VAKDPFGPPD APDKPIVEDV TSNSMLVKWN
EPKDNGSPIL GYWLEKREVN STHWSRVNKS LLNALKANVD GLLEGLTYVF RVCAENAAGP
GKFSPPSDPK TAHDPISPPG PPIPRVTDTS STTIELEWEP PAFNGGGEIV GYFVDKQLVG
TNEWSRCTEK MIKVRQYTVK EIREGADYKL RVSAVNAAGE GPPGETQPVT VAEPQEPPAV
ELDVSVKGGI QIMAGKTLRI PAVVTGRPVP TKVWTKEEGE LDKDRVVIDN VGTKSELIIK
DALRKDHGRY VITATNSCGS KFAAARVEVF DVPGPVLDLK PVVTNRKMCL LNWSDPEDDG
GSEITGFIIE RKDAKMHTWR QPIETERSKC DITGLLEGQE YKFRVIAKNK FGCGPPVEIG
PILAVDPLGP PTSPERLTYT ERTKSTITLD WKEPRSNGGS PIQGYIIEKR RHDKPDFERV
NKRLCPTTSF LVENLDEHQM YEFRVKAVNE IGESEPSLPL NVVIQDDEVP PTIKLRLSVR
GDTIKVKAGE PVHIPADVTG LPMPKIEWSK NETVIEKPTD ALQITKEEVS RSEAKTELSI
PKAVREDKGT YTVTASNRLG SVFRNVHVEV YDRPSPPRNL AVTDIKAESC YLTWDAPLDN
GGSEITHYVI DKRDASRKKA EWEEVTNTAV EKRYGIWKLI PNGQYEFRVR AVNKYGISDE
CKSDKVVIQD PYRLPGPPGK PKVLARTKGS MLVSWTPPLD NGGSPITGYW LEKREEGSPY
WSRVSRAPIT KVGLKGVEFN VPRLLEGVKY QFRAMAINAA GIGPPSEPSD PEVAGDPIFP
PGPPSCPEVK DKTKSSISLG WKPPAKDGGS PIKGYIVEMQ EEGTTDWKRV NEPDKLITTC
ECVVPNLKEL RKYRFRVKAV NEAGESEPSD TTGEIPATDI QEEPEVFIDI GAQDCLVCKA
GSQIRIPAVI KGRPTPKSSW EFDGKAKKAM KDGVHDIPED AQLETAENSS VIIIPECKRS
HTGKYSITAK NKAGQKTANC RVKVMDVPGP PKDLKVSDIT RGSCRLSWKM PDDDGGDRIK
GYVIEKRTID GKAWTKVNPD CGSTTFVVPD LLSEQQYFFR VRAENRFGIG PPVETIQRTT
ARDPIYPPDP PIKLKIGLIT KNTVHLSWKP PKNDGGSPVT HYIVECLAWD PTGTKKEAWR
QCNKRDVEEL QFTVEDLVEG GEYEFRVKAV NAAGVSKPSA TVGPVTVKDQ TCPPSIDLKE
FMEVEEGTNV NIVAKIKGVP FPTLTWFKAP PKKPDNKEPV LYDTHVNKLV VDDTCTLVIP
QSRRSDTGLY TITAVNNLGT ASKEMRLNVL GRPGPPVGPI KFESVSADQM TLSWFPPKDD
GGSKITNYVI EKREANRKTW VHVSSEPKEC TYTIPKLLEG HEYVFRIMAQ NKYGIGEPLD
SEPETARNLF SVPGAPDKPT VSSVTRNSMT VNWEEPEYDG GSPVTGYWLE MKDTTSKRWK
RVNRDPIKAM TLGVSYKVTG LIEGSDYQFR VYAINAAGVG PASLPSDPAT ARDPIAPPGP
PFPKVTDWTK SSADLEWSPP LKDGGSKVTG YIVEYKEEGK EEWEKGKDKE VRGTKLVVTG
LKEGAFYKFR VRAVNIAGIG EPGEVTDVIE MKDRLVSPDL QLDASVRDRI VVHAGGVIRI
IAYVSGKPPP TVTWNMNERT LPQEATIETT AISSSMVIKN CQRSHQGVYS LLAKNEAGER
KKTIIVDVLD VPGPVGTPFL AHNLTNESCK LTWFSPEDDG GSPITNYVIE KRESDRRAWT
PVTYTVTRQN ATVQGLIQGK AYFFRIAAEN SIGMGPFVET SEALVIREPI TVPERPEDLE
VKEVTKNTVT LTWNPPKYDG GSEIINYVLE SRLIGTEKFH KVTNDNLLSR KYTVKGLKEG
DTYEYRVSAV NIVGQGKPSF CTKPITCKDE LAPPTLHLDF RDKLTIRVGE AFALTGRYSG
KPKPKVSWFK DEADVLEDDR THIKTTPATL ALEKIKAKRS DSGKYCVVVE NSTGSRKGFC
QVNVVDRPGP PVGPVSFDEV TKDYMVISWK PPLDDGGSKI TNYIIEKKEV GKDVWMPVTS
ASAKTTCKVS KLLEGKDYIF RIHAENLYGI SDPLVSDSMK AKDRFRVPDA PDQPIVTEVT
KDSALVTWNK PHDGGKPITN YILEKRETMS KRWARVTKDP IHPYTKFRVP DLLEGCQYEF
RVSAENEIGI GDPSPPSKPV FAKDPIAKPS PPVNPEAIDT TCNSVDLTWQ PPRHDGGSKI
LGYIVEYQKV GDEEWRRANH TPESCPETKY KVTGLRDGQT YKFRVLAVNA AGESDPAHVP
EPVLVKDRLE PPELILDANM AREQHIKVGD TLRLSAIIKG VPFPKVTWKK EDRDAPTKAR
IDVTPVGSKL EIRNAAHEDG GIYSLTVENP AGSKTVSVKV LVLDKPGPPR DLEVSEIRKD
SCYLTWKEPL DDGGSVITNY VVERRDVASA QWSPLSATSK KKSHFAKHLN EGNQYLFRVA
AENQYGRGPF VETPKPIKAL DPLHPPGPPK DLHHVDVDKT EVSLVWNKPD RDGGSPITGY
LVEYQEEGTQ DWIKFKTVTN LECVVTGLQQ GKTYRFRVKA ENIVGLGLPD TTIPIECQEK
LVPPSVELDV KLIEGLVVKA GTTVRFPAII RGVPVPTAKW TTDGSEIKTD EHYTVETDNF
SSVLTIKNCL RRDTGEYQIT VSNAAGSKTV AVHLTVLDVP GPPTGPINIL DVTPEHMTIS
WQPPKDDGGS PVINYIVEKQ DTRKDTWGVV SSGSSKTKLK IPHLQKGCEY VFRVRAENKI
GVGPPLDSTP TVAKHKFSPP SPPGKPVVTD ITENAATVSW TLPKSDGGSP ITGYYMERRE
VTGKWVRVNK TPIADLKFRV TGLYEGNTYE FRVFAENLAG LSKPSPSSDP IKACRPIKPP
GPPINPKLKD KSRETADLVW TKPLSDGGSP ILGYVVECQK PGTAQWNRIN KDELIRQCAF
RVPGLIEGNE YRFRIKAANI VGEGEPRELA ESVIAKDILH PPEVELDVTC RDVITVRVGQ
TIRILARVKG RPEPDITWTK EGKVLVREKR VDLIQDLPRV ELQIKEAVRA DHGKYIISAK
NSSGHAQGSA IVNVLDRPGP CQNLKVTNVT KENCTISWEN PLDNGGSEIT NFIVEYRKPN
QKGWSIVASD VTKRLIKANL LANNEYYFRV CAENKVGVGP TIETKTPILA INPIDRPGEP
ENLHIADKGK TFVYLKWRRP DYDGGSPNLS YHVERRLKGS DDWERVHKGS IKETHYMVDR
CVENQIYEFR VQTKNEGGES DWVKTEEVVV KEDLQKPVLD LKLSGVLTVK AGDTIRLEAG
VRGKPFPEVA WTKDKDATDL TRSPRVKIDT RADSSKFSLT KAKRSDGGKY VVTATNTAGS
FVAYATVNVL DKPGPVRNLK IVDVSSDRCT VCWDPPEDDG GCEIQNYILE KCETKRMVWS
TYSATVLTPG TTVTRLIEGN EYIFRVRAEN KIGTGPPTES KPVIAKTKYD KPGRPDPPEV
TKVSKEEMTV VWNPPEYDGG KSITGYFLEK KEKHSTRWVP VNKSAIPERR MKVQNLLPDH
EYQFRVKAEN EIGIGEPSLP SRPVVAKDPI EPPGPPTNFR VVDTTKHSIT LGWGKPVYDG
GAPIIGYVVE MRPKIADASP DEGWKRCNAA AQLVRKEFTV TSLDENQEYE FRVCAQNQVG
IGRPAELKEA IKPKEILEPP EIDLDASMRK LVIVRAGCPI RLFAIVRGRP APKVTWRKVG
IDNVVRKGQV DLVDTMAFLV IPNSTRDDSG KYSLTLVNPA GEKAVFVNVR VLDTPGPVSD
LKVSDVTKTS CHVSWAPPEN DGGSQVTHYI VEKREADRKT WSTVTPEVKK TSFHVTNLVP
GNEYYFRVTA VNEYGPGVPT DVPKPVLASD PLSEPDPPRK LEVTEMTKNS ATLAWLPPLR
DGGAKIDGYI TSYREEEQPA DRWTEYSVVK DLSLVVTGLK EGKKYKFRVA ARNAVGVSLP
REAEGVYEAK EQLLPPKILM PEQITIKAGK KLRIEAHVYG KPHPTCKWKK GEDEVVTSSH
LAVHKADSSS ILIIKDVTRK DSGYYSLTAE NSSGTDTQKI KVVVMDAPGP PQPPFDISDI
DADACSLSWH IPLEDGGSNI TNYIVEKCDV SRGDWVTALA SVTKTSCRVG KLIPGQEYIF
RVRAENRFGI SEPLTSPKMV AQFPFGVPSE PKNARVTKVN KDCIFVAWDR PDSDGGSPII
GYLIERKERN SLLWVKANDT LVRSTEYPCA GLVEGLEYSF RIYALNKAGS SPPSKPTEYV
TARMPVDPPG KPEVIDVTKS TVSLIWARPK HDGGSKIIGY FVEACKLPGD KWVRCNTAPH
QIPQEEYTAT GLEEKAQYQF RAIARTAVNI SPPSEPSDPV TILAENVPPR IDLSVAMKSL
LTVKAGTNVC LDATVFGKPM PTVSWKKDGT LLKPAEGIKM AMQRNLCTLE LFSVNRKDSG
DYTITAENSS GSKSATIKLK VLDKPGPPAS VKINKMYSDR AMLSWEPPLE DGGSEITNYI
VDKRETSRPN WAQVSATVPI TSCSVEKLIE GHEYQFRICA ENKYGVGDPV FTEPAIAKNP
YDPPGRCDPP VISNITKDHM TVSWKPPADD GGSPITGYLL EKRETQAVNW TKVNRKPIIE
RTLKATGLQE GTEYEFRVTA INKAGPGKPS DASKAAYARD PQYPPGPPAF PKVYDTTRSS
VSLSWGKPAY DGGSPIIGYL VEVKRADSDN WVRCNLPQNL QKTRFEVTGL MEDTQYQFRV
YAVNKIGYSD PSDVPDKHYP KDILIPPEGE LDADLRKTLI LRAGVTMRLY VPVKGRPPPK
ITWSKPNVNL RDRIGLDIKS TDFDTFLRCE NVNKYDAGKY ILTLENSCGK KEYTIVVKVL
DTPGPPVNVT VKEISKDSAY VTWEPPIIDG GSPIINYVVQ KRDAERKSWS TVTTECSKTS
FRVANLEEGK SYFFRVFAEN EYGIGDPGET RDAVKASQTP GPVVDLKVRS VSKSSCSIGW
KKPHSDGGSR IIGYVVDFLT EENKWQRVMK SLSLQYSAKD LTEGKEYTFR VSAENENGEG
TPSEITVVAR DDVVAPDLDL KGLPDLCYLA KENSNFRLKI PIKGKPAPSV SWKKGEDPLA
TDTRVSVESS AVNTTLIVYD CQKSDAGKYT ITLKNVAGTK EGTISIKVVG KPGIPTGPIK
FDEVTAEAMT LKWAPPKDDG GSEITNYILE KRDSVNNKWV TCASAVQKTT FRVTRLHEGM
EYTFRVSAEN KYGVGEGLKS EPIVARHPFD VPDAPPPPNI VDVRHDSVSL TWTDPKKTGG
SPITGYHLEF KERNSLLWKR ANKTPIRMRD FKVTGLTEGL EYEFRVMAIN LAGVGKPSLP
SEPVVALDPI DPPGKPEVIN ITRNSVTLIW TEPKYDGGHK LTGYIVEKRD LPSKSWMKAN
HVNVPECAFT VTDLVEGGKY EFRIRAKNTA GAISAPSEST ETIICKDEYE APTIVLDPTI
KDGLTIKAGD TIVLNAISIL GKPLPKSSWS KAGKDIRPSD ITQITSTPTS SMLTIKYATR
KDAGEYTITA TNPFGTKVEH VKVTVLDVPG PPGPVEISNV SAEKATLTWT PPLEDGGSPI
KSYILEKRET SRLLWTVVSE DIQSCRHVAT KLIQGNEYIF RVSAVNHYGK GEPVQSEPVK
MVDRFGPPGP PEKPEVSNVT KNTATVSWKR PVDDGGSEIT GYHVERREKK SLRWVRAIKT
PVSDLRCKVT GLQEGSTYEF RVSAENRAGI GPPSEASDSV LMKDAAYPPG PPSNPHVTDT
TKKSASLAWG KPHYDGGLEI TGYVVEHQKV GDEAWIKDTT GTALRITQFV VPDLQTKEKY
NFRISAINDA GVGEPAVIPD VEIVEREMAP DFELDAELRR TLVVRAGLSI RIFVPIKGRP
APEVTWTKDN INLKNRANIE NTESFTLLII PECNRYDTGK FVMTIENPAG KKSGFVNVRV
LDTPGPVLNL RPTDITKDSV TLHWDLPLID GGSRITNYIV EKREATRKSY STATTKCHKC
TYKVTGLSEG CEYFFRVMAE NEYGIGEPTE TTEPVKASEA PSPPDSLNIM DITKSTVSLA
WPKPKHDGGS KITGYVIEAQ RKGSDQWTHI TTVKGLECVV RNLTEGEEYT FQVMAVNSAG
RSAPRESRPV IVKEQTMLPE LDLRGIYQKL VIAKAGDNIK VEIPVLGRPK PTVTWKKGDQ
ILKQTQRVNF ETTATSTILN INECVRSDSG PYPLTARNIV GEVGDVITIQ VHDIPGPPTG
PIKFDEVSSD FVTFSWDPPE NDGGVPISNY VVEMRQTDST TWVELATTVI RTTYKATRLT
TGLEYQFRVK AQNRYGVGPG ITSACIVANY PFKVPGPPGT PQVTAVTKDS MTISWHEPLS
DGGSPILGYH VERKERNGIL WQTVSKALVP GNIFKSSGLT DGIAYEFRVI AENMAGKSKP
SKPSEPMLAL DPIDPPGKPV PLNITRHTVT LKWAKPEYTG GFKITSYIVE KRDLPNGRWL
KANFSNILEN EFTVSGLTED AAYEFRVIAK NAAGAISPPS EPSDAITCRD DVEAPKIKVD
VKFKDTVILK AGEAFRLEAD VSGRPPPTME WSKDGKELEG TAKLEIKIAD FSTNLVNKDS
TRRDSGAYTL TATNPGGFAK HIFNVKVLDR PGPPEGPLAV TEVTSEKCVL SWFPPLDDGG
AKIDHYIVQK RETSRLAWTN VASEVQVTKL KVTKLLKGNE YIFRVMAVNK YGVGEPLESE
PVLAVNPYGP PDPPKNPEVT TITKDSMVVC WGHPDSDGGS EIINYIVERR DKAGQRWIKC
NKKTLTDLRY KVSGLTEGHE YEFRIMAENA AGISAPSPTS PFYKACDTVF KPGPPGNPRV
LDTSRSSISI AWNKPIYDGG SEITGYMVEI ALPEEDEWQI VTPPAGLKAT SYTITGLTEN
QEYKIRIYAM NSEGLGEPAL VPGTPKAEDR MLPPEIELDA DLRKVVTIRA CCTLRLFVPI
KGRPAPEVKW ARDHGESLDK ASIESTSSYT LLIVGNVNRF DSGKYILTVE NSSGSKSAFV
NVRVLDTPGP PQDLKVKEVT KTSVTLTWDP PLLDGGSKIK NYIVEKREST RKAYSTVATN
CHKTSWKVDQ LQEGCSYYFR VLAENEYGIG LPAETAESVK ASERPLPPGK ITLMDVTRNS
VSLSWEKPEH DGGSRILGYI VEMQTKGSDK WATCATVKVT EATITGLIQG EEYSFRVSAQ
NEKGISDPRQ LSVPVIAKDL VIPPAFKLLF NTFTVLAGED LKVDVPFIGR PTPAVTWHKD
NVPLKQTTRV NAESTENNSL LTIKDACRED VGHYVVKLTN SAGEAIETLN VIVLDKPGPP
TGPVKMDEVT ADSITLSWGP PKYDGGSSIN NYIVEKRDTS TTTWQIVSAT VARTTIKACR
LKTGCEYQFR IAAENRYGKS TYLNSEPTVA QYPFKVPGPP GTPVVTLSSR DSMEVQWNEP
ISDGGSRVIG YHLERKERNS ILWVKLNKTP IPQTKFKTTG LEEGVEYEFR VSAENIVGIG
KPSKVSECYV ARDPCDPPGR PEAIIVTRNS VTLQWKKPTY DGGSKITGYI VEKKELPEGR
WMKASFTNII DTHFEVTGLV EDHRYEFRVI ARNAAGVFSE PSESTGAITA RDEVDPPRIS
MDPKYKDTIV VHAGESFKVD ADIYGKPIPT IQWIKGDQEL SNTARLEIKS TDFATSLSVK
DAVRVDSGNY ILKAKNVAGE RSVTVNVKVL DRPGPPEGPV VISGVTAEKC TLAWKPPLQD
GGSDIINYIV ERRETSRLVW TVVDANVQTL SCKVTKLLEG NEYTFRIMAV NKYGVGEPLE
SEPVVAKNPF VVPDAPKAPE VTTVTKDSMI VVWERPASDG GSEILGYVLE KRDKEGIRWT
RCHKRLIGEL RLRVTGLIEN HDYEFRVSAE NAAGLSEPSP PSAYQKACDP IYKPGPPNNP
KVIDITRSSV FLSWSKPIYD GGCEIQGYIV EKCDVSVGEW TMCTPPTGIN KTNIEVEKLL
EKHEYNFRIC AINKAGVGEH ADVPGPIIVE EKLEAPDIDL DLELRKIINI RAGGSLRLFV
PIKGRPTPEV KWGKVDGEIR DAAIIDVTSS FTSLVLDNVN RYDSGKYTLT LENSSGTKSA
FVTVRVLDTP SPPVNLKVTE ITKDSVSITW EPPLLDGGSK IKNYIVEKRE ATRKSYAAVV
TNCHKNSWKI DQLQEGCSYY FRVTAENEYG IGLPAQTADP IKVAEVPQPP GKITVDDVTR
NSVSLSWTKP EHDGGSKIIQ YIVEMQAKHS EKWSECARVK SLQAVITNLT QGEEYLFRVV
AVNEKGRSDP RSLAVPIVAK DLVIEPDVKP AFSSYSVQVG QDLKIEVPIS GRPKPTITWT
KDGLPLKQTT RINVTDSLDL TTLSIKETHK DDGGQYGITV ANVVGQKTAS IEIVTLDKPD
PPKGPVKFDD VSAESITLSW NPPLYTGGCQ ITNYIVQKRD TTTTVWDVVS ATVARTTLKV
TKLKTGTEYQ FRIFAENRYG QSFALESDPI VAQYPYKEPG PPGTPFATAI SKDSMVIQWH
EPVNNGGSPV IGYHLERKER NSILWTKVNK TIIHDTQFKA QNLEEGIEYE FRVYAENIVG
VGKASKNSEC YVARDPCDPP GTPEPIMVKR NEITLQWTKP VYDGGSMITG YIVEKRDLPD
GRWMKASFTN VIETQFTVSG LTEDQRYEFR VIAKNAAGAI SKPSDSTGPI TAKDEVELPR
ISMDPKFRDT IVVNAGETFR LEADVHGKPL PTIEWLRGDK EIEESARCEI KNTDFKALLI
VKDAIRIDGG QYILRASNVA GSKSFPVNVK VLDRPGPPEG PVQVTGVTSE KCSLTWSPPL
QDGGSDISHY VVEKRETSRL AWTVVASEVV TNSLKVTKLL EGNEYVFRIM AVNKYGVGEP
LESAPVLMKN PFVLPGPPKS LEVTNIAKDS MTVCWNRPDS DGGSEIIGYI VEKRDRSGIR
WIKCNKRRIT DLRLRVTGLT EDHEYEFRVS AENAAGVGEP SPATVYYKAC DPVFKPGPPT
NAHIVDTTKN SITLAWGKPI YDGGSEILGY VVEICKADEE EWQIVTPQTG LRVTRFEISK
LTEHQEYKIR VCALNKVGLG EATSVPGTVK PEDKLEAPEL DLDSELRKGI VVRAGGSARI
HIPFKGRPTP EITWSREEGE FTDKVQIEKG VNYTQLSIDN CDRNDAGKYI LKLENSSGSK
SAFVTVKVLD TPGPPQNLAV KEVRKDSAFL VWEPPIIDGG AKVKNYVIDK RESTRKAYAN
VSSKCSKTSF KVENLTEGAI YYFRVMAENE FGVGVPVETV DAVKAAEPPS PPGKVTLTDV
SQTSASLMWE KPEHDGGSRV LGYVVEMQPK GTEKWSIVAE SKVCNAVVTG LSSGQEYQFR
VKAYNEKGKS DPRVLGVPVI AKDLTIQPSL KLPFNTYSIQ AGEDLKIEIP VIGRPRPNIS
WVKDGEPLKQ TTRVNVEETA TSTVLHIKEG NKDDFGKYTV TATNSAGTAT ENLSVIVLEK
PGPPVGPVRF DEVSADFVVI SWEPPAYTGG CQISNYIVEK RDTTTTTWHM VSATVARTTI
KITKLKTGTE YQFRIFAENR YGKSAPLDSK AVIVQYPFKE PGPPGTPFVT SISKDQMLVQ
WHEPVNDGGT KIIGYHLEQK EKNSILWVKL NKTPIQDTKF KTTGLDEGLE YEFKVSAENI
VGIGKPSKVS ECFVARDPCD PPGRPEAIVI TRNNVTLKWK KPAYDGGSKI TGYIVEKKDL
PDGRWMKASF TNVLETEFTV SGLVEDQRYE FRVIARNAAG NFSEPSDSSG AITARDEIDA
PNASLDPKYK DVIVVHAGET FVLEADIRGK PIPDVVWSKD GKELEETAAR MEIKSTIQKT
TLVVKDCIRT DGGQYILKLS NVGGTKSIPI TVKVLDRPGP PEGPLKVTGV TAEKCYLAWN
PPLQDGGANI SHYIIEKRET SRLSWTQVST EVQALNYKVT KLLPGNEYIF RVMAVNKYGI
GEPLESGPVT ACNPYKPPGP PSTPEVSAIT KDSMVVTWAR PVDDGGTEIE GYILEKRDKE
GVRWTKCNKK TLTDLRLRVT GLTEGHSYEF RVAAENAAGV GEPSEPSVFY RACDALYPPG
PPSNPKVTDT SRSSVSLAWS KPIYDGGAPV KGYVVEVKEA AADEWTTCTP PTGLQGKQFT
VTKLKENTEY NFRICAINSE GVGEPATLPG SVVAQERIEP PEIELDADLR KVVVLRASAT
LRLFVTIKGR PEPEVKWEKA EGILTDRAQI EVTSSFTMLV IDNVTRFDSG RYNLTLENNS
GSKTAFVNVR VLDSPSAPVN LTIREVKKDS VTLSWEPPLI DGGAKITNYI VEKRETTRKA
YATITNNCTK TTFRIENLQE GCSYYFRVLA SNEYGIGLPA ETTEPVKVSE PPLPPGRVTL
VDVTRNTATI KWEKPESDGG SKITGYVVEM QTKGSEKWST CTQVKTLEAT ISGLTAGEEY
VFRVAAVNEK GRSDPRQLGV PVIARDIEIK PSVELPFHTF NVKAREQLKI DVPFKGRPQA
TVNWRKDGQT LKETTRVNVS SSKTVTSLSI KEASKEDVGT YELCVSNSAG SITVPITIIV
LDRPGPPGPI RIDEVSCDSI TISWNPPEYD GGCQISNYIV EKKETTSTTW HIVSQAVART
SIKIVRLTTG SEYQFRVCAE NRYGKSSYSE SSAVVAEYPF SPPGPPGTPK VVHATKSTML
VTWQVPVNDG GSRVIGYHLE YKERSSILWS KANKILIADT QMKVSGLDEG LMYEYRVYAE
NIAGIGKCSK SCEPVPARDP CDPPGQPEVT NITRKSVSLK WSKPHYDGGA KITGYIVERR
ELPDGRWLKC NYTNIQETYF EVTELTEDQR YEFRVFARNA ADSVSEPSES TGPIIVKDDV
EPPRVMMDVK FRDVIVVKAG EVLKINADIA GRPLPVISWA KDGIEIEERA RTEIISTDNH
TLLTVKDCIR RDTGQYVLTL KNVAGTRSVA VNCKVLDKPG PPAGPLEING LTAEKCSLSW
GRPQEDGGAD IDYYIVEKRE TSHLAWTICE GELQMTSCKV TKLLKGNEYI FRVTGVNKYG
VGEPLESVAI KALDPFTVPS PPTSLEITSV TKESMTLCWS RPESDGGSEI SGYIIERREK
NSLRWVRVNK KPVYDLRVKS TGLREGCEYE YRVYAENAAG LSLPSETSPL IRAEDPVFLP
SPPSKPKIVD SGKTTITIAW VKPLFDGGAP ITGYTVEYKK SDDTDWKTSI QSLRGTEYTI
SGLTTGAEYV FRVKSVNKVG ASDPSDSSDP QIAKEREEEP LFDIDSEMRK TLIVKAGASF
TMTVPFRGRP VPNVLWSKPD TDLRTRAYVD TTDSRTSLTI ENANRNDSGK YTLTIQNVLS
AASLTLVVKV LDTPGPPTNI TVQDVTKESA VLSWDVPEND GGAPVKNYHI EKREASKKAW
VSVTNNCNRL SYKVTNLQEG AIYYFRVSGE NEFGVGIPAE TKEGVKITEK PSPPEKLGVT
SISKDSVSLT WLKPEHDGGS RIVHYVVEAL EKGQKNWVKC AVAKSTHHVV SGLRENSEYF
FRVFAENQAG LSDPRELLLP VLIKEQLEPP EIDMKNFPSH TVYVRAGSNL KVDIPISGKP
LPKVTLSRDG VPLKATMRFN TEITAENLTI NLKESVTADA GRYEITAANS SGTTKAFINI
VVLDRPGPPT GPVVISDITE ESVTLKWEPP KYDGGSQVTN YILLKRETST AVWTEVSATV
ARTMMKVMKL TTGEEYQFRI KAENRFGISD HIDSACVTVK LPYTTPGPPS TPWVTNVTRE
SITVGWHEPV SNGGSAVVGY HLEMKDRNSI LWQKANKLVI RTTHFKVTTI SAGLIYEFRV
YAENAAGVGK PSHPSEPVLA IDACEPPRNV RITDISKNSV SLSWQQPAFD GGSKITGYIV
ERRDLPDGRW TKASFTNVTE TQFIISGLTQ NSQYEFRVFA RNAVGSISNP SEVVGPITCI
DSYGGPVIDL PLEYTEVVKY RAGTSVKLRA GISGKPAPTI EWYKDDKELQ TNALVCVENT
TDLASILIKD ADRLNSGCYE LKLRNAMGSA SATIRVQILD KPGPPGGPIE FKTVTAEKIT
LLWRPPADDG GAKITHYIVE KRETSRVVWS MVSEHLEECI ITTTKIIKGN EYIFRVRAVN
KYGIGEPLES DSVVAKNAFV TPGPPGIPEV TKITKNSMTV VWSRPIADGG SDISGYFLEK
RDKKSLGWFK VLKETIRDTR QKVTGLTENS DYQYRVCAVN AAGQGPFSEP SEFYKAADPI
DPPGPPAKIR IADSTKSSIT LGWSKPVYDG GSAVTGYVVE IRQGEEEEWT TVSTKGEVRT
TEYVVSNLKP GVNYYFRVSA VNCAGQGEPI EMNEPVQAKD ILEAPEIDLD VALRTSVIAK
AGEDVQVLIP FKGRPPPTVT WRKDEKNLGS DARYSIENTD SSSLLTIPQV TRNDTGKYIL
TIENGVGEPK SSTVSVKVLD TPAACQKLQV KHVSRGTVTL LWDPPLIDGG SPIINYVIEK
RDATKRTWSV VSHKCSSTSF KLIDLSEKTP FFFRVLAENE IGIGEPCETT EPVKAAEVPA
PIRDLSMKDS TKTSVILSWT KPDFDGGSVI TEYVVERKGK GEQTWSHAGI SKTCEIEVSQ
LKEQSVLEFR VFAKNEKGLS DPVTIGPITV KELIITPEVD LSDIPGAQVT VRIGHNVHLE
LPYKGKPKPS ISWLKDGLPL KESEFVRFSK TENKITLSIK NAKKEHGGKY TVILDNAVCR
IAVPITVITL GPPSKPKGPI RFDEIKADSV ILSWDVPEDN GGGEITCYSI EKRETSQTNW
KMVCSSVART TFKVPNLVKD AEYQFRVRAE NRYGVSQPLV SSIIVAKHQF RIPGPPGKPV
IYNVTSDGMS LTWDAPVYDG GSEVTGFHVE KKERNSILWQ KVNTSPISGR EYRATGLVEG
LDYQFRVYAE NSAGLSSPSD PSKFTLAVSP VDPPGTPDYI DVTRETITLK WNPPLRDGGS
KIVGYSIEKR QGNERWVRCN FTDVSECQYT VTGLSPGDRY EFRIIARNAV GTISPPSQSS
GIIMTRDENV PPIVEFGPEY FDGLIIKSGE SLRIKALVQG RPVPRVTWFK DGVEIEKRMN
MEITDVLGST SLFVRDATRD HRGVYTVEAK NASGSAKAEI KVKVQDTPGK VVGPIRFTNI
TGEKMTLWWD APLNDGCAPI THYIIEKRET SRLAWALIED KCEAQSYTAI KLINGNEYQF
RVSAVNKFGV GRPLDSDPVV AQIQYTVPDA PGIPEPSNIT GNSITLTWAR PESDGGSEIQ
QYILERREKK STRWVKVISK RPISETRFKV TGLTEGNEYE FHVMAENAAG VGPASGISRL
IKCREPVNPP GPPTVVKVTD TSKTTVSLEW SKPVFDGGME IIGYIIEMCK ADLGDWHKVN
AEACVKTRYT VTDLQAGEEY KFRVSAINGA GKGDSCEVTG TIKAVDRLTA PELDIDANFK
QTHVVRAGAS IRLFIAYQGR PTPTAVWSKP DSNLSLRADI HTTDSFSTLT VENCNRNDAG
KYTLTVENNS GSKSITFTVK VLDTPGPPGP ITFKDVTRGS ATLMWDAPLL DGGARIHHYV
VEKREASRRS WQVISEKCTR QIFKVNDLAE GVPYYFRVSA VNEYGVGEPY EMPEPIVATE
QPAPPRRLDV VDTSKSSAVL AWLKPDHDGG SRITGYLLEM RQKGSDFWVE AGHTKQLTFT
VERLVEKTEY EFRVKAKNDA GYSEPREAFS SVIIKEPQIE PTADLTGITN QLITCKAGSP
FTIDVPISGR PAPKVTWKLE EMRLKETDRV SITTTKDRTT LTVKDSMRGD SGRYFLTLEN
TAGVKTFSVT VVVIGRPGPV TGPIEVSSVS AESCVLSWGE PKDGGGTEIT NYIVEKRESG
TTAWQLVNSS VKRTQIKVTH LTKYMEYSFR VSSENRFGVS KPLESAPIIA EHPFVPPSAP
TRPEVYHVSA NAMSIRWEEP YHDGGSKIIG YWVEKKERNT ILWVKENKVP CLECNYKVTG
LVEGLEYQFR TYALNAAGVS KASEASRPIM AQNPVDAPGR PEVTDVTRST VSLIWSAPAY
DGGSKVVGYI IERKPVSEVG DGRWLKCNYT IVSDNFFTVT ALSEGDTYEF RVLAKNAAGV
ISKGSESTGP VTCRDEYAPP KAELDARLHG DLVTIRAGSD LVLDAAVGGK PEPKIIWTKG
DKELDLCEKV SLQYTGKRAT AVIKFCDRSD SGKYTLTVKN ASGTKAVSVM VKVLDSPGPC
GKLTVSRVTQ EKCTLAWSLP QEDGGAEITH YIVERRETSR LNWVIVEGEC PTLSYVVTRL
IKNNEYIFRV RAVNKYGPGV PVESEPIVAR NSFTIPSPPG IPEEVGTGKE HIIIQWTKPE
SDGGNEISNY LVDKREKKSL RWTRVNKDYV VYDTRLKVTS LMEGCDYQFR VTAVNAAGNS
EPSEASNFIS CREPSYTPGP PSAPRVVDTT KHSISLAWTK PMYDGGTDIV GYVLEMQEKD
TDQWYRVHTN ATIRNTEFTV PDLKMGQKYS FRVAAVNVKG MSEYSESIAE IEPVERIEIP
DLELADDLKK TVTIRAGASL RLMVSVSGRP PPVITWSKQG IDLASRAIID TTESYSLLIV
DKVNRYDAGK YTIEAENQSG KKSATVLVKV YDTPGPCPSV KVKEVSRDSV TITWEIPTID
GGAPVNNYIV EKREAAMRAF KTVTTKCSKT LYRISGLVEG TMYYFRVLPE NIYGIGEPCE
TSDAVLVSEV PLVPAKLEVV DVTKSTVTLA WEKPLYDGGS RLTGYVLEAC KAGTERWMKV
VTLKPTVLEH TVTSLNEGEQ YLFRIRAQNE KGVSEPRETV TAVTVQDLRV LPTIDLSTMP
QKTIHVPAGR PVELVIPIAG RPPPAASWFF AGSKLRESER VTVETHTKVA KLTIRETTIR
DTGEYTLELK NVTGTTSETI KVIILDKPGP PTGPIKIDEI DATSITISWE PPELDGGAPL
SGYVVEQRDA HRPGWLPVSE SVTRSTFKFT RLTEGNEYVF RVAATNRFGI GSYLQSEVIE
CRSSIRIPGP PETLQIFDVS RDGMTLTWYP PEDDGGSQVT GYIVERKEVR ADRWVRVNKV
PVTMTRYRST GLTEGLEYEH RVTAINARGS GKPSRPSKPI VAMDPIAPPG KPQNPRVTDT
TRTSVSLAWS VPEDEGGSKV TGYLIEMQKV DQHEWTKCNT TPTKIREYTL THLPQGAEYR
FRVLACNAGG PGEPAEVPGT VKVTEMLEYP DYELDERYQE GIFVRQGGVI RLTIPIKGKP
FPICKWTKEG QDISKRAMIA TSETHTELVI KEADRGDSGT YDLVLENKCG KKAVYIKVRV
IGSPNSPEGP LEYDDIQVRS VRVSWRPPAD DGGADILGYI LERREVPKAA WYTIDSRVRG
TSLVVKGLKE NVEYHFRVSA ENQFGISKPL KSEEPVTPKT PLNPPEPPSN PPEVLDVTKS
SVSLSWSRPK DDGGSRVTGY YIERKETSTD KWVRHNKTQI TTTMYTVTGL VPDAEYQFRI
IAQNDVGLSE TSPASEPVVC KDPFDKPSQP GELEILSISK DSVTLQWEKP ECDGGKEILG
YWVEYRQSGD SAWKKSNKER IKDKQFTIGG LLEATEYEFR VFAENETGLS RPRRTAMSIK
TKLTSGEAPG IRKEMKDVTT KLGEAAQLSC QIVGRPLPDI KWYRFGKELI QSRKYKMSSD
GRTHTLTVMT EEQEDEGVYT CIATNEVGEV ETSSKLLLQA TPQFHPGYPL KEKYYGAVGS
TLRLHVMYIG RPVPAMTWFH GQKLLQNSEN ITIENTEHYT HLVMKNVQRK THAGKYKVQL
SNVFGTVDAI LDVEIQDKPD KPTGPIVIEA LLKNSAVISW KPPADDGGSW ITNYVVEKCE
AKEGAEWQLV SSAISVTTCR IVNLTENAGY YFRVSAQNTF GISDPLEVSS VVIIKSPFEK
PGAPGKPTIT AVTKDSCVVA WKPPASDGGA KIRNYYLEKR EKKQNKWISV TTEEIRETVF
SVKNLIEGLE YEFRVKCENL GGESEWSEIS EPITPKSDVP IQAPHFKEEL RNLNVRYQSN
ATLVCKVTGH PKPIVKWYRQ GKEIIADGLK YRIQEFKGGY HQLIIASVTD DDATVYQVRA
TNQGGSVSGT ASLEVEVPAK IHLPKTLEGM GAVHALRGEV VSIKIPFSGK PDPVITWQKG
QDLIDNNGHY QVIVTRSFTS LVFPNGVERK DAGFYVVCAK NRFGIDQKTV ELDVADVPDP
PRGVKVSDVS RDSVNLTWTE PASDGGSKIT NYIVEKCATT AERWLRVGQA RETRYTVINL
FGKTSYQFRV IAENKFGLSK PSEPSEPTIT KEDKTRAMNY DEEVDETREV SMTKASHSST
KELYEKYMIA EDLGRGEFGI VHRCVETSSK KTYMAKFVKV KGTDQVLVKK EISILNIARH
RNILHLHESF ESMEELVMIF EFISGLDIFE RINTSAFELN EREIVSYVHQ VCEALQFLHS
HNIGHFDIRP ENIIYQTRRS STIKIIEFGQ ARQLKPGDNF RLLFTAPEYY APEVHQHDVV
STATDMWSLG TLVYVLLSGI NPFLAETNQQ IIENIMNAEY TFDEEAFKEI SIEAMDFVDR
LLVKERKSRM TASEALQHPW LKQKIERVST KVIRTLKHRR YYHTLIKKDL NMVVSAARIS
CGGAIRSQKG VSVAKVKVAS IEIGPVSGQI MHAVGEEGGH VKYVCKIENY DQSTQVTWYF
GVRQLENSEK YEITYEDGVA ILYVKDITKL DDGTYRCKVV NDYGEDSSYA ELFVKGVREV
YDYYCRRTMK KIKRRTDTMR LLERPPEFTL PLYNKTAYVG ENVRFGVTIT VHPEPHVTWY
KSGQKIKPGD NDKKYTFESD KGLYQLTINS VTTDDDAEYT VVARNKYGED SCKAKLTVTL
HPPPTDSTLR PMFKRLLANA ECQEGQSVCF EIRVSGIPPP TLKWEKDGQP LSLGPNIEII
HEGLDYYALH IRDTLPEDTG YYRVTATNTA GSTSCQAHLQ VERLRYKKQE FKSKEEHERH
VQKQIDKTLR MAEILSGTES VPLTQVAKEA LREAAVLYKP AVSTKTVKGE FRLEIEEKKE
ERKLRMPYDV PEPRKYKQTT IEEDQRIKQF VPMSDMKWYK KIRDQYEMPG KLDRVVQKRP
KRIRLSRWEQ FYVMPLPRIT DQYRPKWRIP KLSQDDLEIV RPARRRTPSP DYDFYYRPRR
RSLGDISDEE LLLPIDDYLA MKRTEEERLR LEEELELGFS ASPPSRSPPH FELSSLRYSS
PQAHVKVEET RKDFRYSTYH IPTKAEASTS YAELRERHAQ AAYRQPKQRQ RIMAEREDEE
LLRPVTTTQH LSEYKSELDF MSKEEKSRKK SRRQREVTEI TEIEEEYEIS KHAQRESSSS
ASRLLRRRRS LSPTYIELMR PVSELIRSRP QPAEEYEDDT ERRSPTPERT RPRSPSPVSS
ERSLSRFERS ARFDIFSRYE SMKAALKTQK TSERKYEVLS QQPFTLDHAP RITLRMRSHR
VPCGQNTRFI LNVQSKPTAE VKWYHNGVEL QESSKIHYTN TSGVLTLEIL DCHTDDSGTY
RAVCTNYKGE ASDYATLDVT GGDYTTYASQ RRDEEVPRSV FPELTRTEAY AVSSFKKTSE
MEASSSVREV KSQMTETRES LSSYEHSASA EMKSAALEEK SLEEKSTTRK IKTTLAARIL
TKPRSMTVYE GESARFSCDT DGEPVPTVTW LRKGQVLSTS ARHQVTTTKY KSTFEISSVQ
ASDEGNYSVV VENSEGKQEA EFTLTIQKAR VTEKAVTSPP RVKSPEPRVK SPEAVKSPKR
VKSPEPSHPK AVSPTETKPT PTEKVQHLPV SAPPKITQFL KAEASKEIAK LTCVVESSVL
RAKEVTWYKD GKKLKENGHF QFHYSADGTY ELKINNLTES DQGEYVCEIS GEGGTSKTNL
QFMGQAFKSI HEKVSKISET KKSDQKTTES TVTRKTEPKA PEPISSKPVI VTGLQDTTVS
SDSVAKFAVK ATGEPRPTAI WTKDGKAITQ GGKYKLSEDK GGFFLEIHKT DTSDSGLYTC
TVKNSAGSVS SSCKLTIKAI KDTEAQKVST QKTSEITPQK KAVVQEEISQ KALRSEEIKM
SEAKSQEKLA LKEEASKVLI SEEVKKSAAT SLEKSIVHEE ITKTSQASEE VRTHAEIKAF
STQMSINEGQ RLVLKANIAG ATDVKWVLNG VELTNSEEYR YGVSGSDQTL TIKQASHRDE
GILTCISKTK EGIVKCQYDL TLSKELSDAP AFISQPRSQN INEGQNVLFT CEISGEPSPE
IEWFKNNLPI SISSNVSISR SRNVYSLEIR NASVSDSGKY TIKAKNFRGQ CSATASLMVL
PLVEEPSREV VLRTSGDTSL QGSFSSQSVQ MSASKQEASF SSFSSSSASS MTEMKFASMS
AQSMSSMQES FVEMSSSSFM GISNMTQLES STSKMLKAGI RGIPPKIEAL PSDISIDEGK
VLTVACAFTG EPTPEVTWSC GGRKIHSQEQ GRFHIENTDD LTTLIIMDVQ KQDGGLYTLS
LGNEFGSDSA TVNIHIRSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107629

Theoretical NMD boundary in CDS

107353

Length of CDS

107700

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.07 s

Back to summary table

Variant:

2:178745884C>A_8_ENST00000446966

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 125|75 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 1.19, LOF (oe): 0.86, misssense (oe): 1.18, synonymous (oe): 0.90 ? (gnomAD)

Ensembl transcript ID

ENST00000446966.2

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11312-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV
IPEGETPIVK RRKTPSPTVP ESPREIVPVK ETPMAAPLEI EIPPTKAPEA MKEVVPEMKI
FEDVPEEPET PRMKTPEAPQ EIIPAKTVPS KKREPPSVKV PEALQEIVPE KKTLVVPLRK
PEVLPDEVPE ALREVVPEKK VHPPQRAEVV PVKVHEAPKE IIPEKKVSVV PPKKPEVPPV
KVPEASKEVI REEKVPLAPP KEPEVPPVKV PEPPKEVVPE KKAPVAPPKE PEVPPVKVPE
APKEVVPEKK VPVPPPKKPE VPPTKVPEVP KAAVPEKKLP EAIPPKPESP PPEVPEVLPP
KEVVPEKKVP VPPAKKPEAP PPKVPEAPKE VVLEKKASVA VPKKPEAPRA KVPEAAQEVV
PEKKIPKAPI KKPEAPAVTV PEVPQEATEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP
KAPPTKPEAP PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPSAPPK
KPEVPPVKVP EAPKEVVPEK KVPVPPPKKP EVPPTKVPEV PKAAVPEKKV PEAIPPKPES
PPPEVPEVLP PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVLEKKASV AVPKKPEAPR
AKVPEAAQEV VPEKKIPKAP IKKPEAPAVT VPEVPQEAAE KEIPVAPPKK PEAPIVPVPE
AQEVVPEKKV PKAPPTKPEA PPATVPEVPQ EIVPEKKTLV LPKKPEVPPV TVPEAPKEVV
LEKKVPSTPP KKPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK
VPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP KEVVLEKKVS
VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAA EKEIPVAPPK
KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL VLPKKPEVPP
VTVPEAPKEV VLEKKVPLAP PKKPEVPPVK VPEAPKEVVP EKKVPVTPPK KPEVPPVKVP
EAPIEVVPEK KMPLAPPKKP EVPPVKVPEA PKEVVPEKKV PSAPPKKPEV PPVKVPEAPK
EVVPEKKVPA APPKKPEVTP VKVPEAPKEV VPEKKVPVPP PKKPEVPPTK VPEVPKVAVP
EKKVPEAIPP KPESPPPEVF EEPEEVALEE PPAEVVEEPE PAAPPQVTVP PKKPVPEKKA
PAVVAKKPEL PPVKVPEVPK EVVPEKKVPL VVPKKPEAPP AKVPEVPKEV VPEKKVAVPK
KPEVPPAKVP EVPKKPVLEE KPAVPVPERA ESPPPEVYEE PEEIAPEEEI APEEEKPVPV
AEEEEPEVPP PAVPEEPKKI IPEKKVPVIK KPEAPPPKEP EMPKKVVPVK KVPTVKKPET
PAAKVPEVPK KLVPVKKEPV PVTKKPEVLP EKVPKVPEKI IPEKEVSVPI PAEPEVPPAE
VEETPEEIIY EEKASITIGR KETPPVEERE IEKYIKPEEP EPEPQPEEIP VKEPEPEKVI
EKPKLKPRPP PPPPAPPKED VKEKIFQLKA IPKKKVPEKP QVPEKVELTP LKVPEPPPPK
PVEEVEVPTV TKRERKIPEP TKVPEIKPAI PLPAPEPKPK PEAEVKTIKP PPVEPEPTPI
AAPVTVPVVG KKAEAKAPKE EAAKPKGPIK GVPKKTPSPI EAERRKLRPG SGGEKPPDEA
PFTYQLKAVP LKFVKEIKDI ILTESEFVGS SAIFECLVSP STAITTWMKD GSNIRESPKH
RFIADGKDRK LHIIDVQLSD AGEYTCVLRL GNKEKTSTAK LVVEELPVRF VKTLEEEVTV
VKGQPLYLSC ELNKERDVVW RKDGKIVVEK PGRIVPGVIG LMRALTINDA DDTDAGTYTV
TVENANNLEC SSCVKVVEVI RDWLVKPIRD QHVKPKGTAI FACDIAKDTP NIKWFKGYDE
IPAEPNDKTE ILRDGNHLYL KIKNAMPEDI AEYAVEIEGK RYPAKLTLGE REVELLKPIE
DVTIYEKESA SFDAEISEAD IPGQWKLKGE LLRPSPTCEI KAEGGKRFLT LHKVKLDQAG
EVLYQALNAI TTAILTVKEI ELDFAVPLKD VTVPERRQAR FECVLTREAN VIWSKGPDII
KSSDKFDIIA DGKKHILVIN DSQFDDEGVY TAEVEGKKTS ARLFVTGIRL KFMSPLEDQT
VKEGETATFV CELSHEKMHV VWFKNDAKLH TSRTVLISSE GKTHKLEMKE VTLDDISQIK
AQVKELSSTA QLKVLEADPY FTVKLHDKTA VEKDEITLKC EVSKDVPVKW FKDGEEIVPS
PKYSIKADGL RRILKIKKAD LKDKGEYVCD CGTDKTKANV TVEARLIKVE KPLYGVEVFV
GETAHFEIEL SEPDVHGQWK LKGQPLTASP DCEIIEDGKK HILILHNCQL GMTGEVSFQA
ANAKSAANLK VKELPLIFIT PLSDVKVFEK DEAKFECEVS REPKTFRWLK GTQEITGDDR
FELIKDGTKH SMVIKSAAFE DEAKYMFEAE DKHTSGKLII EGIRLKFLTP LKDVTAKEKE
SAVFTVELSH DNIRVKWFKN DQRLHTTRSV SMQDEGKTHS ITFKDLSIDD TSQIRVEAMG
MSSEAKLTVL EGDPYFTGKL QDYTGVEKDE VILQCEISKA DAPVKWFKDG KEIKPSKNAV
IKADGKKRML ILKKALKSDI GQYTCDCGTD KTSGKLDIED REIKLVRPLH SVEVMETETA
RFETEISEDD IHANWKLKGE ALLQTPDCEI KEEGKIHSLV LHNCRLDQTG GVDFQAANVK
SSAHLRVKPR VIGLLRPLKD VTVTAGETAT FDCELSYEDI PVEWYLKGKK LEPSDKVVPR
SEGKVHTLTL RDVKLEDAGE VQLTAKDFKT HANLFVKEPP VEFTKPLEDQ TVEEGATAVL
ECEVSRENAK VKWFKNGTEI LKSKKYEIVA DGRVRKLVIH DCTPEDIKTY TCDAKDFKTS
CNLNVVPPHV EFLRPLTDLQ VREKEMARFE CELSRENAKV KWFKDGAEIK KGKKYDIISK
GAVRILVINK CLLDDEAEYS CEVRTARTSG MLTVLEEEAV FTKNLANIEV SETDTIKLVC
EVSKPGAEVI WYKGDEEIIE TGRYEILTEG RKRILVIQNA HLEDAGNYNC RLPSSRTDGK
VKVHELAAEF ISKPQNLEIL EGEKAEFVCS ISKESFPVQW KRDDKTLESG DKYDVIADGK
KRVLVVKDAT LQDMGTYVVM VGAARAAAHL TVIEKLRIVV PLKDTRVKEQ QEVVFNCEVN
TEGAKAKWFR NEEAIFDSSK YIILQKDLVY TLRIRDAHLD DQANYNVSLT NHRGENVKSA
ANLIVEEEDL RIVEPLKDIE TMEKKSVTFW CKVNRLNVTL KWTKNGEEVP FDNRVSYRVD
KYKHMLTIKD CGFPDEGEYI VTAGQDKSVA ELLIIEAPTE FVEHLEDQTV TEFDDAVFSC
QLSREKANVK WYRNGREIKE GKKYKFEKDG SIHRLIIKDC RLDDECEYAC GVEDRKSRAR
LFVEEIPVEI IRPPQDILEA PGADVVFLAE LNKDKVEVQW LRNNMVVVQG DKHQMMSEGK
IHRLQICDIK PRDQGEYRFI AKDKEARAKL ELAAAPKIKT ADQDLVVDVG KPLTMVVPYD
AYPKAEAEWF KENEPLSTKT IDTTAEQTSF RILEAKKGDK GRYKIVLQNK HGKAEGFINL
KVIDVPGPVR NLEVTETFDG EVSLAWEEPL TDGGSKIIGY VVERRDIKRK TWVLATDRAE
SCEFTVTGLQ KGGVEYLFRV SARNRVGTGE PVETDNPVEA RSKYDVPGPP LNVTITDVNR
FGVSLTWEPP EYDGGAEITN YVIELRDKTS IRWDTAMTVR AEDLSATVTD VVEGQEYSFR
VRAQNRIGVG KPSAATPFVK VADPIERPSP PVNLTSSDQT QSSVQLKWEP PLKDGGSPIL
GYIIERCEEG KDNWIRCNMK LVPELTYKVT GLEKGNKYLY RVSAENKAGV SDPSEILGPL
TADDAFVEPT MDLSAFKDGL EVIVPNPITI LVPSTGYPRP TATWCFGDKV LETGDRVKMK
TLSAYAELVI SPSERSDKGI YTLKLENRVK TISGEIDVNV IARPSAPKEL KFGDITKDSV
HLTWEPPDDD GGSPLTGYVV EKREVSRKTW TKVMDFVTDL EFTVPDLVQG KEYLFKVCAR
NKCGPGEPAY VDEPVNMSTP ATVPDPPENV KWRDRTANSI FLTWDPPKND GGSRIKGYIV
ERCPRGSDKW VACGEPVAET KMEVTGLEEG KWYAYRVKAL NRQGASKPSR PTEEIQAVDT
QEAPEIFLDV KLLAGLTVKA GTKIELPATV TGKPEPKITW TKADMILKQD KRITIENVPK
KSTVTIVDSK RSDTGTYIIE AVNVCGRATA VVEVNVLDKP GPPAAFDITD VTNESCLLTW
NPPRDDGGSK ITNYVVERRA TDSEVWHKLS STVKDTNFKA TKLIPNKEYI FRVAAENMYG
VGEPVQASPI TAKYQFDPPG PPTRLEPSDI TKDAVTLTWC EPDDDGGSPI TGYWVERLDP
DTDKWVRCNK MPVKDTTYRV KGLTNKKKYR FRVLAENLAG PGKPSKSTEP ILIKDPIDPP
WPPGKPTVKD VGKTSVRLNW TKPEHDGGAK IESYVIEMLK TGTDEWVRVA EGVPTTQHLL
PGLMEGQEYS FRVRAVNKAG ESEPSEPSDP VLCREKLYPP SPPRWLEVIN ITKNTADLKW
TVPEKDGGSP ITNYIVEKRD VRRKGWQTVD TTVKDTKCTV TPLTEGSLYV FRVAAENAIG
QSDYTEIEDS VLAKDTFTTP GPPYALAVVD VTKRHVDLKW EPPKNDGGRP IQRYVIEKKE
RLGTRWVKAG KTAGPDCNFR VTDVIEGTEV QFQVRAENEA GVGHPSEPTE ILSIEDPTSP
PSPPLDLHVT DAGRKHIAIA WKPPEKNGGS PIIGYHVEMC PVGTEKWMRV NSRPIKDLKF
KVEEGVVPDK EYVLRVRAVN AIGVSEPSEI SENVVAKDPD CKPTIDLETH DIIVIEGEKL
SIPVPFRAVP VPTVSWHKDG KEVKASDRLT MKNDHISAHL EVPKSVRADA GIYTITLENK
LGSATASINV KVIGLPGPCK DIKASDITKS SCKLTWEPPE FDGGTPILHY VLERREAGRR
TYIPVMSGEN KLSWTVKDLI PNGEYFFRVK AVNKVGGGEY IELKNPVIAQ DPKQPPDPPV
DVEVHNPTAE AMTITWKPPL YDGGSKIMGY IIEKIAKGEE RWKRCNEHLV PILTYTAKGL
EEGKEYQFRV RAENAAGISE PSRATPPTKA VDPIDAPKVI LRTSLEVKRG DEIALDASIS
GSPYPTITWI KDENVIVPEE IKKRAAPLVR RRKGEVQEEE PFVLPLTQRL SIDNSKKGES
QLRVRDSLRP DHGLYMIKVE NDHGIAKAPC TVSVLDTPGP PINFVFEDIR KTSVLCKWEP
PLDDGGSEII NYTLEKKDKT KPDSEWIVVT STLRHCKYSV TKLIEGKEYL FRVRAENRFG
PGPPCVSKPL VAKDPFGPPD APDKPIVEDV TSNSMLVKWN EPKDNGSPIL GYWLEKREVN
STHWSRVNKS LLNALKANVD GLLEGLTYVF RVCAENAAGP GKFSPPSDPK TAHDPISPPG
PPIPRVTDTS STTIELEWEP PAFNGGGEIV GYFVDKQLVG TNEWSRCTEK MIKVRQYTVK
EIREGADYKL RVSAVNAAGE GPPGETQPVT VAEPQEPPAV ELDVSVKGGI QIMAGKTLRI
PAVVTGRPVP TKVWTKEEGE LDKDRVVIDN VGTKSELIIK DALRKDHGRY VITATNSCGS
KFAAARVEVF DVPGPVLDLK PVVTNRKMCL LNWSDPEDDG GSEITGFIIE RKDAKMHTWR
QPIETERSKC DITGLLEGQE YKFRVIAKNK FGCGPPVEIG PILAVDPLGP PTSPERLTYT
ERTKSTITLD WKEPRSNGGS PIQGYIIEKR RHDKPDFERV NKRLCPTTSF LVENLDEHQM
YEFRVKAVNE IGESEPSLPL NVVIQDDEVP PTIKLRLSVR GDTIKVKAGE PVHIPADVTG
LPMPKIEWSK NETVIEKPTD ALQITKEEVS RSEAKTELSI PKAVREDKGT YTVTASNRLG
SVFRNVHVEV YDRPSPPRNL AVTDIKAESC YLTWDAPLDN GGSEITHYVI DKRDASRKKA
EWEEVTNTAV EKRYGIWKLI PNGQYEFRVR AVNKYGISDE CKSDKVVIQD PYRLPGPPGK
PKVLARTKGS MLVSWTPPLD NGGSPITGYW LEKREEGSPY WSRVSRAPIT KVGLKGVEFN
VPRLLEGVKY QFRAMAINAA GIGPPSEPSD PEVAGDPIFP PGPPSCPEVK DKTKSSISLG
WKPPAKDGGS PIKGYIVEMQ EEGTTDWKRV NEPDKLITTC ECVVPNLKEL RKYRFRVKAV
NEAGESEPSD TTGEIPATDI QEEPEVFIDI GAQDCLVCKA GSQIRIPAVI KGRPTPKSSW
EFDGKAKKAM KDGVHDIPED AQLETAENSS VIIIPECKRS HTGKYSITAK NKAGQKTANC
RVKVMDVPGP PKDLKVSDIT RGSCRLSWKM PDDDGGDRIK GYVIEKRTID GKAWTKVNPD
CGSTTFVVPD LLSEQQYFFR VRAENRFGIG PPVETIQRTT ARDPIYPPDP PIKLKIGLIT
KNTVHLSWKP PKNDGGSPVT HYIVECLAWD PTGTKKEAWR QCNKRDVEEL QFTVEDLVEG
GEYEFRVKAV NAAGVSKPSA TVGPVTVKDQ TCPPSIDLKE FMEVEEGTNV NIVAKIKGVP
FPTLTWFKAP PKKPDNKEPV LYDTHVNKLV VDDTCTLVIP QSRRSDTGLY TITAVNNLGT
ASKEMRLNVL GRPGPPVGPI KFESVSADQM TLSWFPPKDD GGSKITNYVI EKREANRKTW
VHVSSEPKEC TYTIPKLLEG HEYVFRIMAQ NKYGIGEPLD SEPETARNLF SVPGAPDKPT
VSSVTRNSMT VNWEEPEYDG GSPVTGYWLE MKDTTSKRWK RVNRDPIKAM TLGVSYKVTG
LIEGSDYQFR VYAINAAGVG PASLPSDPAT ARDPIAPPGP PFPKVTDWTK SSADLEWSPP
LKDGGSKVTG YIVEYKEEGK EEWEKGKDKE VRGTKLVVTG LKEGAFYKFR VRAVNIAGIG
EPGEVTDVIE MKDRLVSPDL QLDASVRDRI VVHAGGVIRI IAYVSGKPPP TVTWNMNERT
LPQEATIETT AISSSMVIKN CQRSHQGVYS LLAKNEAGER KKTIIVDVLD VPGPVGTPFL
AHNLTNESCK LTWFSPEDDG GSPITNYVIE KRESDRRAWT PVTYTVTRQN ATVQGLIQGK
AYFFRIAAEN SIGMGPFVET SEALVIREPI TVPERPEDLE VKEVTKNTVT LTWNPPKYDG
GSEIINYVLE SRLIGTEKFH KVTNDNLLSR KYTVKGLKEG DTYEYRVSAV NIVGQGKPSF
CTKPITCKDE LAPPTLHLDF RDKLTIRVGE AFALTGRYSG KPKPKVSWFK DEADVLEDDR
THIKTTPATL ALEKIKAKRS DSGKYCVVVE NSTGSRKGFC QVNVVDRPGP PVGPVSFDEV
TKDYMVISWK PPLDDGGSKI TNYIIEKKEV GKDVWMPVTS ASAKTTCKVS KLLEGKDYIF
RIHAENLYGI SDPLVSDSMK AKDRFRVPDA PDQPIVTEVT KDSALVTWNK PHDGGKPITN
YILEKRETMS KRWARVTKDP IHPYTKFRVP DLLEGCQYEF RVSAENEIGI GDPSPPSKPV
FAKDPIAKPS PPVNPEAIDT TCNSVDLTWQ PPRHDGGSKI LGYIVEYQKV GDEEWRRANH
TPESCPETKY KVTGLRDGQT YKFRVLAVNA AGESDPAHVP EPVLVKDRLE PPELILDANM
AREQHIKVGD TLRLSAIIKG VPFPKVTWKK EDRDAPTKAR IDVTPVGSKL EIRNAAHEDG
GIYSLTVENP AGSKTVSVKV LVLDKPGPPR DLEVSEIRKD SCYLTWKEPL DDGGSVITNY
VVERRDVASA QWSPLSATSK KKSHFAKHLN EGNQYLFRVA AENQYGRGPF VETPKPIKAL
DPLHPPGPPK DLHHVDVDKT EVSLVWNKPD RDGGSPITGY LVEYQEEGTQ DWIKFKTVTN
LECVVTGLQQ GKTYRFRVKA ENIVGLGLPD TTIPIECQEK LVPPSVELDV KLIEGLVVKA
GTTVRFPAII RGVPVPTAKW TTDGSEIKTD EHYTVETDNF SSVLTIKNCL RRDTGEYQIT
VSNAAGSKTV AVHLTVLDVP GPPTGPINIL DVTPEHMTIS WQPPKDDGGS PVINYIVEKQ
DTRKDTWGVV SSGSSKTKLK IPHLQKGCEY VFRVRAENKI GVGPPLDSTP TVAKHKFSPP
SPPGKPVVTD ITENAATVSW TLPKSDGGSP ITGYYMERRE VTGKWVRVNK TPIADLKFRV
TGLYEGNTYE FRVFAENLAG LSKPSPSSDP IKACRPIKPP GPPINPKLKD KSRETADLVW
TKPLSDGGSP ILGYVVECQK PGTAQWNRIN KDELIRQCAF RVPGLIEGNE YRFRIKAANI
VGEGEPRELA ESVIAKDILH PPEVELDVTC RDVITVRVGQ TIRILARVKG RPEPDITWTK
EGKVLVREKR VDLIQDLPRV ELQIKEAVRA DHGKYIISAK NSSGHAQGSA IVNVLDRPGP
CQNLKVTNVT KENCTISWEN PLDNGGSEIT NFIVEYRKPN QKGWSIVASD VTKRLIKANL
LANNEYYFRV CAENKVGVGP TIETKTPILA INPIDRPGEP ENLHIADKGK TFVYLKWRRP
DYDGGSPNLS YHVERRLKGS DDWERVHKGS IKETHYMVDR CVENQIYEFR VQTKNEGGES
DWVKTEEVVV KEDLQKPVLD LKLSGVLTVK AGDTIRLEAG VRGKPFPEVA WTKDKDATDL
TRSPRVKIDT RADSSKFSLT KAKRSDGGKY VVTATNTAGS FVAYATVNVL DKPGPVRNLK
IVDVSSDRCT VCWDPPEDDG GCEIQNYILE KCETKRMVWS TYSATVLTPG TTVTRLIEGN
EYIFRVRAEN KIGTGPPTES KPVIAKTKYD KPGRPDPPEV TKVSKEEMTV VWNPPEYDGG
KSITGYFLEK KEKHSTRWVP VNKSAIPERR MKVQNLLPDH EYQFRVKAEN EIGIGEPSLP
SRPVVAKDPI EPPGPPTNFR VVDTTKHSIT LGWGKPVYDG GAPIIGYVVE MRPKIADASP
DEGWKRCNAA AQLVRKEFTV TSLDENQEYE FRVCAQNQVG IGRPAELKEA IKPKEILEPP
EIDLDASMRK LVIVRAGCPI RLFAIVRGRP APKVTWRKVG IDNVVRKGQV DLVDTMAFLV
IPNSTRDDSG KYSLTLVNPA GEKAVFVNVR VLDTPGPVSD LKVSDVTKTS CHVSWAPPEN
DGGSQVTHYI VEKREADRKT WSTVTPEVKK TSFHVTNLVP GNEYYFRVTA VNEYGPGVPT
DVPKPVLASD PLSEPDPPRK LEVTEMTKNS ATLAWLPPLR DGGAKIDGYI TSYREEEQPA
DRWTEYSVVK DLSLVVTGLK EGKKYKFRVA ARNAVGVSLP REAEGVYEAK EQLLPPKILM
PEQITIKAGK KLRIEAHVYG KPHPTCKWKK GEDEVVTSSH LAVHKADSSS ILIIKDVTRK
DSGYYSLTAE NSSGTDTQKI KVVVMDAPGP PQPPFDISDI DADACSLSWH IPLEDGGSNI
TNYIVEKCDV SRGDWVTALA SVTKTSCRVG KLIPGQEYIF RVRAENRFGI SEPLTSPKMV
AQFPFGVPSE PKNARVTKVN KDCIFVAWDR PDSDGGSPII GYLIERKERN SLLWVKANDT
LVRSTEYPCA GLVEGLEYSF RIYALNKAGS SPPSKPTEYV TARMPVDPPG KPEVIDVTKS
TVSLIWARPK HDGGSKIIGY FVEACKLPGD KWVRCNTAPH QIPQEEYTAT GLEEKAQYQF
RAIARTAVNI SPPSEPSDPV TILAENVPPR IDLSVAMKSL LTVKAGTNVC LDATVFGKPM
PTVSWKKDGT LLKPAEGIKM AMQRNLCTLE LFSVNRKDSG DYTITAENSS GSKSATIKLK
VLDKPGPPAS VKINKMYSDR AMLSWEPPLE DGGSEITNYI VDKRETSRPN WAQVSATVPI
TSCSVEKLIE GHEYQFRICA ENKYGVGDPV FTEPAIAKNP YDPPGRCDPP VISNITKDHM
TVSWKPPADD GGSPITGYLL EKRETQAVNW TKVNRKPIIE RTLKATGLQE GTEYEFRVTA
INKAGPGKPS DASKAAYARD PQYPPGPPAF PKVYDTTRSS VSLSWGKPAY DGGSPIIGYL
VEVKRADSDN WVRCNLPQNL QKTRFEVTGL MEDTQYQFRV YAVNKIGYSD PSDVPDKHYP
KDILIPPEGE LDADLRKTLI LRAGVTMRLY VPVKGRPPPK ITWSKPNVNL RDRIGLDIKS
TDFDTFLRCE NVNKYDAGKY ILTLENSCGK KEYTIVVKVL DTPGPPVNVT VKEISKDSAY
VTWEPPIIDG GSPIINYVVQ KRDAERKSWS TVTTECSKTS FRVANLEEGK SYFFRVFAEN
EYGIGDPGET RDAVKASQTP GPVVDLKVRS VSKSSCSIGW KKPHSDGGSR IIGYVVDFLT
EENKWQRVMK SLSLQYSAKD LTEGKEYTFR VSAENENGEG TPSEITVVAR DDVVAPDLDL
KGLPDLCYLA KENSNFRLKI PIKGKPAPSV SWKKGEDPLA TDTRVSVESS AVNTTLIVYD
CQKSDAGKYT ITLKNVAGTK EGTISIKVVG KPGIPTGPIK FDEVTAEAMT LKWAPPKDDG
GSEITNYILE KRDSVNNKWV TCASAVQKTT FRVTRLHEGM EYTFRVSAEN KYGVGEGLKS
EPIVARHPFD VPDAPPPPNI VDVRHDSVSL TWTDPKKTGG SPITGYHLEF KERNSLLWKR
ANKTPIRMRD FKVTGLTEGL EYEFRVMAIN LAGVGKPSLP SEPVVALDPI DPPGKPEVIN
ITRNSVTLIW TEPKYDGGHK LTGYIVEKRD LPSKSWMKAN HVNVPECAFT VTDLVEGGKY
EFRIRAKNTA GAISAPSEST ETIICKDEYE APTIVLDPTI KDGLTIKAGD TIVLNAISIL
GKPLPKSSWS KAGKDIRPSD ITQITSTPTS SMLTIKYATR KDAGEYTITA TNPFGTKVEH
VKVTVLDVPG PPGPVEISNV SAEKATLTWT PPLEDGGSPI KSYILEKRET SRLLWTVVSE
DIQSCRHVAT KLIQGNEYIF RVSAVNHYGK GEPVQSEPVK MVDRFGPPGP PEKPEVSNVT
KNTATVSWKR PVDDGGSEIT GYHVERREKK SLRWVRAIKT PVSDLRCKVT GLQEGSTYEF
RVSAENRAGI GPPSEASDSV LMKDAAYPPG PPSNPHVTDT TKKSASLAWG KPHYDGGLEI
TGYVVEHQKV GDEAWIKDTT GTALRITQFV VPDLQTKEKY NFRISAINDA GVGEPAVIPD
VEIVEREMAP DFELDAELRR TLVVRAGLSI RIFVPIKGRP APEVTWTKDN INLKNRANIE
NTESFTLLII PECNRYDTGK FVMTIENPAG KKSGFVNVRV LDTPGPVLNL RPTDITKDSV
TLHWDLPLID GGSRITNYIV EKREATRKSY STATTKCHKC TYKVTGLSEG CEYFFRVMAE
NEYGIGEPTE TTEPVKASEA PSPPDSLNIM DITKSTVSLA WPKPKHDGGS KITGYVIEAQ
RKGSDQWTHI TTVKGLECVV RNLTEGEEYT FQVMAVNSAG RSAPRESRPV IVKEQTMLPE
LDLRGIYQKL VIAKAGDNIK VEIPVLGRPK PTVTWKKGDQ ILKQTQRVNF ETTATSTILN
INECVRSDSG PYPLTARNIV GEVGDVITIQ VHDIPGPPTG PIKFDEVSSD FVTFSWDPPE
NDGGVPISNY VVEMRQTDST TWVELATTVI RTTYKATRLT TGLEYQFRVK AQNRYGVGPG
ITSACIVANY PFKVPGPPGT PQVTAVTKDS MTISWHEPLS DGGSPILGYH VERKERNGIL
WQTVSKALVP GNIFKSSGLT DGIAYEFRVI AENMAGKSKP SKPSEPMLAL DPIDPPGKPV
PLNITRHTVT LKWAKPEYTG GFKITSYIVE KRDLPNGRWL KANFSNILEN EFTVSGLTED
AAYEFRVIAK NAAGAISPPS EPSDAITCRD DVEAPKIKVD VKFKDTVILK AGEAFRLEAD
VSGRPPPTME WSKDGKELEG TAKLEIKIAD FSTNLVNKDS TRRDSGAYTL TATNPGGFAK
HIFNVKVLDR PGPPEGPLAV TEVTSEKCVL SWFPPLDDGG AKIDHYIVQK RETSRLAWTN
VASEVQVTKL KVTKLLKGNE YIFRVMAVNK YGVGEPLESE PVLAVNPYGP PDPPKNPEVT
TITKDSMVVC WGHPDSDGGS EIINYIVERR DKAGQRWIKC NKKTLTDLRY KVSGLTEGHE
YEFRIMAENA AGISAPSPTS PFYKACDTVF KPGPPGNPRV LDTSRSSISI AWNKPIYDGG
SEITGYMVEI ALPEEDEWQI VTPPAGLKAT SYTITGLTEN QEYKIRIYAM NSEGLGEPAL
VPGTPKAEDR MLPPEIELDA DLRKVVTIRA CCTLRLFVPI KGRPAPEVKW ARDHGESLDK
ASIESTSSYT LLIVGNVNRF DSGKYILTVE NSSGSKSAFV NVRVLDTPGP PQDLKVKEVT
KTSVTLTWDP PLLDGGSKIK NYIVEKREST RKAYSTVATN CHKTSWKVDQ LQEGCSYYFR
VLAENEYGIG LPAETAESVK ASERPLPPGK ITLMDVTRNS VSLSWEKPEH DGGSRILGYI
VEMQTKGSDK WATCATVKVT EATITGLIQG EEYSFRVSAQ NEKGISDPRQ LSVPVIAKDL
VIPPAFKLLF NTFTVLAGED LKVDVPFIGR PTPAVTWHKD NVPLKQTTRV NAESTENNSL
LTIKDACRED VGHYVVKLTN SAGEAIETLN VIVLDKPGPP TGPVKMDEVT ADSITLSWGP
PKYDGGSSIN NYIVEKRDTS TTTWQIVSAT VARTTIKACR LKTGCEYQFR IAAENRYGKS
TYLNSEPTVA QYPFKVPGPP GTPVVTLSSR DSMEVQWNEP ISDGGSRVIG YHLERKERNS
ILWVKLNKTP IPQTKFKTTG LEEGVEYEFR VSAENIVGIG KPSKVSECYV ARDPCDPPGR
PEAIIVTRNS VTLQWKKPTY DGGSKITGYI VEKKELPEGR WMKASFTNII DTHFEVTGLV
EDHRYEFRVI ARNAAGVFSE PSESTGAITA RDEVDPPRIS MDPKYKDTIV VHAGESFKVD
ADIYGKPIPT IQWIKGDQEL SNTARLEIKS TDFATSLSVK DAVRVDSGNY ILKAKNVAGE
RSVTVNVKVL DRPGPPEGPV VISGVTAEKC TLAWKPPLQD GGSDIINYIV ERRETSRLVW
TVVDANVQTL SCKVTKLLEG NEYTFRIMAV NKYGVGEPLE SEPVVAKNPF VVPDAPKAPE
VTTVTKDSMI VVWERPASDG GSEILGYVLE KRDKEGIRWT RCHKRLIGEL RLRVTGLIEN
HDYEFRVSAE NAAGLSEPSP PSAYQKACDP IYKPGPPNNP KVIDITRSSV FLSWSKPIYD
GGCEIQGYIV EKCDVSVGEW TMCTPPTGIN KTNIEVEKLL EKHEYNFRIC AINKAGVGEH
ADVPGPIIVE EKLEAPDIDL DLELRKIINI RAGGSLRLFV PIKGRPTPEV KWGKVDGEIR
DAAIIDVTSS FTSLVLDNVN RYDSGKYTLT LENSSGTKSA FVTVRVLDTP SPPVNLKVTE
ITKDSVSITW EPPLLDGGSK IKNYIVEKRE ATRKSYAAVV TNCHKNSWKI DQLQEGCSYY
FRVTAENEYG IGLPAQTADP IKVAEVPQPP GKITVDDVTR NSVSLSWTKP EHDGGSKIIQ
YIVEMQAKHS EKWSECARVK SLQAVITNLT QGEEYLFRVV AVNEKGRSDP RSLAVPIVAK
DLVIEPDVKP AFSSYSVQVG QDLKIEVPIS GRPKPTITWT KDGLPLKQTT RINVTDSLDL
TTLSIKETHK DDGGQYGITV ANVVGQKTAS IEIVTLDKPD PPKGPVKFDD VSAESITLSW
NPPLYTGGCQ ITNYIVQKRD TTTTVWDVVS ATVARTTLKV TKLKTGTEYQ FRIFAENRYG
QSFALESDPI VAQYPYKEPG PPGTPFATAI SKDSMVIQWH EPVNNGGSPV IGYHLERKER
NSILWTKVNK TIIHDTQFKA QNLEEGIEYE FRVYAENIVG VGKASKNSEC YVARDPCDPP
GTPEPIMVKR NEITLQWTKP VYDGGSMITG YIVEKRDLPD GRWMKASFTN VIETQFTVSG
LTEDQRYEFR VIAKNAAGAI SKPSDSTGPI TAKDEVELPR ISMDPKFRDT IVVNAGETFR
LEADVHGKPL PTIEWLRGDK EIEESARCEI KNTDFKALLI VKDAIRIDGG QYILRASNVA
GSKSFPVNVK VLDRPGPPEG PVQVTGVTSE KCSLTWSPPL QDGGSDISHY VVEKRETSRL
AWTVVASEVV TNSLKVTKLL EGNEYVFRIM AVNKYGVGEP LESAPVLMKN PFVLPGPPKS
LEVTNIAKDS MTVCWNRPDS DGGSEIIGYI VEKRDRSGIR WIKCNKRRIT DLRLRVTGLT
EDHEYEFRVS AENAAGVGEP SPATVYYKAC DPVFKPGPPT NAHIVDTTKN SITLAWGKPI
YDGGSEILGY VVEICKADEE EWQIVTPQTG LRVTRFEISK LTEHQEYKIR VCALNKVGLG
EATSVPGTVK PEDKLEAPEL DLDSELRKGI VVRAGGSARI HIPFKGRPTP EITWSREEGE
FTDKVQIEKG VNYTQLSIDN CDRNDAGKYI LKLENSSGSK SAFVTVKVLD TPGPPQNLAV
KEVRKDSAFL VWEPPIIDGG AKVKNYVIDK RESTRKAYAN VSSKCSKTSF KVENLTEGAI
YYFRVMAENE FGVGVPVETV DAVKAAEPPS PPGKVTLTDV SQTSASLMWE KPEHDGGSRV
LGYVVEMQPK GTEKWSIVAE SKVCNAVVTG LSSGQEYQFR VKAYNEKGKS DPRVLGVPVI
AKDLTIQPSL KLPFNTYSIQ AGEDLKIEIP VIGRPRPNIS WVKDGEPLKQ TTRVNVEETA
TSTVLHIKEG NKDDFGKYTV TATNSAGTAT ENLSVIVLEK PGPPVGPVRF DEVSADFVVI
SWEPPAYTGG CQISNYIVEK RDTTTTTWHM VSATVARTTI KITKLKTGTE YQFRIFAENR
YGKSAPLDSK AVIVQYPFKE PGPPGTPFVT SISKDQMLVQ WHEPVNDGGT KIIGYHLEQK
EKNSILWVKL NKTPIQDTKF KTTGLDEGLE YEFKVSAENI VGIGKPSKVS ECFVARDPCD
PPGRPEAIVI TRNNVTLKWK KPAYDGGSKI TGYIVEKKDL PDGRWMKASF TNVLETEFTV
SGLVEDQRYE FRVIARNAAG NFSEPSDSSG AITARDEIDA PNASLDPKYK DVIVVHAGET
FVLEADIRGK PIPDVVWSKD GKELEETAAR MEIKSTIQKT TLVVKDCIRT DGGQYILKLS
NVGGTKSIPI TVKVLDRPGP PEGPLKVTGV TAEKCYLAWN PPLQDGGANI SHYIIEKRET
SRLSWTQVST EVQALNYKVT KLLPGNEYIF RVMAVNKYGI GEPLESGPVT ACNPYKPPGP
PSTPEVSAIT KDSMVVTWAR PVDDGGTEIE GYILEKRDKE GVRWTKCNKK TLTDLRLRVT
GLTEGHSYEF RVAAENAAGV GEPSEPSVFY RACDALYPPG PPSNPKVTDT SRSSVSLAWS
KPIYDGGAPV KGYVVEVKEA AADEWTTCTP PTGLQGKQFT VTKLKENTEY NFRICAINSE
GVGEPATLPG SVVAQERIEP PEIELDADLR KVVVLRASAT LRLFVTIKGR PEPEVKWEKA
EGILTDRAQI EVTSSFTMLV IDNVTRFDSG RYNLTLENNS GSKTAFVNVR VLDSPSAPVN
LTIREVKKDS VTLSWEPPLI DGGAKITNYI VEKRETTRKA YATITNNCTK TTFRIENLQE
GCSYYFRVLA SNEYGIGLPA ETTEPVKVSE PPLPPGRVTL VDVTRNTATI KWEKPESDGG
SKITGYVVEM QTKGSEKWST CTQVKTLEAT ISGLTAGEEY VFRVAAVNEK GRSDPRQLGV
PVIARDIEIK PSVELPFHTF NVKAREQLKI DVPFKGRPQA TVNWRKDGQT LKETTRVNVS
SSKTVTSLSI KEASKEDVGT YELCVSNSAG SITVPITIIV LDRPGPPGPI RIDEVSCDSI
TISWNPPEYD GGCQISNYIV EKKETTSTTW HIVSQAVART SIKIVRLTTG SEYQFRVCAE
NRYGKSSYSE SSAVVAEYPF SPPGPPGTPK VVHATKSTML VTWQVPVNDG GSRVIGYHLE
YKERSSILWS KANKILIADT QMKVSGLDEG LMYEYRVYAE NIAGIGKCSK SCEPVPARDP
CDPPGQPEVT NITRKSVSLK WSKPHYDGGA KITGYIVERR ELPDGRWLKC NYTNIQETYF
EVTELTEDQR YEFRVFARNA ADSVSEPSES TGPIIVKDDV EPPRVMMDVK FRDVIVVKAG
EVLKINADIA GRPLPVISWA KDGIEIEERA RTEIISTDNH TLLTVKDCIR RDTGQYVLTL
KNVAGTRSVA VNCKVLDKPG PPAGPLEING LTAEKCSLSW GRPQEDGGAD IDYYIVEKRE
TSHLAWTICE GELQMTSCKV TKLLKGNEYI FRVTGVNKYG VGEPLESVAI KALDPFTVPS
PPTSLEITSV TKESMTLCWS RPESDGGSEI SGYIIERREK NSLRWVRVNK KPVYDLRVKS
TGLREGCEYE YRVYAENAAG LSLPSETSPL IRAEDPVFLP SPPSKPKIVD SGKTTITIAW
VKPLFDGGAP ITGYTVEYKK SDDTDWKTSI QSLRGTEYTI SGLTTGAEYV FRVKSVNKVG
ASDPSDSSDP QIAKEREEEP LFDIDSEMRK TLIVKAGASF TMTVPFRGRP VPNVLWSKPD
TDLRTRAYVD TTDSRTSLTI ENANRNDSGK YTLTIQNVLS AASLTLVVKV LDTPGPPTNI
TVQDVTKESA VLSWDVPEND GGAPVKNYHI EKREASKKAW VSVTNNCNRL SYKVTNLQEG
AIYYFRVSGE NEFGVGIPAE TKEGVKITEK PSPPEKLGVT SISKDSVSLT WLKPEHDGGS
RIVHYVVEAL EKGQKNWVKC AVAKSTHHVV SGLRENSEYF FRVFAENQAG LSDPRELLLP
VLIKEQLEPP EIDMKNFPSH TVYVRAGSNL KVDIPISGKP LPKVTLSRDG VPLKATMRFN
TEITAENLTI NLKESVTADA GRYEITAANS SGTTKAFINI VVLDRPGPPT GPVVISDITE
ESVTLKWEPP KYDGGSQVTN YILLKRETST AVWTEVSATV ARTMMKVMKL TTGEEYQFRI
KAENRFGISD HIDSACVTVK LPYTTPGPPS TPWVTNVTRE SITVGWHEPV SNGGSAVVGY
HLEMKDRNSI LWQKANKLVI RTTHFKVTTI SAGLIYEFRV YAENAAGVGK PSHPSEPVLA
IDACEPPRNV RITDISKNSV SLSWQQPAFD GGSKITGYIV ERRDLPDGRW TKASFTNVTE
TQFIISGLTQ NSQYEFRVFA RNAVGSISNP SEVVGPITCI DSYGGPVIDL PLEYTEVVKY
RAGTSVKLRA GISGKPAPTI EWYKDDKELQ TNALVCVENT TDLASILIKD ADRLNSGCYE
LKLRNAMGSA SATIRVQILD KPGPPGGPIE FKTVTAEKIT LLWRPPADDG GAKITHYIVE
KRETSRVVWS MVSEHLEECI ITTTKIIKGN EYIFRVRAVN KYGIGEPLES DSVVAKNAFV
TPGPPGIPEV TKITKNSMTV VWSRPIADGG SDISGYFLEK RDKKSLGWFK VLKETIRDTR
QKVTGLTENS DYQYRVCAVN AAGQGPFSEP SEFYKAADPI DPPGPPAKIR IADSTKSSIT
LGWSKPVYDG GSAVTGYVVE IRQGEEEEWT TVSTKGEVRT TEYVVSNLKP GVNYYFRVSA
VNCAGQGEPI EMNEPVQAKD ILEAPEIDLD VALRTSVIAK AGEDVQVLIP FKGRPPPTVT
WRKDEKNLGS DARYSIENTD SSSLLTIPQV TRNDTGKYIL TIENGVGEPK SSTVSVKVLD
TPAACQKLQV KHVSRGTVTL LWDPPLIDGG SPIINYVIEK RDATKRTWSV VSHKCSSTSF
KLIDLSEKTP FFFRVLAENE IGIGEPCETT EPVKAAEVPA PIRDLSMKDS TKTSVILSWT
KPDFDGGSVI TEYVVERKGK GEQTWSHAGI SKTCEIEVSQ LKEQSVLEFR VFAKNEKGLS
DPVTIGPITV KELIITPEVD LSDIPGAQVT VRIGHNVHLE LPYKGKPKPS ISWLKDGLPL
KESEFVRFSK TENKITLSIK NAKKEHGGKY TVILDNAVCR IAVPITVITL GPPSKPKGPI
RFDEIKADSV ILSWDVPEDN GGGEITCYSI EKRETSQTNW KMVCSSVART TFKVPNLVKD
AEYQFRVRAE NRYGVSQPLV SSIIVAKHQF RIPGPPGKPV IYNVTSDGMS LTWDAPVYDG
GSEVTGFHVE KKERNSILWQ KVNTSPISGR EYRATGLVEG LDYQFRVYAE NSAGLSSPSD
PSKFTLAVSP VDPPGTPDYI DVTRETITLK WNPPLRDGGS KIVGYSIEKR QGNERWVRCN
FTDVSECQYT VTGLSPGDRY EFRIIARNAV GTISPPSQSS GIIMTRDENV PPIVEFGPEY
FDGLIIKSGE SLRIKALVQG RPVPRVTWFK DGVEIEKRMN MEITDVLGST SLFVRDATRD
HRGVYTVEAK NASGSAKAEI KVKVQDTPGK VVGPIRFTNI TGEKMTLWWD APLNDGCAPI
THYIIEKRET SRLAWALIED KCEAQSYTAI KLINGNEYQF RVSAVNKFGV GRPLDSDPVV
AQIQYTVPDA PGIPEPSNIT GNSITLTWAR PESDGGSEIQ QYILERREKK STRWVKVISK
RPISETRFKV TGLTEGNEYE FHVMAENAAG VGPASGISRL IKCREPVNPP GPPTVVKVTD
TSKTTVSLEW SKPVFDGGME IIGYIIEMCK ADLGDWHKVN AEACVKTRYT VTDLQAGEEY
KFRVSAINGA GKGDSCEVTG TIKAVDRLTA PELDIDANFK QTHVVRAGAS IRLFIAYQGR
PTPTAVWSKP DSNLSLRADI HTTDSFSTLT VENCNRNDAG KYTLTVENNS GSKSITFTVK
VLDTPGPPGP ITFKDVTRGS ATLMWDAPLL DGGARIHHYV VEKREASRRS WQVISEKCTR
QIFKVNDLAE GVPYYFRVSA VNEYGVGEPY EMPEPIVATE QPAPPRRLDV VDTSKSSAVL
AWLKPDHDGG SRITGYLLEM RQKGSDFWVE AGHTKQLTFT VERLVEKTEY EFRVKAKNDA
GYSEPREAFS SVIIKEPQIE PTADLTGITN QLITCKAGSP FTIDVPISGR PAPKVTWKLE
EMRLKETDRV SITTTKDRTT LTVKDSMRGD SGRYFLTLEN TAGVKTFSVT VVVIGRPGPV
TGPIEVSSVS AESCVLSWGE PKDGGGTEIT NYIVEKRESG TTAWQLVNSS VKRTQIKVTH
LTKYMEYSFR VSSENRFGVS KPLESAPIIA EHPFVPPSAP TRPEVYHVSA NAMSIRWEEP
YHDGGSKIIG YWVEKKERNT ILWVKENKVP CLECNYKVTG LVEGLEYQFR TYALNAAGVS
KASEASRPIM AQNPVDAPGR PEVTDVTRST VSLIWSAPAY DGGSKVVGYI IERKPVSEVG
DGRWLKCNYT IVSDNFFTVT ALSEGDTYEF RVLAKNAAGV ISKGSESTGP VTCRDEYAPP
KAELDARLHG DLVTIRAGSD LVLDAAVGGK PEPKIIWTKG DKELDLCEKV SLQYTGKRAT
AVIKFCDRSD SGKYTLTVKN ASGTKAVSVM VKVLDSPGPC GKLTVSRVTQ EKCTLAWSLP
QEDGGAEITH YIVERRETSR LNWVIVEGEC PTLSYVVTRL IKNNEYIFRV RAVNKYGPGV
PVESEPIVAR NSFTIPSPPG IPEEVGTGKE HIIIQWTKPE SDGGNEISNY LVDKREKKSL
RWTRVNKDYV VYDTRLKVTS LMEGCDYQFR VTAVNAAGNS EPSEASNFIS CREPSYTPGP
PSAPRVVDTT KHSISLAWTK PMYDGGTDIV GYVLEMQEKD TDQWYRVHTN ATIRNTEFTV
PDLKMGQKYS FRVAAVNVKG MSEYSESIAE IEPVERIEIP DLELADDLKK TVTIRAGASL
RLMVSVSGRP PPVITWSKQG IDLASRAIID TTESYSLLIV DKVNRYDAGK YTIEAENQSG
KKSATVLVKV YDTPGPCPSV KVKEVSRDSV TITWEIPTID GGAPVNNYIV EKREAAMRAF
KTVTTKCSKT LYRISGLVEG TMYYFRVLPE NIYGIGEPCE TSDAVLVSEV PLVPAKLEVV
DVTKSTVTLA WEKPLYDGGS RLTGYVLEAC KAGTERWMKV VTLKPTVLEH TVTSLNEGEQ
YLFRIRAQNE KGVSEPRETV TAVTVQDLRV LPTIDLSTMP QKTIHVPAGR PVELVIPIAG
RPPPAASWFF AGSKLRESER VTVETHTKVA KLTIRETTIR DTGEYTLELK NVTGTTSETI
KVIILDKPGP PTGPIKIDEI DATSITISWE PPELDGGAPL SGYVVEQRDA HRPGWLPVSE
SVTRSTFKFT RLTEGNEYVF RVAATNRFGI GSYLQSEVIE CRSSIRIPGP PETLQIFDVS
RDGMTLTWYP PEDDGGSQVT GYIVERKEVR ADRWVRVNKV PVTMTRYRST GLTEGLEYEH
RVTAINARGS GKPSRPSKPI VAMDPIAPPG KPQNPRVTDT TRTSVSLAWS VPEDEGGSKV
TGYLIEMQKV DQHEWTKCNT TPTKIREYTL THLPQGAEYR FRVLACNAGG PGEPAEVPGT
VKVTEMLEYP DYELDERYQE GIFVRQGGVI RLTIPIKGKP FPICKWTKEG QDISKRAMIA
TSETHTELVI KEADRGDSGT YDLVLENKCG KKAVYIKVRV IGSPNSPEGP LEYDDIQVRS
VRVSWRPPAD DGGADILGYI LERREVPKAA WYTIDSRVRG TSLVVKGLKE NVEYHFRVSA
ENQFGISKPL KSEEPVTPKT PLNPPEPPSN PPEVLDVTKS SVSLSWSRPK DDGGSRVTGY
YIERKETSTD KWVRHNKTQI TTTMYTVTGL VPDAEYQFRI IAQNDVGLSE TSPASEPVVC
KDPFDKPSQP GELEILSISK DSVTLQWEKP ECDGGKEILG YWVEYRQSGD SAWKKSNKER
IKDKQFTIGG LLEATEYEFR VFAENETGLS RPRRTAMSIK TKLTSGEAPG IRKEMKDVTT
KLGEAAQLSC QIVGRPLPDI KWYRFGKELI QSRKYKMSSD GRTHTLTVMT EEQEDEGVYT
CIATNEVGEV ETSSKLLLQA TPQFHPGYPL KEKYYGAVGS TLRLHVMYIG RPVPAMTWFH
GQKLLQNSEN ITIENTEHYT HLVMKNVQRK THAGKYKVQL SNVFGTVDAI LDVEIQDKPD
KPTGPIVIEA LLKNSAVISW KPPADDGGSW ITNYVVEKCE AKEGAEWQLV SSAISVTTCR
IVNLTENAGY YFRVSAQNTF GISDPLEVSS VVIIKSPFEK PGAPGKPTIT AVTKDSCVVA
WKPPASDGGA KIRNYYLEKR EKKQNKWISV TTEEIRETVF SVKNLIEGLE YEFRVKCENL
GGESEWSEIS EPITPKSDVP IQAPHFKEEL RNLNVRYQSN ATLVCKVTGH PKPIVKWYRQ
GKEIIADGLK YRIQEFKGGY HQLIIASVTD DDATVYQVRA TNQGGSVSGT ASLEVEVPAK
IHLPKTLEGM GAVHALRGEV VSIKIPFSGK PDPVITWQKG QDLIDNNGHY QVIVTRSFTS
LVFPNGVERK DAGFYVVCAK NRFGIDQKTV ELDVADVPDP PRGVKVSDVS RDSVNLTWTE
PASDGGSKIT NYIVEKCATT AERWLRVGQA RETRYTVINL FGKTSYQFRV IAENKFGLSK
PSEPSEPTIT KEDKTRAMNY DEEVDETREV SMTKASHSST KELYEKYMIA EDLGRGEFGI
VHRCVETSSK KTYMAKFVKV KGTDQVLVKK EISILNIARH RNILHLHESF ESMEELVMIF
EFISGLDIFE RINTSAFELN EREIVSYVHQ VCEALQFLHS HNIGHFDIRP ENIIYQTRRS
STIKIIEFGQ ARQLKPGDNF RLLFTAPEYY APEVHQHDVV STATDMWSLG TLVYVLLSGI
NPFLAETNQQ IIENIMNAEY TFDEEAFKEI SIEAMDFVDR LLVKERKSRM TASEALQHPW
LKQKIERVST KVIRTLKHRR YYHTLIKKDL NMVVSAARIS CGGAIRSQKG VSVAKVKVAS
IEIGPVSGQI MHAVGEEGGH VKYVCKIENY DQSTQVTWYF GVRQLENSEK YEITYEDGVA
ILYVKDITKL DDGTYRCKVV NDYGEDSSYA ELFVKGVREV YDYYCRRTMK KIKRRTDTMR
LLERPPEFTL PLYNKTAYVG ENVRFGVTIT VHPEPHVTWY KSGQKIKPGD NDKKYTFESD
KGLYQLTINS VTTDDDAEYT VVARNKYGED SCKAKLTVTL HPPPTDSTLR PMFKRLLANA
ECQEGQSVCF EIRVSGIPPP TLKWEKDGQP LSLGPNIEII HEGLDYYALH IRDTLPEDTG
YYRVTATNTA GSTSCQAHLQ VERLRYKKQE FKSKEEHERH VQKQIDKTLR MAEILSGTES
VPLTQVAKEA LREAAVLYKP AVSTKTVKGE FRLEIEEKKE ERKLRMPYDV PEPRKYKQTT
IEEDQRIKQF VPMSDMKWYK KIRDQYEMPG KLDRVVQKRP KRIRLSRWEQ FYVMPLPRIT
DQYRPKWRIP KLSQDDLEIV RPARRRTPSP DYDFYYRPRR RSLGDISDEE LLLPIDDYLA
MKRTEEERLR LEEELELGFS ASPPSRSPPH FELSSLRYSS PQAHVKVEET RKDFRYSTYH
IPTKAEASTS YAELRERHAQ AAYRQPKQRQ RIMAEREDEE LLRPVTTTQH LSEYKSELDF
MSKEEKSRKK SRRQREVTEI TEIEEEYEIS KHAQRESSSS ASRLLRRRRS LSPTYIELMR
PVSELIRSRP QPAEEYEDDT ERRSPTPERT RPRSPSPVSS ERSLSRFERS ARFDIFSRYE
SMKAALKTQK TSERKYEVLS QQPFTLDHAP RITLRMRSHR VPCGQNTRFI LNVQSKPTAE
VKWYHNGVEL QESSKIHYTN TSGVLTLEIL DCHTDDSGTY RAVCTNYKGE ASDYATLDVT
GGDYTTYASQ RRDEEVPRSV FPELTRTEAY AVSSFKKTSE MEASSSVREV KSQMTETRES
LSSYEHSASA EMKSAALEEK SLEEKSTTRK IKTTLAARIL TKPRSMTVYE GESARFSCDT
DGEPVPTVTW LRKGQVLSTS ARHQVTTTKY KSTFEISSVQ ASDEGNYSVV VENSEGKQEA
EFTLTIQKAR VTEKAVTSPP RVKSPEPRVK SPEAVKSPKR VKSPEPSHPK AVSPTETKPT
PTEKVQHLPV SAPPKITQFL KAEASKEIAK LTCVVESSVL RAKEVTWYKD GKKLKENGHF
QFHYSADGTY ELKINNLTES DQGEYVCEIS GEGGTSKTNL QFMGQAFKSI HEKVSKISET
KKSDQKTTES TVTRKTEPKA PEPISSKPVI VTGLQDTTVS SDSVAKFAVK ATGEPRPTAI
WTKDGKAITQ GGKYKLSEDK GGFFLEIHKT DTSDSGLYTC TVKNSAGSVS SSCKLTIKAI
KDTEAQKVST QKTSEITPQK KAVVQEEISQ KALRSEEIKM SEAKSQEKLA LKEEASKVLI
SEEVKKSAAT SLEKSIVHEE ITKTSQASEE VRTHAEIKAF STQMSINEGQ RLVLKANIAG
ATDVKWVLNG VELTNSEEYR YGVSGSDQTL TIKQASHRDE GILTCISKTK EGIVKCQYDL
TLSKELSDAP AFISQPRSQN INEGQNVLFT CEISGEPSPE IEWFKNNLPI SISSNVSISR
SRNVYSLEIR NASVSDSGKY TIKAKNFRGQ CSATASLMVL PLVEEPSREV VLRTSGDTSL
QGSFSSQSVQ MSASKQEASF SSFSSSSASS MTEMKFASMS AQSMSSMQES FVEMSSSSFM
GISNMTQLES STSKMLKAGI RGIPPKIEAL PSDISIDEGK VLTVACAFTG EPTPEVTWSC
GGRKIHSQEQ GRFHIENTDD LTTLIIMDVQ KQDGGLYTLS LGNEFGSDSA TVNIHIRSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107749

Theoretical NMD boundary in CDS

107473

Length of CDS

107820

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.05 s

Back to summary table

Variant:

2:178745884C>A_5_ENST00000425332

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 133|67 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 1.50, LOF (oe): 1.11, misssense (oe): 1.33, synonymous (oe): 1.37 ? (gnomAD)

Ensembl transcript ID

ENST00000425332.3

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11312-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV
IPEGETPIVK RRKTPSPTAP EAMKEVVPEM KIFEDVPEEP ETPRMKTPEA PQEIIPAKTV
PSKKREPPSV KVPEALQEIV PEKKTLVVPL RKPEVLPDEV PEALREVVPE KKVHPPQRAE
VVPVKVHEAP KEIIPEKKVS VVPPKKPEVP PVKVPEASKE VIREEKVPLA PPKEPEVPPV
KVPEPPKEVV PEKKAPVAPP KEPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE
VPKAAVPEKK LPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP
KEVVLEKKAS VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAT
EKEIPVAPPK KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL
VLPKKPEVPP VTVPEAPKEV VLEKKVPSAP PKKPEVPPVK VPEAPKEVVP EKKVPVPPPK
KPEVPPTKVP EVPKAAVPEK KVPEAIPPKP ESPPPEVPEV LPPKEVVPEK KVPVPPAKKP
EAPPPKVPEA PKEVVLEKKA SVAVPKKPEA PRAKVPEAAQ EVVPEKKIPK APIKKPEAPA
VTVPEVPQEA AEKEIPVAPP KKPEAPIVPV PEAQEVVPEK KVPKAPPTKP EAPPATVPEV
PQEIVPEKKT LVLPKKPEVP PVTVPEAPKE VVLEKKVPST PPKKPEVPPV KVPEAPKEVV
PEKKVPVPPP KKPEVPPTKV PEVPKAAVPE KKVPEAIPPK PESPPPEVPE VLPPKEVVPE
KKVPVPPAKK PEAPPPKVPE APKEVVLEKK VSVAVPKKPE APRAKVPEAA QEVVPEKKIP
KAPIKKPEAP AVTVPEVPQE AAEKEIPVAP PKKPEAPIVP VPEAQEVVPE KKVPKAPPTK
PEAPPATVPE VPQEIVPEKK TLVLPKKPEV PPVTVPEAPK EVVLEKKVPL APPKKPEVPP
VKVPEAPKEV VPEKKVPVTP PKKPEVPPVK VPEAPIEVVP EKKMPLAPPK KPEVPPVKVP
EAPKEVVPEK KVPSAPPKKP EVPPVKVPEA PKEVVPEKKV PAAPPKKPEV TPVKVPEAPK
EVVPEKKVPV PPPKKPEVPP TKVPEVPKVA VPEKKVPEAI PPKPESPPPE VFEEPEEVAL
EEPPAEVVEE PEPAAPPQVT VPPKKPVPEK KAPAVVAKKP ELPPVKVPEV PKEVVPEKKV
PLVVPKKPEA PPAKVPEVPK EVVPEKKVAV PKKPEVPPAK VPEVPKKPVL EEKPAVPVPE
RAESPPPEVY EEPEEIAPEE EIAPEEEKPV PVAEEEEPEV PPPAVPEEPK KIIPEKKVPV
IKKPEAPPPK EPEMPKKVVP VKKVPTVKKP ETPAAKVPEV PKKLVPVKKE PVPVTKKPEV
LPEKVPKVPE KIIPEKEVSV PIPAEPEVPP AEVEETPEEI IYEEKASITI GRKETPPVEE
REIEKYIKPE EPEPEPQPEE IPVKEPEPEK VIEKPKLKPR PPPPPPAPPK EDVKEKIFQL
KAIPKKKVPE KPQVPEKVEL TPLKVPGGEK KVRKLLPERK PEPKEEVVLK SVLRKRPEEE
EPKVEPKKLE KVKKPAVPEP PPPKPVEEVE VPTVTKRERK IPEPTKVPEI KPAIPLPAPE
PKPKPEAEVK TIKPPPVEPE PTPIAAPVTV PVVGKKAEAK APKEEAAKPK GPIKGVPKKT
PSPIEAERRK LRPGSGGEKP PDEAPFTYQL KAVPLKFVKE IKDIILTESE FVGSSAIFEC
LVSPSTAITT WMKDGSNIRE SPKHRFIADG KDRKLHIIDV QLSDAGEYTC VLRLGNKEKT
STAKLVVEEL PVRFVKTLEE EVTVVKGQPL YLSCELNKER DVVWRKDGKI VVEKPGRIVP
GVIGLMRALT INDADDTDAG TYTVTVENAN NLECSSCVKV VEVIRDWLVK PIRDQHVKPK
GTAIFACDIA KDTPNIKWFK GYDEIPAEPN DKTEILRDGN HLYLKIKNAM PEDIAEYAVE
IEGKRYPAKL TLGEREVELL KPIEDVTIYE KESASFDAEI SEADIPGQWK LKGELLRPSP
TCEIKAEGGK RFLTLHKVKL DQAGEVLYQA LNAITTAILT VKEIELDFAV PLKDVTVPER
RQARFECVLT REANVIWSKG PDIIKSSDKF DIIADGKKHI LVINDSQFDD EGVYTAEVEG
KKTSARLFVT GIRLKFMSPL EDQTVKEGET ATFVCELSHE KMHVVWFKND AKLHTSRTVL
ISSEGKTHKL EMKEVTLDDI SQIKAQVKEL SSTAQLKVLE ADPYFTVKLH DKTAVEKDEI
TLKCEVSKDV PVKWFKDGEE IVPSPKYSIK ADGLRRILKI KKADLKDKGE YVCDCGTDKT
KANVTVEARL IKVEKPLYGV EVFVGETAHF EIELSEPDVH GQWKLKGQPL TASPDCEIIE
DGKKHILILH NCQLGMTGEV SFQAANAKSA ANLKVKELPL IFITPLSDVK VFEKDEAKFE
CEVSREPKTF RWLKGTQEIT GDDRFELIKD GTKHSMVIKS AAFEDEAKYM FEAEDKHTSG
KLIIEGIRLK FLTPLKDVTA KEKESAVFTV ELSHDNIRVK WFKNDQRLHT TRSVSMQDEG
KTHSITFKDL SIDDTSQIRV EAMGMSSEAK LTVLEGDPYF TGKLQDYTGV EKDEVILQCE
ISKADAPVKW FKDGKEIKPS KNAVIKADGK KRMLILKKAL KSDIGQYTCD CGTDKTSGKL
DIEDREIKLV RPLHSVEVME TETARFETEI SEDDIHANWK LKGEALLQTP DCEIKEEGKI
HSLVLHNCRL DQTGGVDFQA ANVKSSAHLR VKPRVIGLLR PLKDVTVTAG ETATFDCELS
YEDIPVEWYL KGKKLEPSDK VVPRSEGKVH TLTLRDVKLE DAGEVQLTAK DFKTHANLFV
KEPPVEFTKP LEDQTVEEGA TAVLECEVSR ENAKVKWFKN GTEILKSKKY EIVADGRVRK
LVIHDCTPED IKTYTCDAKD FKTSCNLNVV PPHVEFLRPL TDLQVREKEM ARFECELSRE
NAKVKWFKDG AEIKKGKKYD IISKGAVRIL VINKCLLDDE AEYSCEVRTA RTSGMLTVLE
EEAVFTKNLA NIEVSETDTI KLVCEVSKPG AEVIWYKGDE EIIETGRYEI LTEGRKRILV
IQNAHLEDAG NYNCRLPSSR TDGKVKVHEL AAEFISKPQN LEILEGEKAE FVCSISKESF
PVQWKRDDKT LESGDKYDVI ADGKKRVLVV KDATLQDMGT YVVMVGAARA AAHLTVIEKL
RIVVPLKDTR VKEQQEVVFN CEVNTEGAKA KWFRNEEAIF DSSKYIILQK DLVYTLRIRD
AHLDDQANYN VSLTNHRGEN VKSAANLIVE EEDLRIVEPL KDIETMEKKS VTFWCKVNRL
NVTLKWTKNG EEVPFDNRVS YRVDKYKHML TIKDCGFPDE GEYIVTAGQD KSVAELLIIE
APTEFVEHLE DQTVTEFDDA VFSCQLSREK ANVKWYRNGR EIKEGKKYKF EKDGSIHRLI
IKDCRLDDEC EYACGVEDRK SRARLFVEEI PVEIIRPPQD ILEAPGADVV FLAELNKDKV
EVQWLRNNMV VVQGDKHQMM SEGKIHRLQI CDIKPRDQGE YRFIAKDKEA RAKLELAAAP
KIKTADQDLV VDVGKPLTMV VPYDAYPKAE AEWFKENEPL STKTIDTTAE QTSFRILEAK
KGDKGRYKIV LQNKHGKAEG FINLKVIDVP GPVRNLEVTE TFDGEVSLAW EEPLTDGGSK
IIGYVVERRD IKRKTWVLAT DRAESCEFTV TGLQKGGVEY LFRVSARNRV GTGEPVETDN
PVEARSKYDV PGPPLNVTIT DVNRFGVSLT WEPPEYDGGA EITNYVIELR DKTSIRWDTA
MTVRAEDLSA TVTDVVEGQE YSFRVRAQNR IGVGKPSAAT PFVKVADPIE RPSPPVNLTS
SDQTQSSVQL KWEPPLKDGG SPILGYIIER CEEGKDNWIR CNMKLVPELT YKVTGLEKGN
KYLYRVSAEN KAGVSDPSEI LGPLTADDAF VEPTMDLSAF KDGLEVIVPN PITILVPSTG
YPRPTATWCF GDKVLETGDR VKMKTLSAYA ELVISPSERS DKGIYTLKLE NRVKTISGEI
DVNVIARPSA PKELKFGDIT KDSVHLTWEP PDDDGGSPLT GYVVEKREVS RKTWTKVMDF
VTDLEFTVPD LVQGKEYLFK VCARNKCGPG EPAYVDEPVN MSTPATVPDP PENVKWRDRT
ANSIFLTWDP PKNDGGSRIK GYIVERCPRG SDKWVACGEP VAETKMEVTG LEEGKWYAYR
VKALNRQGAS KPSRPTEEIQ AVDTQEAPEI FLDVKLLAGL TVKAGTKIEL PATVTGKPEP
KITWTKADMI LKQDKRITIE NVPKKSTVTI VDSKRSDTGT YIIEAVNVCG RATAVVEVNV
LDKPGPPAAF DITDVTNESC LLTWNPPRDD GGSKITNYVV ERRATDSEVW HKLSSTVKDT
NFKATKLIPN KEYIFRVAAE NMYGVGEPVQ ASPITAKYQF DPPGPPTRLE PSDITKDAVT
LTWCEPDDDG GSPITGYWVE RLDPDTDKWV RCNKMPVKDT TYRVKGLTNK KKYRFRVLAE
NLAGPGKPSK STEPILIKDP IDPPWPPGKP TVKDVGKTSV RLNWTKPEHD GGAKIESYVI
EMLKTGTDEW VRVAEGVPTT QHLLPGLMEG QEYSFRVRAV NKAGESEPSE PSDPVLCREK
LYPPSPPRWL EVINITKNTA DLKWTVPEKD GGSPITNYIV EKRDVRRKGW QTVDTTVKDT
KCTVTPLTEG SLYVFRVAAE NAIGQSDYTE IEDSVLAKDT FTTPGPPYAL AVVDVTKRHV
DLKWEPPKND GGRPIQRYVI EKKERLGTRW VKAGKTAGPD CNFRVTDVIE GTEVQFQVRA
ENEAGVGHPS EPTEILSIED PTSPPSPPLD LHVTDAGRKH IAIAWKPPEK NGGSPIIGYH
VEMCPVGTEK WMRVNSRPIK DLKFKVEEGV VPDKEYVLRV RAVNAIGVSE PSEISENVVA
KDPDCKPTID LETHDIIVIE GEKLSIPVPF RAVPVPTVSW HKDGKEVKAS DRLTMKNDHI
SAHLEVPKSV RADAGIYTIT LENKLGSATA SINVKVIGLP GPCKDIKASD ITKSSCKLTW
EPPEFDGGTP ILHYVLERRE AGRRTYIPVM SGENKLSWTV KDLIPNGEYF FRVKAVNKVG
GGEYIELKNP VIAQDPKQPP DPPVDVEVHN PTAEAMTITW KPPLYDGGSK IMGYIIEKIA
KGEERWKRCN EHLVPILTYT AKGLEEGKEY QFRVRAENAA GISEPSRATP PTKAVDPIDA
PKVILRTSLE VKRGDEIALD ASISGSPYPT ITWIKDENVI VPEEIKKRAA PLVRRRKGEV
QEEEPFVLPL TQRLSIDNSK KGESQLRVRD SLRPDHGLYM IKVENDHGIA KAPCTVSVLD
TPGPPINFVF EDIRKTSVLC KWEPPLDDGG SEIINYTLEK KDKTKPDSEW IVVTSTLRHC
KYSVTKLIEG KEYLFRVRAE NRFGPGPPCV SKPLVAKDPF GPPDAPDKPI VEDVTSNSML
VKWNEPKDNG SPILGYWLEK REVNSTHWSR VNKSLLNALK ANVDGLLEGL TYVFRVCAEN
AAGPGKFSPP SDPKTAHDPI SPPGPPIPRV TDTSSTTIEL EWEPPAFNGG GEIVGYFVDK
QLVGTNEWSR CTEKMIKVRQ YTVKEIREGA DYKLRVSAVN AAGEGPPGET QPVTVAEPQE
PPAVELDVSV KGGIQIMAGK TLRIPAVVTG RPVPTKVWTK EEGELDKDRV VIDNVGTKSE
LIIKDALRKD HGRYVITATN SCGSKFAAAR VEVFDVPGPV LDLKPVVTNR KMCLLNWSDP
EDDGGSEITG FIIERKDAKM HTWRQPIETE RSKCDITGLL EGQEYKFRVI AKNKFGCGPP
VEIGPILAVD PLGPPTSPER LTYTERTKST ITLDWKEPRS NGGSPIQGYI IEKRRHDKPD
FERVNKRLCP TTSFLVENLD EHQMYEFRVK AVNEIGESEP SLPLNVVIQD DEVPPTIKLR
LSVRGDTIKV KAGEPVHIPA DVTGLPMPKI EWSKNETVIE KPTDALQITK EEVSRSEAKT
ELSIPKAVRE DKGTYTVTAS NRLGSVFRNV HVEVYDRPSP PRNLAVTDIK AESCYLTWDA
PLDNGGSEIT HYVIDKRDAS RKKAEWEEVT NTAVEKRYGI WKLIPNGQYE FRVRAVNKYG
ISDECKSDKV VIQDPYRLPG PPGKPKVLAR TKGSMLVSWT PPLDNGGSPI TGYWLEKREE
GSPYWSRVSR APITKVGLKG VEFNVPRLLE GVKYQFRAMA INAAGIGPPS EPSDPEVAGD
PIFPPGPPSC PEVKDKTKSS ISLGWKPPAK DGGSPIKGYI VEMQEEGTTD WKRVNEPDKL
ITTCECVVPN LKELRKYRFR VKAVNEAGES EPSDTTGEIP ATDIQEEPEV FIDIGAQDCL
VCKAGSQIRI PAVIKGRPTP KSSWEFDGKA KKAMKDGVHD IPEDAQLETA ENSSVIIIPE
CKRSHTGKYS ITAKNKAGQK TANCRVKVMD VPGPPKDLKV SDITRGSCRL SWKMPDDDGG
DRIKGYVIEK RTIDGKAWTK VNPDCGSTTF VVPDLLSEQQ YFFRVRAENR FGIGPPVETI
QRTTARDPIY PPDPPIKLKI GLITKNTVHL SWKPPKNDGG SPVTHYIVEC LAWDPTGTKK
EAWRQCNKRD VEELQFTVED LVEGGEYEFR VKAVNAAGVS KPSATVGPVT VKDQTCPPSI
DLKEFMEVEE GTNVNIVAKI KGVPFPTLTW FKAPPKKPDN KEPVLYDTHV NKLVVDDTCT
LVIPQSRRSD TGLYTITAVN NLGTASKEMR LNVLGRPGPP VGPIKFESVS ADQMTLSWFP
PKDDGGSKIT NYVIEKREAN RKTWVHVSSE PKECTYTIPK LLEGHEYVFR IMAQNKYGIG
EPLDSEPETA RNLFSVPGAP DKPTVSSVTR NSMTVNWEEP EYDGGSPVTG YWLEMKDTTS
KRWKRVNRDP IKAMTLGVSY KVTGLIEGSD YQFRVYAINA AGVGPASLPS DPATARDPIA
PPGPPFPKVT DWTKSSADLE WSPPLKDGGS KVTGYIVEYK EEGKEEWEKG KDKEVRGTKL
VVTGLKEGAF YKFRVRAVNI AGIGEPGEVT DVIEMKDRLV SPDLQLDASV RDRIVVHAGG
VIRIIAYVSG KPPPTVTWNM NERTLPQEAT IETTAISSSM VIKNCQRSHQ GVYSLLAKNE
AGERKKTIIV DVLDVPGPVG TPFLAHNLTN ESCKLTWFSP EDDGGSPITN YVIEKRESDR
RAWTPVTYTV TRQNATVQGL IQGKAYFFRI AAENSIGMGP FVETSEALVI REPITVPERP
EDLEVKEVTK NTVTLTWNPP KYDGGSEIIN YVLESRLIGT EKFHKVTNDN LLSRKYTVKG
LKEGDTYEYR VSAVNIVGQG KPSFCTKPIT CKDELAPPTL HLDFRDKLTI RVGEAFALTG
RYSGKPKPKV SWFKDEADVL EDDRTHIKTT PATLALEKIK AKRSDSGKYC VVVENSTGSR
KGFCQVNVVD RPGPPVGPVS FDEVTKDYMV ISWKPPLDDG GSKITNYIIE KKEVGKDVWM
PVTSASAKTT CKVSKLLEGK DYIFRIHAEN LYGISDPLVS DSMKAKDRFR VPDAPDQPIV
TEVTKDSALV TWNKPHDGGK PITNYILEKR ETMSKRWARV TKDPIHPYTK FRVPDLLEGC
QYEFRVSAEN EIGIGDPSPP SKPVFAKDPI AKPSPPVNPE AIDTTCNSVD LTWQPPRHDG
GSKILGYIVE YQKVGDEEWR RANHTPESCP ETKYKVTGLR DGQTYKFRVL AVNAAGESDP
AHVPEPVLVK DRLEPPELIL DANMAREQHI KVGDTLRLSA IIKGVPFPKV TWKKEDRDAP
TKARIDVTPV GSKLEIRNAA HEDGGIYSLT VENPAGSKTV SVKVLVLDKP GPPRDLEVSE
IRKDSCYLTW KEPLDDGGSV ITNYVVERRD VASAQWSPLS ATSKKKSHFA KHLNEGNQYL
FRVAAENQYG RGPFVETPKP IKALDPLHPP GPPKDLHHVD VDKTEVSLVW NKPDRDGGSP
ITGYLVEYQE EGTQDWIKFK TVTNLECVVT GLQQGKTYRF RVKAENIVGL GLPDTTIPIE
CQEKLVPPSV ELDVKLIEGL VVKAGTTVRF PAIIRGVPVP TAKWTTDGSE IKTDEHYTVE
TDNFSSVLTI KNCLRRDTGE YQITVSNAAG SKTVAVHLTV LDVPGPPTGP INILDVTPEH
MTISWQPPKD DGGSPVINYI VEKQDTRKDT WGVVSSGSSK TKLKIPHLQK GCEYVFRVRA
ENKIGVGPPL DSTPTVAKHK FSPPSPPGKP VVTDITENAA TVSWTLPKSD GGSPITGYYM
ERREVTGKWV RVNKTPIADL KFRVTGLYEG NTYEFRVFAE NLAGLSKPSP SSDPIKACRP
IKPPGPPINP KLKDKSRETA DLVWTKPLSD GGSPILGYVV ECQKPGTAQW NRINKDELIR
QCAFRVPGLI EGNEYRFRIK AANIVGEGEP RELAESVIAK DILHPPEVEL DVTCRDVITV
RVGQTIRILA RVKGRPEPDI TWTKEGKVLV REKRVDLIQD LPRVELQIKE AVRADHGKYI
ISAKNSSGHA QGSAIVNVLD RPGPCQNLKV TNVTKENCTI SWENPLDNGG SEITNFIVEY
RKPNQKGWSI VASDVTKRLI KANLLANNEY YFRVCAENKV GVGPTIETKT PILAINPIDR
PGEPENLHIA DKGKTFVYLK WRRPDYDGGS PNLSYHVERR LKGSDDWERV HKGSIKETHY
MVDRCVENQI YEFRVQTKNE GGESDWVKTE EVVVKEDLQK PVLDLKLSGV LTVKAGDTIR
LEAGVRGKPF PEVAWTKDKD ATDLTRSPRV KIDTRADSSK FSLTKAKRSD GGKYVVTATN
TAGSFVAYAT VNVLDKPGPV RNLKIVDVSS DRCTVCWDPP EDDGGCEIQN YILEKCETKR
MVWSTYSATV LTPGTTVTRL IEGNEYIFRV RAENKIGTGP PTESKPVIAK TKYDKPGRPD
PPEVTKVSKE EMTVVWNPPE YDGGKSITGY FLEKKEKHST RWVPVNKSAI PERRMKVQNL
LPDHEYQFRV KAENEIGIGE PSLPSRPVVA KDPIEPPGPP TNFRVVDTTK HSITLGWGKP
VYDGGAPIIG YVVEMRPKIA DASPDEGWKR CNAAAQLVRK EFTVTSLDEN QEYEFRVCAQ
NQVGIGRPAE LKEAIKPKEI LEPPEIDLDA SMRKLVIVRA GCPIRLFAIV RGRPAPKVTW
RKVGIDNVVR KGQVDLVDTM AFLVIPNSTR DDSGKYSLTL VNPAGEKAVF VNVRVLDTPG
PVSDLKVSDV TKTSCHVSWA PPENDGGSQV THYIVEKREA DRKTWSTVTP EVKKTSFHVT
NLVPGNEYYF RVTAVNEYGP GVPTDVPKPV LASDPLSEPD PPRKLEVTEM TKNSATLAWL
PPLRDGGAKI DGYITSYREE EQPADRWTEY SVVKDLSLVV TGLKEGKKYK FRVAARNAVG
VSLPREAEGV YEAKEQLLPP KILMPEQITI KAGKKLRIEA HVYGKPHPTC KWKKGEDEVV
TSSHLAVHKA DSSSILIIKD VTRKDSGYYS LTAENSSGTD TQKIKVVVMD APGPPQPPFD
ISDIDADACS LSWHIPLEDG GSNITNYIVE KCDVSRGDWV TALASVTKTS CRVGKLIPGQ
EYIFRVRAEN RFGISEPLTS PKMVAQFPFG VPSEPKNARV TKVNKDCIFV AWDRPDSDGG
SPIIGYLIER KERNSLLWVK ANDTLVRSTE YPCAGLVEGL EYSFRIYALN KAGSSPPSKP
TEYVTARMPV DPPGKPEVID VTKSTVSLIW ARPKHDGGSK IIGYFVEACK LPGDKWVRCN
TAPHQIPQEE YTATGLEEKA QYQFRAIART AVNISPPSEP SDPVTILAEN VPPRIDLSVA
MKSLLTVKAG TNVCLDATVF GKPMPTVSWK KDGTLLKPAE GIKMAMQRNL CTLELFSVNR
KDSGDYTITA ENSSGSKSAT IKLKVLDKPG PPASVKINKM YSDRAMLSWE PPLEDGGSEI
TNYIVDKRET SRPNWAQVSA TVPITSCSVE KLIEGHEYQF RICAENKYGV GDPVFTEPAI
AKNPYDPPGR CDPPVISNIT KDHMTVSWKP PADDGGSPIT GYLLEKRETQ AVNWTKVNRK
PIIERTLKAT GLQEGTEYEF RVTAINKAGP GKPSDASKAA YARDPQYPPG PPAFPKVYDT
TRSSVSLSWG KPAYDGGSPI IGYLVEVKRA DSDNWVRCNL PQNLQKTRFE VTGLMEDTQY
QFRVYAVNKI GYSDPSDVPD KHYPKDILIP PEGELDADLR KTLILRAGVT MRLYVPVKGR
PPPKITWSKP NVNLRDRIGL DIKSTDFDTF LRCENVNKYD AGKYILTLEN SCGKKEYTIV
VKVLDTPGPP VNVTVKEISK DSAYVTWEPP IIDGGSPIIN YVVQKRDAER KSWSTVTTEC
SKTSFRVANL EEGKSYFFRV FAENEYGIGD PGETRDAVKA SQTPGPVVDL KVRSVSKSSC
SIGWKKPHSD GGSRIIGYVV DFLTEENKWQ RVMKSLSLQY SAKDLTEGKE YTFRVSAENE
NGEGTPSEIT VVARDDVVAP DLDLKGLPDL CYLAKENSNF RLKIPIKGKP APSVSWKKGE
DPLATDTRVS VESSAVNTTL IVYDCQKSDA GKYTITLKNV AGTKEGTISI KVVGKPGIPT
GPIKFDEVTA EAMTLKWAPP KDDGGSEITN YILEKRDSVN NKWVTCASAV QKTTFRVTRL
HEGMEYTFRV SAENKYGVGE GLKSEPIVAR HPFDVPDAPP PPNIVDVRHD SVSLTWTDPK
KTGGSPITGY HLEFKERNSL LWKRANKTPI RMRDFKVTGL TEGLEYEFRV MAINLAGVGK
PSLPSEPVVA LDPIDPPGKP EVINITRNSV TLIWTEPKYD GGHKLTGYIV EKRDLPSKSW
MKANHVNVPE CAFTVTDLVE GGKYEFRIRA KNTAGAISAP SESTETIICK DEYEAPTIVL
DPTIKDGLTI KAGDTIVLNA ISILGKPLPK SSWSKAGKDI RPSDITQITS TPTSSMLTIK
YATRKDAGEY TITATNPFGT KVEHVKVTVL DVPGPPGPVE ISNVSAEKAT LTWTPPLEDG
GSPIKSYILE KRETSRLLWT VVSEDIQSCR HVATKLIQGN EYIFRVSAVN HYGKGEPVQS
EPVKMVDRFG PPGPPEKPEV SNVTKNTATV SWKRPVDDGG SEITGYHVER REKKSLRWVR
AIKTPVSDLR CKVTGLQEGS TYEFRVSAEN RAGIGPPSEA SDSVLMKDAA YPPGPPSNPH
VTDTTKKSAS LAWGKPHYDG GLEITGYVVE HQKVGDEAWI KDTTGTALRI TQFVVPDLQT
KEKYNFRISA INDAGVGEPA VIPDVEIVER EMAPDFELDA ELRRTLVVRA GLSIRIFVPI
KGRPAPEVTW TKDNINLKNR ANIENTESFT LLIIPECNRY DTGKFVMTIE NPAGKKSGFV
NVRVLDTPGP VLNLRPTDIT KDSVTLHWDL PLIDGGSRIT NYIVEKREAT RKSYSTATTK
CHKCTYKVTG LSEGCEYFFR VMAENEYGIG EPTETTEPVK ASEAPSPPDS LNIMDITKST
VSLAWPKPKH DGGSKITGYV IEAQRKGSDQ WTHITTVKGL ECVVRNLTEG EEYTFQVMAV
NSAGRSAPRE SRPVIVKEQT MLPELDLRGI YQKLVIAKAG DNIKVEIPVL GRPKPTVTWK
KGDQILKQTQ RVNFETTATS TILNINECVR SDSGPYPLTA RNIVGEVGDV ITIQVHDIPG
PPTGPIKFDE VSSDFVTFSW DPPENDGGVP ISNYVVEMRQ TDSTTWVELA TTVIRTTYKA
TRLTTGLEYQ FRVKAQNRYG VGPGITSACI VANYPFKVPG PPGTPQVTAV TKDSMTISWH
EPLSDGGSPI LGYHVERKER NGILWQTVSK ALVPGNIFKS SGLTDGIAYE FRVIAENMAG
KSKPSKPSEP MLALDPIDPP GKPVPLNITR HTVTLKWAKP EYTGGFKITS YIVEKRDLPN
GRWLKANFSN ILENEFTVSG LTEDAAYEFR VIAKNAAGAI SPPSEPSDAI TCRDDVEAPK
IKVDVKFKDT VILKAGEAFR LEADVSGRPP PTMEWSKDGK ELEGTAKLEI KIADFSTNLV
NKDSTRRDSG AYTLTATNPG GFAKHIFNVK VLDRPGPPEG PLAVTEVTSE KCVLSWFPPL
DDGGAKIDHY IVQKRETSRL AWTNVASEVQ VTKLKVTKLL KGNEYIFRVM AVNKYGVGEP
LESEPVLAVN PYGPPDPPKN PEVTTITKDS MVVCWGHPDS DGGSEIINYI VERRDKAGQR
WIKCNKKTLT DLRYKVSGLT EGHEYEFRIM AENAAGISAP SPTSPFYKAC DTVFKPGPPG
NPRVLDTSRS SISIAWNKPI YDGGSEITGY MVEIALPEED EWQIVTPPAG LKATSYTITG
LTENQEYKIR IYAMNSEGLG EPALVPGTPK AEDRMLPPEI ELDADLRKVV TIRACCTLRL
FVPIKGRPAP EVKWARDHGE SLDKASIEST SSYTLLIVGN VNRFDSGKYI LTVENSSGSK
SAFVNVRVLD TPGPPQDLKV KEVTKTSVTL TWDPPLLDGG SKIKNYIVEK RESTRKAYST
VATNCHKTSW KVDQLQEGCS YYFRVLAENE YGIGLPAETA ESVKASERPL PPGKITLMDV
TRNSVSLSWE KPEHDGGSRI LGYIVEMQTK GSDKWATCAT VKVTEATITG LIQGEEYSFR
VSAQNEKGIS DPRQLSVPVI AKDLVIPPAF KLLFNTFTVL AGEDLKVDVP FIGRPTPAVT
WHKDNVPLKQ TTRVNAESTE NNSLLTIKDA CREDVGHYVV KLTNSAGEAI ETLNVIVLDK
PGPPTGPVKM DEVTADSITL SWGPPKYDGG SSINNYIVEK RDTSTTTWQI VSATVARTTI
KACRLKTGCE YQFRIAAENR YGKSTYLNSE PTVAQYPFKV PGPPGTPVVT LSSRDSMEVQ
WNEPISDGGS RVIGYHLERK ERNSILWVKL NKTPIPQTKF KTTGLEEGVE YEFRVSAENI
VGIGKPSKVS ECYVARDPCD PPGRPEAIIV TRNSVTLQWK KPTYDGGSKI TGYIVEKKEL
PEGRWMKASF TNIIDTHFEV TGLVEDHRYE FRVIARNAAG VFSEPSESTG AITARDEVDP
PRISMDPKYK DTIVVHAGES FKVDADIYGK PIPTIQWIKG DQELSNTARL EIKSTDFATS
LSVKDAVRVD SGNYILKAKN VAGERSVTVN VKVLDRPGPP EGPVVISGVT AEKCTLAWKP
PLQDGGSDII NYIVERRETS RLVWTVVDAN VQTLSCKVTK LLEGNEYTFR IMAVNKYGVG
EPLESEPVVA KNPFVVPDAP KAPEVTTVTK DSMIVVWERP ASDGGSEILG YVLEKRDKEG
IRWTRCHKRL IGELRLRVTG LIENHDYEFR VSAENAAGLS EPSPPSAYQK ACDPIYKPGP
PNNPKVIDIT RSSVFLSWSK PIYDGGCEIQ GYIVEKCDVS VGEWTMCTPP TGINKTNIEV
EKLLEKHEYN FRICAINKAG VGEHADVPGP IIVEEKLEAP DIDLDLELRK IINIRAGGSL
RLFVPIKGRP TPEVKWGKVD GEIRDAAIID VTSSFTSLVL DNVNRYDSGK YTLTLENSSG
TKSAFVTVRV LDTPSPPVNL KVTEITKDSV SITWEPPLLD GGSKIKNYIV EKREATRKSY
AAVVTNCHKN SWKIDQLQEG CSYYFRVTAE NEYGIGLPAQ TADPIKVAEV PQPPGKITVD
DVTRNSVSLS WTKPEHDGGS KIIQYIVEMQ AKHSEKWSEC ARVKSLQAVI TNLTQGEEYL
FRVVAVNEKG RSDPRSLAVP IVAKDLVIEP DVKPAFSSYS VQVGQDLKIE VPISGRPKPT
ITWTKDGLPL KQTTRINVTD SLDLTTLSIK ETHKDDGGQY GITVANVVGQ KTASIEIVTL
DKPDPPKGPV KFDDVSAESI TLSWNPPLYT GGCQITNYIV QKRDTTTTVW DVVSATVART
TLKVTKLKTG TEYQFRIFAE NRYGQSFALE SDPIVAQYPY KEPGPPGTPF ATAISKDSMV
IQWHEPVNNG GSPVIGYHLE RKERNSILWT KVNKTIIHDT QFKAQNLEEG IEYEFRVYAE
NIVGVGKASK NSECYVARDP CDPPGTPEPI MVKRNEITLQ WTKPVYDGGS MITGYIVEKR
DLPDGRWMKA SFTNVIETQF TVSGLTEDQR YEFRVIAKNA AGAISKPSDS TGPITAKDEV
ELPRISMDPK FRDTIVVNAG ETFRLEADVH GKPLPTIEWL RGDKEIEESA RCEIKNTDFK
ALLIVKDAIR IDGGQYILRA SNVAGSKSFP VNVKVLDRPG PPEGPVQVTG VTSEKCSLTW
SPPLQDGGSD ISHYVVEKRE TSRLAWTVVA SEVVTNSLKV TKLLEGNEYV FRIMAVNKYG
VGEPLESAPV LMKNPFVLPG PPKSLEVTNI AKDSMTVCWN RPDSDGGSEI IGYIVEKRDR
SGIRWIKCNK RRITDLRLRV TGLTEDHEYE FRVSAENAAG VGEPSPATVY YKACDPVFKP
GPPTNAHIVD TTKNSITLAW GKPIYDGGSE ILGYVVEICK ADEEEWQIVT PQTGLRVTRF
EISKLTEHQE YKIRVCALNK VGLGEATSVP GTVKPEDKLE APELDLDSEL RKGIVVRAGG
SARIHIPFKG RPTPEITWSR EEGEFTDKVQ IEKGVNYTQL SIDNCDRNDA GKYILKLENS
SGSKSAFVTV KVLDTPGPPQ NLAVKEVRKD SAFLVWEPPI IDGGAKVKNY VIDKRESTRK
AYANVSSKCS KTSFKVENLT EGAIYYFRVM AENEFGVGVP VETVDAVKAA EPPSPPGKVT
LTDVSQTSAS LMWEKPEHDG GSRVLGYVVE MQPKGTEKWS IVAESKVCNA VVTGLSSGQE
YQFRVKAYNE KGKSDPRVLG VPVIAKDLTI QPSLKLPFNT YSIQAGEDLK IEIPVIGRPR
PNISWVKDGE PLKQTTRVNV EETATSTVLH IKEGNKDDFG KYTVTATNSA GTATENLSVI
VLEKPGPPVG PVRFDEVSAD FVVISWEPPA YTGGCQISNY IVEKRDTTTT TWHMVSATVA
RTTIKITKLK TGTEYQFRIF AENRYGKSAP LDSKAVIVQY PFKEPGPPGT PFVTSISKDQ
MLVQWHEPVN DGGTKIIGYH LEQKEKNSIL WVKLNKTPIQ DTKFKTTGLD EGLEYEFKVS
AENIVGIGKP SKVSECFVAR DPCDPPGRPE AIVITRNNVT LKWKKPAYDG GSKITGYIVE
KKDLPDGRWM KASFTNVLET EFTVSGLVED QRYEFRVIAR NAAGNFSEPS DSSGAITARD
EIDAPNASLD PKYKDVIVVH AGETFVLEAD IRGKPIPDVV WSKDGKELEE TAARMEIKST
IQKTTLVVKD CIRTDGGQYI LKLSNVGGTK SIPITVKVLD RPGPPEGPLK VTGVTAEKCY
LAWNPPLQDG GANISHYIIE KRETSRLSWT QVSTEVQALN YKVTKLLPGN EYIFRVMAVN
KYGIGEPLES GPVTACNPYK PPGPPSTPEV SAITKDSMVV TWARPVDDGG TEIEGYILEK
RDKEGVRWTK CNKKTLTDLR LRVTGLTEGH SYEFRVAAEN AAGVGEPSEP SVFYRACDAL
YPPGPPSNPK VTDTSRSSVS LAWSKPIYDG GAPVKGYVVE VKEAAADEWT TCTPPTGLQG
KQFTVTKLKE NTEYNFRICA INSEGVGEPA TLPGSVVAQE RIEPPEIELD ADLRKVVVLR
ASATLRLFVT IKGRPEPEVK WEKAEGILTD RAQIEVTSSF TMLVIDNVTR FDSGRYNLTL
ENNSGSKTAF VNVRVLDSPS APVNLTIREV KKDSVTLSWE PPLIDGGAKI TNYIVEKRET
TRKAYATITN NCTKTTFRIE NLQEGCSYYF RVLASNEYGI GLPAETTEPV KVSEPPLPPG
RVTLVDVTRN TATIKWEKPE SDGGSKITGY VVEMQTKGSE KWSTCTQVKT LEATISGLTA
GEEYVFRVAA VNEKGRSDPR QLGVPVIARD IEIKPSVELP FHTFNVKARE QLKIDVPFKG
RPQATVNWRK DGQTLKETTR VNVSSSKTVT SLSIKEASKE DVGTYELCVS NSAGSITVPI
TIIVLDRPGP PGPIRIDEVS CDSITISWNP PEYDGGCQIS NYIVEKKETT STTWHIVSQA
VARTSIKIVR LTTGSEYQFR VCAENRYGKS SYSESSAVVA EYPFSPPGPP GTPKVVHATK
STMLVTWQVP VNDGGSRVIG YHLEYKERSS ILWSKANKIL IADTQMKVSG LDEGLMYEYR
VYAENIAGIG KCSKSCEPVP ARDPCDPPGQ PEVTNITRKS VSLKWSKPHY DGGAKITGYI
VERRELPDGR WLKCNYTNIQ ETYFEVTELT EDQRYEFRVF ARNAADSVSE PSESTGPIIV
KDDVEPPRVM MDVKFRDVIV VKAGEVLKIN ADIAGRPLPV ISWAKDGIEI EERARTEIIS
TDNHTLLTVK DCIRRDTGQY VLTLKNVAGT RSVAVNCKVL DKPGPPAGPL EINGLTAEKC
SLSWGRPQED GGADIDYYIV EKRETSHLAW TICEGELQMT SCKVTKLLKG NEYIFRVTGV
NKYGVGEPLE SVAIKALDPF TVPSPPTSLE ITSVTKESMT LCWSRPESDG GSEISGYIIE
RREKNSLRWV RVNKKPVYDL RVKSTGLREG CEYEYRVYAE NAAGLSLPSE TSPLIRAEDP
VFLPSPPSKP KIVDSGKTTI TIAWVKPLFD GGAPITGYTV EYKKSDDTDW KTSIQSLRGT
EYTISGLTTG AEYVFRVKSV NKVGASDPSD SSDPQIAKER EEEPLFDIDS EMRKTLIVKA
GASFTMTVPF RGRPVPNVLW SKPDTDLRTR AYVDTTDSRT SLTIENANRN DSGKYTLTIQ
NVLSAASLTL VVKVLDTPGP PTNITVQDVT KESAVLSWDV PENDGGAPVK NYHIEKREAS
KKAWVSVTNN CNRLSYKVTN LQEGAIYYFR VSGENEFGVG IPAETKEGVK ITEKPSPPEK
LGVTSISKDS VSLTWLKPEH DGGSRIVHYV VEALEKGQKN WVKCAVAKST HHVVSGLREN
SEYFFRVFAE NQAGLSDPRE LLLPVLIKEQ LEPPEIDMKN FPSHTVYVRA GSNLKVDIPI
SGKPLPKVTL SRDGVPLKAT MRFNTEITAE NLTINLKESV TADAGRYEIT AANSSGTTKA
FINIVVLDRP GPPTGPVVIS DITEESVTLK WEPPKYDGGS QVTNYILLKR ETSTAVWTEV
SATVARTMMK VMKLTTGEEY QFRIKAENRF GISDHIDSAC VTVKLPYTTP GPPSTPWVTN
VTRESITVGW HEPVSNGGSA VVGYHLEMKD RNSILWQKAN KLVIRTTHFK VTTISAGLIY
EFRVYAENAA GVGKPSHPSE PVLAIDACEP PRNVRITDIS KNSVSLSWQQ PAFDGGSKIT
GYIVERRDLP DGRWTKASFT NVTETQFIIS GLTQNSQYEF RVFARNAVGS ISNPSEVVGP
ITCIDSYGGP VIDLPLEYTE VVKYRAGTSV KLRAGISGKP APTIEWYKDD KELQTNALVC
VENTTDLASI LIKDADRLNS GCYELKLRNA MGSASATIRV QILDKPGPPG GPIEFKTVTA
EKITLLWRPP ADDGGAKITH YIVEKRETSR VVWSMVSEHL EECIITTTKI IKGNEYIFRV
RAVNKYGIGE PLESDSVVAK NAFVTPGPPG IPEVTKITKN SMTVVWSRPI ADGGSDISGY
FLEKRDKKSL GWFKVLKETI RDTRQKVTGL TENSDYQYRV CAVNAAGQGP FSEPSEFYKA
ADPIDPPGPP AKIRIADSTK SSITLGWSKP VYDGGSAVTG YVVEIRQGEE EEWTTVSTKG
EVRTTEYVVS NLKPGVNYYF RVSAVNCAGQ GEPIEMNEPV QAKDILEAPE IDLDVALRTS
VIAKAGEDVQ VLIPFKGRPP PTVTWRKDEK NLGSDARYSI ENTDSSSLLT IPQVTRNDTG
KYILTIENGV GEPKSSTVSV KVLDTPAACQ KLQVKHVSRG TVTLLWDPPL IDGGSPIINY
VIEKRDATKR TWSVVSHKCS STSFKLIDLS EKTPFFFRVL AENEIGIGEP CETTEPVKAA
EVPAPIRDLS MKDSTKTSVI LSWTKPDFDG GSVITEYVVE RKGKGEQTWS HAGISKTCEI
EVSQLKEQSV LEFRVFAKNE KGLSDPVTIG PITVKELIIT PEVDLSDIPG AQVTVRIGHN
VHLELPYKGK PKPSISWLKD GLPLKESEFV RFSKTENKIT LSIKNAKKEH GGKYTVILDN
AVCRIAVPIT VITLGPPSKP KGPIRFDEIK ADSVILSWDV PEDNGGGEIT CYSIEKRETS
QTNWKMVCSS VARTTFKVPN LVKDAEYQFR VRAENRYGVS QPLVSSIIVA KHQFRIPGPP
GKPVIYNVTS DGMSLTWDAP VYDGGSEVTG FHVEKKERNS ILWQKVNTSP ISGREYRATG
LVEGLDYQFR VYAENSAGLS SPSDPSKFTL AVSPVDPPGT PDYIDVTRET ITLKWNPPLR
DGGSKIVGYS IEKRQGNERW VRCNFTDVSE CQYTVTGLSP GDRYEFRIIA RNAVGTISPP
SQSSGIIMTR DENVPPIVEF GPEYFDGLII KSGESLRIKA LVQGRPVPRV TWFKDGVEIE
KRMNMEITDV LGSTSLFVRD ATRDHRGVYT VEAKNASGSA KAEIKVKVQD TPGKVVGPIR
FTNITGEKMT LWWDAPLNDG CAPITHYIIE KRETSRLAWA LIEDKCEAQS YTAIKLINGN
EYQFRVSAVN KFGVGRPLDS DPVVAQIQYT VPDAPGIPEP SNITGNSITL TWARPESDGG
SEIQQYILER REKKSTRWVK VISKRPISET RFKVTGLTEG NEYEFHVMAE NAAGVGPASG
ISRLIKCREP VNPPGPPTVV KVTDTSKTTV SLEWSKPVFD GGMEIIGYII EMCKADLGDW
HKVNAEACVK TRYTVTDLQA GEEYKFRVSA INGAGKGDSC EVTGTIKAVD RLTAPELDID
ANFKQTHVVR AGASIRLFIA YQGRPTPTAV WSKPDSNLSL RADIHTTDSF STLTVENCNR
NDAGKYTLTV ENNSGSKSIT FTVKVLDTPG PPGPITFKDV TRGSATLMWD APLLDGGARI
HHYVVEKREA SRRSWQVISE KCTRQIFKVN DLAEGVPYYF RVSAVNEYGV GEPYEMPEPI
VATEQPAPPR RLDVVDTSKS SAVLAWLKPD HDGGSRITGY LLEMRQKGSD FWVEAGHTKQ
LTFTVERLVE KTEYEFRVKA KNDAGYSEPR EAFSSVIIKE PQIEPTADLT GITNQLITCK
AGSPFTIDVP ISGRPAPKVT WKLEEMRLKE TDRVSITTTK DRTTLTVKDS MRGDSGRYFL
TLENTAGVKT FSVTVVVIGR PGPVTGPIEV SSVSAESCVL SWGEPKDGGG TEITNYIVEK
RESGTTAWQL VNSSVKRTQI KVTHLTKYME YSFRVSSENR FGVSKPLESA PIIAEHPFVP
PSAPTRPEVY HVSANAMSIR WEEPYHDGGS KIIGYWVEKK ERNTILWVKE NKVPCLECNY
KVTGLVEGLE YQFRTYALNA AGVSKASEAS RPIMAQNPVD APGRPEVTDV TRSTVSLIWS
APAYDGGSKV VGYIIERKPV SEVGDGRWLK CNYTIVSDNF FTVTALSEGD TYEFRVLAKN
AAGVISKGSE STGPVTCRDE YAPPKAELDA RLHGDLVTIR AGSDLVLDAA VGGKPEPKII
WTKGDKELDL CEKVSLQYTG KRATAVIKFC DRSDSGKYTL TVKNASGTKA VSVMVKVLDS
PGPCGKLTVS RVTQEKCTLA WSLPQEDGGA EITHYIVERR ETSRLNWVIV EGECPTLSYV
VTRLIKNNEY IFRVRAVNKY GPGVPVESEP IVARNSFTIP SPPGIPEEVG TGKEHIIIQW
TKPESDGGNE ISNYLVDKRE KKSLRWTRVN KDYVVYDTRL KVTSLMEGCD YQFRVTAVNA
AGNSEPSEAS NFISCREPSY TPGPPSAPRV VDTTKHSISL AWTKPMYDGG TDIVGYVLEM
QEKDTDQWYR VHTNATIRNT EFTVPDLKMG QKYSFRVAAV NVKGMSEYSE SIAEIEPVER
IEIPDLELAD DLKKTVTIRA GASLRLMVSV SGRPPPVITW SKQGIDLASR AIIDTTESYS
LLIVDKVNRY DAGKYTIEAE NQSGKKSATV LVKVYDTPGP CPSVKVKEVS RDSVTITWEI
PTIDGGAPVN NYIVEKREAA MRAFKTVTTK CSKTLYRISG LVEGTMYYFR VLPENIYGIG
EPCETSDAVL VSEVPLVPAK LEVVDVTKST VTLAWEKPLY DGGSRLTGYV LEACKAGTER
WMKVVTLKPT VLEHTVTSLN EGEQYLFRIR AQNEKGVSEP RETVTAVTVQ DLRVLPTIDL
STMPQKTIHV PAGRPVELVI PIAGRPPPAA SWFFAGSKLR ESERVTVETH TKVAKLTIRE
TTIRDTGEYT LELKNVTGTT SETIKVIILD KPGPPTGPIK IDEIDATSIT ISWEPPELDG
GAPLSGYVVE QRDAHRPGWL PVSESVTRST FKFTRLTEGN EYVFRVAATN RFGIGSYLQS
EVIECRSSIR IPGPPETLQI FDVSRDGMTL TWYPPEDDGG SQVTGYIVER KEVRADRWVR
VNKVPVTMTR YRSTGLTEGL EYEHRVTAIN ARGSGKPSRP SKPIVAMDPI APPGKPQNPR
VTDTTRTSVS LAWSVPEDEG GSKVTGYLIE MQKVDQHEWT KCNTTPTKIR EYTLTHLPQG
AEYRFRVLAC NAGGPGEPAE VPGTVKVTEM LEYPDYELDE RYQEGIFVRQ GGVIRLTIPI
KGKPFPICKW TKEGQDISKR AMIATSETHT ELVIKEADRG DSGTYDLVLE NKCGKKAVYI
KVRVIGSPNS PEGPLEYDDI QVRSVRVSWR PPADDGGADI LGYILERREV PKAAWYTIDS
RVRGTSLVVK GLKENVEYHF RVSAENQFGI SKPLKSEEPV TPKTPLNPPE PPSNPPEVLD
VTKSSVSLSW SRPKDDGGSR VTGYYIERKE TSTDKWVRHN KTQITTTMYT VTGLVPDAEY
QFRIIAQNDV GLSETSPASE PVVCKDPFDK PSQPGELEIL SISKDSVTLQ WEKPECDGGK
EILGYWVEYR QSGDSAWKKS NKERIKDKQF TIGGLLEATE YEFRVFAENE TGLSRPRRTA
MSIKTKLTSG EAPGIRKEMK DVTTKLGEAA QLSCQIVGRP LPDIKWYRFG KELIQSRKYK
MSSDGRTHTL TVMTEEQEDE GVYTCIATNE VGEVETSSKL LLQATPQFHP GYPLKEKYYG
AVGSTLRLHV MYIGRPVPAM TWFHGQKLLQ NSENITIENT EHYTHLVMKN VQRKTHAGKY
KVQLSNVFGT VDAILDVEIQ DKPDKPTGPI VIEALLKNSA VISWKPPADD GGSWITNYVV
EKCEAKEGAE WQLVSSAISV TTCRIVNLTE NAGYYFRVSA QNTFGISDPL EVSSVVIIKS
PFEKPGAPGK PTITAVTKDS CVVAWKPPAS DGGAKIRNYY LEKREKKQNK WISVTTEEIR
ETVFSVKNLI EGLEYEFRVK CENLGGESEW SEISEPITPK SDVPIQAPHF KEELRNLNVR
YQSNATLVCK VTGHPKPIVK WYRQGKEIIA DGLKYRIQEF KGGYHQLIIA SVTDDDATVY
QVRATNQGGS VSGTASLEVE VPAKIHLPKT LEGMGAVHAL RGEVVSIKIP FSGKPDPVIT
WQKGQDLIDN NGHYQVIVTR SFTSLVFPNG VERKDAGFYV VCAKNRFGID QKTVELDVAD
VPDPPRGVKV SDVSRDSVNL TWTEPASDGG SKITNYIVEK CATTAERWLR VGQARETRYT
VINLFGKTSY QFRVIAENKF GLSKPSEPSE PTITKEDKTR AMNYDEEVDE TREVSMTKAS
HSSTKELYEK YMIAEDLGRG EFGIVHRCVE TSSKKTYMAK FVKVKGTDQV LVKKEISILN
IARHRNILHL HESFESMEEL VMIFEFISGL DIFERINTSA FELNEREIVS YVHQVCEALQ
FLHSHNIGHF DIRPENIIYQ TRRSSTIKII EFGQARQLKP GDNFRLLFTA PEYYAPEVHQ
HDVVSTATDM WSLGTLVYVL LSGINPFLAE TNQQIIENIM NAEYTFDEEA FKEISIEAMD
FVDRLLVKER KSRMTASEAL QHPWLKQKIE RVSTKVIRTL KHRRYYHTLI KKDLNMVVSA
ARISCGGAIR SQKGVSVAKV KVASIEIGPV SGQIMHAVGE EGGHVKYVCK IENYDQSTQV
TWYFGVRQLE NSEKYEITYE DGVAILYVKD ITKLDDGTYR CKVVNDYGED SSYAELFVKG
VREVYDYYCR RTMKKIKRRT DTMRLLERPP EFTLPLYNKT AYVGENVRFG VTITVHPEPH
VTWYKSGQKI KPGDNDKKYT FESDKGLYQL TINSVTTDDD AEYTVVARNK YGEDSCKAKL
TVTLHPPPTD STLRPMFKRL LANAECQEGQ SVCFEIRVSG IPPPTLKWEK DGQPLSLGPN
IEIIHEGLDY YALHIRDTLP EDTGYYRVTA TNTAGSTSCQ AHLQVERLRY KKQEFKSKEE
HERHVQKQID KTLRMAEILS GTESVPLTQV AKEALREAAV LYKPAVSTKT VKGEFRLEIE
EKKEERKLRM PYDVPEPRKY KQTTIEEDQR IKQFVPMSDM KWYKKIRDQY EMPGKLDRVV
QKRPKRIRLS RWEQFYVMPL PRITDQYRPK WRIPKLSQDD LEIVRPARRR TPSPDYDFYY
RPRRRSLGDI SDEELLLPID DYLAMKRTEE ERLRLEEELE LGFSASPPSR SPPHFELSSL
RYSSPQAHVK VEETRKDFRY STYHIPTKAE ASTSYAELRE RHAQAAYRQP KQRQRIMAER
EDEELLRPVT TTQHLSEYKS ELDFMSKEEK SRKKSRRQRE VTEITEIEEE YEISKHAQRE
SSSSASRLLR RRRSLSPTYI ELMRPVSELI RSRPQPAEEY EDDTERRSPT PERTRPRSPS
PVSSERSLSR FERSARFDIF SRYESMKAAL KTQKTSERKY EVLSQQPFTL DHAPRITLRM
RSHRVPCGQN TRFILNVQSK PTAEVKWYHN GVELQESSKI HYTNTSGVLT LEILDCHTDD
SGTYRAVCTN YKGEASDYAT LDVTGGDYTT YASQRRDEEV PRSVFPELTR TEAYAVSSFK
KTSEMEASSS VREVKSQMTE TRESLSSYEH SASAEMKSAA LEEKSLEEKS TTRKIKTTLA
ARILTKPRSM TVYEGESARF SCDTDGEPVP TVTWLRKGQV LSTSARHQVT TTKYKSTFEI
SSVQASDEGN YSVVVENSEG KQEAEFTLTI QKARVTEKAV TSPPRVKSPE PRVKSPEAVK
SPKRVKSPEP SHPKAVSPTE TKPTPTEKVQ HLPVSAPPKI TQFLKAEASK EIAKLTCVVE
SSVLRAKEVT WYKDGKKLKE NGHFQFHYSA DGTYELKINN LTESDQGEYV CEISGEGGTS
KTNLQFMGQA FKSIHEKVSK ISETKKSDQK TTESTVTRKT EPKAPEPISS KPVIVTGLQD
TTVSSDSVAK FAVKATGEPR PTAIWTKDGK AITQGGKYKL SEDKGGFFLE IHKTDTSDSG
LYTCTVKNSA GSVSSSCKLT IKAIKDTEAQ KVSTQKTSEI TPQKKAVVQE EISQKALRSE
EIKMSEAKSQ EKLALKEEAS KVLISEEVKK SAATSLEKSI VHEEITKTSQ ASEEVRTHAE
IKAFSTQMSI NEGQRLVLKA NIAGATDVKW VLNGVELTNS EEYRYGVSGS DQTLTIKQAS
HRDEGILTCI SKTKEGIVKC QYDLTLSKEL SDAPAFISQP RSQNINEGQN VLFTCEISGE
PSPEIEWFKN NLPISISSNV SISRSRNVYS LEIRNASVSD SGKYTIKAKN FRGQCSATAS
LMVLPLVEEP SREVVLRTSG DTSLQGSFSS QSVQMSASKQ EASFSSFSSS SASSMTEMKF
ASMSAQSMSS MQESFVEMSS SSFMGISNMT QLESSTSKML KAGIRGIPPK IEALPSDISI
DEGKVLTVAC AFTGEPTPEV TWSCGGRKIH SQEQGRFHIE NTDDLTTLII MDVQKQDGGL
YTLSLGNEFG SDSATVNIHI RSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107821

Theoretical NMD boundary in CDS

107545

Length of CDS

107892

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_11_ENST00000412264

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 136|64 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 1.37, LOF (oe): 0.54, misssense (oe): 0.98, synonymous (oe): 0.94 ? (gnomAD)

Ensembl transcript ID

ENST00000412264.2

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11312-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV
IPEGETPIVK RRKTPSPTVP ESPREIVPVK ETPMAAPLEI EIPPTKAPEA MKEVVPEMKI
FEDVPEEPET PRMKTPEAPQ EIIPAKTVPS KKREPPSVKV PEALQEIVPE KKTLVVPLRK
PEVLPDEVPE ALREVVPEKK VHPPQRAEVV PVKVHEAPKE IIPEKKVSVV PPKKPEVPPV
KVPEASKEVI REEKVPLAPP KEPEVPPVKV PEPPKEVVPE KKAPVAPPKE PEVPPVKVPE
APKEVVPEKK VPVPPPKKPE VPPTKVPEVP KAAVPEKKLP EAIPPKPESP PPEVPEVLPP
KEVVPEKKVP VPPAKKPEAP PPKVPEAPKE VVLEKKASVA VPKKPEAPRA KVPEAAQEVV
PEKKIPKAPI KKPEAPAVTV PEVPQEATEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP
KAPPTKPEAP PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPSAPPK
KPEVPPVKVP EAPKEVVPEK KVPVPPPKKP EVPPTKVPEV PKAAVPEKKV PEAIPPKPES
PPPEVPEVLP PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVLEKKASV AVPKKPEAPR
AKVPEAAQEV VPEKKIPKAP IKKPEAPAVT VPEVPQEAAE KEIPVAPPKK PEAPIVPVPE
AQEVVPEKKV PKAPPTKPEA PPATVPEVPQ EIVPEKKTLV LPKKPEVPPV TVPEAPKEVV
LEKKVPSTPP KKPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK
VPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP KEVVLEKKVS
VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAA EKEIPVAPPK
KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL VLPKKPEVPP
VTVPEAPKEV VLEKKVPLAP PKKPEVPPVK VPEAPKEVVP EKKVPVTPPK KPEVPPVKVP
EAPIEVVPEK KMPLAPPKKP EVPPVKVPEA PKEVVPEKKV PSAPPKKPEV PPVKVPEAPK
EVVPEKKVPA APPKKPEVTP VKVPEAPKEV VPEKKVPVPP PKKPEVPPTK VPEVPKVAVP
EKKVPEAIPP KPESPPPEVF EEPEEVALEE PPAEVVEEPE PAAPPQVTVP PKKPVPEKKA
PAVVAKKPEL PPVKVPEVPK EVVPEKKVPL VVPKKPEAPP AKVPEVPKEV VPEKKVAVPK
KPEVPPAKVP EVPKKPVLEE KPAVPVPERA ESPPPEVYEE PEEIAPEEEI APEEEKPVPV
AEEEEPEVPP PAVPEEPKKI IPEKKVPVIK KPEAPPPKEP EMPKKVVPVK KVPTVKKPET
PAAKVPEVPK KLVPVKKEPV PVTKKPEVLP EKVPKVPEKI IPEKEVSVPI PAEPEVPPAE
VEETPEEIIY EEKASITIGR KETPPVEERE IEKYIKPEEP EPEPQPEEIP VKEPEPEKVI
EKPKLKPRPP PPPPAPPKED VKEKIFQLKA IPKKKVPEKP QVPEKVELTP LKVPGGEKKV
RKLLPERKPE PKEEVVLKSV LRKRPEEEEP KVEPKKLEKV KKPAVPEPPP PKPVEEVEVP
TVTKRERKIP EPTKVPEIKP AIPLPAPEPK PKPEAEVKTI KPPPVEPEPT PIAAPVTVPV
VGKKAEAKAP KEEAAKPKGP IKGVPKKTPS PIEAERRKLR PGSGGEKPPD EAPFTYQLKA
VPLKFVKEIK DIILTESEFV GSSAIFECLV SPSTAITTWM KDGSNIRESP KHRFIADGKD
RKLHIIDVQL SDAGEYTCVL RLGNKEKTST AKLVVEELPV RFVKTLEEEV TVVKGQPLYL
SCELNKERDV VWRKDGKIVV EKPGRIVPGV IGLMRALTIN DADDTDAGTY TVTVENANNL
ECSSCVKVVE VIRDWLVKPI RDQHVKPKGT AIFACDIAKD TPNIKWFKGY DEIPAEPNDK
TEILRDGNHL YLKIKNAMPE DIAEYAVEIE GKRYPAKLTL GEREVELLKP IEDVTIYEKE
SASFDAEISE ADIPGQWKLK GELLRPSPTC EIKAEGGKRF LTLHKVKLDQ AGEVLYQALN
AITTAILTVK EIELDFAVPL KDVTVPERRQ ARFECVLTRE ANVIWSKGPD IIKSSDKFDI
IADGKKHILV INDSQFDDEG VYTAEVEGKK TSARLFVTGI RLKFMSPLED QTVKEGETAT
FVCELSHEKM HVVWFKNDAK LHTSRTVLIS SEGKTHKLEM KEVTLDDISQ IKAQVKELSS
TAQLKVLEAD PYFTVKLHDK TAVEKDEITL KCEVSKDVPV KWFKDGEEIV PSPKYSIKAD
GLRRILKIKK ADLKDKGEYV CDCGTDKTKA NVTVEARLIK VEKPLYGVEV FVGETAHFEI
ELSEPDVHGQ WKLKGQPLTA SPDCEIIEDG KKHILILHNC QLGMTGEVSF QAANAKSAAN
LKVKELPLIF ITPLSDVKVF EKDEAKFECE VSREPKTFRW LKGTQEITGD DRFELIKDGT
KHSMVIKSAA FEDEAKYMFE AEDKHTSGKL IIEGIRLKFL TPLKDVTAKE KESAVFTVEL
SHDNIRVKWF KNDQRLHTTR SVSMQDEGKT HSITFKDLSI DDTSQIRVEA MGMSSEAKLT
VLEGDPYFTG KLQDYTGVEK DEVILQCEIS KADAPVKWFK DGKEIKPSKN AVIKADGKKR
MLILKKALKS DIGQYTCDCG TDKTSGKLDI EDREIKLVRP LHSVEVMETE TARFETEISE
DDIHANWKLK GEALLQTPDC EIKEEGKIHS LVLHNCRLDQ TGGVDFQAAN VKSSAHLRVK
PRVIGLLRPL KDVTVTAGET ATFDCELSYE DIPVEWYLKG KKLEPSDKVV PRSEGKVHTL
TLRDVKLEDA GEVQLTAKDF KTHANLFVKE PPVEFTKPLE DQTVEEGATA VLECEVSREN
AKVKWFKNGT EILKSKKYEI VADGRVRKLV IHDCTPEDIK TYTCDAKDFK TSCNLNVVPP
HVEFLRPLTD LQVREKEMAR FECELSRENA KVKWFKDGAE IKKGKKYDII SKGAVRILVI
NKCLLDDEAE YSCEVRTART SGMLTVLEEE AVFTKNLANI EVSETDTIKL VCEVSKPGAE
VIWYKGDEEI IETGRYEILT EGRKRILVIQ NAHLEDAGNY NCRLPSSRTD GKVKVHELAA
EFISKPQNLE ILEGEKAEFV CSISKESFPV QWKRDDKTLE SGDKYDVIAD GKKRVLVVKD
ATLQDMGTYV VMVGAARAAA HLTVIEKLRI VVPLKDTRVK EQQEVVFNCE VNTEGAKAKW
FRNEEAIFDS SKYIILQKDL VYTLRIRDAH LDDQANYNVS LTNHRGENVK SAANLIVEEE
DLRIVEPLKD IETMEKKSVT FWCKVNRLNV TLKWTKNGEE VPFDNRVSYR VDKYKHMLTI
KDCGFPDEGE YIVTAGQDKS VAELLIIEAP TEFVEHLEDQ TVTEFDDAVF SCQLSREKAN
VKWYRNGREI KEGKKYKFEK DGSIHRLIIK DCRLDDECEY ACGVEDRKSR ARLFVEEIPV
EIIRPPQDIL EAPGADVVFL AELNKDKVEV QWLRNNMVVV QGDKHQMMSE GKIHRLQICD
IKPRDQGEYR FIAKDKEARA KLELAAAPKI KTADQDLVVD VGKPLTMVVP YDAYPKAEAE
WFKENEPLST KTIDTTAEQT SFRILEAKKG DKGRYKIVLQ NKHGKAEGFI NLKVIDVPGP
VRNLEVTETF DGEVSLAWEE PLTDGGSKII GYVVERRDIK RKTWVLATDR AESCEFTVTG
LQKGGVEYLF RVSARNRVGT GEPVETDNPV EARSKYDVPG PPLNVTITDV NRFGVSLTWE
PPEYDGGAEI TNYVIELRDK TSIRWDTAMT VRAEDLSATV TDVVEGQEYS FRVRAQNRIG
VGKPSAATPF VKVADPIERP SPPVNLTSSD QTQSSVQLKW EPPLKDGGSP ILGYIIERCE
EGKDNWIRCN MKLVPELTYK VTGLEKGNKY LYRVSAENKA GVSDPSEILG PLTADDAFVE
PTMDLSAFKD GLEVIVPNPI TILVPSTGYP RPTATWCFGD KVLETGDRVK MKTLSAYAEL
VISPSERSDK GIYTLKLENR VKTISGEIDV NVIARPSAPK ELKFGDITKD SVHLTWEPPD
DDGGSPLTGY VVEKREVSRK TWTKVMDFVT DLEFTVPDLV QGKEYLFKVC ARNKCGPGEP
AYVDEPVNMS TPATVPDPPE NVKWRDRTAN SIFLTWDPPK NDGGSRIKGY IVERCPRGSD
KWVACGEPVA ETKMEVTGLE EGKWYAYRVK ALNRQGASKP SRPTEEIQAV DTQEAPEIFL
DVKLLAGLTV KAGTKIELPA TVTGKPEPKI TWTKADMILK QDKRITIENV PKKSTVTIVD
SKRSDTGTYI IEAVNVCGRA TAVVEVNVLD KPGPPAAFDI TDVTNESCLL TWNPPRDDGG
SKITNYVVER RATDSEVWHK LSSTVKDTNF KATKLIPNKE YIFRVAAENM YGVGEPVQAS
PITAKYQFDP PGPPTRLEPS DITKDAVTLT WCEPDDDGGS PITGYWVERL DPDTDKWVRC
NKMPVKDTTY RVKGLTNKKK YRFRVLAENL AGPGKPSKST EPILIKDPID PPWPPGKPTV
KDVGKTSVRL NWTKPEHDGG AKIESYVIEM LKTGTDEWVR VAEGVPTTQH LLPGLMEGQE
YSFRVRAVNK AGESEPSEPS DPVLCREKLY PPSPPRWLEV INITKNTADL KWTVPEKDGG
SPITNYIVEK RDVRRKGWQT VDTTVKDTKC TVTPLTEGSL YVFRVAAENA IGQSDYTEIE
DSVLAKDTFT TPGPPYALAV VDVTKRHVDL KWEPPKNDGG RPIQRYVIEK KERLGTRWVK
AGKTAGPDCN FRVTDVIEGT EVQFQVRAEN EAGVGHPSEP TEILSIEDPT SPPSPPLDLH
VTDAGRKHIA IAWKPPEKNG GSPIIGYHVE MCPVGTEKWM RVNSRPIKDL KFKVEEGVVP
DKEYVLRVRA VNAIGVSEPS EISENVVAKD PDCKPTIDLE THDIIVIEGE KLSIPVPFRA
VPVPTVSWHK DGKEVKASDR LTMKNDHISA HLEVPKSVRA DAGIYTITLE NKLGSATASI
NVKVIGLPGP CKDIKASDIT KSSCKLTWEP PEFDGGTPIL HYVLERREAG RRTYIPVMSG
ENKLSWTVKD LIPNGEYFFR VKAVNKVGGG EYIELKNPVI AQDPKQPPDP PVDVEVHNPT
AEAMTITWKP PLYDGGSKIM GYIIEKIAKG EERWKRCNEH LVPILTYTAK GLEEGKEYQF
RVRAENAAGI SEPSRATPPT KAVDPIDAPK VILRTSLEVK RGDEIALDAS ISGSPYPTIT
WIKDENVIVP EEIKKRAAPL VRRRKGEVQE EEPFVLPLTQ RLSIDNSKKG ESQLRVRDSL
RPDHGLYMIK VENDHGIAKA PCTVSVLDTP GPPINFVFED IRKTSVLCKW EPPLDDGGSE
IINYTLEKKD KTKPDSEWIV VTSTLRHCKY SVTKLIEGKE YLFRVRAENR FGPGPPCVSK
PLVAKDPFGP PDAPDKPIVE DVTSNSMLVK WNEPKDNGSP ILGYWLEKRE VNSTHWSRVN
KSLLNALKAN VDGLLEGLTY VFRVCAENAA GPGKFSPPSD PKTAHDPISP PGPPIPRVTD
TSSTTIELEW EPPAFNGGGE IVGYFVDKQL VGTNEWSRCT EKMIKVRQYT VKEIREGADY
KLRVSAVNAA GEGPPGETQP VTVAEPQEPP AVELDVSVKG GIQIMAGKTL RIPAVVTGRP
VPTKVWTKEE GELDKDRVVI DNVGTKSELI IKDALRKDHG RYVITATNSC GSKFAAARVE
VFDVPGPVLD LKPVVTNRKM CLLNWSDPED DGGSEITGFI IERKDAKMHT WRQPIETERS
KCDITGLLEG QEYKFRVIAK NKFGCGPPVE IGPILAVDPL GPPTSPERLT YTERTKSTIT
LDWKEPRSNG GSPIQGYIIE KRRHDKPDFE RVNKRLCPTT SFLVENLDEH QMYEFRVKAV
NEIGESEPSL PLNVVIQDDE VPPTIKLRLS VRGDTIKVKA GEPVHIPADV TGLPMPKIEW
SKNETVIEKP TDALQITKEE VSRSEAKTEL SIPKAVREDK GTYTVTASNR LGSVFRNVHV
EVYDRPSPPR NLAVTDIKAE SCYLTWDAPL DNGGSEITHY VIDKRDASRK KAEWEEVTNT
AVEKRYGIWK LIPNGQYEFR VRAVNKYGIS DECKSDKVVI QDPYRLPGPP GKPKVLARTK
GSMLVSWTPP LDNGGSPITG YWLEKREEGS PYWSRVSRAP ITKVGLKGVE FNVPRLLEGV
KYQFRAMAIN AAGIGPPSEP SDPEVAGDPI FPPGPPSCPE VKDKTKSSIS LGWKPPAKDG
GSPIKGYIVE MQEEGTTDWK RVNEPDKLIT TCECVVPNLK ELRKYRFRVK AVNEAGESEP
SDTTGEIPAT DIQEEPEVFI DIGAQDCLVC KAGSQIRIPA VIKGRPTPKS SWEFDGKAKK
AMKDGVHDIP EDAQLETAEN SSVIIIPECK RSHTGKYSIT AKNKAGQKTA NCRVKVMDVP
GPPKDLKVSD ITRGSCRLSW KMPDDDGGDR IKGYVIEKRT IDGKAWTKVN PDCGSTTFVV
PDLLSEQQYF FRVRAENRFG IGPPVETIQR TTARDPIYPP DPPIKLKIGL ITKNTVHLSW
KPPKNDGGSP VTHYIVECLA WDPTGTKKEA WRQCNKRDVE ELQFTVEDLV EGGEYEFRVK
AVNAAGVSKP SATVGPVTVK DQTCPPSIDL KEFMEVEEGT NVNIVAKIKG VPFPTLTWFK
APPKKPDNKE PVLYDTHVNK LVVDDTCTLV IPQSRRSDTG LYTITAVNNL GTASKEMRLN
VLGRPGPPVG PIKFESVSAD QMTLSWFPPK DDGGSKITNY VIEKREANRK TWVHVSSEPK
ECTYTIPKLL EGHEYVFRIM AQNKYGIGEP LDSEPETARN LFSVPGAPDK PTVSSVTRNS
MTVNWEEPEY DGGSPVTGYW LEMKDTTSKR WKRVNRDPIK AMTLGVSYKV TGLIEGSDYQ
FRVYAINAAG VGPASLPSDP ATARDPIAPP GPPFPKVTDW TKSSADLEWS PPLKDGGSKV
TGYIVEYKEE GKEEWEKGKD KEVRGTKLVV TGLKEGAFYK FRVRAVNIAG IGEPGEVTDV
IEMKDRLVSP DLQLDASVRD RIVVHAGGVI RIIAYVSGKP PPTVTWNMNE RTLPQEATIE
TTAISSSMVI KNCQRSHQGV YSLLAKNEAG ERKKTIIVDV LDVPGPVGTP FLAHNLTNES
CKLTWFSPED DGGSPITNYV IEKRESDRRA WTPVTYTVTR QNATVQGLIQ GKAYFFRIAA
ENSIGMGPFV ETSEALVIRE PITVPERPED LEVKEVTKNT VTLTWNPPKY DGGSEIINYV
LESRLIGTEK FHKVTNDNLL SRKYTVKGLK EGDTYEYRVS AVNIVGQGKP SFCTKPITCK
DELAPPTLHL DFRDKLTIRV GEAFALTGRY SGKPKPKVSW FKDEADVLED DRTHIKTTPA
TLALEKIKAK RSDSGKYCVV VENSTGSRKG FCQVNVVDRP GPPVGPVSFD EVTKDYMVIS
WKPPLDDGGS KITNYIIEKK EVGKDVWMPV TSASAKTTCK VSKLLEGKDY IFRIHAENLY
GISDPLVSDS MKAKDRFRVP DAPDQPIVTE VTKDSALVTW NKPHDGGKPI TNYILEKRET
MSKRWARVTK DPIHPYTKFR VPDLLEGCQY EFRVSAENEI GIGDPSPPSK PVFAKDPIAK
PSPPVNPEAI DTTCNSVDLT WQPPRHDGGS KILGYIVEYQ KVGDEEWRRA NHTPESCPET
KYKVTGLRDG QTYKFRVLAV NAAGESDPAH VPEPVLVKDR LEPPELILDA NMAREQHIKV
GDTLRLSAII KGVPFPKVTW KKEDRDAPTK ARIDVTPVGS KLEIRNAAHE DGGIYSLTVE
NPAGSKTVSV KVLVLDKPGP PRDLEVSEIR KDSCYLTWKE PLDDGGSVIT NYVVERRDVA
SAQWSPLSAT SKKKSHFAKH LNEGNQYLFR VAAENQYGRG PFVETPKPIK ALDPLHPPGP
PKDLHHVDVD KTEVSLVWNK PDRDGGSPIT GYLVEYQEEG TQDWIKFKTV TNLECVVTGL
QQGKTYRFRV KAENIVGLGL PDTTIPIECQ EKLVPPSVEL DVKLIEGLVV KAGTTVRFPA
IIRGVPVPTA KWTTDGSEIK TDEHYTVETD NFSSVLTIKN CLRRDTGEYQ ITVSNAAGSK
TVAVHLTVLD VPGPPTGPIN ILDVTPEHMT ISWQPPKDDG GSPVINYIVE KQDTRKDTWG
VVSSGSSKTK LKIPHLQKGC EYVFRVRAEN KIGVGPPLDS TPTVAKHKFS PPSPPGKPVV
TDITENAATV SWTLPKSDGG SPITGYYMER REVTGKWVRV NKTPIADLKF RVTGLYEGNT
YEFRVFAENL AGLSKPSPSS DPIKACRPIK PPGPPINPKL KDKSRETADL VWTKPLSDGG
SPILGYVVEC QKPGTAQWNR INKDELIRQC AFRVPGLIEG NEYRFRIKAA NIVGEGEPRE
LAESVIAKDI LHPPEVELDV TCRDVITVRV GQTIRILARV KGRPEPDITW TKEGKVLVRE
KRVDLIQDLP RVELQIKEAV RADHGKYIIS AKNSSGHAQG SAIVNVLDRP GPCQNLKVTN
VTKENCTISW ENPLDNGGSE ITNFIVEYRK PNQKGWSIVA SDVTKRLIKA NLLANNEYYF
RVCAENKVGV GPTIETKTPI LAINPIDRPG EPENLHIADK GKTFVYLKWR RPDYDGGSPN
LSYHVERRLK GSDDWERVHK GSIKETHYMV DRCVENQIYE FRVQTKNEGG ESDWVKTEEV
VVKEDLQKPV LDLKLSGVLT VKAGDTIRLE AGVRGKPFPE VAWTKDKDAT DLTRSPRVKI
DTRADSSKFS LTKAKRSDGG KYVVTATNTA GSFVAYATVN VLDKPGPVRN LKIVDVSSDR
CTVCWDPPED DGGCEIQNYI LEKCETKRMV WSTYSATVLT PGTTVTRLIE GNEYIFRVRA
ENKIGTGPPT ESKPVIAKTK YDKPGRPDPP EVTKVSKEEM TVVWNPPEYD GGKSITGYFL
EKKEKHSTRW VPVNKSAIPE RRMKVQNLLP DHEYQFRVKA ENEIGIGEPS LPSRPVVAKD
PIEPPGPPTN FRVVDTTKHS ITLGWGKPVY DGGAPIIGYV VEMRPKIADA SPDEGWKRCN
AAAQLVRKEF TVTSLDENQE YEFRVCAQNQ VGIGRPAELK EAIKPKEILE PPEIDLDASM
RKLVIVRAGC PIRLFAIVRG RPAPKVTWRK VGIDNVVRKG QVDLVDTMAF LVIPNSTRDD
SGKYSLTLVN PAGEKAVFVN VRVLDTPGPV SDLKVSDVTK TSCHVSWAPP ENDGGSQVTH
YIVEKREADR KTWSTVTPEV KKTSFHVTNL VPGNEYYFRV TAVNEYGPGV PTDVPKPVLA
SDPLSEPDPP RKLEVTEMTK NSATLAWLPP LRDGGAKIDG YITSYREEEQ PADRWTEYSV
VKDLSLVVTG LKEGKKYKFR VAARNAVGVS LPREAEGVYE AKEQLLPPKI LMPEQITIKA
GKKLRIEAHV YGKPHPTCKW KKGEDEVVTS SHLAVHKADS SSILIIKDVT RKDSGYYSLT
AENSSGTDTQ KIKVVVMDAP GPPQPPFDIS DIDADACSLS WHIPLEDGGS NITNYIVEKC
DVSRGDWVTA LASVTKTSCR VGKLIPGQEY IFRVRAENRF GISEPLTSPK MVAQFPFGVP
SEPKNARVTK VNKDCIFVAW DRPDSDGGSP IIGYLIERKE RNSLLWVKAN DTLVRSTEYP
CAGLVEGLEY SFRIYALNKA GSSPPSKPTE YVTARMPVDP PGKPEVIDVT KSTVSLIWAR
PKHDGGSKII GYFVEACKLP GDKWVRCNTA PHQIPQEEYT ATGLEEKAQY QFRAIARTAV
NISPPSEPSD PVTILAENVP PRIDLSVAMK SLLTVKAGTN VCLDATVFGK PMPTVSWKKD
GTLLKPAEGI KMAMQRNLCT LELFSVNRKD SGDYTITAEN SSGSKSATIK LKVLDKPGPP
ASVKINKMYS DRAMLSWEPP LEDGGSEITN YIVDKRETSR PNWAQVSATV PITSCSVEKL
IEGHEYQFRI CAENKYGVGD PVFTEPAIAK NPYDPPGRCD PPVISNITKD HMTVSWKPPA
DDGGSPITGY LLEKRETQAV NWTKVNRKPI IERTLKATGL QEGTEYEFRV TAINKAGPGK
PSDASKAAYA RDPQYPPGPP AFPKVYDTTR SSVSLSWGKP AYDGGSPIIG YLVEVKRADS
DNWVRCNLPQ NLQKTRFEVT GLMEDTQYQF RVYAVNKIGY SDPSDVPDKH YPKDILIPPE
GELDADLRKT LILRAGVTMR LYVPVKGRPP PKITWSKPNV NLRDRIGLDI KSTDFDTFLR
CENVNKYDAG KYILTLENSC GKKEYTIVVK VLDTPGPPVN VTVKEISKDS AYVTWEPPII
DGGSPIINYV VQKRDAERKS WSTVTTECSK TSFRVANLEE GKSYFFRVFA ENEYGIGDPG
ETRDAVKASQ TPGPVVDLKV RSVSKSSCSI GWKKPHSDGG SRIIGYVVDF LTEENKWQRV
MKSLSLQYSA KDLTEGKEYT FRVSAENENG EGTPSEITVV ARDDVVAPDL DLKGLPDLCY
LAKENSNFRL KIPIKGKPAP SVSWKKGEDP LATDTRVSVE SSAVNTTLIV YDCQKSDAGK
YTITLKNVAG TKEGTISIKV VGKPGIPTGP IKFDEVTAEA MTLKWAPPKD DGGSEITNYI
LEKRDSVNNK WVTCASAVQK TTFRVTRLHE GMEYTFRVSA ENKYGVGEGL KSEPIVARHP
FDVPDAPPPP NIVDVRHDSV SLTWTDPKKT GGSPITGYHL EFKERNSLLW KRANKTPIRM
RDFKVTGLTE GLEYEFRVMA INLAGVGKPS LPSEPVVALD PIDPPGKPEV INITRNSVTL
IWTEPKYDGG HKLTGYIVEK RDLPSKSWMK ANHVNVPECA FTVTDLVEGG KYEFRIRAKN
TAGAISAPSE STETIICKDE YEAPTIVLDP TIKDGLTIKA GDTIVLNAIS ILGKPLPKSS
WSKAGKDIRP SDITQITSTP TSSMLTIKYA TRKDAGEYTI TATNPFGTKV EHVKVTVLDV
PGPPGPVEIS NVSAEKATLT WTPPLEDGGS PIKSYILEKR ETSRLLWTVV SEDIQSCRHV
ATKLIQGNEY IFRVSAVNHY GKGEPVQSEP VKMVDRFGPP GPPEKPEVSN VTKNTATVSW
KRPVDDGGSE ITGYHVERRE KKSLRWVRAI KTPVSDLRCK VTGLQEGSTY EFRVSAENRA
GIGPPSEASD SVLMKDAAYP PGPPSNPHVT DTTKKSASLA WGKPHYDGGL EITGYVVEHQ
KVGDEAWIKD TTGTALRITQ FVVPDLQTKE KYNFRISAIN DAGVGEPAVI PDVEIVEREM
APDFELDAEL RRTLVVRAGL SIRIFVPIKG RPAPEVTWTK DNINLKNRAN IENTESFTLL
IIPECNRYDT GKFVMTIENP AGKKSGFVNV RVLDTPGPVL NLRPTDITKD SVTLHWDLPL
IDGGSRITNY IVEKREATRK SYSTATTKCH KCTYKVTGLS EGCEYFFRVM AENEYGIGEP
TETTEPVKAS EAPSPPDSLN IMDITKSTVS LAWPKPKHDG GSKITGYVIE AQRKGSDQWT
HITTVKGLEC VVRNLTEGEE YTFQVMAVNS AGRSAPRESR PVIVKEQTML PELDLRGIYQ
KLVIAKAGDN IKVEIPVLGR PKPTVTWKKG DQILKQTQRV NFETTATSTI LNINECVRSD
SGPYPLTARN IVGEVGDVIT IQVHDIPGPP TGPIKFDEVS SDFVTFSWDP PENDGGVPIS
NYVVEMRQTD STTWVELATT VIRTTYKATR LTTGLEYQFR VKAQNRYGVG PGITSACIVA
NYPFKVPGPP GTPQVTAVTK DSMTISWHEP LSDGGSPILG YHVERKERNG ILWQTVSKAL
VPGNIFKSSG LTDGIAYEFR VIAENMAGKS KPSKPSEPML ALDPIDPPGK PVPLNITRHT
VTLKWAKPEY TGGFKITSYI VEKRDLPNGR WLKANFSNIL ENEFTVSGLT EDAAYEFRVI
AKNAAGAISP PSEPSDAITC RDDVEAPKIK VDVKFKDTVI LKAGEAFRLE ADVSGRPPPT
MEWSKDGKEL EGTAKLEIKI ADFSTNLVNK DSTRRDSGAY TLTATNPGGF AKHIFNVKVL
DRPGPPEGPL AVTEVTSEKC VLSWFPPLDD GGAKIDHYIV QKRETSRLAW TNVASEVQVT
KLKVTKLLKG NEYIFRVMAV NKYGVGEPLE SEPVLAVNPY GPPDPPKNPE VTTITKDSMV
VCWGHPDSDG GSEIINYIVE RRDKAGQRWI KCNKKTLTDL RYKVSGLTEG HEYEFRIMAE
NAAGISAPSP TSPFYKACDT VFKPGPPGNP RVLDTSRSSI SIAWNKPIYD GGSEITGYMV
EIALPEEDEW QIVTPPAGLK ATSYTITGLT ENQEYKIRIY AMNSEGLGEP ALVPGTPKAE
DRMLPPEIEL DADLRKVVTI RACCTLRLFV PIKGRPAPEV KWARDHGESL DKASIESTSS
YTLLIVGNVN RFDSGKYILT VENSSGSKSA FVNVRVLDTP GPPQDLKVKE VTKTSVTLTW
DPPLLDGGSK IKNYIVEKRE STRKAYSTVA TNCHKTSWKV DQLQEGCSYY FRVLAENEYG
IGLPAETAES VKASERPLPP GKITLMDVTR NSVSLSWEKP EHDGGSRILG YIVEMQTKGS
DKWATCATVK VTEATITGLI QGEEYSFRVS AQNEKGISDP RQLSVPVIAK DLVIPPAFKL
LFNTFTVLAG EDLKVDVPFI GRPTPAVTWH KDNVPLKQTT RVNAESTENN SLLTIKDACR
EDVGHYVVKL TNSAGEAIET LNVIVLDKPG PPTGPVKMDE VTADSITLSW GPPKYDGGSS
INNYIVEKRD TSTTTWQIVS ATVARTTIKA CRLKTGCEYQ FRIAAENRYG KSTYLNSEPT
VAQYPFKVPG PPGTPVVTLS SRDSMEVQWN EPISDGGSRV IGYHLERKER NSILWVKLNK
TPIPQTKFKT TGLEEGVEYE FRVSAENIVG IGKPSKVSEC YVARDPCDPP GRPEAIIVTR
NSVTLQWKKP TYDGGSKITG YIVEKKELPE GRWMKASFTN IIDTHFEVTG LVEDHRYEFR
VIARNAAGVF SEPSESTGAI TARDEVDPPR ISMDPKYKDT IVVHAGESFK VDADIYGKPI
PTIQWIKGDQ ELSNTARLEI KSTDFATSLS VKDAVRVDSG NYILKAKNVA GERSVTVNVK
VLDRPGPPEG PVVISGVTAE KCTLAWKPPL QDGGSDIINY IVERRETSRL VWTVVDANVQ
TLSCKVTKLL EGNEYTFRIM AVNKYGVGEP LESEPVVAKN PFVVPDAPKA PEVTTVTKDS
MIVVWERPAS DGGSEILGYV LEKRDKEGIR WTRCHKRLIG ELRLRVTGLI ENHDYEFRVS
AENAAGLSEP SPPSAYQKAC DPIYKPGPPN NPKVIDITRS SVFLSWSKPI YDGGCEIQGY
IVEKCDVSVG EWTMCTPPTG INKTNIEVEK LLEKHEYNFR ICAINKAGVG EHADVPGPII
VEEKLEAPDI DLDLELRKII NIRAGGSLRL FVPIKGRPTP EVKWGKVDGE IRDAAIIDVT
SSFTSLVLDN VNRYDSGKYT LTLENSSGTK SAFVTVRVLD TPSPPVNLKV TEITKDSVSI
TWEPPLLDGG SKIKNYIVEK REATRKSYAA VVTNCHKNSW KIDQLQEGCS YYFRVTAENE
YGIGLPAQTA DPIKVAEVPQ PPGKITVDDV TRNSVSLSWT KPEHDGGSKI IQYIVEMQAK
HSEKWSECAR VKSLQAVITN LTQGEEYLFR VVAVNEKGRS DPRSLAVPIV AKDLVIEPDV
KPAFSSYSVQ VGQDLKIEVP ISGRPKPTIT WTKDGLPLKQ TTRINVTDSL DLTTLSIKET
HKDDGGQYGI TVANVVGQKT ASIEIVTLDK PDPPKGPVKF DDVSAESITL SWNPPLYTGG
CQITNYIVQK RDTTTTVWDV VSATVARTTL KVTKLKTGTE YQFRIFAENR YGQSFALESD
PIVAQYPYKE PGPPGTPFAT AISKDSMVIQ WHEPVNNGGS PVIGYHLERK ERNSILWTKV
NKTIIHDTQF KAQNLEEGIE YEFRVYAENI VGVGKASKNS ECYVARDPCD PPGTPEPIMV
KRNEITLQWT KPVYDGGSMI TGYIVEKRDL PDGRWMKASF TNVIETQFTV SGLTEDQRYE
FRVIAKNAAG AISKPSDSTG PITAKDEVEL PRISMDPKFR DTIVVNAGET FRLEADVHGK
PLPTIEWLRG DKEIEESARC EIKNTDFKAL LIVKDAIRID GGQYILRASN VAGSKSFPVN
VKVLDRPGPP EGPVQVTGVT SEKCSLTWSP PLQDGGSDIS HYVVEKRETS RLAWTVVASE
VVTNSLKVTK LLEGNEYVFR IMAVNKYGVG EPLESAPVLM KNPFVLPGPP KSLEVTNIAK
DSMTVCWNRP DSDGGSEIIG YIVEKRDRSG IRWIKCNKRR ITDLRLRVTG LTEDHEYEFR
VSAENAAGVG EPSPATVYYK ACDPVFKPGP PTNAHIVDTT KNSITLAWGK PIYDGGSEIL
GYVVEICKAD EEEWQIVTPQ TGLRVTRFEI SKLTEHQEYK IRVCALNKVG LGEATSVPGT
VKPEDKLEAP ELDLDSELRK GIVVRAGGSA RIHIPFKGRP TPEITWSREE GEFTDKVQIE
KGVNYTQLSI DNCDRNDAGK YILKLENSSG SKSAFVTVKV LDTPGPPQNL AVKEVRKDSA
FLVWEPPIID GGAKVKNYVI DKRESTRKAY ANVSSKCSKT SFKVENLTEG AIYYFRVMAE
NEFGVGVPVE TVDAVKAAEP PSPPGKVTLT DVSQTSASLM WEKPEHDGGS RVLGYVVEMQ
PKGTEKWSIV AESKVCNAVV TGLSSGQEYQ FRVKAYNEKG KSDPRVLGVP VIAKDLTIQP
SLKLPFNTYS IQAGEDLKIE IPVIGRPRPN ISWVKDGEPL KQTTRVNVEE TATSTVLHIK
EGNKDDFGKY TVTATNSAGT ATENLSVIVL EKPGPPVGPV RFDEVSADFV VISWEPPAYT
GGCQISNYIV EKRDTTTTTW HMVSATVART TIKITKLKTG TEYQFRIFAE NRYGKSAPLD
SKAVIVQYPF KEPGPPGTPF VTSISKDQML VQWHEPVNDG GTKIIGYHLE QKEKNSILWV
KLNKTPIQDT KFKTTGLDEG LEYEFKVSAE NIVGIGKPSK VSECFVARDP CDPPGRPEAI
VITRNNVTLK WKKPAYDGGS KITGYIVEKK DLPDGRWMKA SFTNVLETEF TVSGLVEDQR
YEFRVIARNA AGNFSEPSDS SGAITARDEI DAPNASLDPK YKDVIVVHAG ETFVLEADIR
GKPIPDVVWS KDGKELEETA ARMEIKSTIQ KTTLVVKDCI RTDGGQYILK LSNVGGTKSI
PITVKVLDRP GPPEGPLKVT GVTAEKCYLA WNPPLQDGGA NISHYIIEKR ETSRLSWTQV
STEVQALNYK VTKLLPGNEY IFRVMAVNKY GIGEPLESGP VTACNPYKPP GPPSTPEVSA
ITKDSMVVTW ARPVDDGGTE IEGYILEKRD KEGVRWTKCN KKTLTDLRLR VTGLTEGHSY
EFRVAAENAA GVGEPSEPSV FYRACDALYP PGPPSNPKVT DTSRSSVSLA WSKPIYDGGA
PVKGYVVEVK EAAADEWTTC TPPTGLQGKQ FTVTKLKENT EYNFRICAIN SEGVGEPATL
PGSVVAQERI EPPEIELDAD LRKVVVLRAS ATLRLFVTIK GRPEPEVKWE KAEGILTDRA
QIEVTSSFTM LVIDNVTRFD SGRYNLTLEN NSGSKTAFVN VRVLDSPSAP VNLTIREVKK
DSVTLSWEPP LIDGGAKITN YIVEKRETTR KAYATITNNC TKTTFRIENL QEGCSYYFRV
LASNEYGIGL PAETTEPVKV SEPPLPPGRV TLVDVTRNTA TIKWEKPESD GGSKITGYVV
EMQTKGSEKW STCTQVKTLE ATISGLTAGE EYVFRVAAVN EKGRSDPRQL GVPVIARDIE
IKPSVELPFH TFNVKAREQL KIDVPFKGRP QATVNWRKDG QTLKETTRVN VSSSKTVTSL
SIKEASKEDV GTYELCVSNS AGSITVPITI IVLDRPGPPG PIRIDEVSCD SITISWNPPE
YDGGCQISNY IVEKKETTST TWHIVSQAVA RTSIKIVRLT TGSEYQFRVC AENRYGKSSY
SESSAVVAEY PFSPPGPPGT PKVVHATKST MLVTWQVPVN DGGSRVIGYH LEYKERSSIL
WSKANKILIA DTQMKVSGLD EGLMYEYRVY AENIAGIGKC SKSCEPVPAR DPCDPPGQPE
VTNITRKSVS LKWSKPHYDG GAKITGYIVE RRELPDGRWL KCNYTNIQET YFEVTELTED
QRYEFRVFAR NAADSVSEPS ESTGPIIVKD DVEPPRVMMD VKFRDVIVVK AGEVLKINAD
IAGRPLPVIS WAKDGIEIEE RARTEIISTD NHTLLTVKDC IRRDTGQYVL TLKNVAGTRS
VAVNCKVLDK PGPPAGPLEI NGLTAEKCSL SWGRPQEDGG ADIDYYIVEK RETSHLAWTI
CEGELQMTSC KVTKLLKGNE YIFRVTGVNK YGVGEPLESV AIKALDPFTV PSPPTSLEIT
SVTKESMTLC WSRPESDGGS EISGYIIERR EKNSLRWVRV NKKPVYDLRV KSTGLREGCE
YEYRVYAENA AGLSLPSETS PLIRAEDPVF LPSPPSKPKI VDSGKTTITI AWVKPLFDGG
APITGYTVEY KKSDDTDWKT SIQSLRGTEY TISGLTTGAE YVFRVKSVNK VGASDPSDSS
DPQIAKEREE EPLFDIDSEM RKTLIVKAGA SFTMTVPFRG RPVPNVLWSK PDTDLRTRAY
VDTTDSRTSL TIENANRNDS GKYTLTIQNV LSAASLTLVV KVLDTPGPPT NITVQDVTKE
SAVLSWDVPE NDGGAPVKNY HIEKREASKK AWVSVTNNCN RLSYKVTNLQ EGAIYYFRVS
GENEFGVGIP AETKEGVKIT EKPSPPEKLG VTSISKDSVS LTWLKPEHDG GSRIVHYVVE
ALEKGQKNWV KCAVAKSTHH VVSGLRENSE YFFRVFAENQ AGLSDPRELL LPVLIKEQLE
PPEIDMKNFP SHTVYVRAGS NLKVDIPISG KPLPKVTLSR DGVPLKATMR FNTEITAENL
TINLKESVTA DAGRYEITAA NSSGTTKAFI NIVVLDRPGP PTGPVVISDI TEESVTLKWE
PPKYDGGSQV TNYILLKRET STAVWTEVSA TVARTMMKVM KLTTGEEYQF RIKAENRFGI
SDHIDSACVT VKLPYTTPGP PSTPWVTNVT RESITVGWHE PVSNGGSAVV GYHLEMKDRN
SILWQKANKL VIRTTHFKVT TISAGLIYEF RVYAENAAGV GKPSHPSEPV LAIDACEPPR
NVRITDISKN SVSLSWQQPA FDGGSKITGY IVERRDLPDG RWTKASFTNV TETQFIISGL
TQNSQYEFRV FARNAVGSIS NPSEVVGPIT CIDSYGGPVI DLPLEYTEVV KYRAGTSVKL
RAGISGKPAP TIEWYKDDKE LQTNALVCVE NTTDLASILI KDADRLNSGC YELKLRNAMG
SASATIRVQI LDKPGPPGGP IEFKTVTAEK ITLLWRPPAD DGGAKITHYI VEKRETSRVV
WSMVSEHLEE CIITTTKIIK GNEYIFRVRA VNKYGIGEPL ESDSVVAKNA FVTPGPPGIP
EVTKITKNSM TVVWSRPIAD GGSDISGYFL EKRDKKSLGW FKVLKETIRD TRQKVTGLTE
NSDYQYRVCA VNAAGQGPFS EPSEFYKAAD PIDPPGPPAK IRIADSTKSS ITLGWSKPVY
DGGSAVTGYV VEIRQGEEEE WTTVSTKGEV RTTEYVVSNL KPGVNYYFRV SAVNCAGQGE
PIEMNEPVQA KDILEAPEID LDVALRTSVI AKAGEDVQVL IPFKGRPPPT VTWRKDEKNL
GSDARYSIEN TDSSSLLTIP QVTRNDTGKY ILTIENGVGE PKSSTVSVKV LDTPAACQKL
QVKHVSRGTV TLLWDPPLID GGSPIINYVI EKRDATKRTW SVVSHKCSST SFKLIDLSEK
TPFFFRVLAE NEIGIGEPCE TTEPVKAAEV PAPIRDLSMK DSTKTSVILS WTKPDFDGGS
VITEYVVERK GKGEQTWSHA GISKTCEIEV SQLKEQSVLE FRVFAKNEKG LSDPVTIGPI
TVKELIITPE VDLSDIPGAQ VTVRIGHNVH LELPYKGKPK PSISWLKDGL PLKESEFVRF
SKTENKITLS IKNAKKEHGG KYTVILDNAV CRIAVPITVI TLGPPSKPKG PIRFDEIKAD
SVILSWDVPE DNGGGEITCY SIEKRETSQT NWKMVCSSVA RTTFKVPNLV KDAEYQFRVR
AENRYGVSQP LVSSIIVAKH QFRIPGPPGK PVIYNVTSDG MSLTWDAPVY DGGSEVTGFH
VEKKERNSIL WQKVNTSPIS GREYRATGLV EGLDYQFRVY AENSAGLSSP SDPSKFTLAV
SPVDPPGTPD YIDVTRETIT LKWNPPLRDG GSKIVGYSIE KRQGNERWVR CNFTDVSECQ
YTVTGLSPGD RYEFRIIARN AVGTISPPSQ SSGIIMTRDE NVPPIVEFGP EYFDGLIIKS
GESLRIKALV QGRPVPRVTW FKDGVEIEKR MNMEITDVLG STSLFVRDAT RDHRGVYTVE
AKNASGSAKA EIKVKVQDTP GKVVGPIRFT NITGEKMTLW WDAPLNDGCA PITHYIIEKR
ETSRLAWALI EDKCEAQSYT AIKLINGNEY QFRVSAVNKF GVGRPLDSDP VVAQIQYTVP
DAPGIPEPSN ITGNSITLTW ARPESDGGSE IQQYILERRE KKSTRWVKVI SKRPISETRF
KVTGLTEGNE YEFHVMAENA AGVGPASGIS RLIKCREPVN PPGPPTVVKV TDTSKTTVSL
EWSKPVFDGG MEIIGYIIEM CKADLGDWHK VNAEACVKTR YTVTDLQAGE EYKFRVSAIN
GAGKGDSCEV TGTIKAVDRL TAPELDIDAN FKQTHVVRAG ASIRLFIAYQ GRPTPTAVWS
KPDSNLSLRA DIHTTDSFST LTVENCNRND AGKYTLTVEN NSGSKSITFT VKVLDTPGPP
GPITFKDVTR GSATLMWDAP LLDGGARIHH YVVEKREASR RSWQVISEKC TRQIFKVNDL
AEGVPYYFRV SAVNEYGVGE PYEMPEPIVA TEQPAPPRRL DVVDTSKSSA VLAWLKPDHD
GGSRITGYLL EMRQKGSDFW VEAGHTKQLT FTVERLVEKT EYEFRVKAKN DAGYSEPREA
FSSVIIKEPQ IEPTADLTGI TNQLITCKAG SPFTIDVPIS GRPAPKVTWK LEEMRLKETD
RVSITTTKDR TTLTVKDSMR GDSGRYFLTL ENTAGVKTFS VTVVVIGRPG PVTGPIEVSS
VSAESCVLSW GEPKDGGGTE ITNYIVEKRE SGTTAWQLVN SSVKRTQIKV THLTKYMEYS
FRVSSENRFG VSKPLESAPI IAEHPFVPPS APTRPEVYHV SANAMSIRWE EPYHDGGSKI
IGYWVEKKER NTILWVKENK VPCLECNYKV TGLVEGLEYQ FRTYALNAAG VSKASEASRP
IMAQNPVDAP GRPEVTDVTR STVSLIWSAP AYDGGSKVVG YIIERKPVSE VGDGRWLKCN
YTIVSDNFFT VTALSEGDTY EFRVLAKNAA GVISKGSEST GPVTCRDEYA PPKAELDARL
HGDLVTIRAG SDLVLDAAVG GKPEPKIIWT KGDKELDLCE KVSLQYTGKR ATAVIKFCDR
SDSGKYTLTV KNASGTKAVS VMVKVLDSPG PCGKLTVSRV TQEKCTLAWS LPQEDGGAEI
THYIVERRET SRLNWVIVEG ECPTLSYVVT RLIKNNEYIF RVRAVNKYGP GVPVESEPIV
ARNSFTIPSP PGIPEEVGTG KEHIIIQWTK PESDGGNEIS NYLVDKREKK SLRWTRVNKD
YVVYDTRLKV TSLMEGCDYQ FRVTAVNAAG NSEPSEASNF ISCREPSYTP GPPSAPRVVD
TTKHSISLAW TKPMYDGGTD IVGYVLEMQE KDTDQWYRVH TNATIRNTEF TVPDLKMGQK
YSFRVAAVNV KGMSEYSESI AEIEPVERIE IPDLELADDL KKTVTIRAGA SLRLMVSVSG
RPPPVITWSK QGIDLASRAI IDTTESYSLL IVDKVNRYDA GKYTIEAENQ SGKKSATVLV
KVYDTPGPCP SVKVKEVSRD SVTITWEIPT IDGGAPVNNY IVEKREAAMR AFKTVTTKCS
KTLYRISGLV EGTMYYFRVL PENIYGIGEP CETSDAVLVS EVPLVPAKLE VVDVTKSTVT
LAWEKPLYDG GSRLTGYVLE ACKAGTERWM KVVTLKPTVL EHTVTSLNEG EQYLFRIRAQ
NEKGVSEPRE TVTAVTVQDL RVLPTIDLST MPQKTIHVPA GRPVELVIPI AGRPPPAASW
FFAGSKLRES ERVTVETHTK VAKLTIRETT IRDTGEYTLE LKNVTGTTSE TIKVIILDKP
GPPTGPIKID EIDATSITIS WEPPELDGGA PLSGYVVEQR DAHRPGWLPV SESVTRSTFK
FTRLTEGNEY VFRVAATNRF GIGSYLQSEV IECRSSIRIP GPPETLQIFD VSRDGMTLTW
YPPEDDGGSQ VTGYIVERKE VRADRWVRVN KVPVTMTRYR STGLTEGLEY EHRVTAINAR
GSGKPSRPSK PIVAMDPIAP PGKPQNPRVT DTTRTSVSLA WSVPEDEGGS KVTGYLIEMQ
KVDQHEWTKC NTTPTKIREY TLTHLPQGAE YRFRVLACNA GGPGEPAEVP GTVKVTEMLE
YPDYELDERY QEGIFVRQGG VIRLTIPIKG KPFPICKWTK EGQDISKRAM IATSETHTEL
VIKEADRGDS GTYDLVLENK CGKKAVYIKV RVIGSPNSPE GPLEYDDIQV RSVRVSWRPP
ADDGGADILG YILERREVPK AAWYTIDSRV RGTSLVVKGL KENVEYHFRV SAENQFGISK
PLKSEEPVTP KTPLNPPEPP SNPPEVLDVT KSSVSLSWSR PKDDGGSRVT GYYIERKETS
TDKWVRHNKT QITTTMYTVT GLVPDAEYQF RIIAQNDVGL SETSPASEPV VCKDPFDKPS
QPGELEILSI SKDSVTLQWE KPECDGGKEI LGYWVEYRQS GDSAWKKSNK ERIKDKQFTI
GGLLEATEYE FRVFAENETG LSRPRRTAMS IKTKLTSGEA PGIRKEMKDV TTKLGEAAQL
SCQIVGRPLP DIKWYRFGKE LIQSRKYKMS SDGRTHTLTV MTEEQEDEGV YTCIATNEVG
EVETSSKLLL QATPQFHPGY PLKEKYYGAV GSTLRLHVMY IGRPVPAMTW FHGQKLLQNS
ENITIENTEH YTHLVMKNVQ RKTHAGKYKV QLSNVFGTVD AILDVEIQDK PDKPTGPIVI
EALLKNSAVI SWKPPADDGG SWITNYVVEK CEAKEGAEWQ LVSSAISVTT CRIVNLTENA
GYYFRVSAQN TFGISDPLEV SSVVIIKSPF EKPGAPGKPT ITAVTKDSCV VAWKPPASDG
GAKIRNYYLE KREKKQNKWI SVTTEEIRET VFSVKNLIEG LEYEFRVKCE NLGGESEWSE
ISEPITPKSD VPIQAPHFKE ELRNLNVRYQ SNATLVCKVT GHPKPIVKWY RQGKEIIADG
LKYRIQEFKG GYHQLIIASV TDDDATVYQV RATNQGGSVS GTASLEVEVP AKIHLPKTLE
GMGAVHALRG EVVSIKIPFS GKPDPVITWQ KGQDLIDNNG HYQVIVTRSF TSLVFPNGVE
RKDAGFYVVC AKNRFGIDQK TVELDVADVP DPPRGVKVSD VSRDSVNLTW TEPASDGGSK
ITNYIVEKCA TTAERWLRVG QARETRYTVI NLFGKTSYQF RVIAENKFGL SKPSEPSEPT
ITKEDKTRAM NYDEEVDETR EVSMTKASHS STKELYEKYM IAEDLGRGEF GIVHRCVETS
SKKTYMAKFV KVKGTDQVLV KKEISILNIA RHRNILHLHE SFESMEELVM IFEFISGLDI
FERINTSAFE LNEREIVSYV HQVCEALQFL HSHNIGHFDI RPENIIYQTR RSSTIKIIEF
GQARQLKPGD NFRLLFTAPE YYAPEVHQHD VVSTATDMWS LGTLVYVLLS GINPFLAETN
QQIIENIMNA EYTFDEEAFK EISIEAMDFV DRLLVKERKS RMTASEALQH PWLKQKIERV
STKVIRTLKH RRYYHTLIKK DLNMVVSAAR ISCGGAIRSQ KGVSVAKVKV ASIEIGPVSG
QIMHAVGEEG GHVKYVCKIE NYDQSTQVTW YFGVRQLENS EKYEITYEDG VAILYVKDIT
KLDDGTYRCK VVNDYGEDSS YAELFVKGVR EVYDYYCRRT MKKIKRRTDT MRLLERPPEF
TLPLYNKTAY VGENVRFGVT ITVHPEPHVT WYKSGQKIKP GDNDKKYTFE SDKGLYQLTI
NSVTTDDDAE YTVVARNKYG EDSCKAKLTV TLHPPPTDST LRPMFKRLLA NAECQEGQSV
CFEIRVSGIP PPTLKWEKDG QPLSLGPNIE IIHEGLDYYA LHIRDTLPED TGYYRVTATN
TAGSTSCQAH LQVERLRYKK QEFKSKEEHE RHVQKQIDKT LRMAEILSGT ESVPLTQVAK
EALREAAVLY KPAVSTKTVK GEFRLEIEEK KEERKLRMPY DVPEPRKYKQ TTIEEDQRIK
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR
IPKLSQDDLE IVRPARRRTP SPDYDFYYRP RRRSLGDISD EELLLPIDDY LAMKRTEEER
LRLEEELELG FSASPPSRSP PHFELSSLRY SSPQAHVKVE ETRKDFRYST YHIPTKAEAS
TSYAELRERH AQAAYRQPKQ RQRIMAERED EELLRPVTTT QHLSEYKSEL DFMSKEEKSR
KKSRRQREVT EITEIEEEYE ISKHAQRESS SSASRLLRRR RSLSPTYIEL MRPVSELIRS
RPQPAEEYED DTERRSPTPE RTRPRSPSPV SSERSLSRFE RSARFDIFSR YESMKAALKT
QKTSERKYEV LSQQPFTLDH APRITLRMRS HRVPCGQNTR FILNVQSKPT AEVKWYHNGV
ELQESSKIHY TNTSGVLTLE ILDCHTDDSG TYRAVCTNYK GEASDYATLD VTGGDYTTYA
SQRRDEEVPR SVFPELTRTE AYAVSSFKKT SEMEASSSVR EVKSQMTETR ESLSSYEHSA
SAEMKSAALE EKSLEEKSTT RKIKTTLAAR ILTKPRSMTV YEGESARFSC DTDGEPVPTV
TWLRKGQVLS TSARHQVTTT KYKSTFEISS VQASDEGNYS VVVENSEGKQ EAEFTLTIQK
ARVTEKAVTS PPRVKSPEPR VKSPEAVKSP KRVKSPEPSH PKAVSPTETK PTPTEKVQHL
PVSAPPKITQ FLKAEASKEI AKLTCVVESS VLRAKEVTWY KDGKKLKENG HFQFHYSADG
TYELKINNLT ESDQGEYVCE ISGEGGTSKT NLQFMGQAFK SIHEKVSKIS ETKKSDQKTT
ESTVTRKTEP KAPEPISSKP VIVTGLQDTT VSSDSVAKFA VKATGEPRPT AIWTKDGKAI
TQGGKYKLSE DKGGFFLEIH KTDTSDSGLY TCTVKNSAGS VSSSCKLTIK AIKDTEAQKV
STQKTSEITP QKKAVVQEEI SQKALRSEEI KMSEAKSQEK LALKEEASKV LISEEVKKSA
ATSLEKSIVH EEITKTSQAS EEVRTHAEIK AFSTQMSINE GQRLVLKANI AGATDVKWVL
NGVELTNSEE YRYGVSGSDQ TLTIKQASHR DEGILTCISK TKEGIVKCQY DLTLSKELSD
APAFISQPRS QNINEGQNVL FTCEISGEPS PEIEWFKNNL PISISSNVSI SRSRNVYSLE
IRNASVSDSG KYTIKAKNFR GQCSATASLM VLPLVEEPSR EVVLRTSGDT SLQGSFSSQS
VQMSASKQEA SFSSFSSSSA SSMTEMKFAS MSAQSMSSMQ ESFVEMSSSS FMGISNMTQL
ESSTSKMLKA GIRGIPPKIE ALPSDISIDE GKVLTVACAF TGEPTPEVTW SCGGRKIHSQ
EQGRFHIENT DDLTTLIIMD VQKQDGGLYT LSLGNEFGSD SATVNIHIRS I*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

490 / 490

Last intron/exon boundary

108169

Theoretical NMD boundary in CDS

107629

Length of CDS

107976

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_9_ENST00000460472

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 138|62 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.44, LOF (oe): 0.42, misssense (oe): 0.89, synonymous (oe): 0.89 ? (gnomAD)

Ensembl transcript ID

ENST00000460472.6

Genbank transcript ID

NM_003319 (by similarity)

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10223-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIMKETR KTVVPKVIVA TPKVKEQDLV SRGREGITTK REQVQITQEK
MRKEAEKTAL STIAVATAKA KEQETILRTR ETMATRQEQI QVTHGKVDVG KKAEAVATVV
AAVDQARVRE PREPGHLEES YAQQTTLEYG YKERISAAKV AEPPQRPASE PHVVPKAVKP
RVIQAPSETH IKTTDQKGMH ISSQIKKTTD LTTERLVHVD KRPRTASPHF TVSKISVPKT
EHGYEASIAG SAIATLQKEL SATSSAQKIT KSVKAPTVKP SETRVRAEPT PLPQFPFADT
PDTYKSEAGV EVKKEVGVSI TGTTVREERF EVLHGREAKV TETARVPAPV EIPVTPPTLV
SGLKNVTVIE GESVTLECHI SGYPSPTVTW YREDYQIESS IDFQITFQSG IARLMIREAF
AEDSGRFTCS AVNEAGTVST SCYLAVQVSE EFEKETTAVT EKFTTEEKRF VESRDVVMTD
TSLTEEQAGP GEPAAPYFIT KPVVQKLVEG GSVVFGCQVG GNPKPHVYWK KSGVPLTTGY
RYKVSYNKQT GECKLVISMT FADDAGEYTI VVRNKHGETS ASASLLEEAD YELLMKSQQE
MLYQTQVTAF VQEPKVGETA PGFVYSEYEK EYEKEQALIR KKMAKDTVVV RTYVEDQEFH
ISSFEERLIK EIEYRIIKTT LEELLEEDGE EKMAVDISES EAVESGFDSR IKNYRILEGM
GVTFHCKMSG YPLPKIAWYK DGKRIKHGER YQMDFLQDGR ASLRIPVVLP EDEGIYTAFA
SNIKGNAICS GKLYVEPAAP LGAPTYIPTL EPVSRIRSLS PRSVSRSPIR MSPARMSPAR
MSPARMSPAR MSPGRRLEET DESQLERLYK PVFVLKPVSF KCLEGQTARF DLKVVGRPMP
ETFWFHDGQQ IVNDYTHKVV IKEDGTQSLI IVPATPSDSG EWTVVAQNRA GRSSISVILT
VEAVEHQVKP MFVEKLKNVN IKEGSRLEMK VRATGNPNPD IVWLKNSDII VPHKYPKIRI
EGTKGEAALK IDSTVSQDSA WYTATAINKA GRDTTRCKVN VEVEFAEPEP ERKLIIPRGT
YRAKEIAAPE LEPLHLRYGQ EQWEEGDLYD KEKQQKPFFK KKLTSLRLKR FGPAHFECRL
TPIGDPTMVV EWLHDGKPLE AANRLRMINE FGYCSLDYGV AYSRDSGIIT CRATNKYGTD
HTSATLIVKD EKSLVEESQL PEGRKGLQRI EELERMAHEG ALTGVTTDQK EKQKPDIVLY
PEPVRVLEGE TARFRCRVTG YPQPKVNWYL NGQLIRKSKR FRVRYDGIHY LDIVDCKSYD
TGEVKVTAEN PEGVIEHKVK LEIQQREDFR SVLRRAPEPR PEFHVHEPGK LQFEVQKVDR
PVDTTETKEV VKLKRAERIT HEKVPEESEE LRSKFKRRTE EGYYEAITAV ELKSRKKDES
YEELLRKTKD ELLHWTKELT EEEKKALAEE GKITIPTFKP DKIELSPSME APKIFERIQS
QTVGQGSDAH FRVRVVGKPD PECEWYKNGV KIERSDRIYW YWPEDNVCEL VIRDVTAEDS
ASIMVKAINI AGETSSHAFL LVQAKQLITF TQELQDVVAK EKDTMATFEC ETSEPFVKVK
WYKDGMEVHE GDKYRMHSDR KVHFLSILTI DTSDAEDYSC VLVEDENVKT TAKLIVEGAV
VEFVKELQDI EVPESYSGEL ECIVSPENIE GKWYHNDVEL KSNGKYTITS RRGRQNLTVK
DVTKEDQGEY SFVIDGKKTT CKLKMKPRPI AILQGLSDQK VCEGDIVQLE VKVSLESVEG
VWMKDGQEVQ PSDRVHIVID KQSHMLLIED MTKEDAGNYS FTIPALGLST SGRVSVYSVD
VITPLKDVNV IEGTKAVLEC KVSVPDVTSV KWYLNDEQIK PDDRVQAIVK GTKQRLVINR
THASDEGPYK LIVGRVETNC NLSVEKIKII RGLRDLTCTE TQNVVFEVEL SHSGIDVLWN
FKDKEIKPSS KYKIEAHGKI YKLTVLNMMK DDEGKYTFYA GENMTSGKLT VAGGAISKPL
TDQTVAESQE AVFECEVANP DSKGEWLRDG KHLPLTNNIR SESDGHKRRL IIAATKLDDI
GEYTYKVATS KTSAKLKVEA VKIKKTLKNL TVTETQDAVF TVELTHPNVK GVQWIKNGVV
LESNEKYAIS VKGTIYSLRI KNCAIVDESV YGFRLGRLGA SARLHVETVK IIKKPKDVTA
LENATVAFEV SVSHDTVPVK WFHKSVEIKP SDKHRLVSER KVHKLMLQNI SPSDAGEYTA
VVGQLECKAK LFVETLHITK TMKNIEVPET KTASFECEVS HFNVPSMWLK NGVEIEMSEK
FKIVVQGKLH QLIIMNTSTE DSAEYTFVCG NDQVSATLTV TPIMITSMLK DINAEEKDTI
TFEVTVNYEG ISYKWLKNGV EIKSTDKCQM RTKKLTHSLN IRNVHFGDAA DYTFVAGKAT
STATLYVEAR HIEFRKHIKD IKVLEKKRAM FECEVSEPDI TVQWMKDDQE LQITDRIKIQ
KEKYVHRLLI PSTRMSDAGK YTVVAGGNVS TAKLFVEGRD VRIRSIKKEV QVIEKQRAVV
EFEVNEDDVD AHWYKDGIEI NFQVQERHKY VVERRIHRMF ISETRQSDAG EYTFVAGRNR
SSVTLYVNAP EPPQVLQELQ PVTVQSGKPA RFCAVISGRP QPKISWYKEE QLLSTGFKCK
FLHDGQEYTL LLIEAFPEDA AVYTCEAKND YGVATTSASL SVEVPEVVSP DQEMPVYPPA
IITPLQDTVT SEGQPARFQC RVSGTDLKVS WYSKDKKIKP SRFFRMTQFE DTYQLEIAEA
YPEDEGTYTF VASNAVGQVS STANLSLEAP ESILHERIEQ EIEMEMKEFS SSFLSAEEEG
LHSAELQLSK INETLELLSE SPVYPTKFDS EKEGTGPIFI KEVSNADISM GDVATLSVTV
IGIPKPKIQW FFNGVLLTPS ADYKFVFDGD DHSLIILFTK LEDEGEYTCM ASNDYGKTIC
SAYLKINSKG EGHKDTETES AVAKSLEKLG GPCPPHFLKE LKPIRCAQGL PAIFEYTVVG
EPAPTVTWFK ENKQLCTSVY YTIIHNPNGS GTFIVNDPQR EDSGLYICKA ENMLGESTCA
AELLVLLEDT DMTDTPCKAK STPEAPEDFP QTPLKGPAVE ALDSEQEIAT FVKDTILKAA
LITEENQQLS YEHIAKANEL SSQLPLGAQE LQSILEQDKL TPESTREFLC INGSIHFQPL
KEPSPNLQLQ IVQSQKTFSK EGILMPEEPE TQAVLSDTEK IFPSAMSIEQ INSLTVEPLK
TLLAEPEGNY PQSSIEPPMH SYLTSVAEEV LSPKEKTVSD TNREQRVTLQ KQEAQSALIL
SQSLAEGHVE SLQSPDVMIS QVNYEPLVPS EHSCTEGGKI LIESANPLEN AGQDSAVRIE
EGKSLRFPLA LEEKQVLLKE EHSDNVVMPP DQIIESKREP VAIKKVQEVQ GRDLLSKESL
LSGIPEEQRL NLKIQICRAL QAAVASEQPG LFSEWLRNIE KVEVEAVNIT QEPRHIMCMY
LVTSAKSVTE EVTIIIEDVD PQMANLKMEL RDALCAIIYE EIDILTAEGP RIQQGAKTSL
QEEMDSFSGS QKVEPITEPE VESKYLISTE EVSYFNVQSR VKYLDATPVT KGVASAVVSD
EKQDESLKPS EEKEESSSES GTEEVATVKI QEAEGGLIKE DGPMIHTPLV DTVSEEGDIV
HLTTSITNAK EVNWYFENKL VPSDEKFKCL QDQNTYTLVI DKVNTEDHQG EYVCEALNDS
GKTATSAKLT VVKRAAPVIK RKIEPLEVAL GHLAKFTCEI QSAPNVRFQW FKAGREIYES
DKCSIRSSKY ISSLEILRTQ VVDCGEYTCK ASNEYGSVSC TATLTVTVPG GEKKVRKLLP
ERKPEPKEEV VLKSVLRKRP EEEEPKVEPK KLEKVKKPAV PEPPPPKPVE EVEVPTVTKR
ERKIPEPTKV PEIKPAIPLP APEPKPKPEA EVKTIKPPPV EPEPTPIAAP VTVPVVGKKA
EAKAPKEEAA KPKGPIKGVP KKTPSPIEAE RRKLRPGSGG EKPPDEAPFT YQLKAVPLKF
VKEIKDIILT ESEFVGSSAI FECLVSPSTA ITTWMKDGSN IRESPKHRFI ADGKDRKLHI
IDVQLSDAGE YTCVLRLGNK EKTSTAKLVV EELPVRFVKT LEEEVTVVKG QPLYLSCELN
KERDVVWRKD GKIVVEKPGR IVPGVIGLMR ALTINDADDT DAGTYTVTVE NANNLECSSC
VKVVEVIRDW LVKPIRDQHV KPKGTAIFAC DIAKDTPNIK WFKGYDEIPA EPNDKTEILR
DGNHLYLKIK NAMPEDIAEY AVEIEGKRYP AKLTLGEREV ELLKPIEDVT IYEKESASFD
AEISEADIPG QWKLKGELLR PSPTCEIKAE GGKRFLTLHK VKLDQAGEVL YQALNAITTA
ILTVKEIELD FAVPLKDVTV PERRQARFEC VLTREANVIW SKGPDIIKSS DKFDIIADGK
KHILVINDSQ FDDEGVYTAE VEGKKTSARL FVTGIRLKFM SPLEDQTVKE GETATFVCEL
SHEKMHVVWF KNDAKLHTSR TVLISSEGKT HKLEMKEVTL DDISQIKAQV KELSSTAQLK
VLEADPYFTV KLHDKTAVEK DEITLKCEVS KDVPVKWFKD GEEIVPSPKY SIKADGLRRI
LKIKKADLKD KGEYVCDCGT DKTKANVTVE ARLIKVEKPL YGVEVFVGET AHFEIELSEP
DVHGQWKLKG QPLTASPDCE IIEDGKKHIL ILHNCQLGMT GEVSFQAANA KSAANLKVKE
LPLIFITPLS DVKVFEKDEA KFECEVSREP KTFRWLKGTQ EITGDDRFEL IKDGTKHSMV
IKSAAFEDEA KYMFEAEDKH TSGKLIIEGI RLKFLTPLKD VTAKEKESAV FTVELSHDNI
RVKWFKNDQR LHTTRSVSMQ DEGKTHSITF KDLSIDDTSQ IRVEAMGMSS EAKLTVLEGD
PYFTGKLQDY TGVEKDEVIL QCEISKADAP VKWFKDGKEI KPSKNAVIKA DGKKRMLILK
KALKSDIGQY TCDCGTDKTS GKLDIEDREI KLVRPLHSVE VMETETARFE TEISEDDIHA
NWKLKGEALL QTPDCEIKEE GKIHSLVLHN CRLDQTGGVD FQAANVKSSA HLRVKPRVIG
LLRPLKDVTV TAGETATFDC ELSYEDIPVE WYLKGKKLEP SDKVVPRSEG KVHTLTLRDV
KLEDAGEVQL TAKDFKTHAN LFVKEPPVEF TKPLEDQTVE EGATAVLECE VSRENAKVKW
FKNGTEILKS KKYEIVADGR VRKLVIHDCT PEDIKTYTCD AKDFKTSCNL NVVPPHVEFL
RPLTDLQVRE KEMARFECEL SRENAKVKWF KDGAEIKKGK KYDIISKGAV RILVINKCLL
DDEAEYSCEV RTARTSGMLT VLEEEAVFTK NLANIEVSET DTIKLVCEVS KPGAEVIWYK
GDEEIIETGR YEILTEGRKR ILVIQNAHLE DAGNYNCRLP SSRTDGKVKV HELAAEFISK
PQNLEILEGE KAEFVCSISK ESFPVQWKRD DKTLESGDKY DVIADGKKRV LVVKDATLQD
MGTYVVMVGA ARAAAHLTVI EKLRIVVPLK DTRVKEQQEV VFNCEVNTEG AKAKWFRNEE
AIFDSSKYII LQKDLVYTLR IRDAHLDDQA NYNVSLTNHR GENVKSAANL IVEEEDLRIV
EPLKDIETME KKSVTFWCKV NRLNVTLKWT KNGEEVPFDN RVSYRVDKYK HMLTIKDCGF
PDEGEYIVTA GQDKSVAELL IIEAPTEFVE HLEDQTVTEF DDAVFSCQLS REKANVKWYR
NGREIKEGKK YKFEKDGSIH RLIIKDCRLD DECEYACGVE DRKSRARLFV EEIPVEIIRP
PQDILEAPGA DVVFLAELNK DKVEVQWLRN NMVVVQGDKH QMMSEGKIHR LQICDIKPRD
QGEYRFIAKD KEARAKLELA AAPKIKTADQ DLVVDVGKPL TMVVPYDAYP KAEAEWFKEN
EPLSTKTIDT TAEQTSFRIL EAKKGDKGRY KIVLQNKHGK AEGFINLKVI DVPGPVRNLE
VTETFDGEVS LAWEEPLTDG GSKIIGYVVE RRDIKRKTWV LATDRAESCE FTVTGLQKGG
VEYLFRVSAR NRVGTGEPVE TDNPVEARSK YDVPGPPLNV TITDVNRFGV SLTWEPPEYD
GGAEITNYVI ELRDKTSIRW DTAMTVRAED LSATVTDVVE GQEYSFRVRA QNRIGVGKPS
AATPFVKVAD PIERPSPPVN LTSSDQTQSS VQLKWEPPLK DGGSPILGYI IERCEEGKDN
WIRCNMKLVP ELTYKVTGLE KGNKYLYRVS AENKAGVSDP SEILGPLTAD DAFVEPTMDL
SAFKDGLEVI VPNPITILVP STGYPRPTAT WCFGDKVLET GDRVKMKTLS AYAELVISPS
ERSDKGIYTL KLENRVKTIS GEIDVNVIAR PSAPKELKFG DITKDSVHLT WEPPDDDGGS
PLTGYVVEKR EVSRKTWTKV MDFVTDLEFT VPDLVQGKEY LFKVCARNKC GPGEPAYVDE
PVNMSTPATV PDPPENVKWR DRTANSIFLT WDPPKNDGGS RIKGYIVERC PRGSDKWVAC
GEPVAETKME VTGLEEGKWY AYRVKALNRQ GASKPSRPTE EIQAVDTQEA PEIFLDVKLL
AGLTVKAGTK IELPATVTGK PEPKITWTKA DMILKQDKRI TIENVPKKST VTIVDSKRSD
TGTYIIEAVN VCGRATAVVE VNVLDKPGPP AAFDITDVTN ESCLLTWNPP RDDGGSKITN
YVVERRATDS EVWHKLSSTV KDTNFKATKL IPNKEYIFRV AAENMYGVGE PVQASPITAK
YQFDPPGPPT RLEPSDITKD AVTLTWCEPD DDGGSPITGY WVERLDPDTD KWVRCNKMPV
KDTTYRVKGL TNKKKYRFRV LAENLAGPGK PSKSTEPILI KDPIDPPWPP GKPTVKDVGK
TSVRLNWTKP EHDGGAKIES YVIEMLKTGT DEWVRVAEGV PTTQHLLPGL MEGQEYSFRV
RAVNKAGESE PSEPSDPVLC REKLYPPSPP RWLEVINITK NTADLKWTVP EKDGGSPITN
YIVEKRDVRR KGWQTVDTTV KDTKCTVTPL TEGSLYVFRV AAENAIGQSD YTEIEDSVLA
KDTFTTPGPP YALAVVDVTK RHVDLKWEPP KNDGGRPIQR YVIEKKERLG TRWVKAGKTA
GPDCNFRVTD VIEGTEVQFQ VRAENEAGVG HPSEPTEILS IEDPTSPPSP PLDLHVTDAG
RKHIAIAWKP PEKNGGSPII GYHVEMCPVG TEKWMRVNSR PIKDLKFKVE EGVVPDKEYV
LRVRAVNAIG VSEPSEISEN VVAKDPDCKP TIDLETHDII VIEGEKLSIP VPFRAVPVPT
VSWHKDGKEV KASDRLTMKN DHISAHLEVP KSVRADAGIY TITLENKLGS ATASINVKVI
GLPGPCKDIK ASDITKSSCK LTWEPPEFDG GTPILHYVLE RREAGRRTYI PVMSGENKLS
WTVKDLIPNG EYFFRVKAVN KVGGGEYIEL KNPVIAQDPK QPPDPPVDVE VHNPTAEAMT
ITWKPPLYDG GSKIMGYIIE KIAKGEERWK RCNEHLVPIL TYTAKGLEEG KEYQFRVRAE
NAAGISEPSR ATPPTKAVDP IDAPKVILRT SLEVKRGDEI ALDASISGSP YPTITWIKDE
NVIVPEEIKK RAAPLVRRRK GEVQEEEPFV LPLTQRLSID NSKKGESQLR VRDSLRPDHG
LYMIKVENDH GIAKAPCTVS VLDTPGPPIN FVFEDIRKTS VLCKWEPPLD DGGSEIINYT
LEKKDKTKPD SEWIVVTSTL RHCKYSVTKL IEGKEYLFRV RAENRFGPGP PCVSKPLVAK
DPFGPPDAPD KPIVEDVTSN SMLVKWNEPK DNGSPILGYW LEKREVNSTH WSRVNKSLLN
ALKANVDGLL EGLTYVFRVC AENAAGPGKF SPPSDPKTAH DPISPPGPPI PRVTDTSSTT
IELEWEPPAF NGGGEIVGYF VDKQLVGTNE WSRCTEKMIK VRQYTVKEIR EGADYKLRVS
AVNAAGEGPP GETQPVTVAE PQEPPAVELD VSVKGGIQIM AGKTLRIPAV VTGRPVPTKV
WTKEEGELDK DRVVIDNVGT KSELIIKDAL RKDHGRYVIT ATNSCGSKFA AARVEVFDVP
GPVLDLKPVV TNRKMCLLNW SDPEDDGGSE ITGFIIERKD AKMHTWRQPI ETERSKCDIT
GLLEGQEYKF RVIAKNKFGC GPPVEIGPIL AVDPLGPPTS PERLTYTERT KSTITLDWKE
PRSNGGSPIQ GYIIEKRRHD KPDFERVNKR LCPTTSFLVE NLDEHQMYEF RVKAVNEIGE
SEPSLPLNVV IQDDEVPPTI KLRLSVRGDT IKVKAGEPVH IPADVTGLPM PKIEWSKNET
VIEKPTDALQ ITKEEVSRSE AKTELSIPKA VREDKGTYTV TASNRLGSVF RNVHVEVYDR
PSPPRNLAVT DIKAESCYLT WDAPLDNGGS EITHYVIDKR DASRKKAEWE EVTNTAVEKR
YGIWKLIPNG QYEFRVRAVN KYGISDECKS DKVVIQDPYR LPGPPGKPKV LARTKGSMLV
SWTPPLDNGG SPITGYWLEK REEGSPYWSR VSRAPITKVG LKGVEFNVPR LLEGVKYQFR
AMAINAAGIG PPSEPSDPEV AGDPIFPPGP PSCPEVKDKT KSSISLGWKP PAKDGGSPIK
GYIVEMQEEG TTDWKRVNEP DKLITTCECV VPNLKELRKY RFRVKAVNEA GESEPSDTTG
EIPATDIQEE PEVFIDIGAQ DCLVCKAGSQ IRIPAVIKGR PTPKSSWEFD GKAKKAMKDG
VHDIPEDAQL ETAENSSVII IPECKRSHTG KYSITAKNKA GQKTANCRVK VMDVPGPPKD
LKVSDITRGS CRLSWKMPDD DGGDRIKGYV IEKRTIDGKA WTKVNPDCGS TTFVVPDLLS
EQQYFFRVRA ENRFGIGPPV ETIQRTTARD PIYPPDPPIK LKIGLITKNT VHLSWKPPKN
DGGSPVTHYI VECLAWDPTG TKKEAWRQCN KRDVEELQFT VEDLVEGGEY EFRVKAVNAA
GVSKPSATVG PVTVKDQTCP PSIDLKEFME VEEGTNVNIV AKIKGVPFPT LTWFKAPPKK
PDNKEPVLYD THVNKLVVDD TCTLVIPQSR RSDTGLYTIT AVNNLGTASK EMRLNVLGRP
GPPVGPIKFE SVSADQMTLS WFPPKDDGGS KITNYVIEKR EANRKTWVHV SSEPKECTYT
IPKLLEGHEY VFRIMAQNKY GIGEPLDSEP ETARNLFSVP GAPDKPTVSS VTRNSMTVNW
EEPEYDGGSP VTGYWLEMKD TTSKRWKRVN RDPIKAMTLG VSYKVTGLIE GSDYQFRVYA
INAAGVGPAS LPSDPATARD PIAPPGPPFP KVTDWTKSSA DLEWSPPLKD GGSKVTGYIV
EYKEEGKEEW EKGKDKEVRG TKLVVTGLKE GAFYKFRVRA VNIAGIGEPG EVTDVIEMKD
RLVSPDLQLD ASVRDRIVVH AGGVIRIIAY VSGKPPPTVT WNMNERTLPQ EATIETTAIS
SSMVIKNCQR SHQGVYSLLA KNEAGERKKT IIVDVLDVPG PVGTPFLAHN LTNESCKLTW
FSPEDDGGSP ITNYVIEKRE SDRRAWTPVT YTVTRQNATV QGLIQGKAYF FRIAAENSIG
MGPFVETSEA LVIREPITVP ERPEDLEVKE VTKNTVTLTW NPPKYDGGSE IINYVLESRL
IGTEKFHKVT NDNLLSRKYT VKGLKEGDTY EYRVSAVNIV GQGKPSFCTK PITCKDELAP
PTLHLDFRDK LTIRVGEAFA LTGRYSGKPK PKVSWFKDEA DVLEDDRTHI KTTPATLALE
KIKAKRSDSG KYCVVVENST GSRKGFCQVN VVDRPGPPVG PVSFDEVTKD YMVISWKPPL
DDGGSKITNY IIEKKEVGKD VWMPVTSASA KTTCKVSKLL EGKDYIFRIH AENLYGISDP
LVSDSMKAKD RFRVPDAPDQ PIVTEVTKDS ALVTWNKPHD GGKPITNYIL EKRETMSKRW
ARVTKDPIHP YTKFRVPDLL EGCQYEFRVS AENEIGIGDP SPPSKPVFAK DPIAKPSPPV
NPEAIDTTCN SVDLTWQPPR HDGGSKILGY IVEYQKVGDE EWRRANHTPE SCPETKYKVT
GLRDGQTYKF RVLAVNAAGE SDPAHVPEPV LVKDRLEPPE LILDANMARE QHIKVGDTLR
LSAIIKGVPF PKVTWKKEDR DAPTKARIDV TPVGSKLEIR NAAHEDGGIY SLTVENPAGS
KTVSVKVLVL DKPGPPRDLE VSEIRKDSCY LTWKEPLDDG GSVITNYVVE RRDVASAQWS
PLSATSKKKS HFAKHLNEGN QYLFRVAAEN QYGRGPFVET PKPIKALDPL HPPGPPKDLH
HVDVDKTEVS LVWNKPDRDG GSPITGYLVE YQEEGTQDWI KFKTVTNLEC VVTGLQQGKT
YRFRVKAENI VGLGLPDTTI PIECQEKLVP PSVELDVKLI EGLVVKAGTT VRFPAIIRGV
PVPTAKWTTD GSEIKTDEHY TVETDNFSSV LTIKNCLRRD TGEYQITVSN AAGSKTVAVH
LTVLDVPGPP TGPINILDVT PEHMTISWQP PKDDGGSPVI NYIVEKQDTR KDTWGVVSSG
SSKTKLKIPH LQKGCEYVFR VRAENKIGVG PPLDSTPTVA KHKFSPPSPP GKPVVTDITE
NAATVSWTLP KSDGGSPITG YYMERREVTG KWVRVNKTPI ADLKFRVTGL YEGNTYEFRV
FAENLAGLSK PSPSSDPIKA CRPIKPPGPP INPKLKDKSR ETADLVWTKP LSDGGSPILG
YVVECQKPGT AQWNRINKDE LIRQCAFRVP GLIEGNEYRF RIKAANIVGE GEPRELAESV
IAKDILHPPE VELDVTCRDV ITVRVGQTIR ILARVKGRPE PDITWTKEGK VLVREKRVDL
IQDLPRVELQ IKEAVRADHG KYIISAKNSS GHAQGSAIVN VLDRPGPCQN LKVTNVTKEN
CTISWENPLD NGGSEITNFI VEYRKPNQKG WSIVASDVTK RLIKANLLAN NEYYFRVCAE
NKVGVGPTIE TKTPILAINP IDRPGEPENL HIADKGKTFV YLKWRRPDYD GGSPNLSYHV
ERRLKGSDDW ERVHKGSIKE THYMVDRCVE NQIYEFRVQT KNEGGESDWV KTEEVVVKED
LQKPVLDLKL SGVLTVKAGD TIRLEAGVRG KPFPEVAWTK DKDATDLTRS PRVKIDTRAD
SSKFSLTKAK RSDGGKYVVT ATNTAGSFVA YATVNVLDKP GPVRNLKIVD VSSDRCTVCW
DPPEDDGGCE IQNYILEKCE TKRMVWSTYS ATVLTPGTTV TRLIEGNEYI FRVRAENKIG
TGPPTESKPV IAKTKYDKPG RPDPPEVTKV SKEEMTVVWN PPEYDGGKSI TGYFLEKKEK
HSTRWVPVNK SAIPERRMKV QNLLPDHEYQ FRVKAENEIG IGEPSLPSRP VVAKDPIEPP
GPPTNFRVVD TTKHSITLGW GKPVYDGGAP IIGYVVEMRP KIADASPDEG WKRCNAAAQL
VRKEFTVTSL DENQEYEFRV CAQNQVGIGR PAELKEAIKP KEILEPPEID LDASMRKLVI
VRAGCPIRLF AIVRGRPAPK VTWRKVGIDN VVRKGQVDLV DTMAFLVIPN STRDDSGKYS
LTLVNPAGEK AVFVNVRVLD TPGPVSDLKV SDVTKTSCHV SWAPPENDGG SQVTHYIVEK
READRKTWST VTPEVKKTSF HVTNLVPGNE YYFRVTAVNE YGPGVPTDVP KPVLASDPLS
EPDPPRKLEV TEMTKNSATL AWLPPLRDGG AKIDGYITSY REEEQPADRW TEYSVVKDLS
LVVTGLKEGK KYKFRVAARN AVGVSLPREA EGVYEAKEQL LPPKILMPEQ ITIKAGKKLR
IEAHVYGKPH PTCKWKKGED EVVTSSHLAV HKADSSSILI IKDVTRKDSG YYSLTAENSS
GTDTQKIKVV VMDAPGPPQP PFDISDIDAD ACSLSWHIPL EDGGSNITNY IVEKCDVSRG
DWVTALASVT KTSCRVGKLI PGQEYIFRVR AENRFGISEP LTSPKMVAQF PFGVPSEPKN
ARVTKVNKDC IFVAWDRPDS DGGSPIIGYL IERKERNSLL WVKANDTLVR STEYPCAGLV
EGLEYSFRIY ALNKAGSSPP SKPTEYVTAR MPVDPPGKPE VIDVTKSTVS LIWARPKHDG
GSKIIGYFVE ACKLPGDKWV RCNTAPHQIP QEEYTATGLE EKAQYQFRAI ARTAVNISPP
SEPSDPVTIL AENVPPRIDL SVAMKSLLTV KAGTNVCLDA TVFGKPMPTV SWKKDGTLLK
PAEGIKMAMQ RNLCTLELFS VNRKDSGDYT ITAENSSGSK SATIKLKVLD KPGPPASVKI
NKMYSDRAML SWEPPLEDGG SEITNYIVDK RETSRPNWAQ VSATVPITSC SVEKLIEGHE
YQFRICAENK YGVGDPVFTE PAIAKNPYDP PGRCDPPVIS NITKDHMTVS WKPPADDGGS
PITGYLLEKR ETQAVNWTKV NRKPIIERTL KATGLQEGTE YEFRVTAINK AGPGKPSDAS
KAAYARDPQY PPGPPAFPKV YDTTRSSVSL SWGKPAYDGG SPIIGYLVEV KRADSDNWVR
CNLPQNLQKT RFEVTGLMED TQYQFRVYAV NKIGYSDPSD VPDKHYPKDI LIPPEGELDA
DLRKTLILRA GVTMRLYVPV KGRPPPKITW SKPNVNLRDR IGLDIKSTDF DTFLRCENVN
KYDAGKYILT LENSCGKKEY TIVVKVLDTP GPPVNVTVKE ISKDSAYVTW EPPIIDGGSP
IINYVVQKRD AERKSWSTVT TECSKTSFRV ANLEEGKSYF FRVFAENEYG IGDPGETRDA
VKASQTPGPV VDLKVRSVSK SSCSIGWKKP HSDGGSRIIG YVVDFLTEEN KWQRVMKSLS
LQYSAKDLTE GKEYTFRVSA ENENGEGTPS EITVVARDDV VAPDLDLKGL PDLCYLAKEN
SNFRLKIPIK GKPAPSVSWK KGEDPLATDT RVSVESSAVN TTLIVYDCQK SDAGKYTITL
KNVAGTKEGT ISIKVVGKPG IPTGPIKFDE VTAEAMTLKW APPKDDGGSE ITNYILEKRD
SVNNKWVTCA SAVQKTTFRV TRLHEGMEYT FRVSAENKYG VGEGLKSEPI VARHPFDVPD
APPPPNIVDV RHDSVSLTWT DPKKTGGSPI TGYHLEFKER NSLLWKRANK TPIRMRDFKV
TGLTEGLEYE FRVMAINLAG VGKPSLPSEP VVALDPIDPP GKPEVINITR NSVTLIWTEP
KYDGGHKLTG YIVEKRDLPS KSWMKANHVN VPECAFTVTD LVEGGKYEFR IRAKNTAGAI
SAPSESTETI ICKDEYEAPT IVLDPTIKDG LTIKAGDTIV LNAISILGKP LPKSSWSKAG
KDIRPSDITQ ITSTPTSSML TIKYATRKDA GEYTITATNP FGTKVEHVKV TVLDVPGPPG
PVEISNVSAE KATLTWTPPL EDGGSPIKSY ILEKRETSRL LWTVVSEDIQ SCRHVATKLI
QGNEYIFRVS AVNHYGKGEP VQSEPVKMVD RFGPPGPPEK PEVSNVTKNT ATVSWKRPVD
DGGSEITGYH VERREKKSLR WVRAIKTPVS DLRCKVTGLQ EGSTYEFRVS AENRAGIGPP
SEASDSVLMK DAAYPPGPPS NPHVTDTTKK SASLAWGKPH YDGGLEITGY VVEHQKVGDE
AWIKDTTGTA LRITQFVVPD LQTKEKYNFR ISAINDAGVG EPAVIPDVEI VEREMAPDFE
LDAELRRTLV VRAGLSIRIF VPIKGRPAPE VTWTKDNINL KNRANIENTE SFTLLIIPEC
NRYDTGKFVM TIENPAGKKS GFVNVRVLDT PGPVLNLRPT DITKDSVTLH WDLPLIDGGS
RITNYIVEKR EATRKSYSTA TTKCHKCTYK VTGLSEGCEY FFRVMAENEY GIGEPTETTE
PVKASEAPSP PDSLNIMDIT KSTVSLAWPK PKHDGGSKIT GYVIEAQRKG SDQWTHITTV
KGLECVVRNL TEGEEYTFQV MAVNSAGRSA PRESRPVIVK EQTMLPELDL RGIYQKLVIA
KAGDNIKVEI PVLGRPKPTV TWKKGDQILK QTQRVNFETT ATSTILNINE CVRSDSGPYP
LTARNIVGEV GDVITIQVHD IPGPPTGPIK FDEVSSDFVT FSWDPPENDG GVPISNYVVE
MRQTDSTTWV ELATTVIRTT YKATRLTTGL EYQFRVKAQN RYGVGPGITS ACIVANYPFK
VPGPPGTPQV TAVTKDSMTI SWHEPLSDGG SPILGYHVER KERNGILWQT VSKALVPGNI
FKSSGLTDGI AYEFRVIAEN MAGKSKPSKP SEPMLALDPI DPPGKPVPLN ITRHTVTLKW
AKPEYTGGFK ITSYIVEKRD LPNGRWLKAN FSNILENEFT VSGLTEDAAY EFRVIAKNAA
GAISPPSEPS DAITCRDDVE APKIKVDVKF KDTVILKAGE AFRLEADVSG RPPPTMEWSK
DGKELEGTAK LEIKIADFST NLVNKDSTRR DSGAYTLTAT NPGGFAKHIF NVKVLDRPGP
PEGPLAVTEV TSEKCVLSWF PPLDDGGAKI DHYIVQKRET SRLAWTNVAS EVQVTKLKVT
KLLKGNEYIF RVMAVNKYGV GEPLESEPVL AVNPYGPPDP PKNPEVTTIT KDSMVVCWGH
PDSDGGSEII NYIVERRDKA GQRWIKCNKK TLTDLRYKVS GLTEGHEYEF RIMAENAAGI
SAPSPTSPFY KACDTVFKPG PPGNPRVLDT SRSSISIAWN KPIYDGGSEI TGYMVEIALP
EEDEWQIVTP PAGLKATSYT ITGLTENQEY KIRIYAMNSE GLGEPALVPG TPKAEDRMLP
PEIELDADLR KVVTIRACCT LRLFVPIKGR PAPEVKWARD HGESLDKASI ESTSSYTLLI
VGNVNRFDSG KYILTVENSS GSKSAFVNVR VLDTPGPPQD LKVKEVTKTS VTLTWDPPLL
DGGSKIKNYI VEKRESTRKA YSTVATNCHK TSWKVDQLQE GCSYYFRVLA ENEYGIGLPA
ETAESVKASE RPLPPGKITL MDVTRNSVSL SWEKPEHDGG SRILGYIVEM QTKGSDKWAT
CATVKVTEAT ITGLIQGEEY SFRVSAQNEK GISDPRQLSV PVIAKDLVIP PAFKLLFNTF
TVLAGEDLKV DVPFIGRPTP AVTWHKDNVP LKQTTRVNAE STENNSLLTI KDACREDVGH
YVVKLTNSAG EAIETLNVIV LDKPGPPTGP VKMDEVTADS ITLSWGPPKY DGGSSINNYI
VEKRDTSTTT WQIVSATVAR TTIKACRLKT GCEYQFRIAA ENRYGKSTYL NSEPTVAQYP
FKVPGPPGTP VVTLSSRDSM EVQWNEPISD GGSRVIGYHL ERKERNSILW VKLNKTPIPQ
TKFKTTGLEE GVEYEFRVSA ENIVGIGKPS KVSECYVARD PCDPPGRPEA IIVTRNSVTL
QWKKPTYDGG SKITGYIVEK KELPEGRWMK ASFTNIIDTH FEVTGLVEDH RYEFRVIARN
AAGVFSEPSE STGAITARDE VDPPRISMDP KYKDTIVVHA GESFKVDADI YGKPIPTIQW
IKGDQELSNT ARLEIKSTDF ATSLSVKDAV RVDSGNYILK AKNVAGERSV TVNVKVLDRP
GPPEGPVVIS GVTAEKCTLA WKPPLQDGGS DIINYIVERR ETSRLVWTVV DANVQTLSCK
VTKLLEGNEY TFRIMAVNKY GVGEPLESEP VVAKNPFVVP DAPKAPEVTT VTKDSMIVVW
ERPASDGGSE ILGYVLEKRD KEGIRWTRCH KRLIGELRLR VTGLIENHDY EFRVSAENAA
GLSEPSPPSA YQKACDPIYK PGPPNNPKVI DITRSSVFLS WSKPIYDGGC EIQGYIVEKC
DVSVGEWTMC TPPTGINKTN IEVEKLLEKH EYNFRICAIN KAGVGEHADV PGPIIVEEKL
EAPDIDLDLE LRKIINIRAG GSLRLFVPIK GRPTPEVKWG KVDGEIRDAA IIDVTSSFTS
LVLDNVNRYD SGKYTLTLEN SSGTKSAFVT VRVLDTPSPP VNLKVTEITK DSVSITWEPP
LLDGGSKIKN YIVEKREATR KSYAAVVTNC HKNSWKIDQL QEGCSYYFRV TAENEYGIGL
PAQTADPIKV AEVPQPPGKI TVDDVTRNSV SLSWTKPEHD GGSKIIQYIV EMQAKHSEKW
SECARVKSLQ AVITNLTQGE EYLFRVVAVN EKGRSDPRSL AVPIVAKDLV IEPDVKPAFS
SYSVQVGQDL KIEVPISGRP KPTITWTKDG LPLKQTTRIN VTDSLDLTTL SIKETHKDDG
GQYGITVANV VGQKTASIEI VTLDKPDPPK GPVKFDDVSA ESITLSWNPP LYTGGCQITN
YIVQKRDTTT TVWDVVSATV ARTTLKVTKL KTGTEYQFRI FAENRYGQSF ALESDPIVAQ
YPYKEPGPPG TPFATAISKD SMVIQWHEPV NNGGSPVIGY HLERKERNSI LWTKVNKTII
HDTQFKAQNL EEGIEYEFRV YAENIVGVGK ASKNSECYVA RDPCDPPGTP EPIMVKRNEI
TLQWTKPVYD GGSMITGYIV EKRDLPDGRW MKASFTNVIE TQFTVSGLTE DQRYEFRVIA
KNAAGAISKP SDSTGPITAK DEVELPRISM DPKFRDTIVV NAGETFRLEA DVHGKPLPTI
EWLRGDKEIE ESARCEIKNT DFKALLIVKD AIRIDGGQYI LRASNVAGSK SFPVNVKVLD
RPGPPEGPVQ VTGVTSEKCS LTWSPPLQDG GSDISHYVVE KRETSRLAWT VVASEVVTNS
LKVTKLLEGN EYVFRIMAVN KYGVGEPLES APVLMKNPFV LPGPPKSLEV TNIAKDSMTV
CWNRPDSDGG SEIIGYIVEK RDRSGIRWIK CNKRRITDLR LRVTGLTEDH EYEFRVSAEN
AAGVGEPSPA TVYYKACDPV FKPGPPTNAH IVDTTKNSIT LAWGKPIYDG GSEILGYVVE
ICKADEEEWQ IVTPQTGLRV TRFEISKLTE HQEYKIRVCA LNKVGLGEAT SVPGTVKPED
KLEAPELDLD SELRKGIVVR AGGSARIHIP FKGRPTPEIT WSREEGEFTD KVQIEKGVNY
TQLSIDNCDR NDAGKYILKL ENSSGSKSAF VTVKVLDTPG PPQNLAVKEV RKDSAFLVWE
PPIIDGGAKV KNYVIDKRES TRKAYANVSS KCSKTSFKVE NLTEGAIYYF RVMAENEFGV
GVPVETVDAV KAAEPPSPPG KVTLTDVSQT SASLMWEKPE HDGGSRVLGY VVEMQPKGTE
KWSIVAESKV CNAVVTGLSS GQEYQFRVKA YNEKGKSDPR VLGVPVIAKD LTIQPSLKLP
FNTYSIQAGE DLKIEIPVIG RPRPNISWVK DGEPLKQTTR VNVEETATST VLHIKEGNKD
DFGKYTVTAT NSAGTATENL SVIVLEKPGP PVGPVRFDEV SADFVVISWE PPAYTGGCQI
SNYIVEKRDT TTTTWHMVSA TVARTTIKIT KLKTGTEYQF RIFAENRYGK SAPLDSKAVI
VQYPFKEPGP PGTPFVTSIS KDQMLVQWHE PVNDGGTKII GYHLEQKEKN SILWVKLNKT
PIQDTKFKTT GLDEGLEYEF KVSAENIVGI GKPSKVSECF VARDPCDPPG RPEAIVITRN
NVTLKWKKPA YDGGSKITGY IVEKKDLPDG RWMKASFTNV LETEFTVSGL VEDQRYEFRV
IARNAAGNFS EPSDSSGAIT ARDEIDAPNA SLDPKYKDVI VVHAGETFVL EADIRGKPIP
DVVWSKDGKE LEETAARMEI KSTIQKTTLV VKDCIRTDGG QYILKLSNVG GTKSIPITVK
VLDRPGPPEG PLKVTGVTAE KCYLAWNPPL QDGGANISHY IIEKRETSRL SWTQVSTEVQ
ALNYKVTKLL PGNEYIFRVM AVNKYGIGEP LESGPVTACN PYKPPGPPST PEVSAITKDS
MVVTWARPVD DGGTEIEGYI LEKRDKEGVR WTKCNKKTLT DLRLRVTGLT EGHSYEFRVA
AENAAGVGEP SEPSVFYRAC DALYPPGPPS NPKVTDTSRS SVSLAWSKPI YDGGAPVKGY
VVEVKEAAAD EWTTCTPPTG LQGKQFTVTK LKENTEYNFR ICAINSEGVG EPATLPGSVV
AQERIEPPEI ELDADLRKVV VLRASATLRL FVTIKGRPEP EVKWEKAEGI LTDRAQIEVT
SSFTMLVIDN VTRFDSGRYN LTLENNSGSK TAFVNVRVLD SPSAPVNLTI REVKKDSVTL
SWEPPLIDGG AKITNYIVEK RETTRKAYAT ITNNCTKTTF RIENLQEGCS YYFRVLASNE
YGIGLPAETT EPVKVSEPPL PPGRVTLVDV TRNTATIKWE KPESDGGSKI TGYVVEMQTK
GSEKWSTCTQ VKTLEATISG LTAGEEYVFR VAAVNEKGRS DPRQLGVPVI ARDIEIKPSV
ELPFHTFNVK AREQLKIDVP FKGRPQATVN WRKDGQTLKE TTRVNVSSSK TVTSLSIKEA
SKEDVGTYEL CVSNSAGSIT VPITIIVLDR PGPPGPIRID EVSCDSITIS WNPPEYDGGC
QISNYIVEKK ETTSTTWHIV SQAVARTSIK IVRLTTGSEY QFRVCAENRY GKSSYSESSA
VVAEYPFSPP GPPGTPKVVH ATKSTMLVTW QVPVNDGGSR VIGYHLEYKE RSSILWSKAN
KILIADTQMK VSGLDEGLMY EYRVYAENIA GIGKCSKSCE PVPARDPCDP PGQPEVTNIT
RKSVSLKWSK PHYDGGAKIT GYIVERRELP DGRWLKCNYT NIQETYFEVT ELTEDQRYEF
RVFARNAADS VSEPSESTGP IIVKDDVEPP RVMMDVKFRD VIVVKAGEVL KINADIAGRP
LPVISWAKDG IEIEERARTE IISTDNHTLL TVKDCIRRDT GQYVLTLKNV AGTRSVAVNC
KVLDKPGPPA GPLEINGLTA EKCSLSWGRP QEDGGADIDY YIVEKRETSH LAWTICEGEL
QMTSCKVTKL LKGNEYIFRV TGVNKYGVGE PLESVAIKAL DPFTVPSPPT SLEITSVTKE
SMTLCWSRPE SDGGSEISGY IIERREKNSL RWVRVNKKPV YDLRVKSTGL REGCEYEYRV
YAENAAGLSL PSETSPLIRA EDPVFLPSPP SKPKIVDSGK TTITIAWVKP LFDGGAPITG
YTVEYKKSDD TDWKTSIQSL RGTEYTISGL TTGAEYVFRV KSVNKVGASD PSDSSDPQIA
KEREEEPLFD IDSEMRKTLI VKAGASFTMT VPFRGRPVPN VLWSKPDTDL RTRAYVDTTD
SRTSLTIENA NRNDSGKYTL TIQNVLSAAS LTLVVKVLDT PGPPTNITVQ DVTKESAVLS
WDVPENDGGA PVKNYHIEKR EASKKAWVSV TNNCNRLSYK VTNLQEGAIY YFRVSGENEF
GVGIPAETKE GVKITEKPSP PEKLGVTSIS KDSVSLTWLK PEHDGGSRIV HYVVEALEKG
QKNWVKCAVA KSTHHVVSGL RENSEYFFRV FAENQAGLSD PRELLLPVLI KEQLEPPEID
MKNFPSHTVY VRAGSNLKVD IPISGKPLPK VTLSRDGVPL KATMRFNTEI TAENLTINLK
ESVTADAGRY EITAANSSGT TKAFINIVVL DRPGPPTGPV VISDITEESV TLKWEPPKYD
GGSQVTNYIL LKRETSTAVW TEVSATVART MMKVMKLTTG EEYQFRIKAE NRFGISDHID
SACVTVKLPY TTPGPPSTPW VTNVTRESIT VGWHEPVSNG GSAVVGYHLE MKDRNSILWQ
KANKLVIRTT HFKVTTISAG LIYEFRVYAE NAAGVGKPSH PSEPVLAIDA CEPPRNVRIT
DISKNSVSLS WQQPAFDGGS KITGYIVERR DLPDGRWTKA SFTNVTETQF IISGLTQNSQ
YEFRVFARNA VGSISNPSEV VGPITCIDSY GGPVIDLPLE YTEVVKYRAG TSVKLRAGIS
GKPAPTIEWY KDDKELQTNA LVCVENTTDL ASILIKDADR LNSGCYELKL RNAMGSASAT
IRVQILDKPG PPGGPIEFKT VTAEKITLLW RPPADDGGAK ITHYIVEKRE TSRVVWSMVS
EHLEECIITT TKIIKGNEYI FRVRAVNKYG IGEPLESDSV VAKNAFVTPG PPGIPEVTKI
TKNSMTVVWS RPIADGGSDI SGYFLEKRDK KSLGWFKVLK ETIRDTRQKV TGLTENSDYQ
YRVCAVNAAG QGPFSEPSEF YKAADPIDPP GPPAKIRIAD STKSSITLGW SKPVYDGGSA
VTGYVVEIRQ GEEEEWTTVS TKGEVRTTEY VVSNLKPGVN YYFRVSAVNC AGQGEPIEMN
EPVQAKDILE APEIDLDVAL RTSVIAKAGE DVQVLIPFKG RPPPTVTWRK DEKNLGSDAR
YSIENTDSSS LLTIPQVTRN DTGKYILTIE NGVGEPKSST VSVKVLDTPA ACQKLQVKHV
SRGTVTLLWD PPLIDGGSPI INYVIEKRDA TKRTWSVVSH KCSSTSFKLI DLSEKTPFFF
RVLAENEIGI GEPCETTEPV KAAEVPAPIR DLSMKDSTKT SVILSWTKPD FDGGSVITEY
VVERKGKGEQ TWSHAGISKT CEIEVSQLKE QSVLEFRVFA KNEKGLSDPV TIGPITVKEL
IITPEVDLSD IPGAQVTVRI GHNVHLELPY KGKPKPSISW LKDGLPLKES EFVRFSKTEN
KITLSIKNAK KEHGGKYTVI LDNAVCRIAV PITVITLGPP SKPKGPIRFD EIKADSVILS
WDVPEDNGGG EITCYSIEKR ETSQTNWKMV CSSVARTTFK VPNLVKDAEY QFRVRAENRY
GVSQPLVSSI IVAKHQFRIP GPPGKPVIYN VTSDGMSLTW DAPVYDGGSE VTGFHVEKKE
RNSILWQKVN TSPISGREYR ATGLVEGLDY QFRVYAENSA GLSSPSDPSK FTLAVSPVDP
PGTPDYIDVT RETITLKWNP PLRDGGSKIV GYSIEKRQGN ERWVRCNFTD VSECQYTVTG
LSPGDRYEFR IIARNAVGTI SPPSQSSGII MTRDENVPPI VEFGPEYFDG LIIKSGESLR
IKALVQGRPV PRVTWFKDGV EIEKRMNMEI TDVLGSTSLF VRDATRDHRG VYTVEAKNAS
GSAKAEIKVK VQDTPGKVVG PIRFTNITGE KMTLWWDAPL NDGCAPITHY IIEKRETSRL
AWALIEDKCE AQSYTAIKLI NGNEYQFRVS AVNKFGVGRP LDSDPVVAQI QYTVPDAPGI
PEPSNITGNS ITLTWARPES DGGSEIQQYI LERREKKSTR WVKVISKRPI SETRFKVTGL
TEGNEYEFHV MAENAAGVGP ASGISRLIKC REPVNPPGPP TVVKVTDTSK TTVSLEWSKP
VFDGGMEIIG YIIEMCKADL GDWHKVNAEA CVKTRYTVTD LQAGEEYKFR VSAINGAGKG
DSCEVTGTIK AVDRLTAPEL DIDANFKQTH VVRAGASIRL FIAYQGRPTP TAVWSKPDSN
LSLRADIHTT DSFSTLTVEN CNRNDAGKYT LTVENNSGSK SITFTVKVLD TPGPPGPITF
KDVTRGSATL MWDAPLLDGG ARIHHYVVEK REASRRSWQV ISEKCTRQIF KVNDLAEGVP
YYFRVSAVNE YGVGEPYEMP EPIVATEQPA PPRRLDVVDT SKSSAVLAWL KPDHDGGSRI
TGYLLEMRQK GSDFWVEAGH TKQLTFTVER LVEKTEYEFR VKAKNDAGYS EPREAFSSVI
IKEPQIEPTA DLTGITNQLI TCKAGSPFTI DVPISGRPAP KVTWKLEEMR LKETDRVSIT
TTKDRTTLTV KDSMRGDSGR YFLTLENTAG VKTFSVTVVV IGRPGPVTGP IEVSSVSAES
CVLSWGEPKD GGGTEITNYI VEKRESGTTA WQLVNSSVKR TQIKVTHLTK YMEYSFRVSS
ENRFGVSKPL ESAPIIAEHP FVPPSAPTRP EVYHVSANAM SIRWEEPYHD GGSKIIGYWV
EKKERNTILW VKENKVPCLE CNYKVTGLVE GLEYQFRTYA LNAAGVSKAS EASRPIMAQN
PVDAPGRPEV TDVTRSTVSL IWSAPAYDGG SKVVGYIIER KPVSEVGDGR WLKCNYTIVS
DNFFTVTALS EGDTYEFRVL AKNAAGVISK GSESTGPVTC RDEYAPPKAE LDARLHGDLV
TIRAGSDLVL DAAVGGKPEP KIIWTKGDKE LDLCEKVSLQ YTGKRATAVI KFCDRSDSGK
YTLTVKNASG TKAVSVMVKV LDSPGPCGKL TVSRVTQEKC TLAWSLPQED GGAEITHYIV
ERRETSRLNW VIVEGECPTL SYVVTRLIKN NEYIFRVRAV NKYGPGVPVE SEPIVARNSF
TIPSPPGIPE EVGTGKEHII IQWTKPESDG GNEISNYLVD KREKKSLRWT RVNKDYVVYD
TRLKVTSLME GCDYQFRVTA VNAAGNSEPS EASNFISCRE PSYTPGPPSA PRVVDTTKHS
ISLAWTKPMY DGGTDIVGYV LEMQEKDTDQ WYRVHTNATI RNTEFTVPDL KMGQKYSFRV
AAVNVKGMSE YSESIAEIEP VERIEIPDLE LADDLKKTVT IRAGASLRLM VSVSGRPPPV
ITWSKQGIDL ASRAIIDTTE SYSLLIVDKV NRYDAGKYTI EAENQSGKKS ATVLVKVYDT
PGPCPSVKVK EVSRDSVTIT WEIPTIDGGA PVNNYIVEKR EAAMRAFKTV TTKCSKTLYR
ISGLVEGTMY YFRVLPENIY GIGEPCETSD AVLVSEVPLV PAKLEVVDVT KSTVTLAWEK
PLYDGGSRLT GYVLEACKAG TERWMKVVTL KPTVLEHTVT SLNEGEQYLF RIRAQNEKGV
SEPRETVTAV TVQDLRVLPT IDLSTMPQKT IHVPAGRPVE LVIPIAGRPP PAASWFFAGS
KLRESERVTV ETHTKVAKLT IRETTIRDTG EYTLELKNVT GTTSETIKVI ILDKPGPPTG
PIKIDEIDAT SITISWEPPE LDGGAPLSGY VVEQRDAHRP GWLPVSESVT RSTFKFTRLT
EGNEYVFRVA ATNRFGIGSY LQSEVIECRS SIRIPGPPET LQIFDVSRDG MTLTWYPPED
DGGSQVTGYI VERKEVRADR WVRVNKVPVT MTRYRSTGLT EGLEYEHRVT AINARGSGKP
SRPSKPIVAM DPIAPPGKPQ NPRVTDTTRT SVSLAWSVPE DEGGSKVTGY LIEMQKVDQH
EWTKCNTTPT KIREYTLTHL PQGAEYRFRV LACNAGGPGE PAEVPGTVKV TEMLEYPDYE
LDERYQEGIF VRQGGVIRLT IPIKGKPFPI CKWTKEGQDI SKRAMIATSE THTELVIKEA
DRGDSGTYDL VLENKCGKKA VYIKVRVIGS PNSPEGPLEY DDIQVRSVRV SWRPPADDGG
ADILGYILER REVPKAAWYT IDSRVRGTSL VVKGLKENVE YHFRVSAENQ FGISKPLKSE
EPVTPKTPLN PPEPPSNPPE VLDVTKSSVS LSWSRPKDDG GSRVTGYYIE RKETSTDKWV
RHNKTQITTT MYTVTGLVPD AEYQFRIIAQ NDVGLSETSP ASEPVVCKDP FDKPSQPGEL
EILSISKDSV TLQWEKPECD GGKEILGYWV EYRQSGDSAW KKSNKERIKD KQFTIGGLLE
ATEYEFRVFA ENETGLSRPR RTAMSIKTKL TSGEAPGIRK EMKDVTTKLG EAAQLSCQIV
GRPLPDIKWY RFGKELIQSR KYKMSSDGRT HTLTVMTEEQ EDEGVYTCIA TNEVGEVETS
SKLLLQATPQ FHPGYPLKEK YYGAVGSTLR LHVMYIGRPV PAMTWFHGQK LLQNSENITI
ENTEHYTHLV MKNVQRKTHA GKYKVQLSNV FGTVDAILDV EIQDKPDKPT GPIVIEALLK
NSAVISWKPP ADDGGSWITN YVVEKCEAKE GAEWQLVSSA ISVTTCRIVN LTENAGYYFR
VSAQNTFGIS DPLEVSSVVI IKSPFEKPGA PGKPTITAVT KDSCVVAWKP PASDGGAKIR
NYYLEKREKK QNKWISVTTE EIRETVFSVK NLIEGLEYEF RVKCENLGGE SEWSEISEPI
TPKSDVPIQA PHFKEELRNL NVRYQSNATL VCKVTGHPKP IVKWYRQGKE IIADGLKYRI
QEFKGGYHQL IIASVTDDDA TVYQVRATNQ GGSVSGTASL EVEVPAKIHL PKTLEGMGAV
HALRGEVVSI KIPFSGKPDP VITWQKGQDL IDNNGHYQVI VTRSFTSLVF PNGVERKDAG
FYVVCAKNRF GIDQKTVELD VADVPDPPRG VKVSDVSRDS VNLTWTEPAS DGGSKITNYI
VEKCATTAER WLRVGQARET RYTVINLFGK TSYQFRVIAE NKFGLSKPSE PSEPTITKED
KTRAMNYDEE VDETREVSMT KASHSSTKEL YEKYMIAEDL GRGEFGIVHR CVETSSKKTY
MAKFVKVKGT DQVLVKKEIS ILNIARHRNI LHLHESFESM EELVMIFEFI SGLDIFERIN
TSAFELNERE IVSYVHQVCE ALQFLHSHNI GHFDIRPENI IYQTRRSSTI KIIEFGQARQ
LKPGDNFRLL FTAPEYYAPE VHQHDVVSTA TDMWSLGTLV YVLLSGINPF LAETNQQIIE
NIMNAEYTFD EEAFKEISIE AMDFVDRLLV KERKSRMTAS EALQHPWLKQ KIERVSTKVI
RTLKHRRYYH TLIKKDLNMV VSAARISCGG AIRSQKGVSV AKVKVASIEI GPVSGQIMHA
VGEEGGHVKY VCKIENYDQS TQVTWYFGVR QLENSEKYEI TYEDGVAILY VKDITKLDDG
TYRCKVVNDY GEDSSYAELF VKGVREVYDY YCRRTMKKIK RRTDTMRLLE RPPEFTLPLY
NKTAYVGENV RFGVTITVHP EPHVTWYKSG QKIKPGDNDK KYTFESDKGL YQLTINSVTT
DDDAEYTVVA RNKYGEDSCK AKLTVTLHPP PTDSTLRPMF KRLLANAECQ EGQSVCFEIR
VSGIPPPTLK WEKDGQPLSL GPNIEIIHEG LDYYALHIRD TLPEDTGYYR VTATNTAGST
SCQAHLQVER LRYKKQEFKS KEEHERHVQK QIDKTLRMAE ILSGTESVPL TQVAKEALRE
AAVLYKPAVS TKTVKGEFRL EIEEKKEERK LRMPYDVPEP RKYKQTTIEE DQRIKQFVPM
SDMKWYKKIR DQYEMPGKLD RVVQKRPKRI RLSRWEQFYV MPLPRITDQY RPKWRIPKLS
QDDLEIVRPA RRRTPSPDYD FYYRPRRRSL GDISDEELLL PIDDYLAMKR TEEERLRLEE
ELELGFSASP PSRSPPHFEL SSLRYSSPQA HVKVEETRKD FRYSTYHIPT KAEASTSYAE
LRERHAQAAY RQPKQRQRIM AEREDEELLR PVTTTQHLSE YKSELDFMSK EEKSRKKSRR
QREVTEITEI EEEYEISKHA QRESSSSASR LLRRRRSLSP TYIELMRPVS ELIRSRPQPA
EEYEDDTERR SPTPERTRPR SPSPVSSERS LSRFERSARF DIFSRYESMK AALKTQKTSE
RKYEVLSQQP FTLDHAPRIT LRMRSHRVPC GQNTRFILNV QSKPTAEVKW YHNGVELQES
SKIHYTNTSG VLTLEILDCH TDDSGTYRAV CTNYKGEASD YATLDVTGGD YTTYASQRRD
EEVPRSVFPE LTRTEAYAVS SFKKTSEMEA SSSVREVKSQ MTETRESLSS YEHSASAEMK
SAALEEKSLE EKSTTRKIKT TLAARILTKP RSMTVYEGES ARFSCDTDGE PVPTVTWLRK
GQVLSTSARH QVTTTKYKST FEISSVQASD EGNYSVVVEN SEGKQEAEFT LTIQKARVTE
KAVTSPPRVK SPEPRVKSPE AVKSPKRVKS PEPSHPKAVS PTETKPTPTE KVQHLPVSAP
PKITQFLKAE ASKEIAKLTC VVESSVLRAK EVTWYKDGKK LKENGHFQFH YSADGTYELK
INNLTESDQG EYVCEISGEG GTSKTNLQFM GQAFKSIHEK VSKISETKKS DQKTTESTVT
RKTEPKAPEP ISSKPVIVTG LQDTTVSSDS VAKFAVKATG EPRPTAIWTK DGKAITQGGK
YKLSEDKGGF FLEIHKTDTS DSGLYTCTVK NSAGSVSSSC KLTIKAIKDT EAQKVSTQKT
SEITPQKKAV VQEEISQKAL RSEEIKMSEA KSQEKLALKE EASKVLISEE VKKSAATSLE
KSIVHEEITK TSQASEEVRT HAEIKAFSTQ MSINEGQRLV LKANIAGATD VKWVLNGVEL
TNSEEYRYGV SGSDQTLTIK QASHRDEGIL TCISKTKEGI VKCQYDLTLS KELSDAPAFI
SQPRSQNINE GQNVLFTCEI SGEPSPEIEW FKNNLPISIS SNVSISRSRN VYSLEIRNAS
VSDSGKYTIK AKNFRGQCSA TASLMVLPLV EEPSREVVLR TSGDTSLQGS FSSQSVQMSA
SKQEASFSSF SSSSASSMTE MKFASMSAQS MSSMQESFVE MSSSSFMGIS NMTQLESSTS
KMLKAGIRGI PPKIEALPSD ISIDEGKVLT VACAFTGEPT PEVTWSCGGR KIHSQEQGRF
HIENTDDLTT LIIMDVQKQD GGLYTLSLGN EFGSDSATVN IHIRSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

80710

Theoretical NMD boundary in CDS

80434

Length of CDS

80781

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.05 s

Back to summary table

Variant:

2:178745884C>A_1_ENST00000342175

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 140|60 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.44, LOF (oe): 0.42, misssense (oe): 0.89, synonymous (oe): 0.89 ? (gnomAD)

Ensembl transcript ID

ENST00000342175.12

Genbank transcript ID

NM_133437 (by similarity)

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10799-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIMKETR KTVVPKVIVA TPKVKEQDLV SRGREGITTK REQVQITQEK
MRKEAEKTAL STIAVATAKA KEQETILRTR ETMATRQEQI QVTHGKVDVG KKAEAVATVV
AAVDQARVRE PREPGHLEES YAQQTTLEYG YKERISAAKV AEPPQRPASE PHVVPKAVKP
RVIQAPSETH IKTTDQKGMH ISSQIKKTTD LTTERLVHVD KRPRTASPHF TVSKISVPKT
EHGYEASIAG SAIATLQKEL SATSSAQKIT KSVKAPTVKP SETRVRAEPT PLPQFPFADT
PDTYKSEAGV EVKKEVGVSI TGTTVREERF EVLHGREAKV TETARVPAPV EIPVTPPTLV
SGLKNVTVIE GESVTLECHI SGYPSPTVTW YREDYQIESS IDFQITFQSG IARLMIREAF
AEDSGRFTCS AVNEAGTVST SCYLAVQVSE EFEKETTAVT EKFTTEEKRF VESRDVVMTD
TSLTEEQAGP GEPAAPYFIT KPVVQKLVEG GSVVFGCQVG GNPKPHVYWK KSGVPLTTGY
RYKVSYNKQT GECKLVISMT FADDAGEYTI VVRNKHGETS ASASLLEEAD YELLMKSQQE
MLYQTQVTAF VQEPKVGETA PGFVYSEYEK EYEKEQALIR KKMAKDTVVV RTYVEDQEFH
ISSFEERLIK EIEYRIIKTT LEELLEEDGE EKMAVDISES EAVESGFDSR IKNYRILEGM
GVTFHCKMSG YPLPKIAWYK DGKRIKHGER YQMDFLQDGR ASLRIPVVLP EDEGIYTAFA
SNIKGNAICS GKLYVEPAAP LGAPTYIPTL EPVSRIRSLS PRSVSRSPIR MSPARMSPAR
MSPARMSPAR MSPGRRLEET DESQLERLYK PVFVLKPVSF KCLEGQTARF DLKVVGRPMP
ETFWFHDGQQ IVNDYTHKVV IKEDGTQSLI IVPATPSDSG EWTVVAQNRA GRSSISVILT
VEAVEHQVKP MFVEKLKNVN IKEGSRLEMK VRATGNPNPD IVWLKNSDII VPHKYPKIRI
EGTKGEAALK IDSTVSQDSA WYTATAINKA GRDTTRCKVN VEVEFAEPEP ERKLIIPRGT
YRAKEIAAPE LEPLHLRYGQ EQWEEGDLYD KEKQQKPFFK KKLTSLRLKR FGPAHFECRL
TPIGDPTMVV EWLHDGKPLE AANRLRMINE FGYCSLDYGV AYSRDSGIIT CRATNKYGTD
HTSATLIVKD EKSLVEESQL PEGRKGLQRI EELERMAHEG ALTGVTTDQK EKQKPDIVLY
PEPVRVLEGE TARFRCRVTG YPQPKVNWYL NGQLIRKSKR FRVRYDGIHY LDIVDCKSYD
TGEVKVTAEN PEGVIEHKVK LEIQQREDFR SVLRRAPEPR PEFHVHEPGK LQFEVQKVDR
PVDTTETKEV VKLKRAERIT HEKVPEESEE LRSKFKRRTE EGYYEAITAV ELKSRKKDES
YEELLRKTKD ELLHWTKELT EEEKKALAEE GKITIPTFKP DKIELSPSME APKIFERIQS
QTVGQGSDAH FRVRVVGKPD PECEWYKNGV KIERSDRIYW YWPEDNVCEL VIRDVTAEDS
ASIMVKAINI AGETSSHAFL LVQAKQLITF TQELQDVVAK EKDTMATFEC ETSEPFVKVK
WYKDGMEVHE GDKYRMHSDR KVHFLSILTI DTSDAEDYSC VLVEDENVKT TAKLIVEGAV
VEFVKELQDI EVPESYSGEL ECIVSPENIE GKWYHNDVEL KSNGKYTITS RRGRQNLTVK
DVTKEDQGEY SFVIDGKKTT CKLKMKPRPI AILQGLSDQK VCEGDIVQLE VKVSLESVEG
VWMKDGQEVQ PSDRVHIVID KQSHMLLIED MTKEDAGNYS FTIPALGLST SGRVSVYSVD
VITPLKDVNV IEGTKAVLEC KVSVPDVTSV KWYLNDEQIK PDDRVQAIVK GTKQRLVINR
THASDEGPYK LIVGRVETNC NLSVEKIKII RGLRDLTCTE TQNVVFEVEL SHSGIDVLWN
FKDKEIKPSS KYKIEAHGKI YKLTVLNMMK DDEGKYTFYA GENMTSGKLT VAGGAISKPL
TDQTVAESQE AVFECEVANP DSKGEWLRDG KHLPLTNNIR SESDGHKRRL IIAATKLDDI
GEYTYKVATS KTSAKLKVEA VKIKKTLKNL TVTETQDAVF TVELTHPNVK GVQWIKNGVV
LESNEKYAIS VKGTIYSLRI KNCAIVDESV YGFRLGRLGA SARLHVETVK IIKKPKDVTA
LENATVAFEV SVSHDTVPVK WFHKSVEIKP SDKHRLVSER KVHKLMLQNI SPSDAGEYTA
VVGQLECKAK LFVETLHITK TMKNIEVPET KTASFECEVS HFNVPSMWLK NGVEIEMSEK
FKIVVQGKLH QLIIMNTSTE DSAEYTFVCG NDQVSATLTV TPIMITSMLK DINAEEKDTI
TFEVTVNYEG ISYKWLKNGV EIKSTDKCQM RTKKLTHSLN IRNVHFGDAA DYTFVAGKAT
STATLYVEAR HIEFRKHIKD IKVLEKKRAM FECEVSEPDI TVQWMKDDQE LQITDRIKIQ
KEKYVHRLLI PSTRMSDAGK YTVVAGGNVS TAKLFVEGRD VRIRSIKKEV QVIEKQRAVV
EFEVNEDDVD AHWYKDGIEI NFQVQERHKY VVERRIHRMF ISETRQSDAG EYTFVAGRNR
SSVTLYVNAP EPPQVLQELQ PVTVQSGKPA RFCAVISGRP QPKISWYKEE QLLSTGFKCK
FLHDGQEYTL LLIEAFPEDA AVYTCEAKND YGVATTSASL SVEVPEVVSP DQEMPVYPPA
IITPLQDTVT SEGQPARFQC RVSGTDLKVS WYSKDKKIKP SRFFRMTQFE DTYQLEIAEA
YPEDEGTYTF VASNAVGQVS STANLSLEVQ ALDRQSSGKD VRESTKSQAV ADSSFTKEES
KISQKEIKSF QGSSYEYEVQ VFESVSQSSI HTAASVQDTQ LCHTASLSQI AESTELSKEC
AKESTGEAPK IFLHLQDVTV KCGDTAQFLC VLKDDSFIDV TWTHEGAKIE ESERLKQSQN
GNIQFLTICN VQLVDQGLYS CIVHNDCGER TTSAVLSVEG APESILHERI EQEIEMEMKE
FSSSFLSAEE EGLHSAELQL SKINETLELL SESPVYPTKF DSEKEGTGPI FIKEVSNADI
SMGDVATLSV TVIGIPKPKI QWFFNGVLLT PSADYKFVFD GDDHSLIILF TKLEDEGEYT
CMASNDYGKT ICSAYLKINS KGEGHKDTET ESAVAKSLEK LGGPCPPHFL KELKPIRCAQ
GLPAIFEYTV VGEPAPTVTW FKENKQLCTS VYYTIIHNPN GSGTFIVNDP QREDSGLYIC
KAENMLGEST CAAELLVLLE DTDMTDTPCK AKSTPEAPED FPQTPLKGPA VEALDSEQEI
ATFVKDTILK AALITEENQQ LSYEHIAKAN ELSSQLPLGA QELQSILEQD KLTPESTREF
LCINGSIHFQ PLKEPSPNLQ LQIVQSQKTF SKEGILMPEE PETQAVLSDT EKIFPSAMSI
EQINSLTVEP LKTLLAEPEG NYPQSSIEPP MHSYLTSVAE EVLSPKEKTV SDTNREQRVT
LQKQEAQSAL ILSQSLAEGH VESLQSPDVM ISQVNYEPLV PSEHSCTEGG KILIESANPL
ENAGQDSAVR IEEGKSLRFP LALEEKQVLL KEEHSDNVVM PPDQIIESKR EPVAIKKVQE
VQGRDLLSKE SLLSGIPEEQ RLNLKIQICR ALQAAVASEQ PGLFSEWLRN IEKVEVEAVN
ITQEPRHIMC MYLVTSAKSV TEEVTIIIED VDPQMANLKM ELRDALCAII YEEIDILTAE
GPRIQQGAKT SLQEEMDSFS GSQKVEPITE PEVESKYLIS TEEVSYFNVQ SRVKYLDATP
VTKGVASAVV SDEKQDESLK PSEEKEESSS ESGTEEVATV KIQEAEGGLI KEDGPMIHTP
LVDTVSEEGD IVHLTTSITN AKEVNWYFEN KLVPSDEKFK CLQDQNTYTL VIDKVNTEDH
QGEYVCEALN DSGKTATSAK LTVVKRAAPV IKRKIEPLEV ALGHLAKFTC EIQSAPNVRF
QWFKAGREIY ESDKCSIRSS KYISSLEILR TQVVDCGEYT CKASNEYGSV SCTATLTVTV
PGGEKKVRKL LPERKPEPKE EVVLKSVLRK RPEEEEPKVE PKKLEKVKKP AVPEPPPPKP
VEEVEVPTVT KRERKIPEPT KVPEIKPAIP LPAPEPKPKP EAEVKTIKPP PVEPEPTPIA
APVTVPVVGK KAEAKAPKEE AAKPKGPIKG VPKKTPSPIE AERRKLRPGS GGEKPPDEAP
FTYQLKAVPL KFVKEIKDII LTESEFVGSS AIFECLVSPS TAITTWMKDG SNIRESPKHR
FIADGKDRKL HIIDVQLSDA GEYTCVLRLG NKEKTSTAKL VVEELPVRFV KTLEEEVTVV
KGQPLYLSCE LNKERDVVWR KDGKIVVEKP GRIVPGVIGL MRALTINDAD DTDAGTYTVT
VENANNLECS SCVKVVEVIR DWLVKPIRDQ HVKPKGTAIF ACDIAKDTPN IKWFKGYDEI
PAEPNDKTEI LRDGNHLYLK IKNAMPEDIA EYAVEIEGKR YPAKLTLGER EVELLKPIED
VTIYEKESAS FDAEISEADI PGQWKLKGEL LRPSPTCEIK AEGGKRFLTL HKVKLDQAGE
VLYQALNAIT TAILTVKEIE LDFAVPLKDV TVPERRQARF ECVLTREANV IWSKGPDIIK
SSDKFDIIAD GKKHILVIND SQFDDEGVYT AEVEGKKTSA RLFVTGIRLK FMSPLEDQTV
KEGETATFVC ELSHEKMHVV WFKNDAKLHT SRTVLISSEG KTHKLEMKEV TLDDISQIKA
QVKELSSTAQ LKVLEADPYF TVKLHDKTAV EKDEITLKCE VSKDVPVKWF KDGEEIVPSP
KYSIKADGLR RILKIKKADL KDKGEYVCDC GTDKTKANVT VEARLIKVEK PLYGVEVFVG
ETAHFEIELS EPDVHGQWKL KGQPLTASPD CEIIEDGKKH ILILHNCQLG MTGEVSFQAA
NAKSAANLKV KELPLIFITP LSDVKVFEKD EAKFECEVSR EPKTFRWLKG TQEITGDDRF
ELIKDGTKHS MVIKSAAFED EAKYMFEAED KHTSGKLIIE GIRLKFLTPL KDVTAKEKES
AVFTVELSHD NIRVKWFKND QRLHTTRSVS MQDEGKTHSI TFKDLSIDDT SQIRVEAMGM
SSEAKLTVLE GDPYFTGKLQ DYTGVEKDEV ILQCEISKAD APVKWFKDGK EIKPSKNAVI
KADGKKRMLI LKKALKSDIG QYTCDCGTDK TSGKLDIEDR EIKLVRPLHS VEVMETETAR
FETEISEDDI HANWKLKGEA LLQTPDCEIK EEGKIHSLVL HNCRLDQTGG VDFQAANVKS
SAHLRVKPRV IGLLRPLKDV TVTAGETATF DCELSYEDIP VEWYLKGKKL EPSDKVVPRS
EGKVHTLTLR DVKLEDAGEV QLTAKDFKTH ANLFVKEPPV EFTKPLEDQT VEEGATAVLE
CEVSRENAKV KWFKNGTEIL KSKKYEIVAD GRVRKLVIHD CTPEDIKTYT CDAKDFKTSC
NLNVVPPHVE FLRPLTDLQV REKEMARFEC ELSRENAKVK WFKDGAEIKK GKKYDIISKG
AVRILVINKC LLDDEAEYSC EVRTARTSGM LTVLEEEAVF TKNLANIEVS ETDTIKLVCE
VSKPGAEVIW YKGDEEIIET GRYEILTEGR KRILVIQNAH LEDAGNYNCR LPSSRTDGKV
KVHELAAEFI SKPQNLEILE GEKAEFVCSI SKESFPVQWK RDDKTLESGD KYDVIADGKK
RVLVVKDATL QDMGTYVVMV GAARAAAHLT VIEKLRIVVP LKDTRVKEQQ EVVFNCEVNT
EGAKAKWFRN EEAIFDSSKY IILQKDLVYT LRIRDAHLDD QANYNVSLTN HRGENVKSAA
NLIVEEEDLR IVEPLKDIET MEKKSVTFWC KVNRLNVTLK WTKNGEEVPF DNRVSYRVDK
YKHMLTIKDC GFPDEGEYIV TAGQDKSVAE LLIIEAPTEF VEHLEDQTVT EFDDAVFSCQ
LSREKANVKW YRNGREIKEG KKYKFEKDGS IHRLIIKDCR LDDECEYACG VEDRKSRARL
FVEEIPVEII RPPQDILEAP GADVVFLAEL NKDKVEVQWL RNNMVVVQGD KHQMMSEGKI
HRLQICDIKP RDQGEYRFIA KDKEARAKLE LAAAPKIKTA DQDLVVDVGK PLTMVVPYDA
YPKAEAEWFK ENEPLSTKTI DTTAEQTSFR ILEAKKGDKG RYKIVLQNKH GKAEGFINLK
VIDVPGPVRN LEVTETFDGE VSLAWEEPLT DGGSKIIGYV VERRDIKRKT WVLATDRAES
CEFTVTGLQK GGVEYLFRVS ARNRVGTGEP VETDNPVEAR SKYDVPGPPL NVTITDVNRF
GVSLTWEPPE YDGGAEITNY VIELRDKTSI RWDTAMTVRA EDLSATVTDV VEGQEYSFRV
RAQNRIGVGK PSAATPFVKV ADPIERPSPP VNLTSSDQTQ SSVQLKWEPP LKDGGSPILG
YIIERCEEGK DNWIRCNMKL VPELTYKVTG LEKGNKYLYR VSAENKAGVS DPSEILGPLT
ADDAFVEPTM DLSAFKDGLE VIVPNPITIL VPSTGYPRPT ATWCFGDKVL ETGDRVKMKT
LSAYAELVIS PSERSDKGIY TLKLENRVKT ISGEIDVNVI ARPSAPKELK FGDITKDSVH
LTWEPPDDDG GSPLTGYVVE KREVSRKTWT KVMDFVTDLE FTVPDLVQGK EYLFKVCARN
KCGPGEPAYV DEPVNMSTPA TVPDPPENVK WRDRTANSIF LTWDPPKNDG GSRIKGYIVE
RCPRGSDKWV ACGEPVAETK MEVTGLEEGK WYAYRVKALN RQGASKPSRP TEEIQAVDTQ
EAPEIFLDVK LLAGLTVKAG TKIELPATVT GKPEPKITWT KADMILKQDK RITIENVPKK
STVTIVDSKR SDTGTYIIEA VNVCGRATAV VEVNVLDKPG PPAAFDITDV TNESCLLTWN
PPRDDGGSKI TNYVVERRAT DSEVWHKLSS TVKDTNFKAT KLIPNKEYIF RVAAENMYGV
GEPVQASPIT AKYQFDPPGP PTRLEPSDIT KDAVTLTWCE PDDDGGSPIT GYWVERLDPD
TDKWVRCNKM PVKDTTYRVK GLTNKKKYRF RVLAENLAGP GKPSKSTEPI LIKDPIDPPW
PPGKPTVKDV GKTSVRLNWT KPEHDGGAKI ESYVIEMLKT GTDEWVRVAE GVPTTQHLLP
GLMEGQEYSF RVRAVNKAGE SEPSEPSDPV LCREKLYPPS PPRWLEVINI TKNTADLKWT
VPEKDGGSPI TNYIVEKRDV RRKGWQTVDT TVKDTKCTVT PLTEGSLYVF RVAAENAIGQ
SDYTEIEDSV LAKDTFTTPG PPYALAVVDV TKRHVDLKWE PPKNDGGRPI QRYVIEKKER
LGTRWVKAGK TAGPDCNFRV TDVIEGTEVQ FQVRAENEAG VGHPSEPTEI LSIEDPTSPP
SPPLDLHVTD AGRKHIAIAW KPPEKNGGSP IIGYHVEMCP VGTEKWMRVN SRPIKDLKFK
VEEGVVPDKE YVLRVRAVNA IGVSEPSEIS ENVVAKDPDC KPTIDLETHD IIVIEGEKLS
IPVPFRAVPV PTVSWHKDGK EVKASDRLTM KNDHISAHLE VPKSVRADAG IYTITLENKL
GSATASINVK VIGLPGPCKD IKASDITKSS CKLTWEPPEF DGGTPILHYV LERREAGRRT
YIPVMSGENK LSWTVKDLIP NGEYFFRVKA VNKVGGGEYI ELKNPVIAQD PKQPPDPPVD
VEVHNPTAEA MTITWKPPLY DGGSKIMGYI IEKIAKGEER WKRCNEHLVP ILTYTAKGLE
EGKEYQFRVR AENAAGISEP SRATPPTKAV DPIDAPKVIL RTSLEVKRGD EIALDASISG
SPYPTITWIK DENVIVPEEI KKRAAPLVRR RKGEVQEEEP FVLPLTQRLS IDNSKKGESQ
LRVRDSLRPD HGLYMIKVEN DHGIAKAPCT VSVLDTPGPP INFVFEDIRK TSVLCKWEPP
LDDGGSEIIN YTLEKKDKTK PDSEWIVVTS TLRHCKYSVT KLIEGKEYLF RVRAENRFGP
GPPCVSKPLV AKDPFGPPDA PDKPIVEDVT SNSMLVKWNE PKDNGSPILG YWLEKREVNS
THWSRVNKSL LNALKANVDG LLEGLTYVFR VCAENAAGPG KFSPPSDPKT AHDPISPPGP
PIPRVTDTSS TTIELEWEPP AFNGGGEIVG YFVDKQLVGT NEWSRCTEKM IKVRQYTVKE
IREGADYKLR VSAVNAAGEG PPGETQPVTV AEPQEPPAVE LDVSVKGGIQ IMAGKTLRIP
AVVTGRPVPT KVWTKEEGEL DKDRVVIDNV GTKSELIIKD ALRKDHGRYV ITATNSCGSK
FAAARVEVFD VPGPVLDLKP VVTNRKMCLL NWSDPEDDGG SEITGFIIER KDAKMHTWRQ
PIETERSKCD ITGLLEGQEY KFRVIAKNKF GCGPPVEIGP ILAVDPLGPP TSPERLTYTE
RTKSTITLDW KEPRSNGGSP IQGYIIEKRR HDKPDFERVN KRLCPTTSFL VENLDEHQMY
EFRVKAVNEI GESEPSLPLN VVIQDDEVPP TIKLRLSVRG DTIKVKAGEP VHIPADVTGL
PMPKIEWSKN ETVIEKPTDA LQITKEEVSR SEAKTELSIP KAVREDKGTY TVTASNRLGS
VFRNVHVEVY DRPSPPRNLA VTDIKAESCY LTWDAPLDNG GSEITHYVID KRDASRKKAE
WEEVTNTAVE KRYGIWKLIP NGQYEFRVRA VNKYGISDEC KSDKVVIQDP YRLPGPPGKP
KVLARTKGSM LVSWTPPLDN GGSPITGYWL EKREEGSPYW SRVSRAPITK VGLKGVEFNV
PRLLEGVKYQ FRAMAINAAG IGPPSEPSDP EVAGDPIFPP GPPSCPEVKD KTKSSISLGW
KPPAKDGGSP IKGYIVEMQE EGTTDWKRVN EPDKLITTCE CVVPNLKELR KYRFRVKAVN
EAGESEPSDT TGEIPATDIQ EEPEVFIDIG AQDCLVCKAG SQIRIPAVIK GRPTPKSSWE
FDGKAKKAMK DGVHDIPEDA QLETAENSSV IIIPECKRSH TGKYSITAKN KAGQKTANCR
VKVMDVPGPP KDLKVSDITR GSCRLSWKMP DDDGGDRIKG YVIEKRTIDG KAWTKVNPDC
GSTTFVVPDL LSEQQYFFRV RAENRFGIGP PVETIQRTTA RDPIYPPDPP IKLKIGLITK
NTVHLSWKPP KNDGGSPVTH YIVECLAWDP TGTKKEAWRQ CNKRDVEELQ FTVEDLVEGG
EYEFRVKAVN AAGVSKPSAT VGPVTVKDQT CPPSIDLKEF MEVEEGTNVN IVAKIKGVPF
PTLTWFKAPP KKPDNKEPVL YDTHVNKLVV DDTCTLVIPQ SRRSDTGLYT ITAVNNLGTA
SKEMRLNVLG RPGPPVGPIK FESVSADQMT LSWFPPKDDG GSKITNYVIE KREANRKTWV
HVSSEPKECT YTIPKLLEGH EYVFRIMAQN KYGIGEPLDS EPETARNLFS VPGAPDKPTV
SSVTRNSMTV NWEEPEYDGG SPVTGYWLEM KDTTSKRWKR VNRDPIKAMT LGVSYKVTGL
IEGSDYQFRV YAINAAGVGP ASLPSDPATA RDPIAPPGPP FPKVTDWTKS SADLEWSPPL
KDGGSKVTGY IVEYKEEGKE EWEKGKDKEV RGTKLVVTGL KEGAFYKFRV RAVNIAGIGE
PGEVTDVIEM KDRLVSPDLQ LDASVRDRIV VHAGGVIRII AYVSGKPPPT VTWNMNERTL
PQEATIETTA ISSSMVIKNC QRSHQGVYSL LAKNEAGERK KTIIVDVLDV PGPVGTPFLA
HNLTNESCKL TWFSPEDDGG SPITNYVIEK RESDRRAWTP VTYTVTRQNA TVQGLIQGKA
YFFRIAAENS IGMGPFVETS EALVIREPIT VPERPEDLEV KEVTKNTVTL TWNPPKYDGG
SEIINYVLES RLIGTEKFHK VTNDNLLSRK YTVKGLKEGD TYEYRVSAVN IVGQGKPSFC
TKPITCKDEL APPTLHLDFR DKLTIRVGEA FALTGRYSGK PKPKVSWFKD EADVLEDDRT
HIKTTPATLA LEKIKAKRSD SGKYCVVVEN STGSRKGFCQ VNVVDRPGPP VGPVSFDEVT
KDYMVISWKP PLDDGGSKIT NYIIEKKEVG KDVWMPVTSA SAKTTCKVSK LLEGKDYIFR
IHAENLYGIS DPLVSDSMKA KDRFRVPDAP DQPIVTEVTK DSALVTWNKP HDGGKPITNY
ILEKRETMSK RWARVTKDPI HPYTKFRVPD LLEGCQYEFR VSAENEIGIG DPSPPSKPVF
AKDPIAKPSP PVNPEAIDTT CNSVDLTWQP PRHDGGSKIL GYIVEYQKVG DEEWRRANHT
PESCPETKYK VTGLRDGQTY KFRVLAVNAA GESDPAHVPE PVLVKDRLEP PELILDANMA
REQHIKVGDT LRLSAIIKGV PFPKVTWKKE DRDAPTKARI DVTPVGSKLE IRNAAHEDGG
IYSLTVENPA GSKTVSVKVL VLDKPGPPRD LEVSEIRKDS CYLTWKEPLD DGGSVITNYV
VERRDVASAQ WSPLSATSKK KSHFAKHLNE GNQYLFRVAA ENQYGRGPFV ETPKPIKALD
PLHPPGPPKD LHHVDVDKTE VSLVWNKPDR DGGSPITGYL VEYQEEGTQD WIKFKTVTNL
ECVVTGLQQG KTYRFRVKAE NIVGLGLPDT TIPIECQEKL VPPSVELDVK LIEGLVVKAG
TTVRFPAIIR GVPVPTAKWT TDGSEIKTDE HYTVETDNFS SVLTIKNCLR RDTGEYQITV
SNAAGSKTVA VHLTVLDVPG PPTGPINILD VTPEHMTISW QPPKDDGGSP VINYIVEKQD
TRKDTWGVVS SGSSKTKLKI PHLQKGCEYV FRVRAENKIG VGPPLDSTPT VAKHKFSPPS
PPGKPVVTDI TENAATVSWT LPKSDGGSPI TGYYMERREV TGKWVRVNKT PIADLKFRVT
GLYEGNTYEF RVFAENLAGL SKPSPSSDPI KACRPIKPPG PPINPKLKDK SRETADLVWT
KPLSDGGSPI LGYVVECQKP GTAQWNRINK DELIRQCAFR VPGLIEGNEY RFRIKAANIV
GEGEPRELAE SVIAKDILHP PEVELDVTCR DVITVRVGQT IRILARVKGR PEPDITWTKE
GKVLVREKRV DLIQDLPRVE LQIKEAVRAD HGKYIISAKN SSGHAQGSAI VNVLDRPGPC
QNLKVTNVTK ENCTISWENP LDNGGSEITN FIVEYRKPNQ KGWSIVASDV TKRLIKANLL
ANNEYYFRVC AENKVGVGPT IETKTPILAI NPIDRPGEPE NLHIADKGKT FVYLKWRRPD
YDGGSPNLSY HVERRLKGSD DWERVHKGSI KETHYMVDRC VENQIYEFRV QTKNEGGESD
WVKTEEVVVK EDLQKPVLDL KLSGVLTVKA GDTIRLEAGV RGKPFPEVAW TKDKDATDLT
RSPRVKIDTR ADSSKFSLTK AKRSDGGKYV VTATNTAGSF VAYATVNVLD KPGPVRNLKI
VDVSSDRCTV CWDPPEDDGG CEIQNYILEK CETKRMVWST YSATVLTPGT TVTRLIEGNE
YIFRVRAENK IGTGPPTESK PVIAKTKYDK PGRPDPPEVT KVSKEEMTVV WNPPEYDGGK
SITGYFLEKK EKHSTRWVPV NKSAIPERRM KVQNLLPDHE YQFRVKAENE IGIGEPSLPS
RPVVAKDPIE PPGPPTNFRV VDTTKHSITL GWGKPVYDGG APIIGYVVEM RPKIADASPD
EGWKRCNAAA QLVRKEFTVT SLDENQEYEF RVCAQNQVGI GRPAELKEAI KPKEILEPPE
IDLDASMRKL VIVRAGCPIR LFAIVRGRPA PKVTWRKVGI DNVVRKGQVD LVDTMAFLVI
PNSTRDDSGK YSLTLVNPAG EKAVFVNVRV LDTPGPVSDL KVSDVTKTSC HVSWAPPEND
GGSQVTHYIV EKREADRKTW STVTPEVKKT SFHVTNLVPG NEYYFRVTAV NEYGPGVPTD
VPKPVLASDP LSEPDPPRKL EVTEMTKNSA TLAWLPPLRD GGAKIDGYIT SYREEEQPAD
RWTEYSVVKD LSLVVTGLKE GKKYKFRVAA RNAVGVSLPR EAEGVYEAKE QLLPPKILMP
EQITIKAGKK LRIEAHVYGK PHPTCKWKKG EDEVVTSSHL AVHKADSSSI LIIKDVTRKD
SGYYSLTAEN SSGTDTQKIK VVVMDAPGPP QPPFDISDID ADACSLSWHI PLEDGGSNIT
NYIVEKCDVS RGDWVTALAS VTKTSCRVGK LIPGQEYIFR VRAENRFGIS EPLTSPKMVA
QFPFGVPSEP KNARVTKVNK DCIFVAWDRP DSDGGSPIIG YLIERKERNS LLWVKANDTL
VRSTEYPCAG LVEGLEYSFR IYALNKAGSS PPSKPTEYVT ARMPVDPPGK PEVIDVTKST
VSLIWARPKH DGGSKIIGYF VEACKLPGDK WVRCNTAPHQ IPQEEYTATG LEEKAQYQFR
AIARTAVNIS PPSEPSDPVT ILAENVPPRI DLSVAMKSLL TVKAGTNVCL DATVFGKPMP
TVSWKKDGTL LKPAEGIKMA MQRNLCTLEL FSVNRKDSGD YTITAENSSG SKSATIKLKV
LDKPGPPASV KINKMYSDRA MLSWEPPLED GGSEITNYIV DKRETSRPNW AQVSATVPIT
SCSVEKLIEG HEYQFRICAE NKYGVGDPVF TEPAIAKNPY DPPGRCDPPV ISNITKDHMT
VSWKPPADDG GSPITGYLLE KRETQAVNWT KVNRKPIIER TLKATGLQEG TEYEFRVTAI
NKAGPGKPSD ASKAAYARDP QYPPGPPAFP KVYDTTRSSV SLSWGKPAYD GGSPIIGYLV
EVKRADSDNW VRCNLPQNLQ KTRFEVTGLM EDTQYQFRVY AVNKIGYSDP SDVPDKHYPK
DILIPPEGEL DADLRKTLIL RAGVTMRLYV PVKGRPPPKI TWSKPNVNLR DRIGLDIKST
DFDTFLRCEN VNKYDAGKYI LTLENSCGKK EYTIVVKVLD TPGPPVNVTV KEISKDSAYV
TWEPPIIDGG SPIINYVVQK RDAERKSWST VTTECSKTSF RVANLEEGKS YFFRVFAENE
YGIGDPGETR DAVKASQTPG PVVDLKVRSV SKSSCSIGWK KPHSDGGSRI IGYVVDFLTE
ENKWQRVMKS LSLQYSAKDL TEGKEYTFRV SAENENGEGT PSEITVVARD DVVAPDLDLK
GLPDLCYLAK ENSNFRLKIP IKGKPAPSVS WKKGEDPLAT DTRVSVESSA VNTTLIVYDC
QKSDAGKYTI TLKNVAGTKE GTISIKVVGK PGIPTGPIKF DEVTAEAMTL KWAPPKDDGG
SEITNYILEK RDSVNNKWVT CASAVQKTTF RVTRLHEGME YTFRVSAENK YGVGEGLKSE
PIVARHPFDV PDAPPPPNIV DVRHDSVSLT WTDPKKTGGS PITGYHLEFK ERNSLLWKRA
NKTPIRMRDF KVTGLTEGLE YEFRVMAINL AGVGKPSLPS EPVVALDPID PPGKPEVINI
TRNSVTLIWT EPKYDGGHKL TGYIVEKRDL PSKSWMKANH VNVPECAFTV TDLVEGGKYE
FRIRAKNTAG AISAPSESTE TIICKDEYEA PTIVLDPTIK DGLTIKAGDT IVLNAISILG
KPLPKSSWSK AGKDIRPSDI TQITSTPTSS MLTIKYATRK DAGEYTITAT NPFGTKVEHV
KVTVLDVPGP PGPVEISNVS AEKATLTWTP PLEDGGSPIK SYILEKRETS RLLWTVVSED
IQSCRHVATK LIQGNEYIFR VSAVNHYGKG EPVQSEPVKM VDRFGPPGPP EKPEVSNVTK
NTATVSWKRP VDDGGSEITG YHVERREKKS LRWVRAIKTP VSDLRCKVTG LQEGSTYEFR
VSAENRAGIG PPSEASDSVL MKDAAYPPGP PSNPHVTDTT KKSASLAWGK PHYDGGLEIT
GYVVEHQKVG DEAWIKDTTG TALRITQFVV PDLQTKEKYN FRISAINDAG VGEPAVIPDV
EIVEREMAPD FELDAELRRT LVVRAGLSIR IFVPIKGRPA PEVTWTKDNI NLKNRANIEN
TESFTLLIIP ECNRYDTGKF VMTIENPAGK KSGFVNVRVL DTPGPVLNLR PTDITKDSVT
LHWDLPLIDG GSRITNYIVE KREATRKSYS TATTKCHKCT YKVTGLSEGC EYFFRVMAEN
EYGIGEPTET TEPVKASEAP SPPDSLNIMD ITKSTVSLAW PKPKHDGGSK ITGYVIEAQR
KGSDQWTHIT TVKGLECVVR NLTEGEEYTF QVMAVNSAGR SAPRESRPVI VKEQTMLPEL
DLRGIYQKLV IAKAGDNIKV EIPVLGRPKP TVTWKKGDQI LKQTQRVNFE TTATSTILNI
NECVRSDSGP YPLTARNIVG EVGDVITIQV HDIPGPPTGP IKFDEVSSDF VTFSWDPPEN
DGGVPISNYV VEMRQTDSTT WVELATTVIR TTYKATRLTT GLEYQFRVKA QNRYGVGPGI
TSACIVANYP FKVPGPPGTP QVTAVTKDSM TISWHEPLSD GGSPILGYHV ERKERNGILW
QTVSKALVPG NIFKSSGLTD GIAYEFRVIA ENMAGKSKPS KPSEPMLALD PIDPPGKPVP
LNITRHTVTL KWAKPEYTGG FKITSYIVEK RDLPNGRWLK ANFSNILENE FTVSGLTEDA
AYEFRVIAKN AAGAISPPSE PSDAITCRDD VEAPKIKVDV KFKDTVILKA GEAFRLEADV
SGRPPPTMEW SKDGKELEGT AKLEIKIADF STNLVNKDST RRDSGAYTLT ATNPGGFAKH
IFNVKVLDRP GPPEGPLAVT EVTSEKCVLS WFPPLDDGGA KIDHYIVQKR ETSRLAWTNV
ASEVQVTKLK VTKLLKGNEY IFRVMAVNKY GVGEPLESEP VLAVNPYGPP DPPKNPEVTT
ITKDSMVVCW GHPDSDGGSE IINYIVERRD KAGQRWIKCN KKTLTDLRYK VSGLTEGHEY
EFRIMAENAA GISAPSPTSP FYKACDTVFK PGPPGNPRVL DTSRSSISIA WNKPIYDGGS
EITGYMVEIA LPEEDEWQIV TPPAGLKATS YTITGLTENQ EYKIRIYAMN SEGLGEPALV
PGTPKAEDRM LPPEIELDAD LRKVVTIRAC CTLRLFVPIK GRPAPEVKWA RDHGESLDKA
SIESTSSYTL LIVGNVNRFD SGKYILTVEN SSGSKSAFVN VRVLDTPGPP QDLKVKEVTK
TSVTLTWDPP LLDGGSKIKN YIVEKRESTR KAYSTVATNC HKTSWKVDQL QEGCSYYFRV
LAENEYGIGL PAETAESVKA SERPLPPGKI TLMDVTRNSV SLSWEKPEHD GGSRILGYIV
EMQTKGSDKW ATCATVKVTE ATITGLIQGE EYSFRVSAQN EKGISDPRQL SVPVIAKDLV
IPPAFKLLFN TFTVLAGEDL KVDVPFIGRP TPAVTWHKDN VPLKQTTRVN AESTENNSLL
TIKDACREDV GHYVVKLTNS AGEAIETLNV IVLDKPGPPT GPVKMDEVTA DSITLSWGPP
KYDGGSSINN YIVEKRDTST TTWQIVSATV ARTTIKACRL KTGCEYQFRI AAENRYGKST
YLNSEPTVAQ YPFKVPGPPG TPVVTLSSRD SMEVQWNEPI SDGGSRVIGY HLERKERNSI
LWVKLNKTPI PQTKFKTTGL EEGVEYEFRV SAENIVGIGK PSKVSECYVA RDPCDPPGRP
EAIIVTRNSV TLQWKKPTYD GGSKITGYIV EKKELPEGRW MKASFTNIID THFEVTGLVE
DHRYEFRVIA RNAAGVFSEP SESTGAITAR DEVDPPRISM DPKYKDTIVV HAGESFKVDA
DIYGKPIPTI QWIKGDQELS NTARLEIKST DFATSLSVKD AVRVDSGNYI LKAKNVAGER
SVTVNVKVLD RPGPPEGPVV ISGVTAEKCT LAWKPPLQDG GSDIINYIVE RRETSRLVWT
VVDANVQTLS CKVTKLLEGN EYTFRIMAVN KYGVGEPLES EPVVAKNPFV VPDAPKAPEV
TTVTKDSMIV VWERPASDGG SEILGYVLEK RDKEGIRWTR CHKRLIGELR LRVTGLIENH
DYEFRVSAEN AAGLSEPSPP SAYQKACDPI YKPGPPNNPK VIDITRSSVF LSWSKPIYDG
GCEIQGYIVE KCDVSVGEWT MCTPPTGINK TNIEVEKLLE KHEYNFRICA INKAGVGEHA
DVPGPIIVEE KLEAPDIDLD LELRKIINIR AGGSLRLFVP IKGRPTPEVK WGKVDGEIRD
AAIIDVTSSF TSLVLDNVNR YDSGKYTLTL ENSSGTKSAF VTVRVLDTPS PPVNLKVTEI
TKDSVSITWE PPLLDGGSKI KNYIVEKREA TRKSYAAVVT NCHKNSWKID QLQEGCSYYF
RVTAENEYGI GLPAQTADPI KVAEVPQPPG KITVDDVTRN SVSLSWTKPE HDGGSKIIQY
IVEMQAKHSE KWSECARVKS LQAVITNLTQ GEEYLFRVVA VNEKGRSDPR SLAVPIVAKD
LVIEPDVKPA FSSYSVQVGQ DLKIEVPISG RPKPTITWTK DGLPLKQTTR INVTDSLDLT
TLSIKETHKD DGGQYGITVA NVVGQKTASI EIVTLDKPDP PKGPVKFDDV SAESITLSWN
PPLYTGGCQI TNYIVQKRDT TTTVWDVVSA TVARTTLKVT KLKTGTEYQF RIFAENRYGQ
SFALESDPIV AQYPYKEPGP PGTPFATAIS KDSMVIQWHE PVNNGGSPVI GYHLERKERN
SILWTKVNKT IIHDTQFKAQ NLEEGIEYEF RVYAENIVGV GKASKNSECY VARDPCDPPG
TPEPIMVKRN EITLQWTKPV YDGGSMITGY IVEKRDLPDG RWMKASFTNV IETQFTVSGL
TEDQRYEFRV IAKNAAGAIS KPSDSTGPIT AKDEVELPRI SMDPKFRDTI VVNAGETFRL
EADVHGKPLP TIEWLRGDKE IEESARCEIK NTDFKALLIV KDAIRIDGGQ YILRASNVAG
SKSFPVNVKV LDRPGPPEGP VQVTGVTSEK CSLTWSPPLQ DGGSDISHYV VEKRETSRLA
WTVVASEVVT NSLKVTKLLE GNEYVFRIMA VNKYGVGEPL ESAPVLMKNP FVLPGPPKSL
EVTNIAKDSM TVCWNRPDSD GGSEIIGYIV EKRDRSGIRW IKCNKRRITD LRLRVTGLTE
DHEYEFRVSA ENAAGVGEPS PATVYYKACD PVFKPGPPTN AHIVDTTKNS ITLAWGKPIY
DGGSEILGYV VEICKADEEE WQIVTPQTGL RVTRFEISKL TEHQEYKIRV CALNKVGLGE
ATSVPGTVKP EDKLEAPELD LDSELRKGIV VRAGGSARIH IPFKGRPTPE ITWSREEGEF
TDKVQIEKGV NYTQLSIDNC DRNDAGKYIL KLENSSGSKS AFVTVKVLDT PGPPQNLAVK
EVRKDSAFLV WEPPIIDGGA KVKNYVIDKR ESTRKAYANV SSKCSKTSFK VENLTEGAIY
YFRVMAENEF GVGVPVETVD AVKAAEPPSP PGKVTLTDVS QTSASLMWEK PEHDGGSRVL
GYVVEMQPKG TEKWSIVAES KVCNAVVTGL SSGQEYQFRV KAYNEKGKSD PRVLGVPVIA
KDLTIQPSLK LPFNTYSIQA GEDLKIEIPV IGRPRPNISW VKDGEPLKQT TRVNVEETAT
STVLHIKEGN KDDFGKYTVT ATNSAGTATE NLSVIVLEKP GPPVGPVRFD EVSADFVVIS
WEPPAYTGGC QISNYIVEKR DTTTTTWHMV SATVARTTIK ITKLKTGTEY QFRIFAENRY
GKSAPLDSKA VIVQYPFKEP GPPGTPFVTS ISKDQMLVQW HEPVNDGGTK IIGYHLEQKE
KNSILWVKLN KTPIQDTKFK TTGLDEGLEY EFKVSAENIV GIGKPSKVSE CFVARDPCDP
PGRPEAIVIT RNNVTLKWKK PAYDGGSKIT GYIVEKKDLP DGRWMKASFT NVLETEFTVS
GLVEDQRYEF RVIARNAAGN FSEPSDSSGA ITARDEIDAP NASLDPKYKD VIVVHAGETF
VLEADIRGKP IPDVVWSKDG KELEETAARM EIKSTIQKTT LVVKDCIRTD GGQYILKLSN
VGGTKSIPIT VKVLDRPGPP EGPLKVTGVT AEKCYLAWNP PLQDGGANIS HYIIEKRETS
RLSWTQVSTE VQALNYKVTK LLPGNEYIFR VMAVNKYGIG EPLESGPVTA CNPYKPPGPP
STPEVSAITK DSMVVTWARP VDDGGTEIEG YILEKRDKEG VRWTKCNKKT LTDLRLRVTG
LTEGHSYEFR VAAENAAGVG EPSEPSVFYR ACDALYPPGP PSNPKVTDTS RSSVSLAWSK
PIYDGGAPVK GYVVEVKEAA ADEWTTCTPP TGLQGKQFTV TKLKENTEYN FRICAINSEG
VGEPATLPGS VVAQERIEPP EIELDADLRK VVVLRASATL RLFVTIKGRP EPEVKWEKAE
GILTDRAQIE VTSSFTMLVI DNVTRFDSGR YNLTLENNSG SKTAFVNVRV LDSPSAPVNL
TIREVKKDSV TLSWEPPLID GGAKITNYIV EKRETTRKAY ATITNNCTKT TFRIENLQEG
CSYYFRVLAS NEYGIGLPAE TTEPVKVSEP PLPPGRVTLV DVTRNTATIK WEKPESDGGS
KITGYVVEMQ TKGSEKWSTC TQVKTLEATI SGLTAGEEYV FRVAAVNEKG RSDPRQLGVP
VIARDIEIKP SVELPFHTFN VKAREQLKID VPFKGRPQAT VNWRKDGQTL KETTRVNVSS
SKTVTSLSIK EASKEDVGTY ELCVSNSAGS ITVPITIIVL DRPGPPGPIR IDEVSCDSIT
ISWNPPEYDG GCQISNYIVE KKETTSTTWH IVSQAVARTS IKIVRLTTGS EYQFRVCAEN
RYGKSSYSES SAVVAEYPFS PPGPPGTPKV VHATKSTMLV TWQVPVNDGG SRVIGYHLEY
KERSSILWSK ANKILIADTQ MKVSGLDEGL MYEYRVYAEN IAGIGKCSKS CEPVPARDPC
DPPGQPEVTN ITRKSVSLKW SKPHYDGGAK ITGYIVERRE LPDGRWLKCN YTNIQETYFE
VTELTEDQRY EFRVFARNAA DSVSEPSEST GPIIVKDDVE PPRVMMDVKF RDVIVVKAGE
VLKINADIAG RPLPVISWAK DGIEIEERAR TEIISTDNHT LLTVKDCIRR DTGQYVLTLK
NVAGTRSVAV NCKVLDKPGP PAGPLEINGL TAEKCSLSWG RPQEDGGADI DYYIVEKRET
SHLAWTICEG ELQMTSCKVT KLLKGNEYIF RVTGVNKYGV GEPLESVAIK ALDPFTVPSP
PTSLEITSVT KESMTLCWSR PESDGGSEIS GYIIERREKN SLRWVRVNKK PVYDLRVKST
GLREGCEYEY RVYAENAAGL SLPSETSPLI RAEDPVFLPS PPSKPKIVDS GKTTITIAWV
KPLFDGGAPI TGYTVEYKKS DDTDWKTSIQ SLRGTEYTIS GLTTGAEYVF RVKSVNKVGA
SDPSDSSDPQ IAKEREEEPL FDIDSEMRKT LIVKAGASFT MTVPFRGRPV PNVLWSKPDT
DLRTRAYVDT TDSRTSLTIE NANRNDSGKY TLTIQNVLSA ASLTLVVKVL DTPGPPTNIT
VQDVTKESAV LSWDVPENDG GAPVKNYHIE KREASKKAWV SVTNNCNRLS YKVTNLQEGA
IYYFRVSGEN EFGVGIPAET KEGVKITEKP SPPEKLGVTS ISKDSVSLTW LKPEHDGGSR
IVHYVVEALE KGQKNWVKCA VAKSTHHVVS GLRENSEYFF RVFAENQAGL SDPRELLLPV
LIKEQLEPPE IDMKNFPSHT VYVRAGSNLK VDIPISGKPL PKVTLSRDGV PLKATMRFNT
EITAENLTIN LKESVTADAG RYEITAANSS GTTKAFINIV VLDRPGPPTG PVVISDITEE
SVTLKWEPPK YDGGSQVTNY ILLKRETSTA VWTEVSATVA RTMMKVMKLT TGEEYQFRIK
AENRFGISDH IDSACVTVKL PYTTPGPPST PWVTNVTRES ITVGWHEPVS NGGSAVVGYH
LEMKDRNSIL WQKANKLVIR TTHFKVTTIS AGLIYEFRVY AENAAGVGKP SHPSEPVLAI
DACEPPRNVR ITDISKNSVS LSWQQPAFDG GSKITGYIVE RRDLPDGRWT KASFTNVTET
QFIISGLTQN SQYEFRVFAR NAVGSISNPS EVVGPITCID SYGGPVIDLP LEYTEVVKYR
AGTSVKLRAG ISGKPAPTIE WYKDDKELQT NALVCVENTT DLASILIKDA DRLNSGCYEL
KLRNAMGSAS ATIRVQILDK PGPPGGPIEF KTVTAEKITL LWRPPADDGG AKITHYIVEK
RETSRVVWSM VSEHLEECII TTTKIIKGNE YIFRVRAVNK YGIGEPLESD SVVAKNAFVT
PGPPGIPEVT KITKNSMTVV WSRPIADGGS DISGYFLEKR DKKSLGWFKV LKETIRDTRQ
KVTGLTENSD YQYRVCAVNA AGQGPFSEPS EFYKAADPID PPGPPAKIRI ADSTKSSITL
GWSKPVYDGG SAVTGYVVEI RQGEEEEWTT VSTKGEVRTT EYVVSNLKPG VNYYFRVSAV
NCAGQGEPIE MNEPVQAKDI LEAPEIDLDV ALRTSVIAKA GEDVQVLIPF KGRPPPTVTW
RKDEKNLGSD ARYSIENTDS SSLLTIPQVT RNDTGKYILT IENGVGEPKS STVSVKVLDT
PAACQKLQVK HVSRGTVTLL WDPPLIDGGS PIINYVIEKR DATKRTWSVV SHKCSSTSFK
LIDLSEKTPF FFRVLAENEI GIGEPCETTE PVKAAEVPAP IRDLSMKDST KTSVILSWTK
PDFDGGSVIT EYVVERKGKG EQTWSHAGIS KTCEIEVSQL KEQSVLEFRV FAKNEKGLSD
PVTIGPITVK ELIITPEVDL SDIPGAQVTV RIGHNVHLEL PYKGKPKPSI SWLKDGLPLK
ESEFVRFSKT ENKITLSIKN AKKEHGGKYT VILDNAVCRI AVPITVITLG PPSKPKGPIR
FDEIKADSVI LSWDVPEDNG GGEITCYSIE KRETSQTNWK MVCSSVARTT FKVPNLVKDA
EYQFRVRAEN RYGVSQPLVS SIIVAKHQFR IPGPPGKPVI YNVTSDGMSL TWDAPVYDGG
SEVTGFHVEK KERNSILWQK VNTSPISGRE YRATGLVEGL DYQFRVYAEN SAGLSSPSDP
SKFTLAVSPV DPPGTPDYID VTRETITLKW NPPLRDGGSK IVGYSIEKRQ GNERWVRCNF
TDVSECQYTV TGLSPGDRYE FRIIARNAVG TISPPSQSSG IIMTRDENVP PIVEFGPEYF
DGLIIKSGES LRIKALVQGR PVPRVTWFKD GVEIEKRMNM EITDVLGSTS LFVRDATRDH
RGVYTVEAKN ASGSAKAEIK VKVQDTPGKV VGPIRFTNIT GEKMTLWWDA PLNDGCAPIT
HYIIEKRETS RLAWALIEDK CEAQSYTAIK LINGNEYQFR VSAVNKFGVG RPLDSDPVVA
QIQYTVPDAP GIPEPSNITG NSITLTWARP ESDGGSEIQQ YILERREKKS TRWVKVISKR
PISETRFKVT GLTEGNEYEF HVMAENAAGV GPASGISRLI KCREPVNPPG PPTVVKVTDT
SKTTVSLEWS KPVFDGGMEI IGYIIEMCKA DLGDWHKVNA EACVKTRYTV TDLQAGEEYK
FRVSAINGAG KGDSCEVTGT IKAVDRLTAP ELDIDANFKQ THVVRAGASI RLFIAYQGRP
TPTAVWSKPD SNLSLRADIH TTDSFSTLTV ENCNRNDAGK YTLTVENNSG SKSITFTVKV
LDTPGPPGPI TFKDVTRGSA TLMWDAPLLD GGARIHHYVV EKREASRRSW QVISEKCTRQ
IFKVNDLAEG VPYYFRVSAV NEYGVGEPYE MPEPIVATEQ PAPPRRLDVV DTSKSSAVLA
WLKPDHDGGS RITGYLLEMR QKGSDFWVEA GHTKQLTFTV ERLVEKTEYE FRVKAKNDAG
YSEPREAFSS VIIKEPQIEP TADLTGITNQ LITCKAGSPF TIDVPISGRP APKVTWKLEE
MRLKETDRVS ITTTKDRTTL TVKDSMRGDS GRYFLTLENT AGVKTFSVTV VVIGRPGPVT
GPIEVSSVSA ESCVLSWGEP KDGGGTEITN YIVEKRESGT TAWQLVNSSV KRTQIKVTHL
TKYMEYSFRV SSENRFGVSK PLESAPIIAE HPFVPPSAPT RPEVYHVSAN AMSIRWEEPY
HDGGSKIIGY WVEKKERNTI LWVKENKVPC LECNYKVTGL VEGLEYQFRT YALNAAGVSK
ASEASRPIMA QNPVDAPGRP EVTDVTRSTV SLIWSAPAYD GGSKVVGYII ERKPVSEVGD
GRWLKCNYTI VSDNFFTVTA LSEGDTYEFR VLAKNAAGVI SKGSESTGPV TCRDEYAPPK
AELDARLHGD LVTIRAGSDL VLDAAVGGKP EPKIIWTKGD KELDLCEKVS LQYTGKRATA
VIKFCDRSDS GKYTLTVKNA SGTKAVSVMV KVLDSPGPCG KLTVSRVTQE KCTLAWSLPQ
EDGGAEITHY IVERRETSRL NWVIVEGECP TLSYVVTRLI KNNEYIFRVR AVNKYGPGVP
VESEPIVARN SFTIPSPPGI PEEVGTGKEH IIIQWTKPES DGGNEISNYL VDKREKKSLR
WTRVNKDYVV YDTRLKVTSL MEGCDYQFRV TAVNAAGNSE PSEASNFISC REPSYTPGPP
SAPRVVDTTK HSISLAWTKP MYDGGTDIVG YVLEMQEKDT DQWYRVHTNA TIRNTEFTVP
DLKMGQKYSF RVAAVNVKGM SEYSESIAEI EPVERIEIPD LELADDLKKT VTIRAGASLR
LMVSVSGRPP PVITWSKQGI DLASRAIIDT TESYSLLIVD KVNRYDAGKY TIEAENQSGK
KSATVLVKVY DTPGPCPSVK VKEVSRDSVT ITWEIPTIDG GAPVNNYIVE KREAAMRAFK
TVTTKCSKTL YRISGLVEGT MYYFRVLPEN IYGIGEPCET SDAVLVSEVP LVPAKLEVVD
VTKSTVTLAW EKPLYDGGSR LTGYVLEACK AGTERWMKVV TLKPTVLEHT VTSLNEGEQY
LFRIRAQNEK GVSEPRETVT AVTVQDLRVL PTIDLSTMPQ KTIHVPAGRP VELVIPIAGR
PPPAASWFFA GSKLRESERV TVETHTKVAK LTIRETTIRD TGEYTLELKN VTGTTSETIK
VIILDKPGPP TGPIKIDEID ATSITISWEP PELDGGAPLS GYVVEQRDAH RPGWLPVSES
VTRSTFKFTR LTEGNEYVFR VAATNRFGIG SYLQSEVIEC RSSIRIPGPP ETLQIFDVSR
DGMTLTWYPP EDDGGSQVTG YIVERKEVRA DRWVRVNKVP VTMTRYRSTG LTEGLEYEHR
VTAINARGSG KPSRPSKPIV AMDPIAPPGK PQNPRVTDTT RTSVSLAWSV PEDEGGSKVT
GYLIEMQKVD QHEWTKCNTT PTKIREYTLT HLPQGAEYRF RVLACNAGGP GEPAEVPGTV
KVTEMLEYPD YELDERYQEG IFVRQGGVIR LTIPIKGKPF PICKWTKEGQ DISKRAMIAT
SETHTELVIK EADRGDSGTY DLVLENKCGK KAVYIKVRVI GSPNSPEGPL EYDDIQVRSV
RVSWRPPADD GGADILGYIL ERREVPKAAW YTIDSRVRGT SLVVKGLKEN VEYHFRVSAE
NQFGISKPLK SEEPVTPKTP LNPPEPPSNP PEVLDVTKSS VSLSWSRPKD DGGSRVTGYY
IERKETSTDK WVRHNKTQIT TTMYTVTGLV PDAEYQFRII AQNDVGLSET SPASEPVVCK
DPFDKPSQPG ELEILSISKD SVTLQWEKPE CDGGKEILGY WVEYRQSGDS AWKKSNKERI
KDKQFTIGGL LEATEYEFRV FAENETGLSR PRRTAMSIKT KLTSGEAPGI RKEMKDVTTK
LGEAAQLSCQ IVGRPLPDIK WYRFGKELIQ SRKYKMSSDG RTHTLTVMTE EQEDEGVYTC
IATNEVGEVE TSSKLLLQAT PQFHPGYPLK EKYYGAVGST LRLHVMYIGR PVPAMTWFHG
QKLLQNSENI TIENTEHYTH LVMKNVQRKT HAGKYKVQLS NVFGTVDAIL DVEIQDKPDK
PTGPIVIEAL LKNSAVISWK PPADDGGSWI TNYVVEKCEA KEGAEWQLVS SAISVTTCRI
VNLTENAGYY FRVSAQNTFG ISDPLEVSSV VIIKSPFEKP GAPGKPTITA VTKDSCVVAW
KPPASDGGAK IRNYYLEKRE KKQNKWISVT TEEIRETVFS VKNLIEGLEY EFRVKCENLG
GESEWSEISE PITPKSDVPI QAPHFKEELR NLNVRYQSNA TLVCKVTGHP KPIVKWYRQG
KEIIADGLKY RIQEFKGGYH QLIIASVTDD DATVYQVRAT NQGGSVSGTA SLEVEVPAKI
HLPKTLEGMG AVHALRGEVV SIKIPFSGKP DPVITWQKGQ DLIDNNGHYQ VIVTRSFTSL
VFPNGVERKD AGFYVVCAKN RFGIDQKTVE LDVADVPDPP RGVKVSDVSR DSVNLTWTEP
ASDGGSKITN YIVEKCATTA ERWLRVGQAR ETRYTVINLF GKTSYQFRVI AENKFGLSKP
SEPSEPTITK EDKTRAMNYD EEVDETREVS MTKASHSSTK ELYEKYMIAE DLGRGEFGIV
HRCVETSSKK TYMAKFVKVK GTDQVLVKKE ISILNIARHR NILHLHESFE SMEELVMIFE
FISGLDIFER INTSAFELNE REIVSYVHQV CEALQFLHSH NIGHFDIRPE NIIYQTRRSS
TIKIIEFGQA RQLKPGDNFR LLFTAPEYYA PEVHQHDVVS TATDMWSLGT LVYVLLSGIN
PFLAETNQQI IENIMNAEYT FDEEAFKEIS IEAMDFVDRL LVKERKSRMT ASEALQHPWL
KQKIERVSTK VIRTLKHRRY YHTLIKKDLN MVVSAARISC GGAIRSQKGV SVAKVKVASI
EIGPVSGQIM HAVGEEGGHV KYVCKIENYD QSTQVTWYFG VRQLENSEKY EITYEDGVAI
LYVKDITKLD DGTYRCKVVN DYGEDSSYAE LFVKGVREVY DYYCRRTMKK IKRRTDTMRL
LERPPEFTLP LYNKTAYVGE NVRFGVTITV HPEPHVTWYK SGQKIKPGDN DKKYTFESDK
GLYQLTINSV TTDDDAEYTV VARNKYGEDS CKAKLTVTLH PPPTDSTLRP MFKRLLANAE
CQEGQSVCFE IRVSGIPPPT LKWEKDGQPL SLGPNIEIIH EGLDYYALHI RDTLPEDTGY
YRVTATNTAG STSCQAHLQV ERLRYKKQEF KSKEEHERHV QKQIDKTLRM AEILSGTESV
PLTQVAKEAL REAAVLYKPA VSTKTVKGEF RLEIEEKKEE RKLRMPYDVP EPRKYKQTTI
EEDQRIKQFV PMSDMKWYKK IRDQYEMPGK LDRVVQKRPK RIRLSRWEQF YVMPLPRITD
QYRPKWRIPK LSQDDLEIVR PARRRTPSPD YDFYYRPRRR SLGDISDEEL LLPIDDYLAM
KRTEEERLRL EEELELGFSA SPPSRSPPHF ELSSLRYSSP QAHVKVEETR KDFRYSTYHI
PTKAEASTSY AELRERHAQA AYRQPKQRQR IMAEREDEEL LRPVTTTQHL SEYKSELDFM
SKEEKSRKKS RRQREVTEIT EIEEEYEISK HAQRESSSSA SRLLRRRRSL SPTYIELMRP
VSELIRSRPQ PAEEYEDDTE RRSPTPERTR PRSPSPVSSE RSLSRFERSA RFDIFSRYES
MKAALKTQKT SERKYEVLSQ QPFTLDHAPR ITLRMRSHRV PCGQNTRFIL NVQSKPTAEV
KWYHNGVELQ ESSKIHYTNT SGVLTLEILD CHTDDSGTYR AVCTNYKGEA SDYATLDVTG
GDYTTYASQR RDEEVPRSVF PELTRTEAYA VSSFKKTSEM EASSSVREVK SQMTETRESL
SSYEHSASAE MKSAALEEKS LEEKSTTRKI KTTLAARILT KPRSMTVYEG ESARFSCDTD
GEPVPTVTWL RKGQVLSTSA RHQVTTTKYK STFEISSVQA SDEGNYSVVV ENSEGKQEAE
FTLTIQKARV TEKAVTSPPR VKSPEPRVKS PEAVKSPKRV KSPEPSHPKA VSPTETKPTP
TEKVQHLPVS APPKITQFLK AEASKEIAKL TCVVESSVLR AKEVTWYKDG KKLKENGHFQ
FHYSADGTYE LKINNLTESD QGEYVCEISG EGGTSKTNLQ FMGQAFKSIH EKVSKISETK
KSDQKTTEST VTRKTEPKAP EPISSKPVIV TGLQDTTVSS DSVAKFAVKA TGEPRPTAIW
TKDGKAITQG GKYKLSEDKG GFFLEIHKTD TSDSGLYTCT VKNSAGSVSS SCKLTIKAIK
DTEAQKVSTQ KTSEITPQKK AVVQEEISQK ALRSEEIKMS EAKSQEKLAL KEEASKVLIS
EEVKKSAATS LEKSIVHEEI TKTSQASEEV RTHAEIKAFS TQMSINEGQR LVLKANIAGA
TDVKWVLNGV ELTNSEEYRY GVSGSDQTLT IKQASHRDEG ILTCISKTKE GIVKCQYDLT
LSKELSDAPA FISQPRSQNI NEGQNVLFTC EISGEPSPEI EWFKNNLPIS ISSNVSISRS
RNVYSLEIRN ASVSDSGKYT IKAKNFRGQC SATASLMVLP LVEEPSREVV LRTSGDTSLQ
GSFSSQSVQM SASKQEASFS SFSSSSASSM TEMKFASMSA QSMSSMQESF VEMSSSSFMG
ISNMTQLESS TSKMLKAGIR GIPPKIEALP SDISIDEGKV LTVACAFTGE PTPEVTWSCG
GRKIHSQEQG RFHIENTDDL TTLIIMDVQK QDGGLYTLSL GNEFGSDSAT VNIHIRSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

1 / 1

Last intron/exon boundary

81061

Theoretical NMD boundary in CDS

81010

Length of CDS

81357

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.05 s

Back to summary table

Variant:

2:178745884C>A_2_ENST00000359218

Back to summary table

Prediction:

DeleteriousPermalink

Summary:

Model: without_aae
Tree vote: 141|59 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.44, LOF (oe): 0.42, misssense (oe): 0.89, synonymous (oe): 0.89 ? (gnomAD)

Ensembl transcript ID

ENST00000359218.11

Genbank transcript ID

NM_133432 (by similarity)

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10598-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIMKETR KTVVPKVIVA TPKVKEQDLV SRGREGITTK REQVQITQEK
MRKEAEKTAL STIAVATAKA KEQETILRTR ETMATRQEQI QVTHGKVDVG KKAEAVATVV
AAVDQARVRE PREPGHLEES YAQQTTLEYG YKERISAAKV AEPPQRPASE PHVVPKAVKP
RVIQAPSETH IKTTDQKGMH ISSQIKKTTD LTTERLVHVD KRPRTASPHF TVSKISVPKT
EHGYEASIAG SAIATLQKEL SATSSAQKIT KSVKAPTVKP SETRVRAEPT PLPQFPFADT
PDTYKSEAGV EVKKEVGVSI TGTTVREERF EVLHGREAKV TETARVPAPV EIPVTPPTLV
SGLKNVTVIE GESVTLECHI SGYPSPTVTW YREDYQIESS IDFQITFQSG IARLMIREAF
AEDSGRFTCS AVNEAGTVST SCYLAVQVSE EFEKETTAVT EKFTTEEKRF VESRDVVMTD
TSLTEEQAGP GEPAAPYFIT KPVVQKLVEG GSVVFGCQVG GNPKPHVYWK KSGVPLTTGY
RYKVSYNKQT GECKLVISMT FADDAGEYTI VVRNKHGETS ASASLLEEAD YELLMKSQQE
MLYQTQVTAF VQEPKVGETA PGFVYSEYEK EYEKEQALIR KKMAKDTVVV RTYVEDQEFH
ISSFEERLIK EIEYRIIKTT LEELLEEDGE EKMAVDISES EAVESGFDSR IKNYRILEGM
GVTFHCKMSG YPLPKIAWYK DGKRIKHGER YQMDFLQDGR ASLRIPVVLP EDEGIYTAFA
SNIKGNAICS GKLYVEPAAP LGAPTYIPTL EPVSRIRSLS PRSVSRSPIR MSPARMSPAR
MSPARMSPAR MSPGRRLEET DESQLERLYK PVFVLKPVSF KCLEGQTARF DLKVVGRPMP
ETFWFHDGQQ IVNDYTHKVV IKEDGTQSLI IVPATPSDSG EWTVVAQNRA GRSSISVILT
VEAVEHQVKP MFVEKLKNVN IKEGSRLEMK VRATGNPNPD IVWLKNSDII VPHKYPKIRI
EGTKGEAALK IDSTVSQDSA WYTATAINKA GRDTTRCKVN VEVEFAEPEP ERKLIIPRGT
YRAKEIAAPE LEPLHLRYGQ EQWEEGDLYD KEKQQKPFFK KKLTSLRLKR FGPAHFECRL
TPIGDPTMVV EWLHDGKPLE AANRLRMINE FGYCSLDYGV AYSRDSGIIT CRATNKYGTD
HTSATLIVKD EKSLVEESQL PEGRKGLQRI EELERMAHEG ALTGVTTDQK EKQKPDIVLY
PEPVRVLEGE TARFRCRVTG YPQPKVNWYL NGQLIRKSKR FRVRYDGIHY LDIVDCKSYD
TGEVKVTAEN PEGVIEHKVK LEIQQREDFR SVLRRAPEPR PEFHVHEPGK LQFEVQKVDR
PVDTTETKEV VKLKRAERIT HEKVPEESEE LRSKFKRRTE EGYYEAITAV ELKSRKKDES
YEELLRKTKD ELLHWTKELT EEEKKALAEE GKITIPTFKP DKIELSPSME APKIFERIQS
QTVGQGSDAH FRVRVVGKPD PECEWYKNGV KIERSDRIYW YWPEDNVCEL VIRDVTAEDS
ASIMVKAINI AGETSSHAFL LVQAKQLITF TQELQDVVAK EKDTMATFEC ETSEPFVKVK
WYKDGMEVHE GDKYRMHSDR KVHFLSILTI DTSDAEDYSC VLVEDENVKT TAKLIVEGAV
VEFVKELQDI EVPESYSGEL ECIVSPENIE GKWYHNDVEL KSNGKYTITS RRGRQNLTVK
DVTKEDQGEY SFVIDGKKTT CKLKMKPRPI AILQGLSDQK VCEGDIVQLE VKVSLESVEG
VWMKDGQEVQ PSDRVHIVID KQSHMLLIED MTKEDAGNYS FTIPALGLST SGRVSVYSVD
VITPLKDVNV IEGTKAVLEC KVSVPDVTSV KWYLNDEQIK PDDRVQAIVK GTKQRLVINR
THASDEGPYK LIVGRVETNC NLSVEKIKII RGLRDLTCTE TQNVVFEVEL SHSGIDVLWN
FKDKEIKPSS KYKIEAHGKI YKLTVLNMMK DDEGKYTFYA GENMTSGKLT VAGGAISKPL
TDQTVAESQE AVFECEVANP DSKGEWLRDG KHLPLTNNIR SESDGHKRRL IIAATKLDDI
GEYTYKVATS KTSAKLKVEA VKIKKTLKNL TVTETQDAVF TVELTHPNVK GVQWIKNGVV
LESNEKYAIS VKGTIYSLRI KNCAIVDESV YGFRLGRLGA SARLHVETVK IIKKPKDVTA
LENATVAFEV SVSHDTVPVK WFHKSVEIKP SDKHRLVSER KVHKLMLQNI SPSDAGEYTA
VVGQLECKAK LFVETLHITK TMKNIEVPET KTASFECEVS HFNVPSMWLK NGVEIEMSEK
FKIVVQGKLH QLIIMNTSTE DSAEYTFVCG NDQVSATLTV TPIMITSMLK DINAEEKDTI
TFEVTVNYEG ISYKWLKNGV EIKSTDKCQM RTKKLTHSLN IRNVHFGDAA DYTFVAGKAT
STATLYVEAR HIEFRKHIKD IKVLEKKRAM FECEVSEPDI TVQWMKDDQE LQITDRIKIQ
KEKYVHRLLI PSTRMSDAGK YTVVAGGNVS TAKLFVEGRD VRIRSIKKEV QVIEKQRAVV
EFEVNEDDVD AHWYKDGIEI NFQVQERHKY VVERRIHRMF ISETRQSDAG EYTFVAGRNR
SSVTLYVNAP EPPQVLQELQ PVTVQSGKPA RFCAVISGRP QPKISWYKEE QLLSTGFKCK
FLHDGQEYTL LLIEAFPEDA AVYTCEAKND YGVATTSASL SVEVPEVVSP DQEMPVYPPA
IITPLQDTVT SEGQPARFQC RVSGTDLKVS WYSKDKKIKP SRFFRMTQFE DTYQLEIAEA
YPEDEGTYTF VASNAVGQVS STANLSLEGF SKFEENTSNS QWHVSLSVSF KKEPLGQKPS
FIQPLSSLRV HNGETVRFHA RVSGIPKPEI QWFHNQQLIL PTKDVVFHFE ESTGMALMLI
VDAYSEHAGQ YSCKAANSAG EATCAATLTV TPKAPESILH ERIEQEIEME MKEFSSSFLS
AEEEGLHSAE LQLSKINETL ELLSESPVYP TKFDSEKEGT GPIFIKEVSN ADISMGDVAT
LSVTVIGIPK PKIQWFFNGV LLTPSADYKF VFDGDDHSLI ILFTKLEDEG EYTCMASNDY
GKTICSAYLK INSKGEGHKD TETESAVAKS LEKLGGPCPP HFLKELKPIR CAQGLPAIFE
YTVVGEPAPT VTWFKENKQL CTSVYYTIIH NPNGSGTFIV NDPQREDSGL YICKAENMLG
ESTCAAELLV LLEDTDMTDT PCKAKSTPEA PEDFPQTPLK GPAVEALDSE QEIATFVKDT
ILKAALITEE NQQLSYEHIA KANELSSQLP LGAQELQSIL EQDKLTPEST REFLCINGSI
HFQPLKEPSP NLQLQIVQSQ KTFSKEGILM PEEPETQAVL SDTEKIFPSA MSIEQINSLT
VEPLKTLLAE PEGNYPQSSI EPPMHSYLTS VAEEVLSPKE KTVSDTNREQ RVTLQKQEAQ
SALILSQSLA EGHVESLQSP DVMISQVNYE PLVPSEHSCT EGGKILIESA NPLENAGQDS
AVRIEEGKSL RFPLALEEKQ VLLKEEHSDN VVMPPDQIIE SKREPVAIKK VQEVQGRDLL
SKESLLSGIP EEQRLNLKIQ ICRALQAAVA SEQPGLFSEW LRNIEKVEVE AVNITQEPRH
IMCMYLVTSA KSVTEEVTII IEDVDPQMAN LKMELRDALC AIIYEEIDIL TAEGPRIQQG
AKTSLQEEMD SFSGSQKVEP ITEPEVESKY LISTEEVSYF NVQSRVKYLD ATPVTKGVAS
AVVSDEKQDE SLKPSEEKEE SSSESGTEEV ATVKIQEAEG GLIKEDGPMI HTPLVDTVSE
EGDIVHLTTS ITNAKEVNWY FENKLVPSDE KFKCLQDQNT YTLVIDKVNT EDHQGEYVCE
ALNDSGKTAT SAKLTVVKRA APVIKRKIEP LEVALGHLAK FTCEIQSAPN VRFQWFKAGR
EIYESDKCSI RSSKYISSLE ILRTQVVDCG EYTCKASNEY GSVSCTATLT VTVPGGEKKV
RKLLPERKPE PKEEVVLKSV LRKRPEEEEP KVEPKKLEKV KKPAVPEPPP PKPVEEVEVP
TVTKRERKIP EPTKVPEIKP AIPLPAPEPK PKPEAEVKTI KPPPVEPEPT PIAAPVTVPV
VGKKAEAKAP KEEAAKPKGP IKGVPKKTPS PIEAERRKLR PGSGGEKPPD EAPFTYQLKA
VPLKFVKEIK DIILTESEFV GSSAIFECLV SPSTAITTWM KDGSNIRESP KHRFIADGKD
RKLHIIDVQL SDAGEYTCVL RLGNKEKTST AKLVVEELPV RFVKTLEEEV TVVKGQPLYL
SCELNKERDV VWRKDGKIVV EKPGRIVPGV IGLMRALTIN DADDTDAGTY TVTVENANNL
ECSSCVKVVE VIRDWLVKPI RDQHVKPKGT AIFACDIAKD TPNIKWFKGY DEIPAEPNDK
TEILRDGNHL YLKIKNAMPE DIAEYAVEIE GKRYPAKLTL GEREVELLKP IEDVTIYEKE
SASFDAEISE ADIPGQWKLK GELLRPSPTC EIKAEGGKRF LTLHKVKLDQ AGEVLYQALN
AITTAILTVK EIELDFAVPL KDVTVPERRQ ARFECVLTRE ANVIWSKGPD IIKSSDKFDI
IADGKKHILV INDSQFDDEG VYTAEVEGKK TSARLFVTGI RLKFMSPLED QTVKEGETAT
FVCELSHEKM HVVWFKNDAK LHTSRTVLIS SEGKTHKLEM KEVTLDDISQ IKAQVKELSS
TAQLKVLEAD PYFTVKLHDK TAVEKDEITL KCEVSKDVPV KWFKDGEEIV PSPKYSIKAD
GLRRILKIKK ADLKDKGEYV CDCGTDKTKA NVTVEARLIK VEKPLYGVEV FVGETAHFEI
ELSEPDVHGQ WKLKGQPLTA SPDCEIIEDG KKHILILHNC QLGMTGEVSF QAANAKSAAN
LKVKELPLIF ITPLSDVKVF EKDEAKFECE VSREPKTFRW LKGTQEITGD DRFELIKDGT
KHSMVIKSAA FEDEAKYMFE AEDKHTSGKL IIEGIRLKFL TPLKDVTAKE KESAVFTVEL
SHDNIRVKWF KNDQRLHTTR SVSMQDEGKT HSITFKDLSI DDTSQIRVEA MGMSSEAKLT
VLEGDPYFTG KLQDYTGVEK DEVILQCEIS KADAPVKWFK DGKEIKPSKN AVIKADGKKR
MLILKKALKS DIGQYTCDCG TDKTSGKLDI EDREIKLVRP LHSVEVMETE TARFETEISE
DDIHANWKLK GEALLQTPDC EIKEEGKIHS LVLHNCRLDQ TGGVDFQAAN VKSSAHLRVK
PRVIGLLRPL KDVTVTAGET ATFDCELSYE DIPVEWYLKG KKLEPSDKVV PRSEGKVHTL
TLRDVKLEDA GEVQLTAKDF KTHANLFVKE PPVEFTKPLE DQTVEEGATA VLECEVSREN
AKVKWFKNGT EILKSKKYEI VADGRVRKLV IHDCTPEDIK TYTCDAKDFK TSCNLNVVPP
HVEFLRPLTD LQVREKEMAR FECELSRENA KVKWFKDGAE IKKGKKYDII SKGAVRILVI
NKCLLDDEAE YSCEVRTART SGMLTVLEEE AVFTKNLANI EVSETDTIKL VCEVSKPGAE
VIWYKGDEEI IETGRYEILT EGRKRILVIQ NAHLEDAGNY NCRLPSSRTD GKVKVHELAA
EFISKPQNLE ILEGEKAEFV CSISKESFPV QWKRDDKTLE SGDKYDVIAD GKKRVLVVKD
ATLQDMGTYV VMVGAARAAA HLTVIEKLRI VVPLKDTRVK EQQEVVFNCE VNTEGAKAKW
FRNEEAIFDS SKYIILQKDL VYTLRIRDAH LDDQANYNVS LTNHRGENVK SAANLIVEEE
DLRIVEPLKD IETMEKKSVT FWCKVNRLNV TLKWTKNGEE VPFDNRVSYR VDKYKHMLTI
KDCGFPDEGE YIVTAGQDKS VAELLIIEAP TEFVEHLEDQ TVTEFDDAVF SCQLSREKAN
VKWYRNGREI KEGKKYKFEK DGSIHRLIIK DCRLDDECEY ACGVEDRKSR ARLFVEEIPV
EIIRPPQDIL EAPGADVVFL AELNKDKVEV QWLRNNMVVV QGDKHQMMSE GKIHRLQICD
IKPRDQGEYR FIAKDKEARA KLELAAAPKI KTADQDLVVD VGKPLTMVVP YDAYPKAEAE
WFKENEPLST KTIDTTAEQT SFRILEAKKG DKGRYKIVLQ NKHGKAEGFI NLKVIDVPGP
VRNLEVTETF DGEVSLAWEE PLTDGGSKII GYVVERRDIK RKTWVLATDR AESCEFTVTG
LQKGGVEYLF RVSARNRVGT GEPVETDNPV EARSKYDVPG PPLNVTITDV NRFGVSLTWE
PPEYDGGAEI TNYVIELRDK TSIRWDTAMT VRAEDLSATV TDVVEGQEYS FRVRAQNRIG
VGKPSAATPF VKVADPIERP SPPVNLTSSD QTQSSVQLKW EPPLKDGGSP ILGYIIERCE
EGKDNWIRCN MKLVPELTYK VTGLEKGNKY LYRVSAENKA GVSDPSEILG PLTADDAFVE
PTMDLSAFKD GLEVIVPNPI TILVPSTGYP RPTATWCFGD KVLETGDRVK MKTLSAYAEL
VISPSERSDK GIYTLKLENR VKTISGEIDV NVIARPSAPK ELKFGDITKD SVHLTWEPPD
DDGGSPLTGY VVEKREVSRK TWTKVMDFVT DLEFTVPDLV QGKEYLFKVC ARNKCGPGEP
AYVDEPVNMS TPATVPDPPE NVKWRDRTAN SIFLTWDPPK NDGGSRIKGY IVERCPRGSD
KWVACGEPVA ETKMEVTGLE EGKWYAYRVK ALNRQGASKP SRPTEEIQAV DTQEAPEIFL
DVKLLAGLTV KAGTKIELPA TVTGKPEPKI TWTKADMILK QDKRITIENV PKKSTVTIVD
SKRSDTGTYI IEAVNVCGRA TAVVEVNVLD KPGPPAAFDI TDVTNESCLL TWNPPRDDGG
SKITNYVVER RATDSEVWHK LSSTVKDTNF KATKLIPNKE YIFRVAAENM YGVGEPVQAS
PITAKYQFDP PGPPTRLEPS DITKDAVTLT WCEPDDDGGS PITGYWVERL DPDTDKWVRC
NKMPVKDTTY RVKGLTNKKK YRFRVLAENL AGPGKPSKST EPILIKDPID PPWPPGKPTV
KDVGKTSVRL NWTKPEHDGG AKIESYVIEM LKTGTDEWVR VAEGVPTTQH LLPGLMEGQE
YSFRVRAVNK AGESEPSEPS DPVLCREKLY PPSPPRWLEV INITKNTADL KWTVPEKDGG
SPITNYIVEK RDVRRKGWQT VDTTVKDTKC TVTPLTEGSL YVFRVAAENA IGQSDYTEIE
DSVLAKDTFT TPGPPYALAV VDVTKRHVDL KWEPPKNDGG RPIQRYVIEK KERLGTRWVK
AGKTAGPDCN FRVTDVIEGT EVQFQVRAEN EAGVGHPSEP TEILSIEDPT SPPSPPLDLH
VTDAGRKHIA IAWKPPEKNG GSPIIGYHVE MCPVGTEKWM RVNSRPIKDL KFKVEEGVVP
DKEYVLRVRA VNAIGVSEPS EISENVVAKD PDCKPTIDLE THDIIVIEGE KLSIPVPFRA
VPVPTVSWHK DGKEVKASDR LTMKNDHISA HLEVPKSVRA DAGIYTITLE NKLGSATASI
NVKVIGLPGP CKDIKASDIT KSSCKLTWEP PEFDGGTPIL HYVLERREAG RRTYIPVMSG
ENKLSWTVKD LIPNGEYFFR VKAVNKVGGG EYIELKNPVI AQDPKQPPDP PVDVEVHNPT
AEAMTITWKP PLYDGGSKIM GYIIEKIAKG EERWKRCNEH LVPILTYTAK GLEEGKEYQF
RVRAENAAGI SEPSRATPPT KAVDPIDAPK VILRTSLEVK RGDEIALDAS ISGSPYPTIT
WIKDENVIVP EEIKKRAAPL VRRRKGEVQE EEPFVLPLTQ RLSIDNSKKG ESQLRVRDSL
RPDHGLYMIK VENDHGIAKA PCTVSVLDTP GPPINFVFED IRKTSVLCKW EPPLDDGGSE
IINYTLEKKD KTKPDSEWIV VTSTLRHCKY SVTKLIEGKE YLFRVRAENR FGPGPPCVSK
PLVAKDPFGP PDAPDKPIVE DVTSNSMLVK WNEPKDNGSP ILGYWLEKRE VNSTHWSRVN
KSLLNALKAN VDGLLEGLTY VFRVCAENAA GPGKFSPPSD PKTAHDPISP PGPPIPRVTD
TSSTTIELEW EPPAFNGGGE IVGYFVDKQL VGTNEWSRCT EKMIKVRQYT VKEIREGADY
KLRVSAVNAA GEGPPGETQP VTVAEPQEPP AVELDVSVKG GIQIMAGKTL RIPAVVTGRP
VPTKVWTKEE GELDKDRVVI DNVGTKSELI IKDALRKDHG RYVITATNSC GSKFAAARVE
VFDVPGPVLD LKPVVTNRKM CLLNWSDPED DGGSEITGFI IERKDAKMHT WRQPIETERS
KCDITGLLEG QEYKFRVIAK NKFGCGPPVE IGPILAVDPL GPPTSPERLT YTERTKSTIT
LDWKEPRSNG GSPIQGYIIE KRRHDKPDFE RVNKRLCPTT SFLVENLDEH QMYEFRVKAV
NEIGESEPSL PLNVVIQDDE VPPTIKLRLS VRGDTIKVKA GEPVHIPADV TGLPMPKIEW
SKNETVIEKP TDALQITKEE VSRSEAKTEL SIPKAVREDK GTYTVTASNR LGSVFRNVHV
EVYDRPSPPR NLAVTDIKAE SCYLTWDAPL DNGGSEITHY VIDKRDASRK KAEWEEVTNT
AVEKRYGIWK LIPNGQYEFR VRAVNKYGIS DECKSDKVVI QDPYRLPGPP GKPKVLARTK
GSMLVSWTPP LDNGGSPITG YWLEKREEGS PYWSRVSRAP ITKVGLKGVE FNVPRLLEGV
KYQFRAMAIN AAGIGPPSEP SDPEVAGDPI FPPGPPSCPE VKDKTKSSIS LGWKPPAKDG
GSPIKGYIVE MQEEGTTDWK RVNEPDKLIT TCECVVPNLK ELRKYRFRVK AVNEAGESEP
SDTTGEIPAT DIQEEPEVFI DIGAQDCLVC KAGSQIRIPA VIKGRPTPKS SWEFDGKAKK
AMKDGVHDIP EDAQLETAEN SSVIIIPECK RSHTGKYSIT AKNKAGQKTA NCRVKVMDVP
GPPKDLKVSD ITRGSCRLSW KMPDDDGGDR IKGYVIEKRT IDGKAWTKVN PDCGSTTFVV
PDLLSEQQYF FRVRAENRFG IGPPVETIQR TTARDPIYPP DPPIKLKIGL ITKNTVHLSW
KPPKNDGGSP VTHYIVECLA WDPTGTKKEA WRQCNKRDVE ELQFTVEDLV EGGEYEFRVK
AVNAAGVSKP SATVGPVTVK DQTCPPSIDL KEFMEVEEGT NVNIVAKIKG VPFPTLTWFK
APPKKPDNKE PVLYDTHVNK LVVDDTCTLV IPQSRRSDTG LYTITAVNNL GTASKEMRLN
VLGRPGPPVG PIKFESVSAD QMTLSWFPPK DDGGSKITNY VIEKREANRK TWVHVSSEPK
ECTYTIPKLL EGHEYVFRIM AQNKYGIGEP LDSEPETARN LFSVPGAPDK PTVSSVTRNS
MTVNWEEPEY DGGSPVTGYW LEMKDTTSKR WKRVNRDPIK AMTLGVSYKV TGLIEGSDYQ
FRVYAINAAG VGPASLPSDP ATARDPIAPP GPPFPKVTDW TKSSADLEWS PPLKDGGSKV
TGYIVEYKEE GKEEWEKGKD KEVRGTKLVV TGLKEGAFYK FRVRAVNIAG IGEPGEVTDV
IEMKDRLVSP DLQLDASVRD RIVVHAGGVI RIIAYVSGKP PPTVTWNMNE RTLPQEATIE
TTAISSSMVI KNCQRSHQGV YSLLAKNEAG ERKKTIIVDV LDVPGPVGTP FLAHNLTNES
CKLTWFSPED DGGSPITNYV IEKRESDRRA WTPVTYTVTR QNATVQGLIQ GKAYFFRIAA
ENSIGMGPFV ETSEALVIRE PITVPERPED LEVKEVTKNT VTLTWNPPKY DGGSEIINYV
LESRLIGTEK FHKVTNDNLL SRKYTVKGLK EGDTYEYRVS AVNIVGQGKP SFCTKPITCK
DELAPPTLHL DFRDKLTIRV GEAFALTGRY SGKPKPKVSW FKDEADVLED DRTHIKTTPA
TLALEKIKAK RSDSGKYCVV VENSTGSRKG FCQVNVVDRP GPPVGPVSFD EVTKDYMVIS
WKPPLDDGGS KITNYIIEKK EVGKDVWMPV TSASAKTTCK VSKLLEGKDY IFRIHAENLY
GISDPLVSDS MKAKDRFRVP DAPDQPIVTE VTKDSALVTW NKPHDGGKPI TNYILEKRET
MSKRWARVTK DPIHPYTKFR VPDLLEGCQY EFRVSAENEI GIGDPSPPSK PVFAKDPIAK
PSPPVNPEAI DTTCNSVDLT WQPPRHDGGS KILGYIVEYQ KVGDEEWRRA NHTPESCPET
KYKVTGLRDG QTYKFRVLAV NAAGESDPAH VPEPVLVKDR LEPPELILDA NMAREQHIKV
GDTLRLSAII KGVPFPKVTW KKEDRDAPTK ARIDVTPVGS KLEIRNAAHE DGGIYSLTVE
NPAGSKTVSV KVLVLDKPGP PRDLEVSEIR KDSCYLTWKE PLDDGGSVIT NYVVERRDVA
SAQWSPLSAT SKKKSHFAKH LNEGNQYLFR VAAENQYGRG PFVETPKPIK ALDPLHPPGP
PKDLHHVDVD KTEVSLVWNK PDRDGGSPIT GYLVEYQEEG TQDWIKFKTV TNLECVVTGL
QQGKTYRFRV KAENIVGLGL PDTTIPIECQ EKLVPPSVEL DVKLIEGLVV KAGTTVRFPA
IIRGVPVPTA KWTTDGSEIK TDEHYTVETD NFSSVLTIKN CLRRDTGEYQ ITVSNAAGSK
TVAVHLTVLD VPGPPTGPIN ILDVTPEHMT ISWQPPKDDG GSPVINYIVE KQDTRKDTWG
VVSSGSSKTK LKIPHLQKGC EYVFRVRAEN KIGVGPPLDS TPTVAKHKFS PPSPPGKPVV
TDITENAATV SWTLPKSDGG SPITGYYMER REVTGKWVRV NKTPIADLKF RVTGLYEGNT
YEFRVFAENL AGLSKPSPSS DPIKACRPIK PPGPPINPKL KDKSRETADL VWTKPLSDGG
SPILGYVVEC QKPGTAQWNR INKDELIRQC AFRVPGLIEG NEYRFRIKAA NIVGEGEPRE
LAESVIAKDI LHPPEVELDV TCRDVITVRV GQTIRILARV KGRPEPDITW TKEGKVLVRE
KRVDLIQDLP RVELQIKEAV RADHGKYIIS AKNSSGHAQG SAIVNVLDRP GPCQNLKVTN
VTKENCTISW ENPLDNGGSE ITNFIVEYRK PNQKGWSIVA SDVTKRLIKA NLLANNEYYF
RVCAENKVGV GPTIETKTPI LAINPIDRPG EPENLHIADK GKTFVYLKWR RPDYDGGSPN
LSYHVERRLK GSDDWERVHK GSIKETHYMV DRCVENQIYE FRVQTKNEGG ESDWVKTEEV
VVKEDLQKPV LDLKLSGVLT VKAGDTIRLE AGVRGKPFPE VAWTKDKDAT DLTRSPRVKI
DTRADSSKFS LTKAKRSDGG KYVVTATNTA GSFVAYATVN VLDKPGPVRN LKIVDVSSDR
CTVCWDPPED DGGCEIQNYI LEKCETKRMV WSTYSATVLT PGTTVTRLIE GNEYIFRVRA
ENKIGTGPPT ESKPVIAKTK YDKPGRPDPP EVTKVSKEEM TVVWNPPEYD GGKSITGYFL
EKKEKHSTRW VPVNKSAIPE RRMKVQNLLP DHEYQFRVKA ENEIGIGEPS LPSRPVVAKD
PIEPPGPPTN FRVVDTTKHS ITLGWGKPVY DGGAPIIGYV VEMRPKIADA SPDEGWKRCN
AAAQLVRKEF TVTSLDENQE YEFRVCAQNQ VGIGRPAELK EAIKPKEILE PPEIDLDASM
RKLVIVRAGC PIRLFAIVRG RPAPKVTWRK VGIDNVVRKG QVDLVDTMAF LVIPNSTRDD
SGKYSLTLVN PAGEKAVFVN VRVLDTPGPV SDLKVSDVTK TSCHVSWAPP ENDGGSQVTH
YIVEKREADR KTWSTVTPEV KKTSFHVTNL VPGNEYYFRV TAVNEYGPGV PTDVPKPVLA
SDPLSEPDPP RKLEVTEMTK NSATLAWLPP LRDGGAKIDG YITSYREEEQ PADRWTEYSV
VKDLSLVVTG LKEGKKYKFR VAARNAVGVS LPREAEGVYE AKEQLLPPKI LMPEQITIKA
GKKLRIEAHV YGKPHPTCKW KKGEDEVVTS SHLAVHKADS SSILIIKDVT RKDSGYYSLT
AENSSGTDTQ KIKVVVMDAP GPPQPPFDIS DIDADACSLS WHIPLEDGGS NITNYIVEKC
DVSRGDWVTA LASVTKTSCR VGKLIPGQEY IFRVRAENRF GISEPLTSPK MVAQFPFGVP
SEPKNARVTK VNKDCIFVAW DRPDSDGGSP IIGYLIERKE RNSLLWVKAN DTLVRSTEYP
CAGLVEGLEY SFRIYALNKA GSSPPSKPTE YVTARMPVDP PGKPEVIDVT KSTVSLIWAR
PKHDGGSKII GYFVEACKLP GDKWVRCNTA PHQIPQEEYT ATGLEEKAQY QFRAIARTAV
NISPPSEPSD PVTILAENVP PRIDLSVAMK SLLTVKAGTN VCLDATVFGK PMPTVSWKKD
GTLLKPAEGI KMAMQRNLCT LELFSVNRKD SGDYTITAEN SSGSKSATIK LKVLDKPGPP
ASVKINKMYS DRAMLSWEPP LEDGGSEITN YIVDKRETSR PNWAQVSATV PITSCSVEKL
IEGHEYQFRI CAENKYGVGD PVFTEPAIAK NPYDPPGRCD PPVISNITKD HMTVSWKPPA
DDGGSPITGY LLEKRETQAV NWTKVNRKPI IERTLKATGL QEGTEYEFRV TAINKAGPGK
PSDASKAAYA RDPQYPPGPP AFPKVYDTTR SSVSLSWGKP AYDGGSPIIG YLVEVKRADS
DNWVRCNLPQ NLQKTRFEVT GLMEDTQYQF RVYAVNKIGY SDPSDVPDKH YPKDILIPPE
GELDADLRKT LILRAGVTMR LYVPVKGRPP PKITWSKPNV NLRDRIGLDI KSTDFDTFLR
CENVNKYDAG KYILTLENSC GKKEYTIVVK VLDTPGPPVN VTVKEISKDS AYVTWEPPII
DGGSPIINYV VQKRDAERKS WSTVTTECSK TSFRVANLEE GKSYFFRVFA ENEYGIGDPG
ETRDAVKASQ TPGPVVDLKV RSVSKSSCSI GWKKPHSDGG SRIIGYVVDF LTEENKWQRV
MKSLSLQYSA KDLTEGKEYT FRVSAENENG EGTPSEITVV ARDDVVAPDL DLKGLPDLCY
LAKENSNFRL KIPIKGKPAP SVSWKKGEDP LATDTRVSVE SSAVNTTLIV YDCQKSDAGK
YTITLKNVAG TKEGTISIKV VGKPGIPTGP IKFDEVTAEA MTLKWAPPKD DGGSEITNYI
LEKRDSVNNK WVTCASAVQK TTFRVTRLHE GMEYTFRVSA ENKYGVGEGL KSEPIVARHP
FDVPDAPPPP NIVDVRHDSV SLTWTDPKKT GGSPITGYHL EFKERNSLLW KRANKTPIRM
RDFKVTGLTE GLEYEFRVMA INLAGVGKPS LPSEPVVALD PIDPPGKPEV INITRNSVTL
IWTEPKYDGG HKLTGYIVEK RDLPSKSWMK ANHVNVPECA FTVTDLVEGG KYEFRIRAKN
TAGAISAPSE STETIICKDE YEAPTIVLDP TIKDGLTIKA GDTIVLNAIS ILGKPLPKSS
WSKAGKDIRP SDITQITSTP TSSMLTIKYA TRKDAGEYTI TATNPFGTKV EHVKVTVLDV
PGPPGPVEIS NVSAEKATLT WTPPLEDGGS PIKSYILEKR ETSRLLWTVV SEDIQSCRHV
ATKLIQGNEY IFRVSAVNHY GKGEPVQSEP VKMVDRFGPP GPPEKPEVSN VTKNTATVSW
KRPVDDGGSE ITGYHVERRE KKSLRWVRAI KTPVSDLRCK VTGLQEGSTY EFRVSAENRA
GIGPPSEASD SVLMKDAAYP PGPPSNPHVT DTTKKSASLA WGKPHYDGGL EITGYVVEHQ
KVGDEAWIKD TTGTALRITQ FVVPDLQTKE KYNFRISAIN DAGVGEPAVI PDVEIVEREM
APDFELDAEL RRTLVVRAGL SIRIFVPIKG RPAPEVTWTK DNINLKNRAN IENTESFTLL
IIPECNRYDT GKFVMTIENP AGKKSGFVNV RVLDTPGPVL NLRPTDITKD SVTLHWDLPL
IDGGSRITNY IVEKREATRK SYSTATTKCH KCTYKVTGLS EGCEYFFRVM AENEYGIGEP
TETTEPVKAS EAPSPPDSLN IMDITKSTVS LAWPKPKHDG GSKITGYVIE AQRKGSDQWT
HITTVKGLEC VVRNLTEGEE YTFQVMAVNS AGRSAPRESR PVIVKEQTML PELDLRGIYQ
KLVIAKAGDN IKVEIPVLGR PKPTVTWKKG DQILKQTQRV NFETTATSTI LNINECVRSD
SGPYPLTARN IVGEVGDVIT IQVHDIPGPP TGPIKFDEVS SDFVTFSWDP PENDGGVPIS
NYVVEMRQTD STTWVELATT VIRTTYKATR LTTGLEYQFR VKAQNRYGVG PGITSACIVA
NYPFKVPGPP GTPQVTAVTK DSMTISWHEP LSDGGSPILG YHVERKERNG ILWQTVSKAL
VPGNIFKSSG LTDGIAYEFR VIAENMAGKS KPSKPSEPML ALDPIDPPGK PVPLNITRHT
VTLKWAKPEY TGGFKITSYI VEKRDLPNGR WLKANFSNIL ENEFTVSGLT EDAAYEFRVI
AKNAAGAISP PSEPSDAITC RDDVEAPKIK VDVKFKDTVI LKAGEAFRLE ADVSGRPPPT
MEWSKDGKEL EGTAKLEIKI ADFSTNLVNK DSTRRDSGAY TLTATNPGGF AKHIFNVKVL
DRPGPPEGPL AVTEVTSEKC VLSWFPPLDD GGAKIDHYIV QKRETSRLAW TNVASEVQVT
KLKVTKLLKG NEYIFRVMAV NKYGVGEPLE SEPVLAVNPY GPPDPPKNPE VTTITKDSMV
VCWGHPDSDG GSEIINYIVE RRDKAGQRWI KCNKKTLTDL RYKVSGLTEG HEYEFRIMAE
NAAGISAPSP TSPFYKACDT VFKPGPPGNP RVLDTSRSSI SIAWNKPIYD GGSEITGYMV
EIALPEEDEW QIVTPPAGLK ATSYTITGLT ENQEYKIRIY AMNSEGLGEP ALVPGTPKAE
DRMLPPEIEL DADLRKVVTI RACCTLRLFV PIKGRPAPEV KWARDHGESL DKASIESTSS
YTLLIVGNVN RFDSGKYILT VENSSGSKSA FVNVRVLDTP GPPQDLKVKE VTKTSVTLTW
DPPLLDGGSK IKNYIVEKRE STRKAYSTVA TNCHKTSWKV DQLQEGCSYY FRVLAENEYG
IGLPAETAES VKASERPLPP GKITLMDVTR NSVSLSWEKP EHDGGSRILG YIVEMQTKGS
DKWATCATVK VTEATITGLI QGEEYSFRVS AQNEKGISDP RQLSVPVIAK DLVIPPAFKL
LFNTFTVLAG EDLKVDVPFI GRPTPAVTWH KDNVPLKQTT RVNAESTENN SLLTIKDACR
EDVGHYVVKL TNSAGEAIET LNVIVLDKPG PPTGPVKMDE VTADSITLSW GPPKYDGGSS
INNYIVEKRD TSTTTWQIVS ATVARTTIKA CRLKTGCEYQ FRIAAENRYG KSTYLNSEPT
VAQYPFKVPG PPGTPVVTLS SRDSMEVQWN EPISDGGSRV IGYHLERKER NSILWVKLNK
TPIPQTKFKT TGLEEGVEYE FRVSAENIVG IGKPSKVSEC YVARDPCDPP GRPEAIIVTR
NSVTLQWKKP TYDGGSKITG YIVEKKELPE GRWMKASFTN IIDTHFEVTG LVEDHRYEFR
VIARNAAGVF SEPSESTGAI TARDEVDPPR ISMDPKYKDT IVVHAGESFK VDADIYGKPI
PTIQWIKGDQ ELSNTARLEI KSTDFATSLS VKDAVRVDSG NYILKAKNVA GERSVTVNVK
VLDRPGPPEG PVVISGVTAE KCTLAWKPPL QDGGSDIINY IVERRETSRL VWTVVDANVQ
TLSCKVTKLL EGNEYTFRIM AVNKYGVGEP LESEPVVAKN PFVVPDAPKA PEVTTVTKDS
MIVVWERPAS DGGSEILGYV LEKRDKEGIR WTRCHKRLIG ELRLRVTGLI ENHDYEFRVS
AENAAGLSEP SPPSAYQKAC DPIYKPGPPN NPKVIDITRS SVFLSWSKPI YDGGCEIQGY
IVEKCDVSVG EWTMCTPPTG INKTNIEVEK LLEKHEYNFR ICAINKAGVG EHADVPGPII
VEEKLEAPDI DLDLELRKII NIRAGGSLRL FVPIKGRPTP EVKWGKVDGE IRDAAIIDVT
SSFTSLVLDN VNRYDSGKYT LTLENSSGTK SAFVTVRVLD TPSPPVNLKV TEITKDSVSI
TWEPPLLDGG SKIKNYIVEK REATRKSYAA VVTNCHKNSW KIDQLQEGCS YYFRVTAENE
YGIGLPAQTA DPIKVAEVPQ PPGKITVDDV TRNSVSLSWT KPEHDGGSKI IQYIVEMQAK
HSEKWSECAR VKSLQAVITN LTQGEEYLFR VVAVNEKGRS DPRSLAVPIV AKDLVIEPDV
KPAFSSYSVQ VGQDLKIEVP ISGRPKPTIT WTKDGLPLKQ TTRINVTDSL DLTTLSIKET
HKDDGGQYGI TVANVVGQKT ASIEIVTLDK PDPPKGPVKF DDVSAESITL SWNPPLYTGG
CQITNYIVQK RDTTTTVWDV VSATVARTTL KVTKLKTGTE YQFRIFAENR YGQSFALESD
PIVAQYPYKE PGPPGTPFAT AISKDSMVIQ WHEPVNNGGS PVIGYHLERK ERNSILWTKV
NKTIIHDTQF KAQNLEEGIE YEFRVYAENI VGVGKASKNS ECYVARDPCD PPGTPEPIMV
KRNEITLQWT KPVYDGGSMI TGYIVEKRDL PDGRWMKASF TNVIETQFTV SGLTEDQRYE
FRVIAKNAAG AISKPSDSTG PITAKDEVEL PRISMDPKFR DTIVVNAGET FRLEADVHGK
PLPTIEWLRG DKEIEESARC EIKNTDFKAL LIVKDAIRID GGQYILRASN VAGSKSFPVN
VKVLDRPGPP EGPVQVTGVT SEKCSLTWSP PLQDGGSDIS HYVVEKRETS RLAWTVVASE
VVTNSLKVTK LLEGNEYVFR IMAVNKYGVG EPLESAPVLM KNPFVLPGPP KSLEVTNIAK
DSMTVCWNRP DSDGGSEIIG YIVEKRDRSG IRWIKCNKRR ITDLRLRVTG LTEDHEYEFR
VSAENAAGVG EPSPATVYYK ACDPVFKPGP PTNAHIVDTT KNSITLAWGK PIYDGGSEIL
GYVVEICKAD EEEWQIVTPQ TGLRVTRFEI SKLTEHQEYK IRVCALNKVG LGEATSVPGT
VKPEDKLEAP ELDLDSELRK GIVVRAGGSA RIHIPFKGRP TPEITWSREE GEFTDKVQIE
KGVNYTQLSI DNCDRNDAGK YILKLENSSG SKSAFVTVKV LDTPGPPQNL AVKEVRKDSA
FLVWEPPIID GGAKVKNYVI DKRESTRKAY ANVSSKCSKT SFKVENLTEG AIYYFRVMAE
NEFGVGVPVE TVDAVKAAEP PSPPGKVTLT DVSQTSASLM WEKPEHDGGS RVLGYVVEMQ
PKGTEKWSIV AESKVCNAVV TGLSSGQEYQ FRVKAYNEKG KSDPRVLGVP VIAKDLTIQP
SLKLPFNTYS IQAGEDLKIE IPVIGRPRPN ISWVKDGEPL KQTTRVNVEE TATSTVLHIK
EGNKDDFGKY TVTATNSAGT ATENLSVIVL EKPGPPVGPV RFDEVSADFV VISWEPPAYT
GGCQISNYIV EKRDTTTTTW HMVSATVART TIKITKLKTG TEYQFRIFAE NRYGKSAPLD
SKAVIVQYPF KEPGPPGTPF VTSISKDQML VQWHEPVNDG GTKIIGYHLE QKEKNSILWV
KLNKTPIQDT KFKTTGLDEG LEYEFKVSAE NIVGIGKPSK VSECFVARDP CDPPGRPEAI
VITRNNVTLK WKKPAYDGGS KITGYIVEKK DLPDGRWMKA SFTNVLETEF TVSGLVEDQR
YEFRVIARNA AGNFSEPSDS SGAITARDEI DAPNASLDPK YKDVIVVHAG ETFVLEADIR
GKPIPDVVWS KDGKELEETA ARMEIKSTIQ KTTLVVKDCI RTDGGQYILK LSNVGGTKSI
PITVKVLDRP GPPEGPLKVT GVTAEKCYLA WNPPLQDGGA NISHYIIEKR ETSRLSWTQV
STEVQALNYK VTKLLPGNEY IFRVMAVNKY GIGEPLESGP VTACNPYKPP GPPSTPEVSA
ITKDSMVVTW ARPVDDGGTE IEGYILEKRD KEGVRWTKCN KKTLTDLRLR VTGLTEGHSY
EFRVAAENAA GVGEPSEPSV FYRACDALYP PGPPSNPKVT DTSRSSVSLA WSKPIYDGGA
PVKGYVVEVK EAAADEWTTC TPPTGLQGKQ FTVTKLKENT EYNFRICAIN SEGVGEPATL
PGSVVAQERI EPPEIELDAD LRKVVVLRAS ATLRLFVTIK GRPEPEVKWE KAEGILTDRA
QIEVTSSFTM LVIDNVTRFD SGRYNLTLEN NSGSKTAFVN VRVLDSPSAP VNLTIREVKK
DSVTLSWEPP LIDGGAKITN YIVEKRETTR KAYATITNNC TKTTFRIENL QEGCSYYFRV
LASNEYGIGL PAETTEPVKV SEPPLPPGRV TLVDVTRNTA TIKWEKPESD GGSKITGYVV
EMQTKGSEKW STCTQVKTLE ATISGLTAGE EYVFRVAAVN EKGRSDPRQL GVPVIARDIE
IKPSVELPFH TFNVKAREQL KIDVPFKGRP QATVNWRKDG QTLKETTRVN VSSSKTVTSL
SIKEASKEDV GTYELCVSNS AGSITVPITI IVLDRPGPPG PIRIDEVSCD SITISWNPPE
YDGGCQISNY IVEKKETTST TWHIVSQAVA RTSIKIVRLT TGSEYQFRVC AENRYGKSSY
SESSAVVAEY PFSPPGPPGT PKVVHATKST MLVTWQVPVN DGGSRVIGYH LEYKERSSIL
WSKANKILIA DTQMKVSGLD EGLMYEYRVY AENIAGIGKC SKSCEPVPAR DPCDPPGQPE
VTNITRKSVS LKWSKPHYDG GAKITGYIVE RRELPDGRWL KCNYTNIQET YFEVTELTED
QRYEFRVFAR NAADSVSEPS ESTGPIIVKD DVEPPRVMMD VKFRDVIVVK AGEVLKINAD
IAGRPLPVIS WAKDGIEIEE RARTEIISTD NHTLLTVKDC IRRDTGQYVL TLKNVAGTRS
VAVNCKVLDK PGPPAGPLEI NGLTAEKCSL SWGRPQEDGG ADIDYYIVEK RETSHLAWTI
CEGELQMTSC KVTKLLKGNE YIFRVTGVNK YGVGEPLESV AIKALDPFTV PSPPTSLEIT
SVTKESMTLC WSRPESDGGS EISGYIIERR EKNSLRWVRV NKKPVYDLRV KSTGLREGCE
YEYRVYAENA AGLSLPSETS PLIRAEDPVF LPSPPSKPKI VDSGKTTITI AWVKPLFDGG
APITGYTVEY KKSDDTDWKT SIQSLRGTEY TISGLTTGAE YVFRVKSVNK VGASDPSDSS
DPQIAKEREE EPLFDIDSEM RKTLIVKAGA SFTMTVPFRG RPVPNVLWSK PDTDLRTRAY
VDTTDSRTSL TIENANRNDS GKYTLTIQNV LSAASLTLVV KVLDTPGPPT NITVQDVTKE
SAVLSWDVPE NDGGAPVKNY HIEKREASKK AWVSVTNNCN RLSYKVTNLQ EGAIYYFRVS
GENEFGVGIP AETKEGVKIT EKPSPPEKLG VTSISKDSVS LTWLKPEHDG GSRIVHYVVE
ALEKGQKNWV KCAVAKSTHH VVSGLRENSE YFFRVFAENQ AGLSDPRELL LPVLIKEQLE
PPEIDMKNFP SHTVYVRAGS NLKVDIPISG KPLPKVTLSR DGVPLKATMR FNTEITAENL
TINLKESVTA DAGRYEITAA NSSGTTKAFI NIVVLDRPGP PTGPVVISDI TEESVTLKWE
PPKYDGGSQV TNYILLKRET STAVWTEVSA TVARTMMKVM KLTTGEEYQF RIKAENRFGI
SDHIDSACVT VKLPYTTPGP PSTPWVTNVT RESITVGWHE PVSNGGSAVV GYHLEMKDRN
SILWQKANKL VIRTTHFKVT TISAGLIYEF RVYAENAAGV GKPSHPSEPV LAIDACEPPR
NVRITDISKN SVSLSWQQPA FDGGSKITGY IVERRDLPDG RWTKASFTNV TETQFIISGL
TQNSQYEFRV FARNAVGSIS NPSEVVGPIT CIDSYGGPVI DLPLEYTEVV KYRAGTSVKL
RAGISGKPAP TIEWYKDDKE LQTNALVCVE NTTDLASILI KDADRLNSGC YELKLRNAMG
SASATIRVQI LDKPGPPGGP IEFKTVTAEK ITLLWRPPAD DGGAKITHYI VEKRETSRVV
WSMVSEHLEE CIITTTKIIK GNEYIFRVRA VNKYGIGEPL ESDSVVAKNA FVTPGPPGIP
EVTKITKNSM TVVWSRPIAD GGSDISGYFL EKRDKKSLGW FKVLKETIRD TRQKVTGLTE
NSDYQYRVCA VNAAGQGPFS EPSEFYKAAD PIDPPGPPAK IRIADSTKSS ITLGWSKPVY
DGGSAVTGYV VEIRQGEEEE WTTVSTKGEV RTTEYVVSNL KPGVNYYFRV SAVNCAGQGE
PIEMNEPVQA KDILEAPEID LDVALRTSVI AKAGEDVQVL IPFKGRPPPT VTWRKDEKNL
GSDARYSIEN TDSSSLLTIP QVTRNDTGKY ILTIENGVGE PKSSTVSVKV LDTPAACQKL
QVKHVSRGTV TLLWDPPLID GGSPIINYVI EKRDATKRTW SVVSHKCSST SFKLIDLSEK
TPFFFRVLAE NEIGIGEPCE TTEPVKAAEV PAPIRDLSMK DSTKTSVILS WTKPDFDGGS
VITEYVVERK GKGEQTWSHA GISKTCEIEV SQLKEQSVLE FRVFAKNEKG LSDPVTIGPI
TVKELIITPE VDLSDIPGAQ VTVRIGHNVH LELPYKGKPK PSISWLKDGL PLKESEFVRF
SKTENKITLS IKNAKKEHGG KYTVILDNAV CRIAVPITVI TLGPPSKPKG PIRFDEIKAD
SVILSWDVPE DNGGGEITCY SIEKRETSQT NWKMVCSSVA RTTFKVPNLV KDAEYQFRVR
AENRYGVSQP LVSSIIVAKH QFRIPGPPGK PVIYNVTSDG MSLTWDAPVY DGGSEVTGFH
VEKKERNSIL WQKVNTSPIS GREYRATGLV EGLDYQFRVY AENSAGLSSP SDPSKFTLAV
SPVDPPGTPD YIDVTRETIT LKWNPPLRDG GSKIVGYSIE KRQGNERWVR CNFTDVSECQ
YTVTGLSPGD RYEFRIIARN AVGTISPPSQ SSGIIMTRDE NVPPIVEFGP EYFDGLIIKS
GESLRIKALV QGRPVPRVTW FKDGVEIEKR MNMEITDVLG STSLFVRDAT RDHRGVYTVE
AKNASGSAKA EIKVKVQDTP GKVVGPIRFT NITGEKMTLW WDAPLNDGCA PITHYIIEKR
ETSRLAWALI EDKCEAQSYT AIKLINGNEY QFRVSAVNKF GVGRPLDSDP VVAQIQYTVP
DAPGIPEPSN ITGNSITLTW ARPESDGGSE IQQYILERRE KKSTRWVKVI SKRPISETRF
KVTGLTEGNE YEFHVMAENA AGVGPASGIS RLIKCREPVN PPGPPTVVKV TDTSKTTVSL
EWSKPVFDGG MEIIGYIIEM CKADLGDWHK VNAEACVKTR YTVTDLQAGE EYKFRVSAIN
GAGKGDSCEV TGTIKAVDRL TAPELDIDAN FKQTHVVRAG ASIRLFIAYQ GRPTPTAVWS
KPDSNLSLRA DIHTTDSFST LTVENCNRND AGKYTLTVEN NSGSKSITFT VKVLDTPGPP
GPITFKDVTR GSATLMWDAP LLDGGARIHH YVVEKREASR RSWQVISEKC TRQIFKVNDL
AEGVPYYFRV SAVNEYGVGE PYEMPEPIVA TEQPAPPRRL DVVDTSKSSA VLAWLKPDHD
GGSRITGYLL EMRQKGSDFW VEAGHTKQLT FTVERLVEKT EYEFRVKAKN DAGYSEPREA
FSSVIIKEPQ IEPTADLTGI TNQLITCKAG SPFTIDVPIS GRPAPKVTWK LEEMRLKETD
RVSITTTKDR TTLTVKDSMR GDSGRYFLTL ENTAGVKTFS VTVVVIGRPG PVTGPIEVSS
VSAESCVLSW GEPKDGGGTE ITNYIVEKRE SGTTAWQLVN SSVKRTQIKV THLTKYMEYS
FRVSSENRFG VSKPLESAPI IAEHPFVPPS APTRPEVYHV SANAMSIRWE EPYHDGGSKI
IGYWVEKKER NTILWVKENK VPCLECNYKV TGLVEGLEYQ FRTYALNAAG VSKASEASRP
IMAQNPVDAP GRPEVTDVTR STVSLIWSAP AYDGGSKVVG YIIERKPVSE VGDGRWLKCN
YTIVSDNFFT VTALSEGDTY EFRVLAKNAA GVISKGSEST GPVTCRDEYA PPKAELDARL
HGDLVTIRAG SDLVLDAAVG GKPEPKIIWT KGDKELDLCE KVSLQYTGKR ATAVIKFCDR
SDSGKYTLTV KNASGTKAVS VMVKVLDSPG PCGKLTVSRV TQEKCTLAWS LPQEDGGAEI
THYIVERRET SRLNWVIVEG ECPTLSYVVT RLIKNNEYIF RVRAVNKYGP GVPVESEPIV
ARNSFTIPSP PGIPEEVGTG KEHIIIQWTK PESDGGNEIS NYLVDKREKK SLRWTRVNKD
YVVYDTRLKV TSLMEGCDYQ FRVTAVNAAG NSEPSEASNF ISCREPSYTP GPPSAPRVVD
TTKHSISLAW TKPMYDGGTD IVGYVLEMQE KDTDQWYRVH TNATIRNTEF TVPDLKMGQK
YSFRVAAVNV KGMSEYSESI AEIEPVERIE IPDLELADDL KKTVTIRAGA SLRLMVSVSG
RPPPVITWSK QGIDLASRAI IDTTESYSLL IVDKVNRYDA GKYTIEAENQ SGKKSATVLV
KVYDTPGPCP SVKVKEVSRD SVTITWEIPT IDGGAPVNNY IVEKREAAMR AFKTVTTKCS
KTLYRISGLV EGTMYYFRVL PENIYGIGEP CETSDAVLVS EVPLVPAKLE VVDVTKSTVT
LAWEKPLYDG GSRLTGYVLE ACKAGTERWM KVVTLKPTVL EHTVTSLNEG EQYLFRIRAQ
NEKGVSEPRE TVTAVTVQDL RVLPTIDLST MPQKTIHVPA GRPVELVIPI AGRPPPAASW
FFAGSKLRES ERVTVETHTK VAKLTIRETT IRDTGEYTLE LKNVTGTTSE TIKVIILDKP
GPPTGPIKID EIDATSITIS WEPPELDGGA PLSGYVVEQR DAHRPGWLPV SESVTRSTFK
FTRLTEGNEY VFRVAATNRF GIGSYLQSEV IECRSSIRIP GPPETLQIFD VSRDGMTLTW
YPPEDDGGSQ VTGYIVERKE VRADRWVRVN KVPVTMTRYR STGLTEGLEY EHRVTAINAR
GSGKPSRPSK PIVAMDPIAP PGKPQNPRVT DTTRTSVSLA WSVPEDEGGS KVTGYLIEMQ
KVDQHEWTKC NTTPTKIREY TLTHLPQGAE YRFRVLACNA GGPGEPAEVP GTVKVTEMLE
YPDYELDERY QEGIFVRQGG VIRLTIPIKG KPFPICKWTK EGQDISKRAM IATSETHTEL
VIKEADRGDS GTYDLVLENK CGKKAVYIKV RVIGSPNSPE GPLEYDDIQV RSVRVSWRPP
ADDGGADILG YILERREVPK AAWYTIDSRV RGTSLVVKGL KENVEYHFRV SAENQFGISK
PLKSEEPVTP KTPLNPPEPP SNPPEVLDVT KSSVSLSWSR PKDDGGSRVT GYYIERKETS
TDKWVRHNKT QITTTMYTVT GLVPDAEYQF RIIAQNDVGL SETSPASEPV VCKDPFDKPS
QPGELEILSI SKDSVTLQWE KPECDGGKEI LGYWVEYRQS GDSAWKKSNK ERIKDKQFTI
GGLLEATEYE FRVFAENETG LSRPRRTAMS IKTKLTSGEA PGIRKEMKDV TTKLGEAAQL
SCQIVGRPLP DIKWYRFGKE LIQSRKYKMS SDGRTHTLTV MTEEQEDEGV YTCIATNEVG
EVETSSKLLL QATPQFHPGY PLKEKYYGAV GSTLRLHVMY IGRPVPAMTW FHGQKLLQNS
ENITIENTEH YTHLVMKNVQ RKTHAGKYKV QLSNVFGTVD AILDVEIQDK PDKPTGPIVI
EALLKNSAVI SWKPPADDGG SWITNYVVEK CEAKEGAEWQ LVSSAISVTT CRIVNLTENA
GYYFRVSAQN TFGISDPLEV SSVVIIKSPF EKPGAPGKPT ITAVTKDSCV VAWKPPASDG
GAKIRNYYLE KREKKQNKWI SVTTEEIRET VFSVKNLIEG LEYEFRVKCE NLGGESEWSE
ISEPITPKSD VPIQAPHFKE ELRNLNVRYQ SNATLVCKVT GHPKPIVKWY RQGKEIIADG
LKYRIQEFKG GYHQLIIASV TDDDATVYQV RATNQGGSVS GTASLEVEVP AKIHLPKTLE
GMGAVHALRG EVVSIKIPFS GKPDPVITWQ KGQDLIDNNG HYQVIVTRSF TSLVFPNGVE
RKDAGFYVVC AKNRFGIDQK TVELDVADVP DPPRGVKVSD VSRDSVNLTW TEPASDGGSK
ITNYIVEKCA TTAERWLRVG QARETRYTVI NLFGKTSYQF RVIAENKFGL SKPSEPSEPT
ITKEDKTRAM NYDEEVDETR EVSMTKASHS STKELYEKYM IAEDLGRGEF GIVHRCVETS
SKKTYMAKFV KVKGTDQVLV KKEISILNIA RHRNILHLHE SFESMEELVM IFEFISGLDI
FERINTSAFE LNEREIVSYV HQVCEALQFL HSHNIGHFDI RPENIIYQTR RSSTIKIIEF
GQARQLKPGD NFRLLFTAPE YYAPEVHQHD VVSTATDMWS LGTLVYVLLS GINPFLAETN
QQIIENIMNA EYTFDEEAFK EISIEAMDFV DRLLVKERKS RMTASEALQH PWLKQKIERV
STKVIRTLKH RRYYHTLIKK DLNMVVSAAR ISCGGAIRSQ KGVSVAKVKV ASIEIGPVSG
QIMHAVGEEG GHVKYVCKIE NYDQSTQVTW YFGVRQLENS EKYEITYEDG VAILYVKDIT
KLDDGTYRCK VVNDYGEDSS YAELFVKGVR EVYDYYCRRT MKKIKRRTDT MRLLERPPEF
TLPLYNKTAY VGENVRFGVT ITVHPEPHVT WYKSGQKIKP GDNDKKYTFE SDKGLYQLTI
NSVTTDDDAE YTVVARNKYG EDSCKAKLTV TLHPPPTDST LRPMFKRLLA NAECQEGQSV
CFEIRVSGIP PPTLKWEKDG QPLSLGPNIE IIHEGLDYYA LHIRDTLPED TGYYRVTATN
TAGSTSCQAH LQVERLRYKK QEFKSKEEHE RHVQKQIDKT LRMAEILSGT ESVPLTQVAK
EALREAAVLY KPAVSTKTVK GEFRLEIEEK KEERKLRMPY DVPEPRKYKQ TTIEEDQRIK
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR
IPKLSQDDLE IVRPARRRTP SPDYDFYYRP RRRSLGDISD EELLLPIDDY LAMKRTEEER
LRLEEELELG FSASPPSRSP PHFELSSLRY SSPQAHVKVE ETRKDFRYST YHIPTKAEAS
TSYAELRERH AQAAYRQPKQ RQRIMAERED EELLRPVTTT QHLSEYKSEL DFMSKEEKSR
KKSRRQREVT EITEIEEEYE ISKHAQRESS SSASRLLRRR RSLSPTYIEL MRPVSELIRS
RPQPAEEYED DTERRSPTPE RTRPRSPSPV SSERSLSRFE RSARFDIFSR YESMKAALKT
QKTSERKYEV LSQQPFTLDH APRITLRMRS HRVPCGQNTR FILNVQSKPT AEVKWYHNGV
ELQESSKIHY TNTSGVLTLE ILDCHTDDSG TYRAVCTNYK GEASDYATLD VTGGDYTTYA
SQRRDEEVPR SVFPELTRTE AYAVSSFKKT SEMEASSSVR EVKSQMTETR ESLSSYEHSA
SAEMKSAALE EKSLEEKSTT RKIKTTLAAR ILTKPRSMTV YEGESARFSC DTDGEPVPTV
TWLRKGQVLS TSARHQVTTT KYKSTFEISS VQASDEGNYS VVVENSEGKQ EAEFTLTIQK
ARVTEKAVTS PPRVKSPEPR VKSPEAVKSP KRVKSPEPSH PKAVSPTETK PTPTEKVQHL
PVSAPPKITQ FLKAEASKEI AKLTCVVESS VLRAKEVTWY KDGKKLKENG HFQFHYSADG
TYELKINNLT ESDQGEYVCE ISGEGGTSKT NLQFMGQAFK SIHEKVSKIS ETKKSDQKTT
ESTVTRKTEP KAPEPISSKP VIVTGLQDTT VSSDSVAKFA VKATGEPRPT AIWTKDGKAI
TQGGKYKLSE DKGGFFLEIH KTDTSDSGLY TCTVKNSAGS VSSSCKLTIK AIKDTEAQKV
STQKTSEITP QKKAVVQEEI SQKALRSEEI KMSEAKSQEK LALKEEASKV LISEEVKKSA
ATSLEKSIVH EEITKTSQAS EEVRTHAEIK AFSTQMSINE GQRLVLKANI AGATDVKWVL
NGVELTNSEE YRYGVSGSDQ TLTIKQASHR DEGILTCISK TKEGIVKCQY DLTLSKELSD
APAFISQPRS QNINEGQNVL FTCEISGEPS PEIEWFKNNL PISISSNVSI SRSRNVYSLE
IRNASVSDSG KYTIKAKNFR GQCSATASLM VLPLVEEPSR EVVLRTSGDT SLQGSFSSQS
VQMSASKQEA SFSSFSSSSA SSMTEMKFAS MSAQSMSSMQ ESFVEMSSSS FMGISNMTQL
ESSTSKMLKA GIRGIPPKIE ALPSDISIDE GKVLTVACAF TGEPTPEVTW SCGGRKIHSQ
EQGRFHIENT DDLTTLIIMD VQKQDGGLYT LSLGNEFGSD SATVNIHIRS I*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

1 / 1

Last intron/exon boundary

80860

Theoretical NMD boundary in CDS

80809

Length of CDS

81156

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.05 s

Back to summary table

Variant:

2:178745884C>A_3_ENST00000715174

Back to summary table

Prediction:

BenignPermalink

Summary:

Model: without_aae
Tree vote: 10|190 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

no data

Ensembl transcript ID

ENST00000715174.1

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10898-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAVDVGKK AEAVATVVAA VDQARVREPR EPGHLEESYA QQTTLEYGYK
ERISAAKVAE PPQRPASEPH VVPKAVKPRV IQAPSETHIK TTDQKGMHIS SQIKKTTDLT
TERLVHVDKR PRTASPHFTV SKISVPKTEH GYEASIAGSA IATLQKELSA TSSAQKITKS
VKAPTVKPSE TRVRAEPTPL PQFPFADTPD TYKSEAGVEV KKEVGVSITG TTVREERFEV
LHGREAKVTE TARVPAPVEI PVTPPTLVSG LKNVTVIEGE SVTLECHISG YPSPTVTWYR
EDYQIESSID FQITFQSGIA RLMIREAFAE DSGRFTCSAV NEAGTVSTSC YLAVQVSEEF
EKETTAVTEK FTTEEKRFVE SRDVVMTDTS LTEEQAGPGE PAAPYFITKP VVQKLVEGGS
VVFGCQVGGN PKPHVYWKKS GVPLTTGYRY KVSYNKQTGE CKLVISMTFA DDAGEYTIVV
RNKHGETSAS ASLLEEADYE LLMKSQQEML YQTQVTAFVQ EPKVGETAPG FVYSEYEKEY
EKEQALIRKK MAKDTVVVRT YVEDQEFHIS SFEERLIKEI EYRIIKTTLE ELLEEDGEEK
MAVDISESEA VESGFDSRIK NYRILEGMGV TFHCKMSGYP LPKIAWYKDG KRIKHGERYQ
MDFLQDGRAS LRIPVVLPED EGIYTAFASN IKGNAICSGK LYVEPAAPLG APTYIPTLEP
VSRIRSLSPR SVSRSPIRMS PARMSPARMS PARMSPARMS PGRRLEETDE SQLERLYKPV
FVLKPVSFKC LEGQTARFDL KVVGRPMPET FWFHDGQQIV NDYTHKVVIK EDGTQSLIIV
PATPSDSGEW TVVAQNRAGR SSISVILTVE AVEHQVKPMF VEKLKNVNIK EGSRLEMKVR
ATGNPNPDIV WLKNSDIIVP HKYPKIRIEG TKGEAALKID STVSQDSAWY TATAINKAGR
DTTRCKVNVE VEFAEPEPER KLIIPRGTYR AKEIAAPELE PLHLRYGQEQ WEEGDLYDKE
KQQKPFFKKK LTSLRLKRFG PAHFECRLTP IGDPTMVVEW LHDGKPLEAA NRLRMINEFG
YCSLDYGVAY SRDSGIITCR ATNKYGTDHT SATLIVKDEK SLVEESQLPE GRKGLQRIEE
LERMAHEGAL TGVTTDQKEK QKPDIVLYPE PVRVLEGETA RFRCRVTGYP QPKVNWYLNG
QLIRKSKRFR VRYDGIHYLD IVDCKSYDTG EVKVTAENPE GVIEHKVKLE IQQREDFRSV
LRRAPEPRPE FHVHEPGKLQ FEVQKVDRPV DTTETKEVVK LKRAERITHE KVPEESEELR
SKFKRRTEEG YYEAITAVEL KSRKKDESYE ELLRKTKDEL LHWTKELTEE EKKALAEEGK
ITIPTFKPDK IELSPSMEAP KIFERIQSQT VGQGSDAHFR VRVVGKPDPE CEWYKNGVKI
ERSDRIYWYW PEDNVCELVI RDVTAEDSAS IMVKAINIAG ETSSHAFLLV QAKQLITFTQ
ELQDVVAKEK DTMATFECET SEPFVKVKWY KDGMEVHEGD KYRMHSDRKV HFLSILTIDT
SDAEDYSCVL VEDENVKTTA KLIVEGAVVE FVKELQDIEV PESYSGELEC IVSPENIEGK
WYHNDVELKS NGKYTITSRR GRQNLTVKDV TKEDQGEYSF VIDGKKTTCK LKMKPRPIAI
LQGLSDQKVC EGDIVQLEVK VSLESVEGVW MKDGQEVQPS DRVHIVIDKQ SHMLLIEDMT
KEDAGNYSFT IPALGLSTSG RVSVYSVDVI TPLKDVNVIE GTKAVLECKV SVPDVTSVKW
YLNDEQIKPD DRVQAIVKGT KQRLVINRTH ASDEGPYKLI VGRVETNCNL SVEKIKIIRG
LRDLTCTETQ NVVFEVELSH SGIDVLWNFK DKEIKPSSKY KIEAHGKIYK LTVLNMMKDD
EGKYTFYAGE NMTSGKLTVA GGAISKPLTD QTVAESQEAV FECEVANPDS KGEWLRDGKH
LPLTNNIRSE SDGHKRRLII AATKLDDIGE YTYKVATSKT SAKLKVEAVK IKKTLKNLTV
TETQDAVFTV ELTHPNVKGV QWIKNGVVLE SNEKYAISVK GTIYSLRIKN CAIVDESVYG
FRLGRLGASA RLHVETVKII KKPKDVTALE NATVAFEVSV SHDTVPVKWF HKSVEIKPSD
KHRLVSERKV HKLMLQNISP SDAGEYTAVV GQLECKAKLF VETLHITKTM KNIEVPETKT
ASFECEVSHF NVPSMWLKNG VEIEMSEKFK IVVQGKLHQL IIMNTSTEDS AEYTFVCGND
QVSATLTVTP IMITSMLKDI NAEEKDTITF EVTVNYEGIS YKWLKNGVEI KSTDKCQMRT
KKLTHSLNIR NVHFGDAADY TFVAGKATST ATLYVEARHI EFRKHIKDIK VLEKKRAMFE
CEVSEPDITV QWMKDDQELQ ITDRIKIQKE KYVHRLLIPS TRMSDAGKYT VVAGGNVSTA
KLFVEGRDVR IRSIKKEVQV IEKQRAVVEF EVNEDDVDAH WYKDGIEINF QVQERHKYVV
ERRIHRMFIS ETRQSDAGEY TFVAGRNRSS VTLYVNAPEP PQVLQELQPV TVQSGKPARF
CAVISGRPQP KISWYKEEQL LSTGFKCKFL HDGQEYTLLL IEAFPEDAAV YTCEAKNDYG
VATTSASLSV EVPEVVSPDQ EMPVYPPAII TPLQDTVTSE GQPARFQCRV SGTDLKVSWY
SKDKKIKPSR FFRMTQFEDT YQLEIAEAYP EDEGTYTFVA SNAVGQVSST ANLSLEGFSK
FEENTSNSQW HVSLSVSFKK EPLGQKPSFI QPLSSLRVHN GETVRFHARV SGIPKPEIQW
FHNQQLILPT KDVVFHFEES TGMALMLIVD AYSEHAGQYS CKAANSAGEA TCAATLTVTP
KVQALDRQSS GKDVRESTKS QAVADSSFTK EESKISQKEI KSFQGSSYEY EVQVFESVSQ
SSIHTAASVQ DTQLCHTASL SQIAESTELS KECAKESTGE APKIFLHLQD VTVKCGDTAQ
FLCVLKDDSF IDVTWTHEGA KIEESERLKQ SQNGNIQFLT ICNVQLVDQG LYSCIVHNDC
GERTTSAVLS VEGAPESILH ERIEQEIEME MKEFSSSFLS AEEEGLHSAE LQLSKINETL
ELLSESPVYP TKFDSEKEGT GPIFIKEVSN ADISMGDVAT LSVTVIGIPK PKIQWFFNGV
LLTPSADYKF VFDGDDHSLI ILFTKLEDEG EYTCMASNDY GKTICSAYLK INSKGEGHKD
TETESAVAKS LEKLGGPCPP HFLKELKPIR CAQGLPAIFE YTVVGEPAPT VTWFKENKQL
CTSVYYTIIH NPNGSGTFIV NDPQREDSGL YICKAENMLG ESTCAAELLV LLEDTDMTDT
PCKAKSTPEA PEDFPQTPLK GPAVEALDSE QEIATFVKDT ILKAALITEE NQQLSYEHIA
KANELSSQLP LGAQELQSIL EQDKLTPEST REFLCINGSI HFQPLKEPSP NLQLQIVQSQ
KTFSKEGILM PEEPETQAVL SDTEKIFPSA MSIEQINSLT VEPLKTLLAE PEGNYPQSSI
EPPMHSYLTS VAEEVLSPKE KTVSDTNREQ RVTLQKQEAQ SALILSQSLA EGHVESLQSP
DVMISQVNYE PLVPSEHSCT EGGKILIESA NPLENAGQDS AVRIEEGKSL RFPLALEEKQ
VLLKEEHSDN VVMPPDQIIE SKREPVAIKK VQEVQGRDLL SKESLLSGIP EEQRLNLKIQ
ICRALQAAVA SEQPGLFSEW LRNIEKVEVE AVNITQEPRH IMCMYLVTSA KSVTEEVTII
IEDVDPQMAN LKMELRDALC AIIYEEIDIL TAEGPRIQQG AKTSLQEEMD SFSGSQKVEP
ITEPEVESKY LISTEEVSYF NVQSRVKYLD ATPVTKGVAS AVVSDEKQDE SLKPSEEKEE
SSSESGTEEV ATVKIQEAEG GLIKEDGPMI HTPLVDTVSE EGDIVHLTTS ITNAKEVNWY
FENKLVPSDE KFKCLQDQNT YTLVIDKVNT EDHQGEYVCE ALNDSGKTAT SAKLTVVKRA
APVIKRKIEP LEVALGHLAK FTCEIQSAPN VRFQWFKAGR EIYESDKCSI RSSKYISSLE
ILRTQVVDCG EYTCKASNEY GSVSCTATLT VTEAYPPTFL SRPKSLTTFV GKAAKFICTV
TGTPVIETIW QKDGAALSPS PNWRISDAEN KHILELSNLT IQDRGVYSCK ASNKFGADIC
QAELIIIDKP HFIKELEPVQ SAINKKVHLE CQVDEDRKVT VTWSKDGQKL PPGKDYKICF
EDKIATLEIP LAKLKDSGTY VCTASNEAGS SSCSATVTVR EPPSFVKKVD PSYLMLPGES
ARLHCKLKGS PVIQVTWFKN NKELSESNTV RMYFVNSEAI LDITDVKVED SGSYSCEAVN
DVGSDSCSTE IVIKEPPSFI KTLEPADIVR GTNALLQCEV SGTGPFEISW FKDKKQIRSS
KKYRLFSQKS LVCLEIFSFN SADVGEYECV VANEVGKCGC MATHLLKEPP TFVKKVDDLI
ALGGQTVTLQ AAVRGSEPIS VTWMKGQEVI REDGKIKMSF SNGVAVLIIP DVQISFGGKY
TCLAENEAGS QTSVGELIVK EPAKIIERAE LIQVTAGDPA TLEYTVAGTP ELKPKWYKDG
RPLVASKKYR ISFKNNVAQL KFYSAELHDS GQYTFEISNE VGSSSCETTF TVLDRDIAPF
FTKPLRNVDS VVNGTCRLDC KIAGSLPMRV SWFKDGKEIA ASDRYRIAFV EGTASLEIIR
VDMNDAGNFT CRATNSVGSK DSSGALIVQE PPSFVTKPGS KDVLPGSAVC LKSTFQGSTP
LTIRWFKGNK ELVSGGSCYI TKEALESSLE LYLVKTSDSG TYTCKVSNVA GGVECSANLF
VKEPATFVEK LEPSQLLKKG DATQLACKVT GTPPIKITWF ANDREIKESS KHRMSFVEST
AVLRLTDVGI EDSGEYMCEA QNEAGSDHCS SIVIVKESPY FTKEFKPIEV LKEYDVMLLA
EVAGTPPFEI TWFKDNTILR SGRKYKTFIQ DHLVSLQILK FVAADAGEYQ CRVTNEVGSS
ICSARVTLRE PPSFIKKIES TSSLRGGTAA FQATLKGSLP ITVTWLKDSD EITEDDNIRM
TFENNVASLY LSGIEVKHDG KYVCQAKNDA GIQRCSALLS VKEPATITEE AVSIDVTQGD
PATLQVKFSG TKEITAKWFK DGQELTLGSK YKISVTDTVS ILKIISTEKK DSGEYTFEVQ
NDVGRSSCKA RINVLDLIIP PSFTKKLKKM DSIKGSFIDL ECIVAGSHPI SIQWFKDDQE
ISASEKYKFS FHDNTAFLEI SQLEGTDSGT YTCSATNKAG HNQCSGHLTV KEPPYFVEKP
QSQDVNPNTR VQLKALVGGT APMTIKWFKD NKELHSGAAR SVWKDDTSTS LELFAAKATD
SGTYICQLSN DVGTATSKAT LFVKEPPQFI KKPSPVLVLR NGQSTTFECQ ITGTPKIRVS
WYLDGNEITA IQKHGISFID GLATFQISGA RVENSGTYVC EARNDAGTAS CSIELKVKEP
PTFIRELKPV EVVKYSDVEL ECEVTGTPPF EVTWLKNNRE IRSSKKYTLT DRVSVFNLHI
TKCDPSDTGE YQCIVSNEGG SCSCSTRVAL KEPPSFIKKI ENTTTVLKSS ATFQSTVAGS
PPISITWLKD DQILDEDDNV YISFVDSVAT LQIRSVDNGH SGRYTCQAKN ESGVERCYAF
LLVQEPAQIV EKAKSVDVTE KDPMTLECVV AGTPELKVKW LKDGKQIVPS RYFSMSFENN
VASFRIQSVM KQDSGQYTFK VENDFGSSSC DAYLRVLDQN IPPSFTKKLT KMDKVLGSSI
HMECKVSGSL PISAQWFKDG KEISTSAKYR LVCHERSVSL EVNNLELEDT ANYTCKVSNV
AGDDACSGIL TVKEPPSFLV KPGRQQAIPD STVEFKAILK GTPPFKIKWF KDDVELVSGP
KCFIGLEGST SFLNLYSVDA SKTGQYTCHV TNDVGSDSCT TMLLVTEPPK FVKKLEASKI
VKAGDSSRLE CKIAGSPEIR VVWFRNEHEL PASDKYRMTF IDSVAVIQMN NLSTEDSGDF
ICEAQNPAGS TSCSTKVIVK EPPVFSSFPP IVETLKNAEV SLECELSGTP PFEVVWYKDK
RQLRSSKKYK IASKNFHTSI HILNVDTSDI GEYHCKAQNE VGSDTCVCTV KLKEPPRFVS
KLNSLTVVAG EPAELQASIE GAQPIFVQWL KEKEEVIRES ENIRITFVEN VATLQFAKAE
PANAGKYICQ IKNDGGMREN MATLMVLEPA VIVEKAGPMT VTVGETCTLE CKVAGTPELS
VEWYKDGKLL TSSQKHKFSF YNKISSLRIL SVERQDAGTY TFQVQNNVGK SSCTAVVDVS
DRAVPPSFTR RLKNTGGVLG ASCILECKVA GSSPISVAWF HEKTKIVSGA KYQTTFSDNV
CTLQLNSLDS SDMGNYTCVA ANVAGSDECR AVLTVQEPPS FVKEPEPLEV LPGKNVTFTS
VIRGTPPFKV NWFRGARELV KGDRCNIYFE DTVAELELFN IDISQSGEYT CVVSNNAGQA
SCTTRLFVKE PAAFLKRLSD HSVEPGKSII LESTYTGTLP ISVTWKKDGF NITTSEKCNI
VTTEKTCILE ILNSTKRDAG QYSCEIENEA GRDVCGALVS TLEPPYFVTE LEPLEAAVGD
SVSLQCQVAG TPEITVSWYK GDTKLRPTPE YRTYFTNNVA TLVFNKVNIN DSGEYTCKAE
NSIGTASSKT VFRIQERQLP PSFARQLKDI EQTVGLPVTL TCRLNGSAPI QVCWYRDGVL
LRDDENLQTS FVDNVATLKI LQTDLSHSGQ YSCSASNPLG TASSSARLTA REPKKSPFFD
IKPVSIDVIA GESADFECHV TGAQPMRITW SKDNKEIRPG GNYTITCVGN TPHLRILKVG
KGDSGQYTCQ ATNDVGKDMC SAQLSVKEPP KFVKKLEASK VAKQGESIQL ECKISGSPEI
KVSWFRNDSE LHESWKYNMS FINSVALLTI NEASAEDSGD YICEAHNGVG DASCSTALTV
KAPPVFTQKP SPVGALKGSD VILQCEISGT PPFEVVWVKD RKQVRNSKKF KITSKHFDTS
LHILNLEASD VGEYHCKATN EVGSDTCSCS VKFKEPPRFV KKLSDTSTLI GDAVELRAIV
EGFQPISVVW LKDRGEVIRE SENTRISFID NIATLQLGSP EASNSGKYIC QIKNDAGMRE
CSAVLTVLEP ARIIEKPEPM TVTTGNPFAL ECVVTGTPEL SAKWFKDGRE LSADSKHHIT
FINKVASLKI PCAEMSDKGL YSFEVKNSVG KSNCTVSVHV SDRIVPPSFI RKLKDVNAIL
GASVVLECRV SGSAPISVGW FQDGNEIVSG PKCQSSFSEN VCTLNLSLLE PSDTGIYTCV
AANVAGSDEC SAVLTVQEPP SFEQTPDSVE VLPGMSLTFT SVIRGTPPFK VKWFKGSREL
VPGESCNISL EDFVTELELF EVQPLESGDY SCLVTNDAGS ASCTTHLFVK EPATFVKRLA
DFSVETGSPI VLEATYTGTP PISVSWIKDE YLISQSERCS ITMTEKSTIL EILESTIEDY
AQYSCLIENE AGQDICEALV SVLEPPYFIE PLEHVEAVIG EPATLQCKVD GTPEIRISWY
KEHTKLRSAP AYKMQFKNNV ASLVINKVDH SDVGEYSCKA DNSVGAVASS AVLVIKARKL
PPFFARKLKD VHETLGFPVA FECRINGSEP LQVSWYKDGV LLKDDANLQT SFVHNVATLQ
ILQTDQSHIG QYNCSASNPL GTASSSAKLI LSEHEVPPFF DLKPVSVDLA LGESGTFKCH
VTGTAPIKIT WAKDNREIRP GGNYKMTLVE NTATLTVLKV GKGDAGQYTC YASNIAGKDS
CSAQLGVQEP PRFIKKLEPS RIVKQDEFTR YECKIGGSPE IKVLWYKDET EIQESSKFRM
SFVDSVAVLE MHNLSVEDSG DYTCEAHNAA GSASSSTSLK VKEPPIFRKK PHPIETLKGA
DVHLECELQG TPPFHVSWYK DKRELRSGKK YKIMSENFLT SIHILNVDAA DIGEYQCKAT
NDVGSDTCVG SIALKAPPRF VKKLSDISTV VGKEVQLQTT IEGAEPISVV WFKDKGEIVR
ESDNIWISYS ENIATLQFSR VEPANAGKYT CQIKNDAGMQ ECFATLSVLE PATIVEKPES
IKVTTGDTCT LECTVAGTPE LSTKWFKDGK ELTSDNKYKI SFFNKVSGLK IINVAPSDSG
VYSFEVQNPV GKDSCTASLQ VSDRTVPPSF TRKLKETNGL SGSSVVMECK VYGSPPISVS
WFHEGNEISS GRKYQTTLTD NTCALTVNML EESDSGDYTC IATNMAGSDE CSAPLTVREP
PSFVQKPDPM DVLTGTNVTF TSIVKGTPPF SVSWFKGSSE LVPGDRCNVS LEDSVAELEL
FDVDTSQSGE YTCIVSNEAG KASCTTHLYI KAPAKFVKRL NDYSIEKGKP LILEGTFTGT
PPISVTWKKN GINVTPSQRC NITTTEKSAI LEIPSSTVED AGQYNCYIEN ASGKDSCSAQ
ILILEPPYFV KQLEPVKVSV GDSASLQCQL AGTPEIGVSW YKGDTKLRPT TTYKMHFRNN
VATLVFNQVD INDSGEYICK AENSVGEVSA STFLTVQEQK LPPSFSRQLR DVQETVGLPV
VFDCAISGSE PISVSWYKDG KPLKDSPNVQ TSFLDNTATL NIFKTDRSLA GQYSCTATNP
IGSASSSARL ILTEGKNPPF FDIRLAPVDA VVGESADFEC HVTGTQPIKV SWAKDSREIR
SGGKYQISYL ENSAHLTVLK VDKGDSGQYT CYAVNEVGKD SCTAQLNIKE RLIPPSFTKR
LSETVEETEG NSFKLEGRVA GSQPITVAWY KNNIEIQPTS NCEITFKNNT LVLQVRKAGM
NDAGLYTCKV SNDAGSALCT SSIVIKEPKK PPVFDQHLTP VTVSEGEYVQ LSCHVQGSEP
IRIQWLKAGR EIKPSDRCSF SFASGTAVLE LRDVAKADSG DYVCKASNVA GSDTTKSKVT
IKDKPAVAPA TKKAAVDGRL FFVSEPQSIR VVEKTTATFI AKVGGDPIPN VKWTKGKWRQ
LNQGGRVFIH QKGDEAKLEI RDTTKTDSGL YRCVAFNEHG EIESNVNLQV DERKKQEKIE
GDLRAMLKKT PILKKGAGEE EEIDIMELLK NVDPKEYEKY ARMYGITDFR GLLQAFELLK
QSQEEETHRL EIEEIERSER DEKEFEELVS FIQQRLSQTE PVTLIKDIEN QTVLKDNDAV
FEIDIKINYP EIKLSWYKGT EKLEPSDKFE ISIDGDRHTL RVKNCQLKDQ GNYRLVCGPH
IASAKLTVIE PAWERHLQDV TLKEGQTCTM TCQFSVPNVK SEWFRNGRIL KPQGRHKTEV
EHKVHKLTIA DVRAEDQGQY TCKYEDLETS AELRIEAEPI QFTKRIQNIV VSEHQSATFE
CEVSFDDAIV TWYKGPTELT ESQKYNFRND GRCHYMTIHN VTPDDEGVYS VIARLEPRGE
ARSTAELYLT TKEIKLELKP PDIPDSRVPI PTMPIRAVPP EEIPPVVAPP IPLLLPTPEE
KKPPPKRIEV TKKAVKKDAK KVVAKPKEMT PREEIVKKPP PPTTLIPAKA PEIIDVSSKA
EEVKIMTITR KKEVQKEKEA VYEKKQAVHK EKRVFIESFE EPYDELEVEP YTEPFEQPYY
EEPDEDYEEI KVEAKKEVHE EWEEDFEEGQ EYYEREEGYD EGEEEWEEAY QEREVIQVQK
EVYEESHERK VPAKVPEKKA PPPPKVIKKP VIEKIEKTSR RMEEEKVQVT KVPEVSKKIV
PQKPSRTPVQ EEVIEVKVPA VHTKKMVISE EKMFFASHTE EEVSVTVPEV QKEIVTEEKI
HVAISKRVEP PPKVPELPEK PAPEEVAPVP IPKKVEPPAP KVPEVPKKPV PEEKKPVPVP
KKEPAAPPKV PEVPKKPVPE EKIPVPVAKK KEAPPAKVPE VQKGVVTEEK ITIVTQREES
PPPAVPEIPK KKVPEERKPV PRKEEEVPPP PKVPALPKKP VPEEKVAVPV PVAKKAPPPR
AEVSKKTVVE EKRFVAEEKL SFAVPQRVEV TRHEVSAEEE WSYSEEEEGV SISVYREEER
EEEEEAEVTE YEVMEEPEEY VVEEKLHIIS KRVEAEPAEV TERQEKKIVL KPKIPAKIEE
PPPAKVPEAP KKIVPEKKVP APVPKKEKVP PPKVPEEPKK PVPEKKVPPK VIKMEEPLPA
KVTERHMQIT QEEKVLVAVT KKEAPPKARV PEEPKRAVPE EKVLKLKPKR EEEPPAKVTE
FRKRVVKEEK VSIEAPKREP QPIKEVTIME EKERAYTLEE EAVSVQREEE YEEYEEYDYK
EFEEYEPTEE YDQYEEYEER EYERYEEHEE YITEPEKPIP VKPVPEEPVP TKPKAPPAKV
LKKAVPEEKV PVPIPKKLKP PPPKVPEEPK KVFEEKIRIS ITKREKEQVT EPAAKVPMKP
KRVVAEEKVP VPRKEVAPPV RVPEVPKELE PEEVAFEEEV VTHVEEYLVE EEEEYIHEEE
EFITEEEVVP VIPVKVPEVP RKPVPEEKKP VPVPKKKEAP PAKVPEVPKK PEEKVPVLIP
KKEKPPPAKV PEVPKKPVPE EKVPVPVPKK VEAPPAKVPE VPKKPVPEKK VPVPAPKKVE
APPAKVPEVP KKLIPEEKKP TPVPKKVEAP PPKVPKKREP VPVPVALPQE EEVLFEEEIV
PEEEVLPEEE EVLPEEEEVL PEEEEVLPEE EEIPPEEEEV PPEEEYVPEE EEFVPEEEVL
PEVKPKVPVP APVPEVPKKP VPEKKVPVPA PKKVEPPPPP KVPEIKKKVT EKKVVIPKKE
EAPPAKVSVV PKKPEPEKKV PPPGLKKAVA PPAKVPEVPK KVEEKRIILP KEEEVLPVEV
TEEPEEEPIS EEEIPEEPPS IEEVEEVAPP RVPEVIKKAV PEAPTPVPKK VEAPPAKVSK
KIPEEKVPVP VQKKEAPPAK VPEVPKKVPE KKVLVPKKEA VPPAKGRTVL EEKVSVAFRQ
EVVVKERLEL EVVEAEVEEI PEEEEFHEVE EYFEEGEFHE VEEFIKLEQH RVEEEHRVEK
VHRVIEVFEA EEVEVFEKPK APPKGPEISE KIIPPKKPPT KVVPRKEPPA KVPEVPKKIV
VEEKVRVPEE PRVPPTKAPE VPKKIVPEEK VREAVLKKPE VPPAKVPGMP KKSVQEEKSP
IVISEDTEMY IYEASEEAVL EEKVLVTQPQ KTKPKLAKVP EPPKKVVPED KIYVTIPKKR
ETPATKEPDT TRGIFPEVEP PEAIPEIPEH PPTEEFEVFK EVIPEGETPI VKRRKTPSPT
VPESPREIVP VKETPMAAPL EIEIPPTKAP EAMKEVVPEM KIFEDVPEEP ETPRMKTPEA
PQEIIPAKTV PSKKREPPSV KVPEALQEIV PEKKTLVVPL RKPEVLPDEV PEALREVVPE
KKVHPPQRAE VVPVKVHEAP KEIIPEKKVS VVPPKKPEVP PVKVPEASKE VIREEKVPLA
PPKEPEVPPV KVPEPPKEVV PEKKAPVAPP KEPEVPPVKV PEAPKEVVPE KKVPVPPPKK
PEVPPTKVPE VPKAAVPEKK LPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE
APPPKVPEAP KEVVLEKKAS VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV
TVPEVPQEAT EKEIPVAPPK KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP
QEIVPEKKTL VLPKKPEVPP VTVPEAPKEV VLEKKVPSAP PKKPEVPPVK VPEAPKEVVP
EKKVPVPPPK KPEVPPTKVP EVPKAAVPEK KVPEAIPPKP ESPPPEVPEV LPPKEVVPEK
KVPVPPAKKP EAPPPKVPEA PKEVVLEKKA SVAVPKKPEA PRAKVPEAAQ EVVPEKKIPK
APIKKPEAPA VTVPEVPQEA AEKEIPVAPP KKPEAPIVPV PEAQEVVPEK KVPKAPPTKP
EAPPATVPEV PQEIVPEKKT LVLPKKPEVP PVTVPEAPKE VVLEKKVPST PPKKPEVPPV
KVPEAPKEVV PEKKVPVPPP KKPEVPPTKV PEVPKAAVPE KKVPEAIPPK PESPPPEVPE
VLPPKEVVPE KKVPVPPAKK PEAPPPKVPE APKEVVLEKK VSVAVPKKPE APRAKVPEAA
QEVVPEKKIP KAPIKKPEAP AVTVPEVPQE AAEKEIPVAP PKKPEAPIVP VPEAQEVVPE
KKVPKAPPTK PEAPPATVPE VPQEIVPEKK TLVLPKKPEV PPVTVPEAPK EVVLEKKVPL
APPKKPEVPP VKVPEAPKEV VPEKKVPVTP PKKPEVPPVK VPEAPIEVVP EKKMPLAPPK
KPEVPPVKVP EAPKEVVPEK KVPSAPPKKP EVPPVKVPEA PKEVVPEKKV PAAPPKKPEV
TPVKVPEAPK EVVPEKKVPV PPPKKPEVPP TKVPEVPKVA VPEKKVPEAI PPKPESPPPE
VFEEPEEVAL EEPPAEVVEE PEPAAPPQVT VPPKKPVPEK KAPAVVAKKP ELPPVKVPEV
PKEVVPEKKV PLVVPKKPEA PPAKVPEVPK EVVPEKKVAV PKKPEVPPAK VPEVPKKPVL
EEKPAVPVPE RAESPPPEVY EEPEEIAPEE EIAPEEEKPV PVAEEEEPEV PPPAVPEEPK
KIIPEKKVPV IKKPEAPPPK EPEMPKKVVP VKKVPTVKKP ETPAAKVPEV PKKLVPVKKE
PVPVTKKPEV LPEKVPKVPE KIIPEKEVSV PIPAEPEVPP AEVEETPEEI IYEEKASITI
GRKETPPVEE REIEKYIKPE EPEPEPQPEE IPVKEPEPEK VIEKPKLKPR PPPPPPAPPK
EDVKEKIFQL KAIPKKKVPE KPQVPEKVEL TPLKVPGGEK KVRKLLPERK PEPKEEVVLK
SVLRKRPEEE EPKVEPKKLE KVKKPAVPEP PPPKPVEEVE VPTVTKRERK IPEPTKVPEI
KPAIPLPAPE PKPKPEAEVK TIKPPPVEPE PTPIAAPVTV PVVGKKAEAK APKEEAAKPK
GPIKGVPKKT PSPIEAERRK LRPGSGGEKP PDEAPFTYQL KAVPLKFVKE IKDIILTESE
FVGSSAIFEC LVSPSTAITT WMKDGSNIRE SPKHRFIADG KDRKLHIIDV QLSDAGEYTC
VLRLGNKEKT STAKLVVEEL PVRFVKTLEE EVTVVKGQPL YLSCELNKER DVVWRKDGKI
VVEKPGRIVP GVIGLMRALT INDADDTDAG TYTVTVENAN NLECSSCVKV VEVIRDWLVK
PIRDQHVKPK GTAIFACDIA KDTPNIKWFK GYDEIPAEPN DKTEILRDGN HLYLKIKNAM
PEDIAEYAVE IEGKRYPAKL TLGEREVELL KPIEDVTIYE KESASFDAEI SEADIPGQWK
LKGELLRPSP TCEIKAEGGK RFLTLHKVKL DQAGEVLYQA LNAITTAILT VKEIELDFAV
PLKDVTVPER RQARFECVLT REANVIWSKG PDIIKSSDKF DIIADGKKHI LVINDSQFDD
EGVYTAEVEG KKTSARLFVT GIRLKFMSPL EDQTVKEGET ATFVCELSHE KMHVVWFKND
AKLHTSRTVL ISSEGKTHKL EMKEVTLDDI SQIKAQVKEL SSTAQLKVLE ADPYFTVKLH
DKTAVEKDEI TLKCEVSKDV PVKWFKDGEE IVPSPKYSIK ADGLRRILKI KKADLKDKGE
YVCDCGTDKT KANVTVEARL IKVEKPLYGV EVFVGETAHF EIELSEPDVH GQWKLKGQPL
TASPDCEIIE DGKKHILILH NCQLGMTGEV SFQAANAKSA ANLKVKELPL IFITPLSDVK
VFEKDEAKFE CEVSREPKTF RWLKGTQEIT GDDRFELIKD GTKHSMVIKS AAFEDEAKYM
FEAEDKHTSG KLIIEGIRLK FLTPLKDVTA KEKESAVFTV ELSHDNIRVK WFKNDQRLHT
TRSVSMQDEG KTHSITFKDL SIDDTSQIRV EAMGMSSEAK LTVLEGDPYF TGKLQDYTGV
EKDEVILQCE ISKADAPVKW FKDGKEIKPS KNAVIKADGK KRMLILKKAL KSDIGQYTCD
CGTDKTSGKL DIEDREIKLV RPLHSVEVME TETARFETEI SEDDIHANWK LKGEALLQTP
DCEIKEEGKI HSLVLHNCRL DQTGGVDFQA ANVKSSAHLR VKPRVIGLLR PLKDVTVTAG
ETATFDCELS YEDIPVEWYL KGKKLEPSDK VVPRSEGKVH TLTLRDVKLE DAGEVQLTAK
DFKTHANLFV KEPPVEFTKP LEDQTVEEGA TAVLECEVSR ENAKVKWFKN GTEILKSKKY
EIVADGRVRK LVIHDCTPED IKTYTCDAKD FKTSCNLNVV PPHVEFLRPL TDLQVREKEM
ARFECELSRE NAKVKWFKDG AEIKKGKKYD IISKGAVRIL VINKCLLDDE AEYSCEVRTA
RTSGMLTVLE EEAVFTKNLA NIEVSETDTI KLVCEVSKPG AEVIWYKGDE EIIETGRYEI
LTEGRKRILV IQNAHLEDAG NYNCRLPSSR TDGKVKVHEL AAEFISKPQN LEILEGEKAE
FVCSISKESF PVQWKRDDKT LESGDKYDVI ADGKKRVLVV KDATLQDMGT YVVMVGAARA
AAHLTVIEKL RIVVPLKDTR VKEQQEVVFN CEVNTEGAKA KWFRNEEAIF DSSKYIILQK
DLVYTLRIRD AHLDDQANYN VSLTNHRGEN VKSAANLIVE EEDLRIVEPL KDIETMEKKS
VTFWCKVNRL NVTLKWTKNG EEVPFDNRVS YRVDKYKHML TIKDCGFPDE GEYIVTAGQD
KSVAELLIIE APTEFVEHLE DQTVTEFDDA VFSCQLSREK ANVKWYRNGR EIKEGKKYKF
EKDGSIHRLI IKDCRLDDEC EYACGVEDRK SRARLFVEEI PVEIIRPPQD ILEAPGADVV
FLAELNKDKV EVQWLRNNMV VVQGDKHQMM SEGKIHRLQI CDIKPRDQGE YRFIAKDKEA
RAKLELAAAP KIKTADQDLV VDVGKPLTMV VPYDAYPKAE AEWFKENEPL STKTIDTTAE
QTSFRILEAK KGDKGRYKIV LQNKHGKAEG FINLKVIDVP GPVRNLEVTE TFDGEVSLAW
EEPLTDGGSK IIGYVVERRD IKRKTWVLAT DRAESCEFTV TGLQKGGVEY LFRVSARNRV
GTGEPVETDN PVEARSKYDV PGPPLNVTIT DVNRFGVSLT WEPPEYDGGA EITNYVIELR
DKTSIRWDTA MTVRAEDLSA TVTDVVEGQE YSFRVRAQNR IGVGKPSAAT PFVKVADPIE
RPSPPVNLTS SDQTQSSVQL KWEPPLKDGG SPILGYIIER CEEGKDNWIR CNMKLVPELT
YKVTGLEKGN KYLYRVSAEN KAGVSDPSEI LGPLTADDAF VEPTMDLSAF KDGLEVIVPN
PITILVPSTG YPRPTATWCF GDKVLETGDR VKMKTLSAYA ELVISPSERS DKGIYTLKLE
NRVKTISGEI DVNVIARPSA PKELKFGDIT KDSVHLTWEP PDDDGGSPLT GYVVEKREVS
RKTWTKVMDF VTDLEFTVPD LVQGKEYLFK VCARNKCGPG EPAYVDEPVN MSTPATVPDP
PENVKWRDRT ANSIFLTWDP PKNDGGSRIK GYIVERCPRG SDKWVACGEP VAETKMEVTG
LEEGKWYAYR VKALNRQGAS KPSRPTEEIQ AVDTQEAPEI FLDVKLLAGL TVKAGTKIEL
PATVTGKPEP KITWTKADMI LKQDKRITIE NVPKKSTVTI VDSKRSDTGT YIIEAVNVCG
RATAVVEVNV LDKPGPPAAF DITDVTNESC LLTWNPPRDD GGSKITNYVV ERRATDSEVW
HKLSSTVKDT NFKATKLIPN KEYIFRVAAE NMYGVGEPVQ ASPITAKYQF DPPGPPTRLE
PSDITKDAVT LTWCEPDDDG GSPITGYWVE RLDPDTDKWV RCNKMPVKDT TYRVKGLTNK
KKYRFRVLAE NLAGPGKPSK STEPILIKDP IDPPWPPGKP TVKDVGKTSV RLNWTKPEHD
GGAKIESYVI EMLKTGTDEW VRVAEGVPTT QHLLPGLMEG QEYSFRVRAV NKAGESEPSE
PSDPVLCREK LYPPSPPRWL EVINITKNTA DLKWTVPEKD GGSPITNYIV EKRDVRRKGW
QTVDTTVKDT KCTVTPLTEG SLYVFRVAAE NAIGQSDYTE IEDSVLAKDT FTTPGPPYAL
AVVDVTKRHV DLKWEPPKND GGRPIQRYVI EKKERLGTRW VKAGKTAGPD CNFRVTDVIE
GTEVQFQVRA ENEAGVGHPS EPTEILSIED PTSPPSPPLD LHVTDAGRKH IAIAWKPPEK
NGGSPIIGYH VEMCPVGTEK WMRVNSRPIK DLKFKVEEGV VPDKEYVLRV RAVNAIGVSE
PSEISENVVA KDPDCKPTID LETHDIIVIE GEKLSIPVPF RAVPVPTVSW HKDGKEVKAS
DRLTMKNDHI SAHLEVPKSV RADAGIYTIT LENKLGSATA SINVKVIGLP GPCKDIKASD
ITKSSCKLTW EPPEFDGGTP ILHYVLERRE AGRRTYIPVM SGENKLSWTV KDLIPNGEYF
FRVKAVNKVG GGEYIELKNP VIAQDPKQPP DPPVDVEVHN PTAEAMTITW KPPLYDGGSK
IMGYIIEKIA KGEERWKRCN EHLVPILTYT AKGLEEGKEY QFRVRAENAA GISEPSRATP
PTKAVDPIDA PKVILRTSLE VKRGDEIALD ASISGSPYPT ITWIKDENVI VPEEIKKRAA
PLVRRRKGEV QEEEPFVLPL TQRLSIDNSK KGESQLRVRD SLRPDHGLYM IKVENDHGIA
KAPCTVSVLD TPGPPINFVF EDIRKTSVLC KWEPPLDDGG SEIINYTLEK KDKTKPDSEW
IVVTSTLRHC KYSVTKLIEG KEYLFRVRAE NRFGPGPPCV SKPLVAKDPF GPPDAPDKPI
VEDVTSNSML VKWNEPKDNG SPILGYWLEK REVNSTHWSR VNKSLLNALK ANVDGLLEGL
TYVFRVCAEN AAGPGKFSPP SDPKTAHDPI SPPGPPIPRV TDTSSTTIEL EWEPPAFNGG
GEIVGYFVDK QLVGTNEWSR CTEKMIKVRQ YTVKEIREGA DYKLRVSAVN AAGEGPPGET
QPVTVAEPQE PPAVELDVSV KGGIQIMAGK TLRIPAVVTG RPVPTKVWTK EEGELDKDRV
VIDNVGTKSE LIIKDALRKD HGRYVITATN SCGSKFAAAR VEVFDVPGPV LDLKPVVTNR
KMCLLNWSDP EDDGGSEITG FIIERKDAKM HTWRQPIETE RSKCDITGLL EGQEYKFRVI
AKNKFGCGPP VEIGPILAVD PLGPPTSPER LTYTERTKST ITLDWKEPRS NGGSPIQGYI
IEKRRHDKPD FERVNKRLCP TTSFLVENLD EHQMYEFRVK AVNEIGESEP SLPLNVVIQD
DEVPPTIKLR LSVRGDTIKV KAGEPVHIPA DVTGLPMPKI EWSKNETVIE KPTDALQITK
EEVSRSEAKT ELSIPKAVRE DKGTYTVTAS NRLGSVFRNV HVEVYDRPSP PRNLAVTDIK
AESCYLTWDA PLDNGGSEIT HYVIDKRDAS RKKAEWEEVT NTAVEKRYGI WKLIPNGQYE
FRVRAVNKYG ISDECKSDKV VIQDPYRLPG PPGKPKVLAR TKGSMLVSWT PPLDNGGSPI
TGYWLEKREE GSPYWSRVSR APITKVGLKG VEFNVPRLLE GVKYQFRAMA INAAGIGPPS
EPSDPEVAGD PIFPPGPPSC PEVKDKTKSS ISLGWKPPAK DGGSPIKGYI VEMQEEGTTD
WKRVNEPDKL ITTCECVVPN LKELRKYRFR VKAVNEAGES EPSDTTGEIP ATDIQEEPEV
FIDIGAQDCL VCKAGSQIRI PAVIKGRPTP KSSWEFDGKA KKAMKDGVHD IPEDAQLETA
ENSSVIIIPE CKRSHTGKYS ITAKNKAGQK TANCRVKVMD VPGPPKDLKV SDITRGSCRL
SWKMPDDDGG DRIKGYVIEK RTIDGKAWTK VNPDCGSTTF VVPDLLSEQQ YFFRVRAENR
FGIGPPVETI QRTTARDPIY PPDPPIKLKI GLITKNTVHL SWKPPKNDGG SPVTHYIVEC
LAWDPTGTKK EAWRQCNKRD VEELQFTVED LVEGGEYEFR VKAVNAAGVS KPSATVGPVT
VKDQTCPPSI DLKEFMEVEE GTNVNIVAKI KGVPFPTLTW FKAPPKKPDN KEPVLYDTHV
NKLVVDDTCT LVIPQSRRSD TGLYTITAVN NLGTASKEMR LNVLGRPGPP VGPIKFESVS
ADQMTLSWFP PKDDGGSKIT NYVIEKREAN RKTWVHVSSE PKECTYTIPK LLEGHEYVFR
IMAQNKYGIG EPLDSEPETA RNLFSVPGAP DKPTVSSVTR NSMTVNWEEP EYDGGSPVTG
YWLEMKDTTS KRWKRVNRDP IKAMTLGVSY KVTGLIEGSD YQFRVYAINA AGVGPASLPS
DPATARDPIA PPGPPFPKVT DWTKSSADLE WSPPLKDGGS KVTGYIVEYK EEGKEEWEKG
KDKEVRGTKL VVTGLKEGAF YKFRVRAVNI AGIGEPGEVT DVIEMKDRLV SPDLQLDASV
RDRIVVHAGG VIRIIAYVSG KPPPTVTWNM NERTLPQEAT IETTAISSSM VIKNCQRSHQ
GVYSLLAKNE AGERKKTIIV DVLDVPGPVG TPFLAHNLTN ESCKLTWFSP EDDGGSPITN
YVIEKRESDR RAWTPVTYTV TRQNATVQGL IQGKAYFFRI AAENSIGMGP FVETSEALVI
REPITVPERP EDLEVKEVTK NTVTLTWNPP KYDGGSEIIN YVLESRLIGT EKFHKVTNDN
LLSRKYTVKG LKEGDTYEYR VSAVNIVGQG KPSFCTKPIT CKDELAPPTL HLDFRDKLTI
RVGEAFALTG RYSGKPKPKV SWFKDEADVL EDDRTHIKTT PATLALEKIK AKRSDSGKYC
VVVENSTGSR KGFCQVNVVD RPGPPVGPVS FDEVTKDYMV ISWKPPLDDG GSKITNYIIE
KKEVGKDVWM PVTSASAKTT CKVSKLLEGK DYIFRIHAEN LYGISDPLVS DSMKAKDRFR
VPDAPDQPIV TEVTKDSALV TWNKPHDGGK PITNYILEKR ETMSKRWARV TKDPIHPYTK
FRVPDLLEGC QYEFRVSAEN EIGIGDPSPP SKPVFAKDPI AKPSPPVNPE AIDTTCNSVD
LTWQPPRHDG GSKILGYIVE YQKVGDEEWR RANHTPESCP ETKYKVTGLR DGQTYKFRVL
AVNAAGESDP AHVPEPVLVK DRLEPPELIL DANMAREQHI KVGDTLRLSA IIKGVPFPKV
TWKKEDRDAP TKARIDVTPV GSKLEIRNAA HEDGGIYSLT VENPAGSKTV SVKVLVLDKP
GPPRDLEVSE IRKDSCYLTW KEPLDDGGSV ITNYVVERRD VASAQWSPLS ATSKKKSHFA
KHLNEGNQYL FRVAAENQYG RGPFVETPKP IKALDPLHPP GPPKDLHHVD VDKTEVSLVW
NKPDRDGGSP ITGYLVEYQE EGTQDWIKFK TVTNLECVVT GLQQGKTYRF RVKAENIVGL
GLPDTTIPIE CQEKLVPPSV ELDVKLIEGL VVKAGTTVRF PAIIRGVPVP TAKWTTDGSE
IKTDEHYTVE TDNFSSVLTI KNCLRRDTGE YQITVSNAAG SKTVAVHLTV LDVPGPPTGP
INILDVTPEH MTISWQPPKD DGGSPVINYI VEKQDTRKDT WGVVSSGSSK TKLKIPHLQK
GCEYVFRVRA ENKIGVGPPL DSTPTVAKHK FSPPSPPGKP VVTDITENAA TVSWTLPKSD
GGSPITGYYM ERREVTGKWV RVNKTPIADL KFRVTGLYEG NTYEFRVFAE NLAGLSKPSP
SSDPIKACRP IKPPGPPINP KLKDKSRETA DLVWTKPLSD GGSPILGYVV ECQKPGTAQW
NRINKDELIR QCAFRVPGLI EGNEYRFRIK AANIVGEGEP RELAESVIAK DILHPPEVEL
DVTCRDVITV RVGQTIRILA RVKGRPEPDI TWTKEGKVLV REKRVDLIQD LPRVELQIKE
AVRADHGKYI ISAKNSSGHA QGSAIVNVLD RPGPCQNLKV TNVTKENCTI SWENPLDNGG
SEITNFIVEY RKPNQKGWSI VASDVTKRLI KANLLANNEY YFRVCAENKV GVGPTIETKT
PILAINPIDR PGEPENLHIA DKGKTFVYLK WRRPDYDGGS PNLSYHVERR LKGSDDWERV
HKGSIKETHY MVDRCVENQI YEFRVQTKNE GGESDWVKTE EVVVKEDLQK PVLDLKLSGV
LTVKAGDTIR LEAGVRGKPF PEVAWTKDKD ATDLTRSPRV KIDTRADSSK FSLTKAKRSD
GGKYVVTATN TAGSFVAYAT VNVLDKPGPV RNLKIVDVSS DRCTVCWDPP EDDGGCEIQN
YILEKCETKR MVWSTYSATV LTPGTTVTRL IEGNEYIFRV RAENKIGTGP PTESKPVIAK
TKYDKPGRPD PPEVTKVSKE EMTVVWNPPE YDGGKSITGY FLEKKEKHST RWVPVNKSAI
PERRMKVQNL LPDHEYQFRV KAENEIGIGE PSLPSRPVVA KDPIEPPGPP TNFRVVDTTK
HSITLGWGKP VYDGGAPIIG YVVEMRPKIA DASPDEGWKR CNAAAQLVRK EFTVTSLDEN
QEYEFRVCAQ NQVGIGRPAE LKEAIKPKEI LEPPEIDLDA SMRKLVIVRA GCPIRLFAIV
RGRPAPKVTW RKVGIDNVVR KGQVDLVDTM AFLVIPNSTR DDSGKYSLTL VNPAGEKAVF
VNVRVLDTPG PVSDLKVSDV TKTSCHVSWA PPENDGGSQV THYIVEKREA DRKTWSTVTP
EVKKTSFHVT NLVPGNEYYF RVTAVNEYGP GVPTDVPKPV LASDPLSEPD PPRKLEVTEM
TKNSATLAWL PPLRDGGAKI DGYITSYREE EQPADRWTEY SVVKDLSLVV TGLKEGKKYK
FRVAARNAVG VSLPREAEGV YEAKEQLLPP KILMPEQITI KAGKKLRIEA HVYGKPHPTC
KWKKGEDEVV TSSHLAVHKA DSSSILIIKD VTRKDSGYYS LTAENSSGTD TQKIKVVVMD
APGPPQPPFD ISDIDADACS LSWHIPLEDG GSNITNYIVE KCDVSRGDWV TALASVTKTS
CRVGKLIPGQ EYIFRVRAEN RFGISEPLTS PKMVAQFPFG VPSEPKNARV TKVNKDCIFV
AWDRPDSDGG SPIIGYLIER KERNSLLWVK ANDTLVRSTE YPCAGLVEGL EYSFRIYALN
KAGSSPPSKP TEYVTARMPV DPPGKPEVID VTKSTVSLIW ARPKHDGGSK IIGYFVEACK
LPGDKWVRCN TAPHQIPQEE YTATGLEEKA QYQFRAIART AVNISPPSEP SDPVTILAEN
VPPRIDLSVA MKSLLTVKAG TNVCLDATVF GKPMPTVSWK KDGTLLKPAE GIKMAMQRNL
CTLELFSVNR KDSGDYTITA ENSSGSKSAT IKLKVLDKPG PPASVKINKM YSDRAMLSWE
PPLEDGGSEI TNYIVDKRET SRPNWAQVSA TVPITSCSVE KLIEGHEYQF RICAENKYGV
GDPVFTEPAI AKNPYDPPGR CDPPVISNIT KDHMTVSWKP PADDGGSPIT GYLLEKRETQ
AVNWTKVNRK PIIERTLKAT GLQEGTEYEF RVTAINKAGP GKPSDASKAA YARDPQYPPG
PPAFPKVYDT TRSSVSLSWG KPAYDGGSPI IGYLVEVKRA DSDNWVRCNL PQNLQKTRFE
VTGLMEDTQY QFRVYAVNKI GYSDPSDVPD KHYPKDILIP PEGELDADLR KTLILRAGVT
MRLYVPVKGR PPPKITWSKP NVNLRDRIGL DIKSTDFDTF LRCENVNKYD AGKYILTLEN
SCGKKEYTIV VKVLDTPGPP VNVTVKEISK DSAYVTWEPP IIDGGSPIIN YVVQKRDAER
KSWSTVTTEC SKTSFRVANL EEGKSYFFRV FAENEYGIGD PGETRDAVKA SQTPGPVVDL
KVRSVSKSSC SIGWKKPHSD GGSRIIGYVV DFLTEENKWQ RVMKSLSLQY SAKDLTEGKE
YTFRVSAENE NGEGTPSEIT VVARDDVVAP DLDLKGLPDL CYLAKENSNF RLKIPIKGKP
APSVSWKKGE DPLATDTRVS VESSAVNTTL IVYDCQKSDA GKYTITLKNV AGTKEGTISI
KVVGKPGIPT GPIKFDEVTA EAMTLKWAPP KDDGGSEITN YILEKRDSVN NKWVTCASAV
QKTTFRVTRL HEGMEYTFRV SAENKYGVGE GLKSEPIVAR HPFDVPDAPP PPNIVDVRHD
SVSLTWTDPK KTGGSPITGY HLEFKERNSL LWKRANKTPI RMRDFKVTGL TEGLEYEFRV
MAINLAGVGK PSLPSEPVVA LDPIDPPGKP EVINITRNSV TLIWTEPKYD GGHKLTGYIV
EKRDLPSKSW MKANHVNVPE CAFTVTDLVE GGKYEFRIRA KNTAGAISAP SESTETIICK
DEYEAPTIVL DPTIKDGLTI KAGDTIVLNA ISILGKPLPK SSWSKAGKDI RPSDITQITS
TPTSSMLTIK YATRKDAGEY TITATNPFGT KVEHVKVTVL DVPGPPGPVE ISNVSAEKAT
LTWTPPLEDG GSPIKSYILE KRETSRLLWT VVSEDIQSCR HVATKLIQGN EYIFRVSAVN
HYGKGEPVQS EPVKMVDRFG PPGPPEKPEV SNVTKNTATV SWKRPVDDGG SEITGYHVER
REKKSLRWVR AIKTPVSDLR CKVTGLQEGS TYEFRVSAEN RAGIGPPSEA SDSVLMKDAA
YPPGPPSNPH VTDTTKKSAS LAWGKPHYDG GLEITGYVVE HQKVGDEAWI KDTTGTALRI
TQFVVPDLQT KEKYNFRISA INDAGVGEPA VIPDVEIVER EMAPDFELDA ELRRTLVVRA
GLSIRIFVPI KGRPAPEVTW TKDNINLKNR ANIENTESFT LLIIPECNRY DTGKFVMTIE
NPAGKKSGFV NVRVLDTPGP VLNLRPTDIT KDSVTLHWDL PLIDGGSRIT NYIVEKREAT
RKSYSTATTK CHKCTYKVTG LSEGCEYFFR VMAENEYGIG EPTETTEPVK ASEAPSPPDS
LNIMDITKST VSLAWPKPKH DGGSKITGYV IEAQRKGSDQ WTHITTVKGL ECVVRNLTEG
EEYTFQVMAV NSAGRSAPRE SRPVIVKEQT MLPELDLRGI YQKLVIAKAG DNIKVEIPVL
GRPKPTVTWK KGDQILKQTQ RVNFETTATS TILNINECVR SDSGPYPLTA RNIVGEVGDV
ITIQVHDIPG PPTGPIKFDE VSSDFVTFSW DPPENDGGVP ISNYVVEMRQ TDSTTWVELA
TTVIRTTYKA TRLTTGLEYQ FRVKAQNRYG VGPGITSACI VANYPFKVPG PPGTPQVTAV
TKDSMTISWH EPLSDGGSPI LGYHVERKER NGILWQTVSK ALVPGNIFKS SGLTDGIAYE
FRVIAENMAG KSKPSKPSEP MLALDPIDPP GKPVPLNITR HTVTLKWAKP EYTGGFKITS
YIVEKRDLPN GRWLKANFSN ILENEFTVSG LTEDAAYEFR VIAKNAAGAI SPPSEPSDAI
TCRDDVEAPK IKVDVKFKDT VILKAGEAFR LEADVSGRPP PTMEWSKDGK ELEGTAKLEI
KIADFSTNLV NKDSTRRDSG AYTLTATNPG GFAKHIFNVK VLDRPGPPEG PLAVTEVTSE
KCVLSWFPPL DDGGAKIDHY IVQKRETSRL AWTNVASEVQ VTKLKVTKLL KGNEYIFRVM
AVNKYGVGEP LESEPVLAVN PYGPPDPPKN PEVTTITKDS MVVCWGHPDS DGGSEIINYI
VERRDKAGQR WIKCNKKTLT DLRYKVSGLT EGHEYEFRIM AENAAGISAP SPTSPFYKAC
DTVFKPGPPG NPRVLDTSRS SISIAWNKPI YDGGSEITGY MVEIALPEED EWQIVTPPAG
LKATSYTITG LTENQEYKIR IYAMNSEGLG EPALVPGTPK AEDRMLPPEI ELDADLRKVV
TIRACCTLRL FVPIKGRPAP EVKWARDHGE SLDKASIEST SSYTLLIVGN VNRFDSGKYI
LTVENSSGSK SAFVNVRVLD TPGPPQDLKV KEVTKTSVTL TWDPPLLDGG SKIKNYIVEK
RESTRKAYST VATNCHKTSW KVDQLQEGCS YYFRVLAENE YGIGLPAETA ESVKASERPL
PPGKITLMDV TRNSVSLSWE KPEHDGGSRI LGYIVEMQTK GSDKWATCAT VKVTEATITG
LIQGEEYSFR VSAQNEKGIS DPRQLSVPVI AKDLVIPPAF KLLFNTFTVL AGEDLKVDVP
FIGRPTPAVT WHKDNVPLKQ TTRVNAESTE NNSLLTIKDA CREDVGHYVV KLTNSAGEAI
ETLNVIVLDK PGPPTGPVKM DEVTADSITL SWGPPKYDGG SSINNYIVEK RDTSTTTWQI
VSATVARTTI KACRLKTGCE YQFRIAAENR YGKSTYLNSE PTVAQYPFKV PGPPGTPVVT
LSSRDSMEVQ WNEPISDGGS RVIGYHLERK ERNSILWVKL NKTPIPQTKF KTTGLEEGVE
YEFRVSAENI VGIGKPSKVS ECYVARDPCD PPGRPEAIIV TRNSVTLQWK KPTYDGGSKI
TGYIVEKKEL PEGRWMKASF TNIIDTHFEV TGLVEDHRYE FRVIARNAAG VFSEPSESTG
AITARDEVDP PRISMDPKYK DTIVVHAGES FKVDADIYGK PIPTIQWIKG DQELSNTARL
EIKSTDFATS LSVKDAVRVD SGNYILKAKN VAGERSVTVN VKVLDRPGPP EGPVVISGVT
AEKCTLAWKP PLQDGGSDII NYIVERRETS RLVWTVVDAN VQTLSCKVTK LLEGNEYTFR
IMAVNKYGVG EPLESEPVVA KNPFVVPDAP KAPEVTTVTK DSMIVVWERP ASDGGSEILG
YVLEKRDKEG IRWTRCHKRL IGELRLRVTG LIENHDYEFR VSAENAAGLS EPSPPSAYQK
ACDPIYKPGP PNNPKVIDIT RSSVFLSWSK PIYDGGCEIQ GYIVEKCDVS VGEWTMCTPP
TGINKTNIEV EKLLEKHEYN FRICAINKAG VGEHADVPGP IIVEEKLEAP DIDLDLELRK
IINIRAGGSL RLFVPIKGRP TPEVKWGKVD GEIRDAAIID VTSSFTSLVL DNVNRYDSGK
YTLTLENSSG TKSAFVTVRV LDTPSPPVNL KVTEITKDSV SITWEPPLLD GGSKIKNYIV
EKREATRKSY AAVVTNCHKN SWKIDQLQEG CSYYFRVTAE NEYGIGLPAQ TADPIKVAEV
PQPPGKITVD DVTRNSVSLS WTKPEHDGGS KIIQYIVEMQ AKHSEKWSEC ARVKSLQAVI
TNLTQGEEYL FRVVAVNEKG RSDPRSLAVP IVAKDLVIEP DVKPAFSSYS VQVGQDLKIE
VPISGRPKPT ITWTKDGLPL KQTTRINVTD SLDLTTLSIK ETHKDDGGQY GITVANVVGQ
KTASIEIVTL DKPDPPKGPV KFDDVSAESI TLSWNPPLYT GGCQITNYIV QKRDTTTTVW
DVVSATVART TLKVTKLKTG TEYQFRIFAE NRYGQSFALE SDPIVAQYPY KEPGPPGTPF
ATAISKDSMV IQWHEPVNNG GSPVIGYHLE RKERNSILWT KVNKTIIHDT QFKAQNLEEG
IEYEFRVYAE NIVGVGKASK NSECYVARDP CDPPGTPEPI MVKRNEITLQ WTKPVYDGGS
MITGYIVEKR DLPDGRWMKA SFTNVIETQF TVSGLTEDQR YEFRVIAKNA AGAISKPSDS
TGPITAKDEV ELPRISMDPK FRDTIVVNAG ETFRLEADVH GKPLPTIEWL RGDKEIEESA
RCEIKNTDFK ALLIVKDAIR IDGGQYILRA SNVAGSKSFP VNVKVLDRPG PPEGPVQVTG
VTSEKCSLTW SPPLQDGGSD ISHYVVEKRE TSRLAWTVVA SEVVTNSLKV TKLLEGNEYV
FRIMAVNKYG VGEPLESAPV LMKNPFVLPG PPKSLEVTNI AKDSMTVCWN RPDSDGGSEI
IGYIVEKRDR SGIRWIKCNK RRITDLRLRV TGLTEDHEYE FRVSAENAAG VGEPSPATVY
YKACDPVFKP GPPTNAHIVD TTKNSITLAW GKPIYDGGSE ILGYVVEICK ADEEEWQIVT
PQTGLRVTRF EISKLTEHQE YKIRVCALNK VGLGEATSVP GTVKPEDKLE APELDLDSEL
RKGIVVRAGG SARIHIPFKG RPTPEITWSR EEGEFTDKVQ IEKGVNYTQL SIDNCDRNDA
GKYILKLENS SGSKSAFVTV KVLDTPGPPQ NLAVKEVRKD SAFLVWEPPI IDGGAKVKNY
VIDKRESTRK AYANVSSKCS KTSFKVENLT EGAIYYFRVM AENEFGVGVP VETVDAVKAA
EPPSPPGKVT LTDVSQTSAS LMWEKPEHDG GSRVLGYVVE MQPKGTEKWS IVAESKVCNA
VVTGLSSGQE YQFRVKAYNE KGKSDPRVLG VPVIAKDLTI QPSLKLPFNT YSIQAGEDLK
IEIPVIGRPR PNISWVKDGE PLKQTTRVNV EETATSTVLH IKEGNKDDFG KYTVTATNSA
GTATENLSVI VLEKPGPPVG PVRFDEVSAD FVVISWEPPA YTGGCQISNY IVEKRDTTTT
TWHMVSATVA RTTIKITKLK TGTEYQFRIF AENRYGKSAP LDSKAVIVQY PFKEPGPPGT
PFVTSISKDQ MLVQWHEPVN DGGTKIIGYH LEQKEKNSIL WVKLNKTPIQ DTKFKTTGLD
EGLEYEFKVS AENIVGIGKP SKVSECFVAR DPCDPPGRPE AIVITRNNVT LKWKKPAYDG
GSKITGYIVE KKDLPDGRWM KASFTNVLET EFTVSGLVED QRYEFRVIAR NAAGNFSEPS
DSSGAITARD EIDAPNASLD PKYKDVIVVH AGETFVLEAD IRGKPIPDVV WSKDGKELEE
TAARMEIKST IQKTTLVVKD CIRTDGGQYI LKLSNVGGTK SIPITVKVLD RPGPPEGPLK
VTGVTAEKCY LAWNPPLQDG GANISHYIIE KRETSRLSWT QVSTEVQALN YKVTKLLPGN
EYIFRVMAVN KYGIGEPLES GPVTACNPYK PPGPPSTPEV SAITKDSMVV TWARPVDDGG
TEIEGYILEK RDKEGVRWTK CNKKTLTDLR LRVTGLTEGH SYEFRVAAEN AAGVGEPSEP
SVFYRACDAL YPPGPPSNPK VTDTSRSSVS LAWSKPIYDG GAPVKGYVVE VKEAAADEWT
TCTPPTGLQG KQFTVTKLKE NTEYNFRICA INSEGVGEPA TLPGSVVAQE RIEPPEIELD
ADLRKVVVLR ASATLRLFVT IKGRPEPEVK WEKAEGILTD RAQIEVTSSF TMLVIDNVTR
FDSGRYNLTL ENNSGSKTAF VNVRVLDSPS APVNLTIREV KKDSVTLSWE PPLIDGGAKI
TNYIVEKRET TRKAYATITN NCTKTTFRIE NLQEGCSYYF RVLASNEYGI GLPAETTEPV
KVSEPPLPPG RVTLVDVTRN TATIKWEKPE SDGGSKITGY VVEMQTKGSE KWSTCTQVKT
LEATISGLTA GEEYVFRVAA VNEKGRSDPR QLGVPVIARD IEIKPSVELP FHTFNVKARE
QLKIDVPFKG RPQATVNWRK DGQTLKETTR VNVSSSKTVT SLSIKEASKE DVGTYELCVS
NSAGSITVPI TIIVLDRPGP PGPIRIDEVS CDSITISWNP PEYDGGCQIS NYIVEKKETT
STTWHIVSQA VARTSIKIVR LTTGSEYQFR VCAENRYGKS SYSESSAVVA EYPFSPPGPP
GTPKVVHATK STMLVTWQVP VNDGGSRVIG YHLEYKERSS ILWSKANKIL IADTQMKVSG
LDEGLMYEYR VYAENIAGIG KCSKSCEPVP ARDPCDPPGQ PEVTNITRKS VSLKWSKPHY
DGGAKITGYI VERRELPDGR WLKCNYTNIQ ETYFEVTELT EDQRYEFRVF ARNAADSVSE
PSESTGPIIV KDDVEPPRVM MDVKFRDVIV VKAGEVLKIN ADIAGRPLPV ISWAKDGIEI
EERARTEIIS TDNHTLLTVK DCIRRDTGQY VLTLKNVAGT RSVAVNCKVL DKPGPPAGPL
EINGLTAEKC SLSWGRPQED GGADIDYYIV EKRETSHLAW TICEGELQMT SCKVTKLLKG
NEYIFRVTGV NKYGVGEPLE SVAIKALDPF TVPSPPTSLE ITSVTKESMT LCWSRPESDG
GSEISGYIIE RREKNSLRWV RVNKKPVYDL RVKSTGLREG CEYEYRVYAE NAAGLSLPSE
TSPLIRAEDP VFLPSPPSKP KIVDSGKTTI TIAWVKPLFD GGAPITGYTV EYKKSDDTDW
KTSIQSLRGT EYTISGLTTG AEYVFRVKSV NKVGASDPSD SSDPQIAKER EEEPLFDIDS
EMRKTLIVKA GASFTMTVPF RGRPVPNVLW SKPDTDLRTR AYVDTTDSRT SLTIENANRN
DSGKYTLTIQ NVLSAASLTL VVKVLDTPGP PTNITVQDVT KESAVLSWDV PENDGGAPVK
NYHIEKREAS KKAWVSVTNN CNRLSYKVTN LQEGAIYYFR VSGENEFGVG IPAETKEGVK
ITEKPSPPEK LGVTSISKDS VSLTWLKPEH DGGSRIVHYV VEALEKGQKN WVKCAVAKST
HHVVSGLREN SEYFFRVFAE NQAGLSDPRE LLLPVLIKEQ LEPPEIDMKN FPSHTVYVRA
GSNLKVDIPI SGKPLPKVTL SRDGVPLKAT MRFNTEITAE NLTINLKESV TADAGRYEIT
AANSSGTTKA FINIVVLDRP GPPTGPVVIS DITEESVTLK WEPPKYDGGS QVTNYILLKR
ETSTAVWTEV SATVARTMMK VMKLTTGEEY QFRIKAENRF GISDHIDSAC VTVKLPYTTP
GPPSTPWVTN VTRESITVGW HEPVSNGGSA VVGYHLEMKD RNSILWQKAN KLVIRTTHFK
VTTISAGLIY EFRVYAENAA GVGKPSHPSE PVLAIDACEP PRNVRITDIS KNSVSLSWQQ
PAFDGGSKIT GYIVERRDLP DGRWTKASFT NVTETQFIIS GLTQNSQYEF RVFARNAVGS
ISNPSEVVGP ITCIDSYGGP VIDLPLEYTE VVKYRAGTSV KLRAGISGKP APTIEWYKDD
KELQTNALVC VENTTDLASI LIKDADRLNS GCYELKLRNA MGSASATIRV QILDKPGPPG
GPIEFKTVTA EKITLLWRPP ADDGGAKITH YIVEKRETSR VVWSMVSEHL EECIITTTKI
IKGNEYIFRV RAVNKYGIGE PLESDSVVAK NAFVTPGPPG IPEVTKITKN SMTVVWSRPI
ADGGSDISGY FLEKRDKKSL GWFKVLKETI RDTRQKVTGL TENSDYQYRV CAVNAAGQGP
FSEPSEFYKA ADPIDPPGPP AKIRIADSTK SSITLGWSKP VYDGGSAVTG YVVEIRQGEE
EEWTTVSTKG EVRTTEYVVS NLKPGVNYYF RVSAVNCAGQ GEPIEMNEPV QAKDILEAPE
IDLDVALRTS VIAKAGEDVQ VLIPFKGRPP PTVTWRKDEK NLGSDARYSI ENTDSSSLLT
IPQVTRNDTG KYILTIENGV GEPKSSTVSV KVLDTPAACQ KLQVKHVSRG TVTLLWDPPL
IDGGSPIINY VIEKRDATKR TWSVVSHKCS STSFKLIDLS EKTPFFFRVL AENEIGIGEP
CETTEPVKAA EVPAPIRDLS MKDSTKTSVI LSWTKPDFDG GSVITEYVVE RKGKGEQTWS
HAGISKTCEI EVSQLKEQSV LEFRVFAKNE KGLSDPVTIG PITVKELIIT PEVDLSDIPG
AQVTVRIGHN VHLELPYKGK PKPSISWLKD GLPLKESEFV RFSKTENKIT LSIKNAKKEH
GGKYTVILDN AVCRIAVPIT VITLGPPSKP KGPIRFDEIK ADSVILSWDV PEDNGGGEIT
CYSIEKRETS QTNWKMVCSS VARTTFKVPN LVKDAEYQFR VRAENRYGVS QPLVSSIIVA
KHQFRIPGPP GKPVIYNVTS DGMSLTWDAP VYDGGSEVTG FHVEKKERNS ILWQKVNTSP
ISGREYRATG LVEGLDYQFR VYAENSAGLS SPSDPSKFTL AVSPVDPPGT PDYIDVTRET
ITLKWNPPLR DGGSKIVGYS IEKRQGNERW VRCNFTDVSE CQYTVTGLSP GDRYEFRIIA
RNAVGTISPP SQSSGIIMTR DENVPPIVEF GPEYFDGLII KSGESLRIKA LVQGRPVPRV
TWFKDGVEIE KRMNMEITDV LGSTSLFVRD ATRDHRGVYT VEAKNASGSA KAEIKVKVQD
TPGKVVGPIR FTNITGEKMT LWWDAPLNDG CAPITHYIIE KRETSRLAWA LIEDKCEAQS
YTAIKLINGN EYQFRVSAVN KFGVGRPLDS DPVVAQIQYT VPDAPGIPEP SNITGNSITL
TWARPESDGG SEIQQYILER REKKSTRWVK VISKRPISET RFKVTGLTEG NEYEFHVMAE
NAAGVGPASG ISRLIKCREP VNPPGPPTVV KVTDTSKTTV SLEWSKPVFD GGMEIIGYII
EMCKADLGDW HKVNAEACVK TRYTVTDLQA GEEYKFRVSA INGAGKGDSC EVTGTIKAVD
RLTAPELDID ANFKQTHVVR AGASIRLFIA YQGRPTPTAV WSKPDSNLSL RADIHTTDSF
STLTVENCNR NDAGKYTLTV ENNSGSKSIT FTVKVLDTPG PPGPITFKDV TRGSATLMWD
APLLDGGARI HHYVVEKREA SRRSWQVISE KCTRQIFKVN DLAEGVPYYF RVSAVNEYGV
GEPYEMPEPI VATEQPAPPR RLDVVDTSKS SAVLAWLKPD HDGGSRITGY LLEMRQKGSD
FWVEAGHTKQ LTFTVERLVE KTEYEFRVKA KNDAGYSEPR EAFSSVIIKE PQIEPTADLT
GITNQLITCK AGSPFTIDVP ISGRPAPKVT WKLEEMRLKE TDRVSITTTK DRTTLTVKDS
MRGDSGRYFL TLENTAGVKT FSVTVVVIGR PGPVTGPIEV SSVSAESCVL SWGEPKDGGG
TEITNYIVEK RESGTTAWQL VNSSVKRTQI KVTHLTKYME YSFRVSSENR FGVSKPLESA
PIIAEHPFVP PSAPTRPEVY HVSANAMSIR WEEPYHDGGS KIIGYWVEKK ERNTILWVKE
NKVPCLECNY KVTGLVEGLE YQFRTYALNA AGVSKASEAS RPIMAQNPVD APGRPEVTDV
TRSTVSLIWS APAYDGGSKV VGYIIERKPV SEVGDGRWLK CNYTIVSDNF FTVTALSEGD
TYEFRVLAKN AAGVISKGSE STGPVTCRDE YAPPKAELDA RLHGDLVTIR AGSDLVLDAA
VGGKPEPKII WTKGDKELDL CEKVSLQYTG KRATAVIKFC DRSDSGKYTL TVKNASGTKA
VSVMVKVLDS PGPCGKLTVS RVTQEKCTLA WSLPQEDGGA EITHYIVERR ETSRLNWVIV
EGECPTLSYV VTRLIKNNEY IFRVRAVNKY GPGVPVESEP IVARNSFTIP SPPGIPEEVG
TGKEHIIIQW TKPESDGGNE ISNYLVDKRE KKSLRWTRVN KDYVVYDTRL KVTSLMEGCD
YQFRVTAVNA AGNSEPSEAS NFISCREPSY TPGPPSAPRV VDTTKHSISL AWTKPMYDGG
TDIVGYVLEM QEKDTDQWYR VHTNATIRNT EFTVPDLKMG QKYSFRVAAV NVKGMSEYSE
SIAEIEPVER IEIPDLELAD DLKKTVTIRA GASLRLMVSV SGRPPPVITW SKQGIDLASR
AIIDTTESYS LLIVDKVNRY DAGKYTIEAE NQSGKKSATV LVKVYDTPGP CPSVKVKEVS
RDSVTITWEI PTIDGGAPVN NYIVEKREAA MRAFKTVTTK CSKTLYRISG LVEGTMYYFR
VLPENIYGIG EPCETSDAVL VSEVPLVPAK LEVVDVTKST VTLAWEKPLY DGGSRLTGYV
LEACKAGTER WMKVVTLKPT VLEHTVTSLN EGEQYLFRIR AQNEKGVSEP RETVTAVTVQ
DLRVLPTIDL STMPQKTIHV PAGRPVELVI PIAGRPPPAA SWFFAGSKLR ESERVTVETH
TKVAKLTIRE TTIRDTGEYT LELKNVTGTT SETIKVIILD KPGPPTGPIK IDEIDATSIT
ISWEPPELDG GAPLSGYVVE QRDAHRPGWL PVSESVTRST FKFTRLTEGN EYVFRVAATN
RFGIGSYLQS EVIECRSSIR IPGPPETLQI FDVSRDGMTL TWYPPEDDGG SQVTGYIVER
KEVRADRWVR VNKVPVTMTR YRSTGLTEGL EYEHRVTAIN ARGSGKPSRP SKPIVAMDPI
APPGKPQNPR VTDTTRTSVS LAWSVPEDEG GSKVTGYLIE MQKVDQHEWT KCNTTPTKIR
EYTLTHLPQG AEYRFRVLAC NAGGPGEPAE VPGTVKVTEM LEYPDYELDE RYQEGIFVRQ
GGVIRLTIPI KGKPFPICKW TKEGQDISKR AMIATSETHT ELVIKEADRG DSGTYDLVLE
NKCGKKAVYI KVRVIGSPNS PEGPLEYDDI QVRSVRVSWR PPADDGGADI LGYILERREV
PKAAWYTIDS RVRGTSLVVK GLKENVEYHF RVSAENQFGI SKPLKSEEPV TPKTPLNPPE
PPSNPPEVLD VTKSSVSLSW SRPKDDGGSR VTGYYIERKE TSTDKWVRHN KTQITTTMYT
VTGLVPDAEY QFRIIAQNDV GLSETSPASE PVVCKDPFDK PSQPGELEIL SISKDSVTLQ
WEKPECDGGK EILGYWVEYR QSGDSAWKKS NKERIKDKQF TIGGLLEATE YEFRVFAENE
TGLSRPRRTA MSIKTKLTSG EAPGIRKEMK DVTTKLGEAA QLSCQIVGRP LPDIKWYRFG
KELIQSRKYK MSSDGRTHTL TVMTEEQEDE GVYTCIATNE VGEVETSSKL LLQATPQFHP
GYPLKEKYYG AVGSTLRLHV MYIGRPVPAM TWFHGQKLLQ NSENITIENT EHYTHLVMKN
VQRKTHAGKY KVQLSNVFGT VDAILDVEIQ DKPDKPTGPI VIEALLKNSA VISWKPPADD
GGSWITNYVV EKCEAKEGAE WQLVSSAISV TTCRIVNLTE NAGYYFRVSA QNTFGISDPL
EVSSVVIIKS PFEKPGAPGK PTITAVTKDS CVVAWKPPAS DGGAKIRNYY LEKREKKQNK
WISVTTEEIR ETVFSVKNLI EGLEYEFRVK CENLGGESEW SEISEPITPK SDVPIQAPHF
KEELRNLNVR YQSNATLVCK VTGHPKPIVK WYRQGKEIIA DGLKYRIQEF KGGYHQLIIA
SVTDDDATVY QVRATNQGGS VSGTASLEVE VPAKIHLPKT LEGMGAVHAL RGEVVSIKIP
FSGKPDPVIT WQKGQDLIDN NGHYQVIVTR SFTSLVFPNG VERKDAGFYV VCAKNRFGID
QKTVELDVAD VPDPPRGVKV SDVSRDSVNL TWTEPASDGG SKITNYIVEK CATTAERWLR
VGQARETRYT VINLFGKTSY QFRVIAENKF GLSKPSEPSE PTITKEDKTR AMNYDEEVDE
TREVSMTKAS HSSTKELYEK YMIAEDLGRG EFGIVHRCVE TSSKKTYMAK FVKVKGTDQV
LVKKEISILN IARHRNILHL HESFESMEEL VMIFEFISGL DIFERINTSA FELNEREIVS
YVHQVCEALQ FLHSHNIGHF DIRPENIIYQ TRRSSTIKII EFGQARQLKP GDNFRLLFTA
PEYYAPEVHQ HDVVSTATDM WSLGTLVYVL LSGINPFLAE TNQQIIENIM NAEYTFDEEA
FKEISIEAMD FVDRLLVKER KSRMTASEAL QHPWLKQKIE RVSTKVIRTL KHRRYYHTLI
KKDLNMVVSA ARISCGGAIR SQKGVSVAKV KVASIEIGPV SGQIMHAVGE EGGHVKYVCK
IENYDQSTQV TWYFGVRQLE NSEKYEITYE DGVAILYVKD ITKLDDGTYR CKVVNDYGED
SSYAELFVKG VREVYDYYCR RTMKKIKRRT DTMRLLERPP EFTLPLYNKT AYVGENVRFG
VTITVHPEPH VTWYKSGQKI KPGDNDKKYT FESDKGLYQL TINSVTTDDD AEYTVVARNK
YGEDSCKAKL TVTLHPPPTD STLRPMFKRL LANAECQEGQ SVCFEIRVSG IPPPTLKWEK
DGQPLSLGPN IEIIHEGLDY YALHIRDTLP EDTGYYRVTA TNTAGSTSCQ AHLQVERLRY
KKQEFKSKEE HERHVQKQID KTLRMAEILS GTESVPLTQV AKEALREAAV LYKPAVSTKT
VKGEFRLEIE EKKEERKLRM PYDVPEPRKY KQTTIEEDQR IKQFVPMSDM KWYKKIRDQY
EMPGKLDRVV QKRPKRIRLS RWEQFYVMPL PRITDQYRPK WRIPKLSQDD LEIVRPARRR
TPSPDYDFYY RPRRRSLGDI SDEELLLPID DYLAMKRTEE ERLRLEEELE LGFSASPPSR
SPPHFELSSL RYSSPQAHVK VEETRKDFRY STYHIPTKAE ASTSYAELRE RHAQAAYRQP
KQRQRIMAER EDEELLRPVT TTQHLSEYKS ELDFMSKEEK SRKKSRRQRE VTEITEIEEE
YEISKHAQRE SSSSASRLLR RRRSLSPTYI ELMRPVSELI RSRPQPAEEY EDDTERRSPT
PERTRPRSPS PVSSERSLSR FERSARFDIF SRYESMKAAL KTQKTSERKY EVLSQQPFTL
DHAPRITLRM RSHRVPCGQN TRFILNVQSK PTAEVKWYHN GVELQESSKI HYTNTSGVLT
LEILDCHTDD SGTYRAVCTN YKGEASDYAT LDVTGGDYTT YASQRRDEEV PRSVFPELTR
TEAYAVSSFK KTSEMEASSS VREVKSQMTE TRESLSSYEH SASAEMKSAA LEEKSLEEKS
TTRKIKTTLA ARILTKPRSM TVYEGESARF SCDTDGEPVP TVTWLRKGQV LSTSARHQVT
TTKYKSTFEI SSVQASDEGN YSVVVENSEG KQEAEFTLTI QKARVTEKAV TSPPRVKSPE
PRVKSPEAVK SPKRVKSPEP SHPKAVSPTE TKPTPTEKVQ HLPVSAPPKI TQFLKAEASK
EIAKLTCVVE SSVLRAKEVT WYKDGKKLKE NGHFQFHYSA DGTYELKINN LTESDQGEYV
CEISGEGGTS KTNLQFMGQA FKSIHEKVSK ISETKKSDQK TTESTVTRKT EPKAPEPISS
KPVIVTGLQD TTVSSDSVAK FAVKATGEPR PTAIWTKDGK AITQGGKYKL SEDKGGFFLE
IHKTDTSDSG LYTCTVKNSA GSVSSSCKLT IKAIKDTEAQ KVSTQKTSEI TPQKKAVVQE
EISQKALRSE EIKMSEAKSQ EKLALKEEAS KVLISEEVKK SAATSLEKSI VHEEITKTSQ
ASEEVRTHAE IKAFSTQMSI NEGQRLVLKA NIAGATDVKW VLNGVELTNS EEYRYGVSGS
DQTLTIKQAS HRDEGILTCI SKTKEGIVKC QYDLTLSKEL SDAPAFISQP RSQNINEGQN
VLFTCEISGE PSPEIEWFKN NLPISISSNV SISRSRNVYS LEIRNASVSD SGKYTIKAKN
FRGQCSATAS LMVLPLVEEP SREVVLRTSG DTSLQGSFSS QSVQMSASKQ EASFSSFSSS
SASSMTEMKF ASMSAQSMSS MQESFVEMSS SSFMGISNMT QLESSTSKML KAGIRGIPPK
IEALPSDISI DEGKVLTVAC AFTGEPTPEV TWSCGGRKIH SQEQGRFHIE NTDDLTTLII
MDVQKQDGGL YTLSLGNEFG SDSATVNIHI RSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107491

Theoretical NMD boundary in CDS

107215

Length of CDS

107562

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_10_ENST00000589042

Back to summary table

Prediction:

BenignPermalink

Summary:

Model: without_aae
Tree vote: 74|126 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.48, LOF (oe): 0.46, misssense (oe): 0.91, synonymous (oe): 0.90 ? (gnomAD)

Ensembl transcript ID

ENST00000589042.5

Genbank transcript ID

NM_001267550 (exact from MANE)

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.11312-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV
IPEGETPIVK RRKTPSPTVP ESPREIVPVK ETPMAAPLEI EIPPTKAPEA MKEVVPEMKI
FEDVPEEPET PRMKTPEAPQ EIIPAKTVPS KKREPPSVKV PEALQEIVPE KKTLVVPLRK
PEVLPDEVPE ALREVVPEKK VHPPQRAEVV PVKVHEAPKE IIPEKKVSVV PPKKPEVPPV
KVPEASKEVI REEKVPLAPP KEPEVPPVKV PEPPKEVVPE KKAPVAPPKE PEVPPVKVPE
APKEVVPEKK VPVPPPKKPE VPPTKVPEVP KAAVPEKKLP EAIPPKPESP PPEVPEVLPP
KEVVPEKKVP VPPAKKPEAP PPKVPEAPKE VVLEKKASVA VPKKPEAPRA KVPEAAQEVV
PEKKIPKAPI KKPEAPAVTV PEVPQEATEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP
KAPPTKPEAP PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPSAPPK
KPEVPPVKVP EAPKEVVPEK KVPVPPPKKP EVPPTKVPEV PKAAVPEKKV PEAIPPKPES
PPPEVPEVLP PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVLEKKASV AVPKKPEAPR
AKVPEAAQEV VPEKKIPKAP IKKPEAPAVT VPEVPQEAAE KEIPVAPPKK PEAPIVPVPE
AQEVVPEKKV PKAPPTKPEA PPATVPEVPQ EIVPEKKTLV LPKKPEVPPV TVPEAPKEVV
LEKKVPSTPP KKPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK
VPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP KEVVLEKKVS
VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAA EKEIPVAPPK
KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL VLPKKPEVPP
VTVPEAPKEV VLEKKVPLAP PKKPEVPPVK VPEAPKEVVP EKKVPVTPPK KPEVPPVKVP
EAPIEVVPEK KMPLAPPKKP EVPPVKVPEA PKEVVPEKKV PSAPPKKPEV PPVKVPEAPK
EVVPEKKVPA APPKKPEVTP VKVPEAPKEV VPEKKVPVPP PKKPEVPPTK VPEVPKVAVP
EKKVPEAIPP KPESPPPEVF EEPEEVALEE PPAEVVEEPE PAAPPQVTVP PKKPVPEKKA
PAVVAKKPEL PPVKVPEVPK EVVPEKKVPL VVPKKPEAPP AKVPEVPKEV VPEKKVAVPK
KPEVPPAKVP EVPKKPVLEE KPAVPVPERA ESPPPEVYEE PEEIAPEEEI APEEEKPVPV
AEEEEPEVPP PAVPEEPKKI IPEKKVPVIK KPEAPPPKEP EMPKKVVPVK KVPTVKKPET
PAAKVPEVPK KLVPVKKEPV PVTKKPEVLP EKVPKVPEKI IPEKEVSVPI PAEPEVPPAE
VEETPEEIIY EEKASITIGR KETPPVEERE IEKYIKPEEP EPEPQPEEIP VKEPEPEKVI
EKPKLKPRPP PPPPAPPKED VKEKIFQLKA IPKKKVPEKP QVPEKVELTP LKVPGGEKKV
RKLLPERKPE PKEEVVLKSV LRKRPEEEEP KVEPKKLEKV KKPAVPEPPP PKPVEEVEVP
TVTKRERKIP EPTKVPEIKP AIPLPAPEPK PKPEAEVKTI KPPPVEPEPT PIAAPVTVPV
VGKKAEAKAP KEEAAKPKGP IKGVPKKTPS PIEAERRKLR PGSGGEKPPD EAPFTYQLKA
VPLKFVKEIK DIILTESEFV GSSAIFECLV SPSTAITTWM KDGSNIRESP KHRFIADGKD
RKLHIIDVQL SDAGEYTCVL RLGNKEKTST AKLVVEELPV RFVKTLEEEV TVVKGQPLYL
SCELNKERDV VWRKDGKIVV EKPGRIVPGV IGLMRALTIN DADDTDAGTY TVTVENANNL
ECSSCVKVVE VIRDWLVKPI RDQHVKPKGT AIFACDIAKD TPNIKWFKGY DEIPAEPNDK
TEILRDGNHL YLKIKNAMPE DIAEYAVEIE GKRYPAKLTL GEREVELLKP IEDVTIYEKE
SASFDAEISE ADIPGQWKLK GELLRPSPTC EIKAEGGKRF LTLHKVKLDQ AGEVLYQALN
AITTAILTVK EIELDFAVPL KDVTVPERRQ ARFECVLTRE ANVIWSKGPD IIKSSDKFDI
IADGKKHILV INDSQFDDEG VYTAEVEGKK TSARLFVTGI RLKFMSPLED QTVKEGETAT
FVCELSHEKM HVVWFKNDAK LHTSRTVLIS SEGKTHKLEM KEVTLDDISQ IKAQVKELSS
TAQLKVLEAD PYFTVKLHDK TAVEKDEITL KCEVSKDVPV KWFKDGEEIV PSPKYSIKAD
GLRRILKIKK ADLKDKGEYV CDCGTDKTKA NVTVEARLIK VEKPLYGVEV FVGETAHFEI
ELSEPDVHGQ WKLKGQPLTA SPDCEIIEDG KKHILILHNC QLGMTGEVSF QAANAKSAAN
LKVKELPLIF ITPLSDVKVF EKDEAKFECE VSREPKTFRW LKGTQEITGD DRFELIKDGT
KHSMVIKSAA FEDEAKYMFE AEDKHTSGKL IIEGIRLKFL TPLKDVTAKE KESAVFTVEL
SHDNIRVKWF KNDQRLHTTR SVSMQDEGKT HSITFKDLSI DDTSQIRVEA MGMSSEAKLT
VLEGDPYFTG KLQDYTGVEK DEVILQCEIS KADAPVKWFK DGKEIKPSKN AVIKADGKKR
MLILKKALKS DIGQYTCDCG TDKTSGKLDI EDREIKLVRP LHSVEVMETE TARFETEISE
DDIHANWKLK GEALLQTPDC EIKEEGKIHS LVLHNCRLDQ TGGVDFQAAN VKSSAHLRVK
PRVIGLLRPL KDVTVTAGET ATFDCELSYE DIPVEWYLKG KKLEPSDKVV PRSEGKVHTL
TLRDVKLEDA GEVQLTAKDF KTHANLFVKE PPVEFTKPLE DQTVEEGATA VLECEVSREN
AKVKWFKNGT EILKSKKYEI VADGRVRKLV IHDCTPEDIK TYTCDAKDFK TSCNLNVVPP
HVEFLRPLTD LQVREKEMAR FECELSRENA KVKWFKDGAE IKKGKKYDII SKGAVRILVI
NKCLLDDEAE YSCEVRTART SGMLTVLEEE AVFTKNLANI EVSETDTIKL VCEVSKPGAE
VIWYKGDEEI IETGRYEILT EGRKRILVIQ NAHLEDAGNY NCRLPSSRTD GKVKVHELAA
EFISKPQNLE ILEGEKAEFV CSISKESFPV QWKRDDKTLE SGDKYDVIAD GKKRVLVVKD
ATLQDMGTYV VMVGAARAAA HLTVIEKLRI VVPLKDTRVK EQQEVVFNCE VNTEGAKAKW
FRNEEAIFDS SKYIILQKDL VYTLRIRDAH LDDQANYNVS LTNHRGENVK SAANLIVEEE
DLRIVEPLKD IETMEKKSVT FWCKVNRLNV TLKWTKNGEE VPFDNRVSYR VDKYKHMLTI
KDCGFPDEGE YIVTAGQDKS VAELLIIEAP TEFVEHLEDQ TVTEFDDAVF SCQLSREKAN
VKWYRNGREI KEGKKYKFEK DGSIHRLIIK DCRLDDECEY ACGVEDRKSR ARLFVEEIPV
EIIRPPQDIL EAPGADVVFL AELNKDKVEV QWLRNNMVVV QGDKHQMMSE GKIHRLQICD
IKPRDQGEYR FIAKDKEARA KLELAAAPKI KTADQDLVVD VGKPLTMVVP YDAYPKAEAE
WFKENEPLST KTIDTTAEQT SFRILEAKKG DKGRYKIVLQ NKHGKAEGFI NLKVIDVPGP
VRNLEVTETF DGEVSLAWEE PLTDGGSKII GYVVERRDIK RKTWVLATDR AESCEFTVTG
LQKGGVEYLF RVSARNRVGT GEPVETDNPV EARSKYDVPG PPLNVTITDV NRFGVSLTWE
PPEYDGGAEI TNYVIELRDK TSIRWDTAMT VRAEDLSATV TDVVEGQEYS FRVRAQNRIG
VGKPSAATPF VKVADPIERP SPPVNLTSSD QTQSSVQLKW EPPLKDGGSP ILGYIIERCE
EGKDNWIRCN MKLVPELTYK VTGLEKGNKY LYRVSAENKA GVSDPSEILG PLTADDAFVE
PTMDLSAFKD GLEVIVPNPI TILVPSTGYP RPTATWCFGD KVLETGDRVK MKTLSAYAEL
VISPSERSDK GIYTLKLENR VKTISGEIDV NVIARPSAPK ELKFGDITKD SVHLTWEPPD
DDGGSPLTGY VVEKREVSRK TWTKVMDFVT DLEFTVPDLV QGKEYLFKVC ARNKCGPGEP
AYVDEPVNMS TPATVPDPPE NVKWRDRTAN SIFLTWDPPK NDGGSRIKGY IVERCPRGSD
KWVACGEPVA ETKMEVTGLE EGKWYAYRVK ALNRQGASKP SRPTEEIQAV DTQEAPEIFL
DVKLLAGLTV KAGTKIELPA TVTGKPEPKI TWTKADMILK QDKRITIENV PKKSTVTIVD
SKRSDTGTYI IEAVNVCGRA TAVVEVNVLD KPGPPAAFDI TDVTNESCLL TWNPPRDDGG
SKITNYVVER RATDSEVWHK LSSTVKDTNF KATKLIPNKE YIFRVAAENM YGVGEPVQAS
PITAKYQFDP PGPPTRLEPS DITKDAVTLT WCEPDDDGGS PITGYWVERL DPDTDKWVRC
NKMPVKDTTY RVKGLTNKKK YRFRVLAENL AGPGKPSKST EPILIKDPID PPWPPGKPTV
KDVGKTSVRL NWTKPEHDGG AKIESYVIEM LKTGTDEWVR VAEGVPTTQH LLPGLMEGQE
YSFRVRAVNK AGESEPSEPS DPVLCREKLY PPSPPRWLEV INITKNTADL KWTVPEKDGG
SPITNYIVEK RDVRRKGWQT VDTTVKDTKC TVTPLTEGSL YVFRVAAENA IGQSDYTEIE
DSVLAKDTFT TPGPPYALAV VDVTKRHVDL KWEPPKNDGG RPIQRYVIEK KERLGTRWVK
AGKTAGPDCN FRVTDVIEGT EVQFQVRAEN EAGVGHPSEP TEILSIEDPT SPPSPPLDLH
VTDAGRKHIA IAWKPPEKNG GSPIIGYHVE MCPVGTEKWM RVNSRPIKDL KFKVEEGVVP
DKEYVLRVRA VNAIGVSEPS EISENVVAKD PDCKPTIDLE THDIIVIEGE KLSIPVPFRA
VPVPTVSWHK DGKEVKASDR LTMKNDHISA HLEVPKSVRA DAGIYTITLE NKLGSATASI
NVKVIGLPGP CKDIKASDIT KSSCKLTWEP PEFDGGTPIL HYVLERREAG RRTYIPVMSG
ENKLSWTVKD LIPNGEYFFR VKAVNKVGGG EYIELKNPVI AQDPKQPPDP PVDVEVHNPT
AEAMTITWKP PLYDGGSKIM GYIIEKIAKG EERWKRCNEH LVPILTYTAK GLEEGKEYQF
RVRAENAAGI SEPSRATPPT KAVDPIDAPK VILRTSLEVK RGDEIALDAS ISGSPYPTIT
WIKDENVIVP EEIKKRAAPL VRRRKGEVQE EEPFVLPLTQ RLSIDNSKKG ESQLRVRDSL
RPDHGLYMIK VENDHGIAKA PCTVSVLDTP GPPINFVFED IRKTSVLCKW EPPLDDGGSE
IINYTLEKKD KTKPDSEWIV VTSTLRHCKY SVTKLIEGKE YLFRVRAENR FGPGPPCVSK
PLVAKDPFGP PDAPDKPIVE DVTSNSMLVK WNEPKDNGSP ILGYWLEKRE VNSTHWSRVN
KSLLNALKAN VDGLLEGLTY VFRVCAENAA GPGKFSPPSD PKTAHDPISP PGPPIPRVTD
TSSTTIELEW EPPAFNGGGE IVGYFVDKQL VGTNEWSRCT EKMIKVRQYT VKEIREGADY
KLRVSAVNAA GEGPPGETQP VTVAEPQEPP AVELDVSVKG GIQIMAGKTL RIPAVVTGRP
VPTKVWTKEE GELDKDRVVI DNVGTKSELI IKDALRKDHG RYVITATNSC GSKFAAARVE
VFDVPGPVLD LKPVVTNRKM CLLNWSDPED DGGSEITGFI IERKDAKMHT WRQPIETERS
KCDITGLLEG QEYKFRVIAK NKFGCGPPVE IGPILAVDPL GPPTSPERLT YTERTKSTIT
LDWKEPRSNG GSPIQGYIIE KRRHDKPDFE RVNKRLCPTT SFLVENLDEH QMYEFRVKAV
NEIGESEPSL PLNVVIQDDE VPPTIKLRLS VRGDTIKVKA GEPVHIPADV TGLPMPKIEW
SKNETVIEKP TDALQITKEE VSRSEAKTEL SIPKAVREDK GTYTVTASNR LGSVFRNVHV
EVYDRPSPPR NLAVTDIKAE SCYLTWDAPL DNGGSEITHY VIDKRDASRK KAEWEEVTNT
AVEKRYGIWK LIPNGQYEFR VRAVNKYGIS DECKSDKVVI QDPYRLPGPP GKPKVLARTK
GSMLVSWTPP LDNGGSPITG YWLEKREEGS PYWSRVSRAP ITKVGLKGVE FNVPRLLEGV
KYQFRAMAIN AAGIGPPSEP SDPEVAGDPI FPPGPPSCPE VKDKTKSSIS LGWKPPAKDG
GSPIKGYIVE MQEEGTTDWK RVNEPDKLIT TCECVVPNLK ELRKYRFRVK AVNEAGESEP
SDTTGEIPAT DIQEEPEVFI DIGAQDCLVC KAGSQIRIPA VIKGRPTPKS SWEFDGKAKK
AMKDGVHDIP EDAQLETAEN SSVIIIPECK RSHTGKYSIT AKNKAGQKTA NCRVKVMDVP
GPPKDLKVSD ITRGSCRLSW KMPDDDGGDR IKGYVIEKRT IDGKAWTKVN PDCGSTTFVV
PDLLSEQQYF FRVRAENRFG IGPPVETIQR TTARDPIYPP DPPIKLKIGL ITKNTVHLSW
KPPKNDGGSP VTHYIVECLA WDPTGTKKEA WRQCNKRDVE ELQFTVEDLV EGGEYEFRVK
AVNAAGVSKP SATVGPVTVK DQTCPPSIDL KEFMEVEEGT NVNIVAKIKG VPFPTLTWFK
APPKKPDNKE PVLYDTHVNK LVVDDTCTLV IPQSRRSDTG LYTITAVNNL GTASKEMRLN
VLGRPGPPVG PIKFESVSAD QMTLSWFPPK DDGGSKITNY VIEKREANRK TWVHVSSEPK
ECTYTIPKLL EGHEYVFRIM AQNKYGIGEP LDSEPETARN LFSVPGAPDK PTVSSVTRNS
MTVNWEEPEY DGGSPVTGYW LEMKDTTSKR WKRVNRDPIK AMTLGVSYKV TGLIEGSDYQ
FRVYAINAAG VGPASLPSDP ATARDPIAPP GPPFPKVTDW TKSSADLEWS PPLKDGGSKV
TGYIVEYKEE GKEEWEKGKD KEVRGTKLVV TGLKEGAFYK FRVRAVNIAG IGEPGEVTDV
IEMKDRLVSP DLQLDASVRD RIVVHAGGVI RIIAYVSGKP PPTVTWNMNE RTLPQEATIE
TTAISSSMVI KNCQRSHQGV YSLLAKNEAG ERKKTIIVDV LDVPGPVGTP FLAHNLTNES
CKLTWFSPED DGGSPITNYV IEKRESDRRA WTPVTYTVTR QNATVQGLIQ GKAYFFRIAA
ENSIGMGPFV ETSEALVIRE PITVPERPED LEVKEVTKNT VTLTWNPPKY DGGSEIINYV
LESRLIGTEK FHKVTNDNLL SRKYTVKGLK EGDTYEYRVS AVNIVGQGKP SFCTKPITCK
DELAPPTLHL DFRDKLTIRV GEAFALTGRY SGKPKPKVSW FKDEADVLED DRTHIKTTPA
TLALEKIKAK RSDSGKYCVV VENSTGSRKG FCQVNVVDRP GPPVGPVSFD EVTKDYMVIS
WKPPLDDGGS KITNYIIEKK EVGKDVWMPV TSASAKTTCK VSKLLEGKDY IFRIHAENLY
GISDPLVSDS MKAKDRFRVP DAPDQPIVTE VTKDSALVTW NKPHDGGKPI TNYILEKRET
MSKRWARVTK DPIHPYTKFR VPDLLEGCQY EFRVSAENEI GIGDPSPPSK PVFAKDPIAK
PSPPVNPEAI DTTCNSVDLT WQPPRHDGGS KILGYIVEYQ KVGDEEWRRA NHTPESCPET
KYKVTGLRDG QTYKFRVLAV NAAGESDPAH VPEPVLVKDR LEPPELILDA NMAREQHIKV
GDTLRLSAII KGVPFPKVTW KKEDRDAPTK ARIDVTPVGS KLEIRNAAHE DGGIYSLTVE
NPAGSKTVSV KVLVLDKPGP PRDLEVSEIR KDSCYLTWKE PLDDGGSVIT NYVVERRDVA
SAQWSPLSAT SKKKSHFAKH LNEGNQYLFR VAAENQYGRG PFVETPKPIK ALDPLHPPGP
PKDLHHVDVD KTEVSLVWNK PDRDGGSPIT GYLVEYQEEG TQDWIKFKTV TNLECVVTGL
QQGKTYRFRV KAENIVGLGL PDTTIPIECQ EKLVPPSVEL DVKLIEGLVV KAGTTVRFPA
IIRGVPVPTA KWTTDGSEIK TDEHYTVETD NFSSVLTIKN CLRRDTGEYQ ITVSNAAGSK
TVAVHLTVLD VPGPPTGPIN ILDVTPEHMT ISWQPPKDDG GSPVINYIVE KQDTRKDTWG
VVSSGSSKTK LKIPHLQKGC EYVFRVRAEN KIGVGPPLDS TPTVAKHKFS PPSPPGKPVV
TDITENAATV SWTLPKSDGG SPITGYYMER REVTGKWVRV NKTPIADLKF RVTGLYEGNT
YEFRVFAENL AGLSKPSPSS DPIKACRPIK PPGPPINPKL KDKSRETADL VWTKPLSDGG
SPILGYVVEC QKPGTAQWNR INKDELIRQC AFRVPGLIEG NEYRFRIKAA NIVGEGEPRE
LAESVIAKDI LHPPEVELDV TCRDVITVRV GQTIRILARV KGRPEPDITW TKEGKVLVRE
KRVDLIQDLP RVELQIKEAV RADHGKYIIS AKNSSGHAQG SAIVNVLDRP GPCQNLKVTN
VTKENCTISW ENPLDNGGSE ITNFIVEYRK PNQKGWSIVA SDVTKRLIKA NLLANNEYYF
RVCAENKVGV GPTIETKTPI LAINPIDRPG EPENLHIADK GKTFVYLKWR RPDYDGGSPN
LSYHVERRLK GSDDWERVHK GSIKETHYMV DRCVENQIYE FRVQTKNEGG ESDWVKTEEV
VVKEDLQKPV LDLKLSGVLT VKAGDTIRLE AGVRGKPFPE VAWTKDKDAT DLTRSPRVKI
DTRADSSKFS LTKAKRSDGG KYVVTATNTA GSFVAYATVN VLDKPGPVRN LKIVDVSSDR
CTVCWDPPED DGGCEIQNYI LEKCETKRMV WSTYSATVLT PGTTVTRLIE GNEYIFRVRA
ENKIGTGPPT ESKPVIAKTK YDKPGRPDPP EVTKVSKEEM TVVWNPPEYD GGKSITGYFL
EKKEKHSTRW VPVNKSAIPE RRMKVQNLLP DHEYQFRVKA ENEIGIGEPS LPSRPVVAKD
PIEPPGPPTN FRVVDTTKHS ITLGWGKPVY DGGAPIIGYV VEMRPKIADA SPDEGWKRCN
AAAQLVRKEF TVTSLDENQE YEFRVCAQNQ VGIGRPAELK EAIKPKEILE PPEIDLDASM
RKLVIVRAGC PIRLFAIVRG RPAPKVTWRK VGIDNVVRKG QVDLVDTMAF LVIPNSTRDD
SGKYSLTLVN PAGEKAVFVN VRVLDTPGPV SDLKVSDVTK TSCHVSWAPP ENDGGSQVTH
YIVEKREADR KTWSTVTPEV KKTSFHVTNL VPGNEYYFRV TAVNEYGPGV PTDVPKPVLA
SDPLSEPDPP RKLEVTEMTK NSATLAWLPP LRDGGAKIDG YITSYREEEQ PADRWTEYSV
VKDLSLVVTG LKEGKKYKFR VAARNAVGVS LPREAEGVYE AKEQLLPPKI LMPEQITIKA
GKKLRIEAHV YGKPHPTCKW KKGEDEVVTS SHLAVHKADS SSILIIKDVT RKDSGYYSLT
AENSSGTDTQ KIKVVVMDAP GPPQPPFDIS DIDADACSLS WHIPLEDGGS NITNYIVEKC
DVSRGDWVTA LASVTKTSCR VGKLIPGQEY IFRVRAENRF GISEPLTSPK MVAQFPFGVP
SEPKNARVTK VNKDCIFVAW DRPDSDGGSP IIGYLIERKE RNSLLWVKAN DTLVRSTEYP
CAGLVEGLEY SFRIYALNKA GSSPPSKPTE YVTARMPVDP PGKPEVIDVT KSTVSLIWAR
PKHDGGSKII GYFVEACKLP GDKWVRCNTA PHQIPQEEYT ATGLEEKAQY QFRAIARTAV
NISPPSEPSD PVTILAENVP PRIDLSVAMK SLLTVKAGTN VCLDATVFGK PMPTVSWKKD
GTLLKPAEGI KMAMQRNLCT LELFSVNRKD SGDYTITAEN SSGSKSATIK LKVLDKPGPP
ASVKINKMYS DRAMLSWEPP LEDGGSEITN YIVDKRETSR PNWAQVSATV PITSCSVEKL
IEGHEYQFRI CAENKYGVGD PVFTEPAIAK NPYDPPGRCD PPVISNITKD HMTVSWKPPA
DDGGSPITGY LLEKRETQAV NWTKVNRKPI IERTLKATGL QEGTEYEFRV TAINKAGPGK
PSDASKAAYA RDPQYPPGPP AFPKVYDTTR SSVSLSWGKP AYDGGSPIIG YLVEVKRADS
DNWVRCNLPQ NLQKTRFEVT GLMEDTQYQF RVYAVNKIGY SDPSDVPDKH YPKDILIPPE
GELDADLRKT LILRAGVTMR LYVPVKGRPP PKITWSKPNV NLRDRIGLDI KSTDFDTFLR
CENVNKYDAG KYILTLENSC GKKEYTIVVK VLDTPGPPVN VTVKEISKDS AYVTWEPPII
DGGSPIINYV VQKRDAERKS WSTVTTECSK TSFRVANLEE GKSYFFRVFA ENEYGIGDPG
ETRDAVKASQ TPGPVVDLKV RSVSKSSCSI GWKKPHSDGG SRIIGYVVDF LTEENKWQRV
MKSLSLQYSA KDLTEGKEYT FRVSAENENG EGTPSEITVV ARDDVVAPDL DLKGLPDLCY
LAKENSNFRL KIPIKGKPAP SVSWKKGEDP LATDTRVSVE SSAVNTTLIV YDCQKSDAGK
YTITLKNVAG TKEGTISIKV VGKPGIPTGP IKFDEVTAEA MTLKWAPPKD DGGSEITNYI
LEKRDSVNNK WVTCASAVQK TTFRVTRLHE GMEYTFRVSA ENKYGVGEGL KSEPIVARHP
FDVPDAPPPP NIVDVRHDSV SLTWTDPKKT GGSPITGYHL EFKERNSLLW KRANKTPIRM
RDFKVTGLTE GLEYEFRVMA INLAGVGKPS LPSEPVVALD PIDPPGKPEV INITRNSVTL
IWTEPKYDGG HKLTGYIVEK RDLPSKSWMK ANHVNVPECA FTVTDLVEGG KYEFRIRAKN
TAGAISAPSE STETIICKDE YEAPTIVLDP TIKDGLTIKA GDTIVLNAIS ILGKPLPKSS
WSKAGKDIRP SDITQITSTP TSSMLTIKYA TRKDAGEYTI TATNPFGTKV EHVKVTVLDV
PGPPGPVEIS NVSAEKATLT WTPPLEDGGS PIKSYILEKR ETSRLLWTVV SEDIQSCRHV
ATKLIQGNEY IFRVSAVNHY GKGEPVQSEP VKMVDRFGPP GPPEKPEVSN VTKNTATVSW
KRPVDDGGSE ITGYHVERRE KKSLRWVRAI KTPVSDLRCK VTGLQEGSTY EFRVSAENRA
GIGPPSEASD SVLMKDAAYP PGPPSNPHVT DTTKKSASLA WGKPHYDGGL EITGYVVEHQ
KVGDEAWIKD TTGTALRITQ FVVPDLQTKE KYNFRISAIN DAGVGEPAVI PDVEIVEREM
APDFELDAEL RRTLVVRAGL SIRIFVPIKG RPAPEVTWTK DNINLKNRAN IENTESFTLL
IIPECNRYDT GKFVMTIENP AGKKSGFVNV RVLDTPGPVL NLRPTDITKD SVTLHWDLPL
IDGGSRITNY IVEKREATRK SYSTATTKCH KCTYKVTGLS EGCEYFFRVM AENEYGIGEP
TETTEPVKAS EAPSPPDSLN IMDITKSTVS LAWPKPKHDG GSKITGYVIE AQRKGSDQWT
HITTVKGLEC VVRNLTEGEE YTFQVMAVNS AGRSAPRESR PVIVKEQTML PELDLRGIYQ
KLVIAKAGDN IKVEIPVLGR PKPTVTWKKG DQILKQTQRV NFETTATSTI LNINECVRSD
SGPYPLTARN IVGEVGDVIT IQVHDIPGPP TGPIKFDEVS SDFVTFSWDP PENDGGVPIS
NYVVEMRQTD STTWVELATT VIRTTYKATR LTTGLEYQFR VKAQNRYGVG PGITSACIVA
NYPFKVPGPP GTPQVTAVTK DSMTISWHEP LSDGGSPILG YHVERKERNG ILWQTVSKAL
VPGNIFKSSG LTDGIAYEFR VIAENMAGKS KPSKPSEPML ALDPIDPPGK PVPLNITRHT
VTLKWAKPEY TGGFKITSYI VEKRDLPNGR WLKANFSNIL ENEFTVSGLT EDAAYEFRVI
AKNAAGAISP PSEPSDAITC RDDVEAPKIK VDVKFKDTVI LKAGEAFRLE ADVSGRPPPT
MEWSKDGKEL EGTAKLEIKI ADFSTNLVNK DSTRRDSGAY TLTATNPGGF AKHIFNVKVL
DRPGPPEGPL AVTEVTSEKC VLSWFPPLDD GGAKIDHYIV QKRETSRLAW TNVASEVQVT
KLKVTKLLKG NEYIFRVMAV NKYGVGEPLE SEPVLAVNPY GPPDPPKNPE VTTITKDSMV
VCWGHPDSDG GSEIINYIVE RRDKAGQRWI KCNKKTLTDL RYKVSGLTEG HEYEFRIMAE
NAAGISAPSP TSPFYKACDT VFKPGPPGNP RVLDTSRSSI SIAWNKPIYD GGSEITGYMV
EIALPEEDEW QIVTPPAGLK ATSYTITGLT ENQEYKIRIY AMNSEGLGEP ALVPGTPKAE
DRMLPPEIEL DADLRKVVTI RACCTLRLFV PIKGRPAPEV KWARDHGESL DKASIESTSS
YTLLIVGNVN RFDSGKYILT VENSSGSKSA FVNVRVLDTP GPPQDLKVKE VTKTSVTLTW
DPPLLDGGSK IKNYIVEKRE STRKAYSTVA TNCHKTSWKV DQLQEGCSYY FRVLAENEYG
IGLPAETAES VKASERPLPP GKITLMDVTR NSVSLSWEKP EHDGGSRILG YIVEMQTKGS
DKWATCATVK VTEATITGLI QGEEYSFRVS AQNEKGISDP RQLSVPVIAK DLVIPPAFKL
LFNTFTVLAG EDLKVDVPFI GRPTPAVTWH KDNVPLKQTT RVNAESTENN SLLTIKDACR
EDVGHYVVKL TNSAGEAIET LNVIVLDKPG PPTGPVKMDE VTADSITLSW GPPKYDGGSS
INNYIVEKRD TSTTTWQIVS ATVARTTIKA CRLKTGCEYQ FRIAAENRYG KSTYLNSEPT
VAQYPFKVPG PPGTPVVTLS SRDSMEVQWN EPISDGGSRV IGYHLERKER NSILWVKLNK
TPIPQTKFKT TGLEEGVEYE FRVSAENIVG IGKPSKVSEC YVARDPCDPP GRPEAIIVTR
NSVTLQWKKP TYDGGSKITG YIVEKKELPE GRWMKASFTN IIDTHFEVTG LVEDHRYEFR
VIARNAAGVF SEPSESTGAI TARDEVDPPR ISMDPKYKDT IVVHAGESFK VDADIYGKPI
PTIQWIKGDQ ELSNTARLEI KSTDFATSLS VKDAVRVDSG NYILKAKNVA GERSVTVNVK
VLDRPGPPEG PVVISGVTAE KCTLAWKPPL QDGGSDIINY IVERRETSRL VWTVVDANVQ
TLSCKVTKLL EGNEYTFRIM AVNKYGVGEP LESEPVVAKN PFVVPDAPKA PEVTTVTKDS
MIVVWERPAS DGGSEILGYV LEKRDKEGIR WTRCHKRLIG ELRLRVTGLI ENHDYEFRVS
AENAAGLSEP SPPSAYQKAC DPIYKPGPPN NPKVIDITRS SVFLSWSKPI YDGGCEIQGY
IVEKCDVSVG EWTMCTPPTG INKTNIEVEK LLEKHEYNFR ICAINKAGVG EHADVPGPII
VEEKLEAPDI DLDLELRKII NIRAGGSLRL FVPIKGRPTP EVKWGKVDGE IRDAAIIDVT
SSFTSLVLDN VNRYDSGKYT LTLENSSGTK SAFVTVRVLD TPSPPVNLKV TEITKDSVSI
TWEPPLLDGG SKIKNYIVEK REATRKSYAA VVTNCHKNSW KIDQLQEGCS YYFRVTAENE
YGIGLPAQTA DPIKVAEVPQ PPGKITVDDV TRNSVSLSWT KPEHDGGSKI IQYIVEMQAK
HSEKWSECAR VKSLQAVITN LTQGEEYLFR VVAVNEKGRS DPRSLAVPIV AKDLVIEPDV
KPAFSSYSVQ VGQDLKIEVP ISGRPKPTIT WTKDGLPLKQ TTRINVTDSL DLTTLSIKET
HKDDGGQYGI TVANVVGQKT ASIEIVTLDK PDPPKGPVKF DDVSAESITL SWNPPLYTGG
CQITNYIVQK RDTTTTVWDV VSATVARTTL KVTKLKTGTE YQFRIFAENR YGQSFALESD
PIVAQYPYKE PGPPGTPFAT AISKDSMVIQ WHEPVNNGGS PVIGYHLERK ERNSILWTKV
NKTIIHDTQF KAQNLEEGIE YEFRVYAENI VGVGKASKNS ECYVARDPCD PPGTPEPIMV
KRNEITLQWT KPVYDGGSMI TGYIVEKRDL PDGRWMKASF TNVIETQFTV SGLTEDQRYE
FRVIAKNAAG AISKPSDSTG PITAKDEVEL PRISMDPKFR DTIVVNAGET FRLEADVHGK
PLPTIEWLRG DKEIEESARC EIKNTDFKAL LIVKDAIRID GGQYILRASN VAGSKSFPVN
VKVLDRPGPP EGPVQVTGVT SEKCSLTWSP PLQDGGSDIS HYVVEKRETS RLAWTVVASE
VVTNSLKVTK LLEGNEYVFR IMAVNKYGVG EPLESAPVLM KNPFVLPGPP KSLEVTNIAK
DSMTVCWNRP DSDGGSEIIG YIVEKRDRSG IRWIKCNKRR ITDLRLRVTG LTEDHEYEFR
VSAENAAGVG EPSPATVYYK ACDPVFKPGP PTNAHIVDTT KNSITLAWGK PIYDGGSEIL
GYVVEICKAD EEEWQIVTPQ TGLRVTRFEI SKLTEHQEYK IRVCALNKVG LGEATSVPGT
VKPEDKLEAP ELDLDSELRK GIVVRAGGSA RIHIPFKGRP TPEITWSREE GEFTDKVQIE
KGVNYTQLSI DNCDRNDAGK YILKLENSSG SKSAFVTVKV LDTPGPPQNL AVKEVRKDSA
FLVWEPPIID GGAKVKNYVI DKRESTRKAY ANVSSKCSKT SFKVENLTEG AIYYFRVMAE
NEFGVGVPVE TVDAVKAAEP PSPPGKVTLT DVSQTSASLM WEKPEHDGGS RVLGYVVEMQ
PKGTEKWSIV AESKVCNAVV TGLSSGQEYQ FRVKAYNEKG KSDPRVLGVP VIAKDLTIQP
SLKLPFNTYS IQAGEDLKIE IPVIGRPRPN ISWVKDGEPL KQTTRVNVEE TATSTVLHIK
EGNKDDFGKY TVTATNSAGT ATENLSVIVL EKPGPPVGPV RFDEVSADFV VISWEPPAYT
GGCQISNYIV EKRDTTTTTW HMVSATVART TIKITKLKTG TEYQFRIFAE NRYGKSAPLD
SKAVIVQYPF KEPGPPGTPF VTSISKDQML VQWHEPVNDG GTKIIGYHLE QKEKNSILWV
KLNKTPIQDT KFKTTGLDEG LEYEFKVSAE NIVGIGKPSK VSECFVARDP CDPPGRPEAI
VITRNNVTLK WKKPAYDGGS KITGYIVEKK DLPDGRWMKA SFTNVLETEF TVSGLVEDQR
YEFRVIARNA AGNFSEPSDS SGAITARDEI DAPNASLDPK YKDVIVVHAG ETFVLEADIR
GKPIPDVVWS KDGKELEETA ARMEIKSTIQ KTTLVVKDCI RTDGGQYILK LSNVGGTKSI
PITVKVLDRP GPPEGPLKVT GVTAEKCYLA WNPPLQDGGA NISHYIIEKR ETSRLSWTQV
STEVQALNYK VTKLLPGNEY IFRVMAVNKY GIGEPLESGP VTACNPYKPP GPPSTPEVSA
ITKDSMVVTW ARPVDDGGTE IEGYILEKRD KEGVRWTKCN KKTLTDLRLR VTGLTEGHSY
EFRVAAENAA GVGEPSEPSV FYRACDALYP PGPPSNPKVT DTSRSSVSLA WSKPIYDGGA
PVKGYVVEVK EAAADEWTTC TPPTGLQGKQ FTVTKLKENT EYNFRICAIN SEGVGEPATL
PGSVVAQERI EPPEIELDAD LRKVVVLRAS ATLRLFVTIK GRPEPEVKWE KAEGILTDRA
QIEVTSSFTM LVIDNVTRFD SGRYNLTLEN NSGSKTAFVN VRVLDSPSAP VNLTIREVKK
DSVTLSWEPP LIDGGAKITN YIVEKRETTR KAYATITNNC TKTTFRIENL QEGCSYYFRV
LASNEYGIGL PAETTEPVKV SEPPLPPGRV TLVDVTRNTA TIKWEKPESD GGSKITGYVV
EMQTKGSEKW STCTQVKTLE ATISGLTAGE EYVFRVAAVN EKGRSDPRQL GVPVIARDIE
IKPSVELPFH TFNVKAREQL KIDVPFKGRP QATVNWRKDG QTLKETTRVN VSSSKTVTSL
SIKEASKEDV GTYELCVSNS AGSITVPITI IVLDRPGPPG PIRIDEVSCD SITISWNPPE
YDGGCQISNY IVEKKETTST TWHIVSQAVA RTSIKIVRLT TGSEYQFRVC AENRYGKSSY
SESSAVVAEY PFSPPGPPGT PKVVHATKST MLVTWQVPVN DGGSRVIGYH LEYKERSSIL
WSKANKILIA DTQMKVSGLD EGLMYEYRVY AENIAGIGKC SKSCEPVPAR DPCDPPGQPE
VTNITRKSVS LKWSKPHYDG GAKITGYIVE RRELPDGRWL KCNYTNIQET YFEVTELTED
QRYEFRVFAR NAADSVSEPS ESTGPIIVKD DVEPPRVMMD VKFRDVIVVK AGEVLKINAD
IAGRPLPVIS WAKDGIEIEE RARTEIISTD NHTLLTVKDC IRRDTGQYVL TLKNVAGTRS
VAVNCKVLDK PGPPAGPLEI NGLTAEKCSL SWGRPQEDGG ADIDYYIVEK RETSHLAWTI
CEGELQMTSC KVTKLLKGNE YIFRVTGVNK YGVGEPLESV AIKALDPFTV PSPPTSLEIT
SVTKESMTLC WSRPESDGGS EISGYIIERR EKNSLRWVRV NKKPVYDLRV KSTGLREGCE
YEYRVYAENA AGLSLPSETS PLIRAEDPVF LPSPPSKPKI VDSGKTTITI AWVKPLFDGG
APITGYTVEY KKSDDTDWKT SIQSLRGTEY TISGLTTGAE YVFRVKSVNK VGASDPSDSS
DPQIAKEREE EPLFDIDSEM RKTLIVKAGA SFTMTVPFRG RPVPNVLWSK PDTDLRTRAY
VDTTDSRTSL TIENANRNDS GKYTLTIQNV LSAASLTLVV KVLDTPGPPT NITVQDVTKE
SAVLSWDVPE NDGGAPVKNY HIEKREASKK AWVSVTNNCN RLSYKVTNLQ EGAIYYFRVS
GENEFGVGIP AETKEGVKIT EKPSPPEKLG VTSISKDSVS LTWLKPEHDG GSRIVHYVVE
ALEKGQKNWV KCAVAKSTHH VVSGLRENSE YFFRVFAENQ AGLSDPRELL LPVLIKEQLE
PPEIDMKNFP SHTVYVRAGS NLKVDIPISG KPLPKVTLSR DGVPLKATMR FNTEITAENL
TINLKESVTA DAGRYEITAA NSSGTTKAFI NIVVLDRPGP PTGPVVISDI TEESVTLKWE
PPKYDGGSQV TNYILLKRET STAVWTEVSA TVARTMMKVM KLTTGEEYQF RIKAENRFGI
SDHIDSACVT VKLPYTTPGP PSTPWVTNVT RESITVGWHE PVSNGGSAVV GYHLEMKDRN
SILWQKANKL VIRTTHFKVT TISAGLIYEF RVYAENAAGV GKPSHPSEPV LAIDACEPPR
NVRITDISKN SVSLSWQQPA FDGGSKITGY IVERRDLPDG RWTKASFTNV TETQFIISGL
TQNSQYEFRV FARNAVGSIS NPSEVVGPIT CIDSYGGPVI DLPLEYTEVV KYRAGTSVKL
RAGISGKPAP TIEWYKDDKE LQTNALVCVE NTTDLASILI KDADRLNSGC YELKLRNAMG
SASATIRVQI LDKPGPPGGP IEFKTVTAEK ITLLWRPPAD DGGAKITHYI VEKRETSRVV
WSMVSEHLEE CIITTTKIIK GNEYIFRVRA VNKYGIGEPL ESDSVVAKNA FVTPGPPGIP
EVTKITKNSM TVVWSRPIAD GGSDISGYFL EKRDKKSLGW FKVLKETIRD TRQKVTGLTE
NSDYQYRVCA VNAAGQGPFS EPSEFYKAAD PIDPPGPPAK IRIADSTKSS ITLGWSKPVY
DGGSAVTGYV VEIRQGEEEE WTTVSTKGEV RTTEYVVSNL KPGVNYYFRV SAVNCAGQGE
PIEMNEPVQA KDILEAPEID LDVALRTSVI AKAGEDVQVL IPFKGRPPPT VTWRKDEKNL
GSDARYSIEN TDSSSLLTIP QVTRNDTGKY ILTIENGVGE PKSSTVSVKV LDTPAACQKL
QVKHVSRGTV TLLWDPPLID GGSPIINYVI EKRDATKRTW SVVSHKCSST SFKLIDLSEK
TPFFFRVLAE NEIGIGEPCE TTEPVKAAEV PAPIRDLSMK DSTKTSVILS WTKPDFDGGS
VITEYVVERK GKGEQTWSHA GISKTCEIEV SQLKEQSVLE FRVFAKNEKG LSDPVTIGPI
TVKELIITPE VDLSDIPGAQ VTVRIGHNVH LELPYKGKPK PSISWLKDGL PLKESEFVRF
SKTENKITLS IKNAKKEHGG KYTVILDNAV CRIAVPITVI TLGPPSKPKG PIRFDEIKAD
SVILSWDVPE DNGGGEITCY SIEKRETSQT NWKMVCSSVA RTTFKVPNLV KDAEYQFRVR
AENRYGVSQP LVSSIIVAKH QFRIPGPPGK PVIYNVTSDG MSLTWDAPVY DGGSEVTGFH
VEKKERNSIL WQKVNTSPIS GREYRATGLV EGLDYQFRVY AENSAGLSSP SDPSKFTLAV
SPVDPPGTPD YIDVTRETIT LKWNPPLRDG GSKIVGYSIE KRQGNERWVR CNFTDVSECQ
YTVTGLSPGD RYEFRIIARN AVGTISPPSQ SSGIIMTRDE NVPPIVEFGP EYFDGLIIKS
GESLRIKALV QGRPVPRVTW FKDGVEIEKR MNMEITDVLG STSLFVRDAT RDHRGVYTVE
AKNASGSAKA EIKVKVQDTP GKVVGPIRFT NITGEKMTLW WDAPLNDGCA PITHYIIEKR
ETSRLAWALI EDKCEAQSYT AIKLINGNEY QFRVSAVNKF GVGRPLDSDP VVAQIQYTVP
DAPGIPEPSN ITGNSITLTW ARPESDGGSE IQQYILERRE KKSTRWVKVI SKRPISETRF
KVTGLTEGNE YEFHVMAENA AGVGPASGIS RLIKCREPVN PPGPPTVVKV TDTSKTTVSL
EWSKPVFDGG MEIIGYIIEM CKADLGDWHK VNAEACVKTR YTVTDLQAGE EYKFRVSAIN
GAGKGDSCEV TGTIKAVDRL TAPELDIDAN FKQTHVVRAG ASIRLFIAYQ GRPTPTAVWS
KPDSNLSLRA DIHTTDSFST LTVENCNRND AGKYTLTVEN NSGSKSITFT VKVLDTPGPP
GPITFKDVTR GSATLMWDAP LLDGGARIHH YVVEKREASR RSWQVISEKC TRQIFKVNDL
AEGVPYYFRV SAVNEYGVGE PYEMPEPIVA TEQPAPPRRL DVVDTSKSSA VLAWLKPDHD
GGSRITGYLL EMRQKGSDFW VEAGHTKQLT FTVERLVEKT EYEFRVKAKN DAGYSEPREA
FSSVIIKEPQ IEPTADLTGI TNQLITCKAG SPFTIDVPIS GRPAPKVTWK LEEMRLKETD
RVSITTTKDR TTLTVKDSMR GDSGRYFLTL ENTAGVKTFS VTVVVIGRPG PVTGPIEVSS
VSAESCVLSW GEPKDGGGTE ITNYIVEKRE SGTTAWQLVN SSVKRTQIKV THLTKYMEYS
FRVSSENRFG VSKPLESAPI IAEHPFVPPS APTRPEVYHV SANAMSIRWE EPYHDGGSKI
IGYWVEKKER NTILWVKENK VPCLECNYKV TGLVEGLEYQ FRTYALNAAG VSKASEASRP
IMAQNPVDAP GRPEVTDVTR STVSLIWSAP AYDGGSKVVG YIIERKPVSE VGDGRWLKCN
YTIVSDNFFT VTALSEGDTY EFRVLAKNAA GVISKGSEST GPVTCRDEYA PPKAELDARL
HGDLVTIRAG SDLVLDAAVG GKPEPKIIWT KGDKELDLCE KVSLQYTGKR ATAVIKFCDR
SDSGKYTLTV KNASGTKAVS VMVKVLDSPG PCGKLTVSRV TQEKCTLAWS LPQEDGGAEI
THYIVERRET SRLNWVIVEG ECPTLSYVVT RLIKNNEYIF RVRAVNKYGP GVPVESEPIV
ARNSFTIPSP PGIPEEVGTG KEHIIIQWTK PESDGGNEIS NYLVDKREKK SLRWTRVNKD
YVVYDTRLKV TSLMEGCDYQ FRVTAVNAAG NSEPSEASNF ISCREPSYTP GPPSAPRVVD
TTKHSISLAW TKPMYDGGTD IVGYVLEMQE KDTDQWYRVH TNATIRNTEF TVPDLKMGQK
YSFRVAAVNV KGMSEYSESI AEIEPVERIE IPDLELADDL KKTVTIRAGA SLRLMVSVSG
RPPPVITWSK QGIDLASRAI IDTTESYSLL IVDKVNRYDA GKYTIEAENQ SGKKSATVLV
KVYDTPGPCP SVKVKEVSRD SVTITWEIPT IDGGAPVNNY IVEKREAAMR AFKTVTTKCS
KTLYRISGLV EGTMYYFRVL PENIYGIGEP CETSDAVLVS EVPLVPAKLE VVDVTKSTVT
LAWEKPLYDG GSRLTGYVLE ACKAGTERWM KVVTLKPTVL EHTVTSLNEG EQYLFRIRAQ
NEKGVSEPRE TVTAVTVQDL RVLPTIDLST MPQKTIHVPA GRPVELVIPI AGRPPPAASW
FFAGSKLRES ERVTVETHTK VAKLTIRETT IRDTGEYTLE LKNVTGTTSE TIKVIILDKP
GPPTGPIKID EIDATSITIS WEPPELDGGA PLSGYVVEQR DAHRPGWLPV SESVTRSTFK
FTRLTEGNEY VFRVAATNRF GIGSYLQSEV IECRSSIRIP GPPETLQIFD VSRDGMTLTW
YPPEDDGGSQ VTGYIVERKE VRADRWVRVN KVPVTMTRYR STGLTEGLEY EHRVTAINAR
GSGKPSRPSK PIVAMDPIAP PGKPQNPRVT DTTRTSVSLA WSVPEDEGGS KVTGYLIEMQ
KVDQHEWTKC NTTPTKIREY TLTHLPQGAE YRFRVLACNA GGPGEPAEVP GTVKVTEMLE
YPDYELDERY QEGIFVRQGG VIRLTIPIKG KPFPICKWTK EGQDISKRAM IATSETHTEL
VIKEADRGDS GTYDLVLENK CGKKAVYIKV RVIGSPNSPE GPLEYDDIQV RSVRVSWRPP
ADDGGADILG YILERREVPK AAWYTIDSRV RGTSLVVKGL KENVEYHFRV SAENQFGISK
PLKSEEPVTP KTPLNPPEPP SNPPEVLDVT KSSVSLSWSR PKDDGGSRVT GYYIERKETS
TDKWVRHNKT QITTTMYTVT GLVPDAEYQF RIIAQNDVGL SETSPASEPV VCKDPFDKPS
QPGELEILSI SKDSVTLQWE KPECDGGKEI LGYWVEYRQS GDSAWKKSNK ERIKDKQFTI
GGLLEATEYE FRVFAENETG LSRPRRTAMS IKTKLTSGEA PGIRKEMKDV TTKLGEAAQL
SCQIVGRPLP DIKWYRFGKE LIQSRKYKMS SDGRTHTLTV MTEEQEDEGV YTCIATNEVG
EVETSSKLLL QATPQFHPGY PLKEKYYGAV GSTLRLHVMY IGRPVPAMTW FHGQKLLQNS
ENITIENTEH YTHLVMKNVQ RKTHAGKYKV QLSNVFGTVD AILDVEIQDK PDKPTGPIVI
EALLKNSAVI SWKPPADDGG SWITNYVVEK CEAKEGAEWQ LVSSAISVTT CRIVNLTENA
GYYFRVSAQN TFGISDPLEV SSVVIIKSPF EKPGAPGKPT ITAVTKDSCV VAWKPPASDG
GAKIRNYYLE KREKKQNKWI SVTTEEIRET VFSVKNLIEG LEYEFRVKCE NLGGESEWSE
ISEPITPKSD VPIQAPHFKE ELRNLNVRYQ SNATLVCKVT GHPKPIVKWY RQGKEIIADG
LKYRIQEFKG GYHQLIIASV TDDDATVYQV RATNQGGSVS GTASLEVEVP AKIHLPKTLE
GMGAVHALRG EVVSIKIPFS GKPDPVITWQ KGQDLIDNNG HYQVIVTRSF TSLVFPNGVE
RKDAGFYVVC AKNRFGIDQK TVELDVADVP DPPRGVKVSD VSRDSVNLTW TEPASDGGSK
ITNYIVEKCA TTAERWLRVG QARETRYTVI NLFGKTSYQF RVIAENKFGL SKPSEPSEPT
ITKEDKTRAM NYDEEVDETR EVSMTKASHS STKELYEKYM IAEDLGRGEF GIVHRCVETS
SKKTYMAKFV KVKGTDQVLV KKEISILNIA RHRNILHLHE SFESMEELVM IFEFISGLDI
FERINTSAFE LNEREIVSYV HQVCEALQFL HSHNIGHFDI RPENIIYQTR RSSTIKIIEF
GQARQLKPGD NFRLLFTAPE YYAPEVHQHD VVSTATDMWS LGTLVYVLLS GINPFLAETN
QQIIENIMNA EYTFDEEAFK EISIEAMDFV DRLLVKERKS RMTASEALQH PWLKQKIERV
STKVIRTLKH RRYYHTLIKK DLNMVVSAAR ISCGGAIRSQ KGVSVAKVKV ASIEIGPVSG
QIMHAVGEEG GHVKYVCKIE NYDQSTQVTW YFGVRQLENS EKYEITYEDG VAILYVKDIT
KLDDGTYRCK VVNDYGEDSS YAELFVKGVR EVYDYYCRRT MKKIKRRTDT MRLLERPPEF
TLPLYNKTAY VGENVRFGVT ITVHPEPHVT WYKSGQKIKP GDNDKKYTFE SDKGLYQLTI
NSVTTDDDAE YTVVARNKYG EDSCKAKLTV TLHPPPTDST LRPMFKRLLA NAECQEGQSV
CFEIRVSGIP PPTLKWEKDG QPLSLGPNIE IIHEGLDYYA LHIRDTLPED TGYYRVTATN
TAGSTSCQAH LQVERLRYKK QEFKSKEEHE RHVQKQIDKT LRMAEILSGT ESVPLTQVAK
EALREAAVLY KPAVSTKTVK GEFRLEIEEK KEERKLRMPY DVPEPRKYKQ TTIEEDQRIK
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR
IPKLSQDDLE IVRPARRRTP SPDYDFYYRP RRRSLGDISD EELLLPIDDY LAMKRTEEER
LRLEEELELG FSASPPSRSP PHFELSSLRY SSPQAHVKVE ETRKDFRYST YHIPTKAEAS
TSYAELRERH AQAAYRQPKQ RQRIMAERED EELLRPVTTT QHLSEYKSEL DFMSKEEKSR
KKSRRQREVT EITEIEEEYE ISKHAQRESS SSASRLLRRR RSLSPTYIEL MRPVSELIRS
RPQPAEEYED DTERRSPTPE RTRPRSPSPV SSERSLSRFE RSARFDIFSR YESMKAALKT
QKTSERKYEV LSQQPFTLDH APRITLRMRS HRVPCGQNTR FILNVQSKPT AEVKWYHNGV
ELQESSKIHY TNTSGVLTLE ILDCHTDDSG TYRAVCTNYK GEASDYATLD VTGGDYTTYA
SQRRDEEVPR SVFPELTRTE AYAVSSFKKT SEMEASSSVR EVKSQMTETR ESLSSYEHSA
SAEMKSAALE EKSLEEKSTT RKIKTTLAAR ILTKPRSMTV YEGESARFSC DTDGEPVPTV
TWLRKGQVLS TSARHQVTTT KYKSTFEISS VQASDEGNYS VVVENSEGKQ EAEFTLTIQK
ARVTEKAVTS PPRVKSPEPR VKSPEAVKSP KRVKSPEPSH PKAVSPTETK PTPTEKVQHL
PVSAPPKITQ FLKAEASKEI AKLTCVVESS VLRAKEVTWY KDGKKLKENG HFQFHYSADG
TYELKINNLT ESDQGEYVCE ISGEGGTSKT NLQFMGQAFK SIHEKVSKIS ETKKSDQKTT
ESTVTRKTEP KAPEPISSKP VIVTGLQDTT VSSDSVAKFA VKATGEPRPT AIWTKDGKAI
TQGGKYKLSE DKGGFFLEIH KTDTSDSGLY TCTVKNSAGS VSSSCKLTIK AIKDTEAQKV
STQKTSEITP QKKAVVQEEI SQKALRSEEI KMSEAKSQEK LALKEEASKV LISEEVKKSA
ATSLEKSIVH EEITKTSQAS EEVRTHAEIK AFSTQMSINE GQRLVLKANI AGATDVKWVL
NGVELTNSEE YRYGVSGSDQ TLTIKQASHR DEGILTCISK TKEGIVKCQY DLTLSKELSD
APAFISQPRS QNINEGQNVL FTCEISGEPS PEIEWFKNNL PISISSNVSI SRSRNVYSLE
IRNASVSDSG KYTIKAKNFR GQCSATASLM VLPLVEEPSR EVVLRTSGDT SLQGSFSSQS
VQMSASKQEA SFSSFSSSSA SSMTEMKFAS MSAQSMSSMQ ESFVEMSSSS FMGISNMTQL
ESSTSKMLKA GIRGIPPKIE ALPSDISIDE GKVLTVACAF TGEPTPEVTW SCGGRKIHSQ
EQGRFHIENT DDLTTLIIMD VQKQDGGLYT LSLGNEFGSD SATVNIHIRS I*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

107905

Theoretical NMD boundary in CDS

107629

Length of CDS

107976

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_13_ENST00000591111

Back to summary table

Prediction:

BenignPermalink

Summary:

Model: without_aae
Tree vote: 90|110 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.46, LOF (oe): 0.44, misssense (oe): 0.90, synonymous (oe): 0.90 ? (gnomAD)

Ensembl transcript ID

ENST00000591111.5

Genbank transcript ID

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10361-3963G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEAPESIL HERIEQEIEM EMKEFSSSFL SAEEEGLHSA ELQLSKINET
LELLSESPVY PTKFDSEKEG TGPIFIKEVS NADISMGDVA TLSVTVIGIP KPKIQWFFNG
VLLTPSADYK FVFDGDDHSL IILFTKLEDE GEYTCMASND YGKTICSAYL KINSKGEGHK
DTETESAVAK SLEKLGGPCP PHFLKELKPI RCAQGLPAIF EYTVVGEPAP TVTWFKENKQ
LCTSVYYTII HNPNGSGTFI VNDPQREDSG LYICKAENML GESTCAAELL VLLEDTDMTD
TPCKAKSTPE APEDFPQTPL KGPAVEALDS EQEIATFVKD TILKAALITE ENQQLSYEHI
AKANELSSQL PLGAQELQSI LEQDKLTPES TREFLCINGS IHFQPLKEPS PNLQLQIVQS
QKTFSKEGIL MPEEPETQAV LSDTEKIFPS AMSIEQINSL TVEPLKTLLA EPEGNYPQSS
IEPPMHSYLT SVAEEVLSPK EKTVSDTNRE QRVTLQKQEA QSALILSQSL AEGHVESLQS
PDVMISQVNY EPLVPSEHSC TEGGKILIES ANPLENAGQD SAVRIEEGKS LRFPLALEEK
QVLLKEEHSD NVVMPPDQII ESKREPVAIK KVQEVQGRDL LSKESLLSGI PEEQRLNLKI
QICRALQAAV ASEQPGLFSE WLRNIEKVEV EAVNITQEPR HIMCMYLVTS AKSVTEEVTI
IIEDVDPQMA NLKMELRDAL CAIIYEEIDI LTAEGPRIQQ GAKTSLQEEM DSFSGSQKVE
PITEPEVESK YLISTEEVSY FNVQSRVKYL DATPVTKGVA SAVVSDEKQD ESLKPSEEKE
ESSSESGTEE VATVKIQEAE GGLIKEDGPM IHTPLVDTVS EEGDIVHLTT SITNAKEVNW
YFENKLVPSD EKFKCLQDQN TYTLVIDKVN TEDHQGEYVC EALNDSGKTA TSAKLTVVKR
AAPVIKRKIE PLEVALGHLA KFTCEIQSAP NVRFQWFKAG REIYESDKCS IRSSKYISSL
EILRTQVVDC GEYTCKASNE YGSVSCTATL TVTEAYPPTF LSRPKSLTTF VGKAAKFICT
VTGTPVIETI WQKDGAALSP SPNWRISDAE NKHILELSNL TIQDRGVYSC KASNKFGADI
CQAELIIIDK PHFIKELEPV QSAINKKVHL ECQVDEDRKV TVTWSKDGQK LPPGKDYKIC
FEDKIATLEI PLAKLKDSGT YVCTASNEAG SSSCSATVTV REPPSFVKKV DPSYLMLPGE
SARLHCKLKG SPVIQVTWFK NNKELSESNT VRMYFVNSEA ILDITDVKVE DSGSYSCEAV
NDVGSDSCST EIVIKEPPSF IKTLEPADIV RGTNALLQCE VSGTGPFEIS WFKDKKQIRS
SKKYRLFSQK SLVCLEIFSF NSADVGEYEC VVANEVGKCG CMATHLLKEP PTFVKKVDDL
IALGGQTVTL QAAVRGSEPI SVTWMKGQEV IREDGKIKMS FSNGVAVLII PDVQISFGGK
YTCLAENEAG SQTSVGELIV KEPAKIIERA ELIQVTAGDP ATLEYTVAGT PELKPKWYKD
GRPLVASKKY RISFKNNVAQ LKFYSAELHD SGQYTFEISN EVGSSSCETT FTVLDRDIAP
FFTKPLRNVD SVVNGTCRLD CKIAGSLPMR VSWFKDGKEI AASDRYRIAF VEGTASLEII
RVDMNDAGNF TCRATNSVGS KDSSGALIVQ EPPSFVTKPG SKDVLPGSAV CLKSTFQGST
PLTIRWFKGN KELVSGGSCY ITKEALESSL ELYLVKTSDS GTYTCKVSNV AGGVECSANL
FVKEPATFVE KLEPSQLLKK GDATQLACKV TGTPPIKITW FANDREIKES SKHRMSFVES
TAVLRLTDVG IEDSGEYMCE AQNEAGSDHC SSIVIVKESP YFTKEFKPIE VLKEYDVMLL
AEVAGTPPFE ITWFKDNTIL RSGRKYKTFI QDHLVSLQIL KFVAADAGEY QCRVTNEVGS
SICSARVTLR EPPSFIKKIE STSSLRGGTA AFQATLKGSL PITVTWLKDS DEITEDDNIR
MTFENNVASL YLSGIEVKHD GKYVCQAKND AGIQRCSALL SVKEPATITE EAVSIDVTQG
DPATLQVKFS GTKEITAKWF KDGQELTLGS KYKISVTDTV SILKIISTEK KDSGEYTFEV
QNDVGRSSCK ARINVLDLII PPSFTKKLKK MDSIKGSFID LECIVAGSHP ISIQWFKDDQ
EISASEKYKF SFHDNTAFLE ISQLEGTDSG TYTCSATNKA GHNQCSGHLT VKEPPYFVEK
PQSQDVNPNT RVQLKALVGG TAPMTIKWFK DNKELHSGAA RSVWKDDTST SLELFAAKAT
DSGTYICQLS NDVGTATSKA TLFVKEPPQF IKKPSPVLVL RNGQSTTFEC QITGTPKIRV
SWYLDGNEIT AIQKHGISFI DGLATFQISG ARVENSGTYV CEARNDAGTA SCSIELKVKE
PPTFIRELKP VEVVKYSDVE LECEVTGTPP FEVTWLKNNR EIRSSKKYTL TDRVSVFNLH
ITKCDPSDTG EYQCIVSNEG GSCSCSTRVA LKEPPSFIKK IENTTTVLKS SATFQSTVAG
SPPISITWLK DDQILDEDDN VYISFVDSVA TLQIRSVDNG HSGRYTCQAK NESGVERCYA
FLLVQEPAQI VEKAKSVDVT EKDPMTLECV VAGTPELKVK WLKDGKQIVP SRYFSMSFEN
NVASFRIQSV MKQDSGQYTF KVENDFGSSS CDAYLRVLDQ NIPPSFTKKL TKMDKVLGSS
IHMECKVSGS LPISAQWFKD GKEISTSAKY RLVCHERSVS LEVNNLELED TANYTCKVSN
VAGDDACSGI LTVKEPPSFL VKPGRQQAIP DSTVEFKAIL KGTPPFKIKW FKDDVELVSG
PKCFIGLEGS TSFLNLYSVD ASKTGQYTCH VTNDVGSDSC TTMLLVTEPP KFVKKLEASK
IVKAGDSSRL ECKIAGSPEI RVVWFRNEHE LPASDKYRMT FIDSVAVIQM NNLSTEDSGD
FICEAQNPAG STSCSTKVIV KEPPVFSSFP PIVETLKNAE VSLECELSGT PPFEVVWYKD
KRQLRSSKKY KIASKNFHTS IHILNVDTSD IGEYHCKAQN EVGSDTCVCT VKLKEPPRFV
SKLNSLTVVA GEPAELQASI EGAQPIFVQW LKEKEEVIRE SENIRITFVE NVATLQFAKA
EPANAGKYIC QIKNDGGMRE NMATLMVLEP AVIVEKAGPM TVTVGETCTL ECKVAGTPEL
SVEWYKDGKL LTSSQKHKFS FYNKISSLRI LSVERQDAGT YTFQVQNNVG KSSCTAVVDV
SDRAVPPSFT RRLKNTGGVL GASCILECKV AGSSPISVAW FHEKTKIVSG AKYQTTFSDN
VCTLQLNSLD SSDMGNYTCV AANVAGSDEC RAVLTVQEPP SFVKEPEPLE VLPGKNVTFT
SVIRGTPPFK VNWFRGAREL VKGDRCNIYF EDTVAELELF NIDISQSGEY TCVVSNNAGQ
ASCTTRLFVK EPAAFLKRLS DHSVEPGKSI ILESTYTGTL PISVTWKKDG FNITTSEKCN
IVTTEKTCIL EILNSTKRDA GQYSCEIENE AGRDVCGALV STLEPPYFVT ELEPLEAAVG
DSVSLQCQVA GTPEITVSWY KGDTKLRPTP EYRTYFTNNV ATLVFNKVNI NDSGEYTCKA
ENSIGTASSK TVFRIQERQL PPSFARQLKD IEQTVGLPVT LTCRLNGSAP IQVCWYRDGV
LLRDDENLQT SFVDNVATLK ILQTDLSHSG QYSCSASNPL GTASSSARLT AREPKKSPFF
DIKPVSIDVI AGESADFECH VTGAQPMRIT WSKDNKEIRP GGNYTITCVG NTPHLRILKV
GKGDSGQYTC QATNDVGKDM CSAQLSVKEP PKFVKKLEAS KVAKQGESIQ LECKISGSPE
IKVSWFRNDS ELHESWKYNM SFINSVALLT INEASAEDSG DYICEAHNGV GDASCSTALT
VKAPPVFTQK PSPVGALKGS DVILQCEISG TPPFEVVWVK DRKQVRNSKK FKITSKHFDT
SLHILNLEAS DVGEYHCKAT NEVGSDTCSC SVKFKEPPRF VKKLSDTSTL IGDAVELRAI
VEGFQPISVV WLKDRGEVIR ESENTRISFI DNIATLQLGS PEASNSGKYI CQIKNDAGMR
ECSAVLTVLE PARIIEKPEP MTVTTGNPFA LECVVTGTPE LSAKWFKDGR ELSADSKHHI
TFINKVASLK IPCAEMSDKG LYSFEVKNSV GKSNCTVSVH VSDRIVPPSF IRKLKDVNAI
LGASVVLECR VSGSAPISVG WFQDGNEIVS GPKCQSSFSE NVCTLNLSLL EPSDTGIYTC
VAANVAGSDE CSAVLTVQEP PSFEQTPDSV EVLPGMSLTF TSVIRGTPPF KVKWFKGSRE
LVPGESCNIS LEDFVTELEL FEVQPLESGD YSCLVTNDAG SASCTTHLFV KEPATFVKRL
ADFSVETGSP IVLEATYTGT PPISVSWIKD EYLISQSERC SITMTEKSTI LEILESTIED
YAQYSCLIEN EAGQDICEAL VSVLEPPYFI EPLEHVEAVI GEPATLQCKV DGTPEIRISW
YKEHTKLRSA PAYKMQFKNN VASLVINKVD HSDVGEYSCK ADNSVGAVAS SAVLVIKARK
LPPFFARKLK DVHETLGFPV AFECRINGSE PLQVSWYKDG VLLKDDANLQ TSFVHNVATL
QILQTDQSHI GQYNCSASNP LGTASSSAKL ILSEHEVPPF FDLKPVSVDL ALGESGTFKC
HVTGTAPIKI TWAKDNREIR PGGNYKMTLV ENTATLTVLK VGKGDAGQYT CYASNIAGKD
SCSAQLGVQE PPRFIKKLEP SRIVKQDEFT RYECKIGGSP EIKVLWYKDE TEIQESSKFR
MSFVDSVAVL EMHNLSVEDS GDYTCEAHNA AGSASSSTSL KVKEPPIFRK KPHPIETLKG
ADVHLECELQ GTPPFHVSWY KDKRELRSGK KYKIMSENFL TSIHILNVDA ADIGEYQCKA
TNDVGSDTCV GSIALKAPPR FVKKLSDIST VVGKEVQLQT TIEGAEPISV VWFKDKGEIV
RESDNIWISY SENIATLQFS RVEPANAGKY TCQIKNDAGM QECFATLSVL EPATIVEKPE
SIKVTTGDTC TLECTVAGTP ELSTKWFKDG KELTSDNKYK ISFFNKVSGL KIINVAPSDS
GVYSFEVQNP VGKDSCTASL QVSDRTVPPS FTRKLKETNG LSGSSVVMEC KVYGSPPISV
SWFHEGNEIS SGRKYQTTLT DNTCALTVNM LEESDSGDYT CIATNMAGSD ECSAPLTVRE
PPSFVQKPDP MDVLTGTNVT FTSIVKGTPP FSVSWFKGSS ELVPGDRCNV SLEDSVAELE
LFDVDTSQSG EYTCIVSNEA GKASCTTHLY IKAPAKFVKR LNDYSIEKGK PLILEGTFTG
TPPISVTWKK NGINVTPSQR CNITTTEKSA ILEIPSSTVE DAGQYNCYIE NASGKDSCSA
QILILEPPYF VKQLEPVKVS VGDSASLQCQ LAGTPEIGVS WYKGDTKLRP TTTYKMHFRN
NVATLVFNQV DINDSGEYIC KAENSVGEVS ASTFLTVQEQ KLPPSFSRQL RDVQETVGLP
VVFDCAISGS EPISVSWYKD GKPLKDSPNV QTSFLDNTAT LNIFKTDRSL AGQYSCTATN
PIGSASSSAR LILTEGKNPP FFDIRLAPVD AVVGESADFE CHVTGTQPIK VSWAKDSREI
RSGGKYQISY LENSAHLTVL KVDKGDSGQY TCYAVNEVGK DSCTAQLNIK ERLIPPSFTK
RLSETVEETE GNSFKLEGRV AGSQPITVAW YKNNIEIQPT SNCEITFKNN TLVLQVRKAG
MNDAGLYTCK VSNDAGSALC TSSIVIKEPK KPPVFDQHLT PVTVSEGEYV QLSCHVQGSE
PIRIQWLKAG REIKPSDRCS FSFASGTAVL ELRDVAKADS GDYVCKASNV AGSDTTKSKV
TIKDKPAVAP ATKKAAVDGR LFFVSEPQSI RVVEKTTATF IAKVGGDPIP NVKWTKGKWR
QLNQGGRVFI HQKGDEAKLE IRDTTKTDSG LYRCVAFNEH GEIESNVNLQ VDERKKQEKI
EGDLRAMLKK TPILKKGAGE EEEIDIMELL KNVDPKEYEK YARMYGITDF RGLLQAFELL
KQSQEEETHR LEIEEIERSE RDEKEFEELV SFIQQRLSQT EPVTLIKDIE NQTVLKDNDA
VFEIDIKINY PEIKLSWYKG TEKLEPSDKF EISIDGDRHT LRVKNCQLKD QGNYRLVCGP
HIASAKLTVI EPAWERHLQD VTLKEGQTCT MTCQFSVPNV KSEWFRNGRI LKPQGRHKTE
VEHKVHKLTI ADVRAEDQGQ YTCKYEDLET SAELRIEAEP IQFTKRIQNI VVSEHQSATF
ECEVSFDDAI VTWYKGPTEL TESQKYNFRN DGRCHYMTIH NVTPDDEGVY SVIARLEPRG
EARSTAELYL TTKEIKLELK PPDIPDSRVP IPTMPIRAVP PEEIPPVVAP PIPLLLPTPE
EKKPPPKRIE VTKKAVKKDA KKVVAKPKEM TPREEIVKKP PPPTTLIPAK APEIIDVSSK
AEEVKIMTIT RKKEVQKEKE AVYEKKQAVH KEKRVFIESF EEPYDELEVE PYTEPFEQPY
YEEPDEDYEE IKVEAKKEVH EEWEEDFEEG QEYYEREEGY DEGEEEWEEA YQEREVIQVQ
KEVYEESHER KVPAKVPEKK APPPPKVIKK PVIEKIEKTS RRMEEEKVQV TKVPEVSKKI
VPQKPSRTPV QEEVIEVKVP AVHTKKMVIS EEKMFFASHT EEEVSVTVPE VQKEIVTEEK
IHVAISKRVE PPPKVPELPE KPAPEEVAPV PIPKKVEPPA PKVPEVPKKP VPEEKKPVPV
PKKEPAAPPK VPEVPKKPVP EEKIPVPVAK KKEAPPAKVP EVQKGVVTEE KITIVTQREE
SPPPAVPEIP KKKVPEERKP VPRKEEEVPP PPKVPALPKK PVPEEKVAVP VPVAKKAPPP
RAEVSKKTVV EEKRFVAEEK LSFAVPQRVE VTRHEVSAEE EWSYSEEEEG VSISVYREEE
REEEEEAEVT EYEVMEEPEE YVVEEKLHII SKRVEAEPAE VTERQEKKIV LKPKIPAKIE
EPPPAKVPEA PKKIVPEKKV PAPVPKKEKV PPPKVPEEPK KPVPEKKVPP KVIKMEEPLP
AKVTERHMQI TQEEKVLVAV TKKEAPPKAR VPEEPKRAVP EEKVLKLKPK REEEPPAKVT
EFRKRVVKEE KVSIEAPKRE PQPIKEVTIM EEKERAYTLE EEAVSVQREE EYEEYEEYDY
KEFEEYEPTE EYDQYEEYEE REYERYEEHE EYITEPEKPI PVKPVPEEPV PTKPKAPPAK
VLKKAVPEEK VPVPIPKKLK PPPPKVPEEP KKVFEEKIRI SITKREKEQV TEPAAKVPMK
PKRVVAEEKV PVPRKEVAPP VRVPEVPKEL EPEEVAFEEE VVTHVEEYLV EEEEEYIHEE
EEFITEEEVV PVIPVKVPEV PRKPVPEEKK PVPVPKKKEA PPAKVPEVPK KPEEKVPVLI
PKKEKPPPAK VPEVPKKPVP EEKVPVPVPK KVEAPPAKVP EVPKKPVPEK KVPVPAPKKV
EAPPAKVPEV PKKLIPEEKK PTPVPKKVEA PPPKVPKKRE PVPVPVALPQ EEEVLFEEEI
VPEEEVLPEE EEVLPEEEEV LPEEEEVLPE EEEIPPEEEE VPPEEEYVPE EEEFVPEEEV
LPEVKPKVPV PAPVPEIKKK VTEKKVVIPK KEEAPPAKVP EVPKKVEEKR IILPKEEEVL
PVEVTEEPEE EPISEEEIPE EPPSIEEVEE VAPPRVPEVI KKAVPEAPTP VPKKVEAPPA
KVSKKIPEEK VPVPVQKKEA PPAKVPEVPK KVPEKKVLVP KKEAVPPAKG RTVLEEKVSV
AFRQEVVVKE RLELEVVEAE VEEIPEEEEF HEVEEYFEEG EFHEVEEFIK LEQHRVEEEH
RVEKVHRVIE VFEAEEVEVF EKPKAPPKGP EISEKIIPPK KPPTKVVPRK EPPAKVPEVP
KKIVVEEKVR VPEEPRVPPT KVPEVLPPKE VVPEKKVPVP PAKKPEAPPP KVPEAPKEVV
PEKKVPVPPP KKPEVPPTKV PEVPKAAVPE KKVPEAIPPK PESPPPEVPE APKEVVPEKK
VPAAPPKKPE VTPVKVPEAP KEVVPEKKVP VPPPKKPEVP PTKVPEVPKV AVPEKKVPEA
IPPKPESPPP EVFEEPEEVA LEEPPAEVVE EPEPAAPPQV TVPPKKPVPE KKAPAVVAKK
PELPPVKVPE VPKEVVPEKK VPLVVPKKPE APPAKVPEVP KEVVPEKKVA VPKKPEVPPA
KVPEVPKKPV LEEKPAVPVP ERAESPPPEV YEEPEEIAPE EEIAPEEEKP VPVAEEEEPE
VPPPAVPEEP KKIIPEKKVP VIKKPEAPPP KEPEPEKVIE KPKLKPRPPP PPPAPPKEDV
KEKIFQLKAI PKKKVPEKPQ VPEKVELTPL KVPGGEKKVR KLLPERKPEP KEEVVLKSVL
RKRPEEEEPK VEPKKLEKVK KPAVPEPPPP KPVEEVEVPT VTKRERKIPE PTKVPEIKPA
IPLPAPEPKP KPEAEVKTIK PPPVEPEPTP IAAPVTVPVV GKKAEAKAPK EEAAKPKGPI
KGVPKKTPSP IEAERRKLRP GSGGEKPPDE APFTYQLKAV PLKFVKEIKD IILTESEFVG
SSAIFECLVS PSTAITTWMK DGSNIRESPK HRFIADGKDR KLHIIDVQLS DAGEYTCVLR
LGNKEKTSTA KLVVEELPVR FVKTLEEEVT VVKGQPLYLS CELNKERDVV WRKDGKIVVE
KPGRIVPGVI GLMRALTIND ADDTDAGTYT VTVENANNLE CSSCVKVVEV IRDWLVKPIR
DQHVKPKGTA IFACDIAKDT PNIKWFKGYD EIPAEPNDKT EILRDGNHLY LKIKNAMPED
IAEYAVEIEG KRYPAKLTLG EREVELLKPI EDVTIYEKES ASFDAEISEA DIPGQWKLKG
ELLRPSPTCE IKAEGGKRFL TLHKVKLDQA GEVLYQALNA ITTAILTVKE IELDFAVPLK
DVTVPERRQA RFECVLTREA NVIWSKGPDI IKSSDKFDII ADGKKHILVI NDSQFDDEGV
YTAEVEGKKT SARLFVTGIR LKFMSPLEDQ TVKEGETATF VCELSHEKMH VVWFKNDAKL
HTSRTVLISS EGKTHKLEMK EVTLDDISQI KAQVKELSST AQLKVLEADP YFTVKLHDKT
AVEKDEITLK CEVSKDVPVK WFKDGEEIVP SPKYSIKADG LRRILKIKKA DLKDKGEYVC
DCGTDKTKAN VTVEARLIKV EKPLYGVEVF VGETAHFEIE LSEPDVHGQW KLKGQPLTAS
PDCEIIEDGK KHILILHNCQ LGMTGEVSFQ AANAKSAANL KVKELPLIFI TPLSDVKVFE
KDEAKFECEV SREPKTFRWL KGTQEITGDD RFELIKDGTK HSMVIKSAAF EDEAKYMFEA
EDKHTSGKLI IEGIRLKFLT PLKDVTAKEK ESAVFTVELS HDNIRVKWFK NDQRLHTTRS
VSMQDEGKTH SITFKDLSID DTSQIRVEAM GMSSEAKLTV LEGDPYFTGK LQDYTGVEKD
EVILQCEISK ADAPVKWFKD GKEIKPSKNA VIKADGKKRM LILKKALKSD IGQYTCDCGT
DKTSGKLDIE DREIKLVRPL HSVEVMETET ARFETEISED DIHANWKLKG EALLQTPDCE
IKEEGKIHSL VLHNCRLDQT GGVDFQAANV KSSAHLRVKP RVIGLLRPLK DVTVTAGETA
TFDCELSYED IPVEWYLKGK KLEPSDKVVP RSEGKVHTLT LRDVKLEDAG EVQLTAKDFK
THANLFVKEP PVEFTKPLED QTVEEGATAV LECEVSRENA KVKWFKNGTE ILKSKKYEIV
ADGRVRKLVI HDCTPEDIKT YTCDAKDFKT SCNLNVVPPH VEFLRPLTDL QVREKEMARF
ECELSRENAK VKWFKDGAEI KKGKKYDIIS KGAVRILVIN KCLLDDEAEY SCEVRTARTS
GMLTVLEEEA VFTKNLANIE VSETDTIKLV CEVSKPGAEV IWYKGDEEII ETGRYEILTE
GRKRILVIQN AHLEDAGNYN CRLPSSRTDG KVKVHELAAE FISKPQNLEI LEGEKAEFVC
SISKESFPVQ WKRDDKTLES GDKYDVIADG KKRVLVVKDA TLQDMGTYVV MVGAARAAAH
LTVIEKLRIV VPLKDTRVKE QQEVVFNCEV NTEGAKAKWF RNEEAIFDSS KYIILQKDLV
YTLRIRDAHL DDQANYNVSL TNHRGENVKS AANLIVEEED LRIVEPLKDI ETMEKKSVTF
WCKVNRLNVT LKWTKNGEEV PFDNRVSYRV DKYKHMLTIK DCGFPDEGEY IVTAGQDKSV
AELLIIEAPT EFVEHLEDQT VTEFDDAVFS CQLSREKANV KWYRNGREIK EGKKYKFEKD
GSIHRLIIKD CRLDDECEYA CGVEDRKSRA RLFVEEIPVE IIRPPQDILE APGADVVFLA
ELNKDKVEVQ WLRNNMVVVQ GDKHQMMSEG KIHRLQICDI KPRDQGEYRF IAKDKEARAK
LELAAAPKIK TADQDLVVDV GKPLTMVVPY DAYPKAEAEW FKENEPLSTK TIDTTAEQTS
FRILEAKKGD KGRYKIVLQN KHGKAEGFIN LKVIDVPGPV RNLEVTETFD GEVSLAWEEP
LTDGGSKIIG YVVERRDIKR KTWVLATDRA ESCEFTVTGL QKGGVEYLFR VSARNRVGTG
EPVETDNPVE ARSKYDVPGP PLNVTITDVN RFGVSLTWEP PEYDGGAEIT NYVIELRDKT
SIRWDTAMTV RAEDLSATVT DVVEGQEYSF RVRAQNRIGV GKPSAATPFV KVADPIERPS
PPVNLTSSDQ TQSSVQLKWE PPLKDGGSPI LGYIIERCEE GKDNWIRCNM KLVPELTYKV
TGLEKGNKYL YRVSAENKAG VSDPSEILGP LTADDAFVEP TMDLSAFKDG LEVIVPNPIT
ILVPSTGYPR PTATWCFGDK VLETGDRVKM KTLSAYAELV ISPSERSDKG IYTLKLENRV
KTISGEIDVN VIARPSAPKE LKFGDITKDS VHLTWEPPDD DGGSPLTGYV VEKREVSRKT
WTKVMDFVTD LEFTVPDLVQ GKEYLFKVCA RNKCGPGEPA YVDEPVNMST PATVPDPPEN
VKWRDRTANS IFLTWDPPKN DGGSRIKGYI VERCPRGSDK WVACGEPVAE TKMEVTGLEE
GKWYAYRVKA LNRQGASKPS RPTEEIQAVD TQEAPEIFLD VKLLAGLTVK AGTKIELPAT
VTGKPEPKIT WTKADMILKQ DKRITIENVP KKSTVTIVDS KRSDTGTYII EAVNVCGRAT
AVVEVNVLDK PGPPAAFDIT DVTNESCLLT WNPPRDDGGS KITNYVVERR ATDSEVWHKL
SSTVKDTNFK ATKLIPNKEY IFRVAAENMY GVGEPVQASP ITAKYQFDPP GPPTRLEPSD
ITKDAVTLTW CEPDDDGGSP ITGYWVERLD PDTDKWVRCN KMPVKDTTYR VKGLTNKKKY
RFRVLAENLA GPGKPSKSTE PILIKDPIDP PWPPGKPTVK DVGKTSVRLN WTKPEHDGGA
KIESYVIEML KTGTDEWVRV AEGVPTTQHL LPGLMEGQEY SFRVRAVNKA GESEPSEPSD
PVLCREKLYP PSPPRWLEVI NITKNTADLK WTVPEKDGGS PITNYIVEKR DVRRKGWQTV
DTTVKDTKCT VTPLTEGSLY VFRVAAENAI GQSDYTEIED SVLAKDTFTT PGPPYALAVV
DVTKRHVDLK WEPPKNDGGR PIQRYVIEKK ERLGTRWVKA GKTAGPDCNF RVTDVIEGTE
VQFQVRAENE AGVGHPSEPT EILSIEDPTS PPSPPLDLHV TDAGRKHIAI AWKPPEKNGG
SPIIGYHVEM CPVGTEKWMR VNSRPIKDLK FKVEEGVVPD KEYVLRVRAV NAIGVSEPSE
ISENVVAKDP DCKPTIDLET HDIIVIEGEK LSIPVPFRAV PVPTVSWHKD GKEVKASDRL
TMKNDHISAH LEVPKSVRAD AGIYTITLEN KLGSATASIN VKVIGLPGPC KDIKASDITK
SSCKLTWEPP EFDGGTPILH YVLERREAGR RTYIPVMSGE NKLSWTVKDL IPNGEYFFRV
KAVNKVGGGE YIELKNPVIA QDPKQPPDPP VDVEVHNPTA EAMTITWKPP LYDGGSKIMG
YIIEKIAKGE ERWKRCNEHL VPILTYTAKG LEEGKEYQFR VRAENAAGIS EPSRATPPTK
AVDPIDAPKV ILRTSLEVKR GDEIALDASI SGSPYPTITW IKDENVIVPE EIKKRAAPLV
RRRKGEVQEE EPFVLPLTQR LSIDNSKKGE SQLRVRDSLR PDHGLYMIKV ENDHGIAKAP
CTVSVLDTPG PPINFVFEDI RKTSVLCKWE PPLDDGGSEI INYTLEKKDK TKPDSEWIVV
TSTLRHCKYS VTKLIEGKEY LFRVRAENRF GPGPPCVSKP LVAKDPFGPP DAPDKPIVED
VTSNSMLVKW NEPKDNGSPI LGYWLEKREV NSTHWSRVNK SLLNALKANV DGLLEGLTYV
FRVCAENAAG PGKFSPPSDP KTAHDPISPP GPPIPRVTDT SSTTIELEWE PPAFNGGGEI
VGYFVDKQLV GTNEWSRCTE KMIKVRQYTV KEIREGADYK LRVSAVNAAG EGPPGETQPV
TVAEPQEPPA VELDVSVKGG IQIMAGKTLR IPAVVTGRPV PTKVWTKEEG ELDKDRVVID
NVGTKSELII KDALRKDHGR YVITATNSCG SKFAAARVEV FDVPGPVLDL KPVVTNRKMC
LLNWSDPEDD GGSEITGFII ERKDAKMHTW RQPIETERSK CDITGLLEGQ EYKFRVIAKN
KFGCGPPVEI GPILAVDPLG PPTSPERLTY TERTKSTITL DWKEPRSNGG SPIQGYIIEK
RRHDKPDFER VNKRLCPTTS FLVENLDEHQ MYEFRVKAVN EIGESEPSLP LNVVIQDDEV
PPTIKLRLSV RGDTIKVKAG EPVHIPADVT GLPMPKIEWS KNETVIEKPT DALQITKEEV
SRSEAKTELS IPKAVREDKG TYTVTASNRL GSVFRNVHVE VYDRPSPPRN LAVTDIKAES
CYLTWDAPLD NGGSEITHYV IDKRDASRKK AEWEEVTNTA VEKRYGIWKL IPNGQYEFRV
RAVNKYGISD ECKSDKVVIQ DPYRLPGPPG KPKVLARTKG SMLVSWTPPL DNGGSPITGY
WLEKREEGSP YWSRVSRAPI TKVGLKGVEF NVPRLLEGVK YQFRAMAINA AGIGPPSEPS
DPEVAGDPIF PPGPPSCPEV KDKTKSSISL GWKPPAKDGG SPIKGYIVEM QEEGTTDWKR
VNEPDKLITT CECVVPNLKE LRKYRFRVKA VNEAGESEPS DTTGEIPATD IQEEPEVFID
IGAQDCLVCK AGSQIRIPAV IKGRPTPKSS WEFDGKAKKA MKDGVHDIPE DAQLETAENS
SVIIIPECKR SHTGKYSITA KNKAGQKTAN CRVKVMDVPG PPKDLKVSDI TRGSCRLSWK
MPDDDGGDRI KGYVIEKRTI DGKAWTKVNP DCGSTTFVVP DLLSEQQYFF RVRAENRFGI
GPPVETIQRT TARDPIYPPD PPIKLKIGLI TKNTVHLSWK PPKNDGGSPV THYIVECLAW
DPTGTKKEAW RQCNKRDVEE LQFTVEDLVE GGEYEFRVKA VNAAGVSKPS ATVGPVTVKD
QTCPPSIDLK EFMEVEEGTN VNIVAKIKGV PFPTLTWFKA PPKKPDNKEP VLYDTHVNKL
VVDDTCTLVI PQSRRSDTGL YTITAVNNLG TASKEMRLNV LGRPGPPVGP IKFESVSADQ
MTLSWFPPKD DGGSKITNYV IEKREANRKT WVHVSSEPKE CTYTIPKLLE GHEYVFRIMA
QNKYGIGEPL DSEPETARNL FSVPGAPDKP TVSSVTRNSM TVNWEEPEYD GGSPVTGYWL
EMKDTTSKRW KRVNRDPIKA MTLGVSYKVT GLIEGSDYQF RVYAINAAGV GPASLPSDPA
TARDPIAPPG PPFPKVTDWT KSSADLEWSP PLKDGGSKVT GYIVEYKEEG KEEWEKGKDK
EVRGTKLVVT GLKEGAFYKF RVRAVNIAGI GEPGEVTDVI EMKDRLVSPD LQLDASVRDR
IVVHAGGVIR IIAYVSGKPP PTVTWNMNER TLPQEATIET TAISSSMVIK NCQRSHQGVY
SLLAKNEAGE RKKTIIVDVL DVPGPVGTPF LAHNLTNESC KLTWFSPEDD GGSPITNYVI
EKRESDRRAW TPVTYTVTRQ NATVQGLIQG KAYFFRIAAE NSIGMGPFVE TSEALVIREP
ITVPERPEDL EVKEVTKNTV TLTWNPPKYD GGSEIINYVL ESRLIGTEKF HKVTNDNLLS
RKYTVKGLKE GDTYEYRVSA VNIVGQGKPS FCTKPITCKD ELAPPTLHLD FRDKLTIRVG
EAFALTGRYS GKPKPKVSWF KDEADVLEDD RTHIKTTPAT LALEKIKAKR SDSGKYCVVV
ENSTGSRKGF CQVNVVDRPG PPVGPVSFDE VTKDYMVISW KPPLDDGGSK ITNYIIEKKE
VGKDVWMPVT SASAKTTCKV SKLLEGKDYI FRIHAENLYG ISDPLVSDSM KAKDRFRVPD
APDQPIVTEV TKDSALVTWN KPHDGGKPIT NYILEKRETM SKRWARVTKD PIHPYTKFRV
PDLLEGCQYE FRVSAENEIG IGDPSPPSKP VFAKDPIAKP SPPVNPEAID TTCNSVDLTW
QPPRHDGGSK ILGYIVEYQK VGDEEWRRAN HTPESCPETK YKVTGLRDGQ TYKFRVLAVN
AAGESDPAHV PEPVLVKDRL EPPELILDAN MAREQHIKVG DTLRLSAIIK GVPFPKVTWK
KEDRDAPTKA RIDVTPVGSK LEIRNAAHED GGIYSLTVEN PAGSKTVSVK VLVLDKPGPP
RDLEVSEIRK DSCYLTWKEP LDDGGSVITN YVVERRDVAS AQWSPLSATS KKKSHFAKHL
NEGNQYLFRV AAENQYGRGP FVETPKPIKA LDPLHPPGPP KDLHHVDVDK TEVSLVWNKP
DRDGGSPITG YLVEYQEEGT QDWIKFKTVT NLECVVTGLQ QGKTYRFRVK AENIVGLGLP
DTTIPIECQE KLVPPSVELD VKLIEGLVVK AGTTVRFPAI IRGVPVPTAK WTTDGSEIKT
DEHYTVETDN FSSVLTIKNC LRRDTGEYQI TVSNAAGSKT VAVHLTVLDV PGPPTGPINI
LDVTPEHMTI SWQPPKDDGG SPVINYIVEK QDTRKDTWGV VSSGSSKTKL KIPHLQKGCE
YVFRVRAENK IGVGPPLDST PTVAKHKFSP PSPPGKPVVT DITENAATVS WTLPKSDGGS
PITGYYMERR EVTGKWVRVN KTPIADLKFR VTGLYEGNTY EFRVFAENLA GLSKPSPSSD
PIKACRPIKP PGPPINPKLK DKSRETADLV WTKPLSDGGS PILGYVVECQ KPGTAQWNRI
NKDELIRQCA FRVPGLIEGN EYRFRIKAAN IVGEGEPREL AESVIAKDIL HPPEVELDVT
CRDVITVRVG QTIRILARVK GRPEPDITWT KEGKVLVREK RVDLIQDLPR VELQIKEAVR
ADHGKYIISA KNSSGHAQGS AIVNVLDRPG PCQNLKVTNV TKENCTISWE NPLDNGGSEI
TNFIVEYRKP NQKGWSIVAS DVTKRLIKAN LLANNEYYFR VCAENKVGVG PTIETKTPIL
AINPIDRPGE PENLHIADKG KTFVYLKWRR PDYDGGSPNL SYHVERRLKG SDDWERVHKG
SIKETHYMVD RCVENQIYEF RVQTKNEGGE SDWVKTEEVV VKEDLQKPVL DLKLSGVLTV
KAGDTIRLEA GVRGKPFPEV AWTKDKDATD LTRSPRVKID TRADSSKFSL TKAKRSDGGK
YVVTATNTAG SFVAYATVNV LDKPGPVRNL KIVDVSSDRC TVCWDPPEDD GGCEIQNYIL
EKCETKRMVW STYSATVLTP GTTVTRLIEG NEYIFRVRAE NKIGTGPPTE SKPVIAKTKY
DKPGRPDPPE VTKVSKEEMT VVWNPPEYDG GKSITGYFLE KKEKHSTRWV PVNKSAIPER
RMKVQNLLPD HEYQFRVKAE NEIGIGEPSL PSRPVVAKDP IEPPGPPTNF RVVDTTKHSI
TLGWGKPVYD GGAPIIGYVV EMRPKIADAS PDEGWKRCNA AAQLVRKEFT VTSLDENQEY
EFRVCAQNQV GIGRPAELKE AIKPKEILEP PEIDLDASMR KLVIVRAGCP IRLFAIVRGR
PAPKVTWRKV GIDNVVRKGQ VDLVDTMAFL VIPNSTRDDS GKYSLTLVNP AGEKAVFVNV
RVLDTPGPVS DLKVSDVTKT SCHVSWAPPE NDGGSQVTHY IVEKREADRK TWSTVTPEVK
KTSFHVTNLV PGNEYYFRVT AVNEYGPGVP TDVPKPVLAS DPLSEPDPPR KLEVTEMTKN
SATLAWLPPL RDGGAKIDGY ITSYREEEQP ADRWTEYSVV KDLSLVVTGL KEGKKYKFRV
AARNAVGVSL PREAEGVYEA KEQLLPPKIL MPEQITIKAG KKLRIEAHVY GKPHPTCKWK
KGEDEVVTSS HLAVHKADSS SILIIKDVTR KDSGYYSLTA ENSSGTDTQK IKVVVMDAPG
PPQPPFDISD IDADACSLSW HIPLEDGGSN ITNYIVEKCD VSRGDWVTAL ASVTKTSCRV
GKLIPGQEYI FRVRAENRFG ISEPLTSPKM VAQFPFGVPS EPKNARVTKV NKDCIFVAWD
RPDSDGGSPI IGYLIERKER NSLLWVKAND TLVRSTEYPC AGLVEGLEYS FRIYALNKAG
SSPPSKPTEY VTARMPVDPP GKPEVIDVTK STVSLIWARP KHDGGSKIIG YFVEACKLPG
DKWVRCNTAP HQIPQEEYTA TGLEEKAQYQ FRAIARTAVN ISPPSEPSDP VTILAENVPP
RIDLSVAMKS LLTVKAGTNV CLDATVFGKP MPTVSWKKDG TLLKPAEGIK MAMQRNLCTL
ELFSVNRKDS GDYTITAENS SGSKSATIKL KVLDKPGPPA SVKINKMYSD RAMLSWEPPL
EDGGSEITNY IVDKRETSRP NWAQVSATVP ITSCSVEKLI EGHEYQFRIC AENKYGVGDP
VFTEPAIAKN PYDPPGRCDP PVISNITKDH MTVSWKPPAD DGGSPITGYL LEKRETQAVN
WTKVNRKPII ERTLKATGLQ EGTEYEFRVT AINKAGPGKP SDASKAAYAR DPQYPPGPPA
FPKVYDTTRS SVSLSWGKPA YDGGSPIIGY LVEVKRADSD NWVRCNLPQN LQKTRFEVTG
LMEDTQYQFR VYAVNKIGYS DPSDVPDKHY PKDILIPPEG ELDADLRKTL ILRAGVTMRL
YVPVKGRPPP KITWSKPNVN LRDRIGLDIK STDFDTFLRC ENVNKYDAGK YILTLENSCG
KKEYTIVVKV LDTPGPPVNV TVKEISKDSA YVTWEPPIID GGSPIINYVV QKRDAERKSW
STVTTECSKT SFRVANLEEG KSYFFRVFAE NEYGIGDPGE TRDAVKASQT PGPVVDLKVR
SVSKSSCSIG WKKPHSDGGS RIIGYVVDFL TEENKWQRVM KSLSLQYSAK DLTEGKEYTF
RVSAENENGE GTPSEITVVA RDDVVAPDLD LKGLPDLCYL AKENSNFRLK IPIKGKPAPS
VSWKKGEDPL ATDTRVSVES SAVNTTLIVY DCQKSDAGKY TITLKNVAGT KEGTISIKVV
GKPGIPTGPI KFDEVTAEAM TLKWAPPKDD GGSEITNYIL EKRDSVNNKW VTCASAVQKT
TFRVTRLHEG MEYTFRVSAE NKYGVGEGLK SEPIVARHPF DVPDAPPPPN IVDVRHDSVS
LTWTDPKKTG GSPITGYHLE FKERNSLLWK RANKTPIRMR DFKVTGLTEG LEYEFRVMAI
NLAGVGKPSL PSEPVVALDP IDPPGKPEVI NITRNSVTLI WTEPKYDGGH KLTGYIVEKR
DLPSKSWMKA NHVNVPECAF TVTDLVEGGK YEFRIRAKNT AGAISAPSES TETIICKDEY
EAPTIVLDPT IKDGLTIKAG DTIVLNAISI LGKPLPKSSW SKAGKDIRPS DITQITSTPT
SSMLTIKYAT RKDAGEYTIT ATNPFGTKVE HVKVTVLDVP GPPGPVEISN VSAEKATLTW
TPPLEDGGSP IKSYILEKRE TSRLLWTVVS EDIQSCRHVA TKLIQGNEYI FRVSAVNHYG
KGEPVQSEPV KMVDRFGPPG PPEKPEVSNV TKNTATVSWK RPVDDGGSEI TGYHVERREK
KSLRWVRAIK TPVSDLRCKV TGLQEGSTYE FRVSAENRAG IGPPSEASDS VLMKDAAYPP
GPPSNPHVTD TTKKSASLAW GKPHYDGGLE ITGYVVEHQK VGDEAWIKDT TGTALRITQF
VVPDLQTKEK YNFRISAIND AGVGEPAVIP DVEIVEREMA PDFELDAELR RTLVVRAGLS
IRIFVPIKGR PAPEVTWTKD NINLKNRANI ENTESFTLLI IPECNRYDTG KFVMTIENPA
GKKSGFVNVR VLDTPGPVLN LRPTDITKDS VTLHWDLPLI DGGSRITNYI VEKREATRKS
YSTATTKCHK CTYKVTGLSE GCEYFFRVMA ENEYGIGEPT ETTEPVKASE APSPPDSLNI
MDITKSTVSL AWPKPKHDGG SKITGYVIEA QRKGSDQWTH ITTVKGLECV VRNLTEGEEY
TFQVMAVNSA GRSAPRESRP VIVKEQTMLP ELDLRGIYQK LVIAKAGDNI KVEIPVLGRP
KPTVTWKKGD QILKQTQRVN FETTATSTIL NINECVRSDS GPYPLTARNI VGEVGDVITI
QVHDIPGPPT GPIKFDEVSS DFVTFSWDPP ENDGGVPISN YVVEMRQTDS TTWVELATTV
IRTTYKATRL TTGLEYQFRV KAQNRYGVGP GITSACIVAN YPFKVPGPPG TPQVTAVTKD
SMTISWHEPL SDGGSPILGY HVERKERNGI LWQTVSKALV PGNIFKSSGL TDGIAYEFRV
IAENMAGKSK PSKPSEPMLA LDPIDPPGKP VPLNITRHTV TLKWAKPEYT GGFKITSYIV
EKRDLPNGRW LKANFSNILE NEFTVSGLTE DAAYEFRVIA KNAAGAISPP SEPSDAITCR
DDVEAPKIKV DVKFKDTVIL KAGEAFRLEA DVSGRPPPTM EWSKDGKELE GTAKLEIKIA
DFSTNLVNKD STRRDSGAYT LTATNPGGFA KHIFNVKVLD RPGPPEGPLA VTEVTSEKCV
LSWFPPLDDG GAKIDHYIVQ KRETSRLAWT NVASEVQVTK LKVTKLLKGN EYIFRVMAVN
KYGVGEPLES EPVLAVNPYG PPDPPKNPEV TTITKDSMVV CWGHPDSDGG SEIINYIVER
RDKAGQRWIK CNKKTLTDLR YKVSGLTEGH EYEFRIMAEN AAGISAPSPT SPFYKACDTV
FKPGPPGNPR VLDTSRSSIS IAWNKPIYDG GSEITGYMVE IALPEEDEWQ IVTPPAGLKA
TSYTITGLTE NQEYKIRIYA MNSEGLGEPA LVPGTPKAED RMLPPEIELD ADLRKVVTIR
ACCTLRLFVP IKGRPAPEVK WARDHGESLD KASIESTSSY TLLIVGNVNR FDSGKYILTV
ENSSGSKSAF VNVRVLDTPG PPQDLKVKEV TKTSVTLTWD PPLLDGGSKI KNYIVEKRES
TRKAYSTVAT NCHKTSWKVD QLQEGCSYYF RVLAENEYGI GLPAETAESV KASERPLPPG
KITLMDVTRN SVSLSWEKPE HDGGSRILGY IVEMQTKGSD KWATCATVKV TEATITGLIQ
GEEYSFRVSA QNEKGISDPR QLSVPVIAKD LVIPPAFKLL FNTFTVLAGE DLKVDVPFIG
RPTPAVTWHK DNVPLKQTTR VNAESTENNS LLTIKDACRE DVGHYVVKLT NSAGEAIETL
NVIVLDKPGP PTGPVKMDEV TADSITLSWG PPKYDGGSSI NNYIVEKRDT STTTWQIVSA
TVARTTIKAC RLKTGCEYQF RIAAENRYGK STYLNSEPTV AQYPFKVPGP PGTPVVTLSS
RDSMEVQWNE PISDGGSRVI GYHLERKERN SILWVKLNKT PIPQTKFKTT GLEEGVEYEF
RVSAENIVGI GKPSKVSECY VARDPCDPPG RPEAIIVTRN SVTLQWKKPT YDGGSKITGY
IVEKKELPEG RWMKASFTNI IDTHFEVTGL VEDHRYEFRV IARNAAGVFS EPSESTGAIT
ARDEVDPPRI SMDPKYKDTI VVHAGESFKV DADIYGKPIP TIQWIKGDQE LSNTARLEIK
STDFATSLSV KDAVRVDSGN YILKAKNVAG ERSVTVNVKV LDRPGPPEGP VVISGVTAEK
CTLAWKPPLQ DGGSDIINYI VERRETSRLV WTVVDANVQT LSCKVTKLLE GNEYTFRIMA
VNKYGVGEPL ESEPVVAKNP FVVPDAPKAP EVTTVTKDSM IVVWERPASD GGSEILGYVL
EKRDKEGIRW TRCHKRLIGE LRLRVTGLIE NHDYEFRVSA ENAAGLSEPS PPSAYQKACD
PIYKPGPPNN PKVIDITRSS VFLSWSKPIY DGGCEIQGYI VEKCDVSVGE WTMCTPPTGI
NKTNIEVEKL LEKHEYNFRI CAINKAGVGE HADVPGPIIV EEKLEAPDID LDLELRKIIN
IRAGGSLRLF VPIKGRPTPE VKWGKVDGEI RDAAIIDVTS SFTSLVLDNV NRYDSGKYTL
TLENSSGTKS AFVTVRVLDT PSPPVNLKVT EITKDSVSIT WEPPLLDGGS KIKNYIVEKR
EATRKSYAAV VTNCHKNSWK IDQLQEGCSY YFRVTAENEY GIGLPAQTAD PIKVAEVPQP
PGKITVDDVT RNSVSLSWTK PEHDGGSKII QYIVEMQAKH SEKWSECARV KSLQAVITNL
TQGEEYLFRV VAVNEKGRSD PRSLAVPIVA KDLVIEPDVK PAFSSYSVQV GQDLKIEVPI
SGRPKPTITW TKDGLPLKQT TRINVTDSLD LTTLSIKETH KDDGGQYGIT VANVVGQKTA
SIEIVTLDKP DPPKGPVKFD DVSAESITLS WNPPLYTGGC QITNYIVQKR DTTTTVWDVV
SATVARTTLK VTKLKTGTEY QFRIFAENRY GQSFALESDP IVAQYPYKEP GPPGTPFATA
ISKDSMVIQW HEPVNNGGSP VIGYHLERKE RNSILWTKVN KTIIHDTQFK AQNLEEGIEY
EFRVYAENIV GVGKASKNSE CYVARDPCDP PGTPEPIMVK RNEITLQWTK PVYDGGSMIT
GYIVEKRDLP DGRWMKASFT NVIETQFTVS GLTEDQRYEF RVIAKNAAGA ISKPSDSTGP
ITAKDEVELP RISMDPKFRD TIVVNAGETF RLEADVHGKP LPTIEWLRGD KEIEESARCE
IKNTDFKALL IVKDAIRIDG GQYILRASNV AGSKSFPVNV KVLDRPGPPE GPVQVTGVTS
EKCSLTWSPP LQDGGSDISH YVVEKRETSR LAWTVVASEV VTNSLKVTKL LEGNEYVFRI
MAVNKYGVGE PLESAPVLMK NPFVLPGPPK SLEVTNIAKD SMTVCWNRPD SDGGSEIIGY
IVEKRDRSGI RWIKCNKRRI TDLRLRVTGL TEDHEYEFRV SAENAAGVGE PSPATVYYKA
CDPVFKPGPP TNAHIVDTTK NSITLAWGKP IYDGGSEILG YVVEICKADE EEWQIVTPQT
GLRVTRFEIS KLTEHQEYKI RVCALNKVGL GEATSVPGTV KPEDKLEAPE LDLDSELRKG
IVVRAGGSAR IHIPFKGRPT PEITWSREEG EFTDKVQIEK GVNYTQLSID NCDRNDAGKY
ILKLENSSGS KSAFVTVKVL DTPGPPQNLA VKEVRKDSAF LVWEPPIIDG GAKVKNYVID
KRESTRKAYA NVSSKCSKTS FKVENLTEGA IYYFRVMAEN EFGVGVPVET VDAVKAAEPP
SPPGKVTLTD VSQTSASLMW EKPEHDGGSR VLGYVVEMQP KGTEKWSIVA ESKVCNAVVT
GLSSGQEYQF RVKAYNEKGK SDPRVLGVPV IAKDLTIQPS LKLPFNTYSI QAGEDLKIEI
PVIGRPRPNI SWVKDGEPLK QTTRVNVEET ATSTVLHIKE GNKDDFGKYT VTATNSAGTA
TENLSVIVLE KPGPPVGPVR FDEVSADFVV ISWEPPAYTG GCQISNYIVE KRDTTTTTWH
MVSATVARTT IKITKLKTGT EYQFRIFAEN RYGKSAPLDS KAVIVQYPFK EPGPPGTPFV
TSISKDQMLV QWHEPVNDGG TKIIGYHLEQ KEKNSILWVK LNKTPIQDTK FKTTGLDEGL
EYEFKVSAEN IVGIGKPSKV SECFVARDPC DPPGRPEAIV ITRNNVTLKW KKPAYDGGSK
ITGYIVEKKD LPDGRWMKAS FTNVLETEFT VSGLVEDQRY EFRVIARNAA GNFSEPSDSS
GAITARDEID APNASLDPKY KDVIVVHAGE TFVLEADIRG KPIPDVVWSK DGKELEETAA
RMEIKSTIQK TTLVVKDCIR TDGGQYILKL SNVGGTKSIP ITVKVLDRPG PPEGPLKVTG
VTAEKCYLAW NPPLQDGGAN ISHYIIEKRE TSRLSWTQVS TEVQALNYKV TKLLPGNEYI
FRVMAVNKYG IGEPLESGPV TACNPYKPPG PPSTPEVSAI TKDSMVVTWA RPVDDGGTEI
EGYILEKRDK EGVRWTKCNK KTLTDLRLRV TGLTEGHSYE FRVAAENAAG VGEPSEPSVF
YRACDALYPP GPPSNPKVTD TSRSSVSLAW SKPIYDGGAP VKGYVVEVKE AAADEWTTCT
PPTGLQGKQF TVTKLKENTE YNFRICAINS EGVGEPATLP GSVVAQERIE PPEIELDADL
RKVVVLRASA TLRLFVTIKG RPEPEVKWEK AEGILTDRAQ IEVTSSFTML VIDNVTRFDS
GRYNLTLENN SGSKTAFVNV RVLDSPSAPV NLTIREVKKD SVTLSWEPPL IDGGAKITNY
IVEKRETTRK AYATITNNCT KTTFRIENLQ EGCSYYFRVL ASNEYGIGLP AETTEPVKVS
EPPLPPGRVT LVDVTRNTAT IKWEKPESDG GSKITGYVVE MQTKGSEKWS TCTQVKTLEA
TISGLTAGEE YVFRVAAVNE KGRSDPRQLG VPVIARDIEI KPSVELPFHT FNVKAREQLK
IDVPFKGRPQ ATVNWRKDGQ TLKETTRVNV SSSKTVTSLS IKEASKEDVG TYELCVSNSA
GSITVPITII VLDRPGPPGP IRIDEVSCDS ITISWNPPEY DGGCQISNYI VEKKETTSTT
WHIVSQAVAR TSIKIVRLTT GSEYQFRVCA ENRYGKSSYS ESSAVVAEYP FSPPGPPGTP
KVVHATKSTM LVTWQVPVND GGSRVIGYHL EYKERSSILW SKANKILIAD TQMKVSGLDE
GLMYEYRVYA ENIAGIGKCS KSCEPVPARD PCDPPGQPEV TNITRKSVSL KWSKPHYDGG
AKITGYIVER RELPDGRWLK CNYTNIQETY FEVTELTEDQ RYEFRVFARN AADSVSEPSE
STGPIIVKDD VEPPRVMMDV KFRDVIVVKA GEVLKINADI AGRPLPVISW AKDGIEIEER
ARTEIISTDN HTLLTVKDCI RRDTGQYVLT LKNVAGTRSV AVNCKVLDKP GPPAGPLEIN
GLTAEKCSLS WGRPQEDGGA DIDYYIVEKR ETSHLAWTIC EGELQMTSCK VTKLLKGNEY
IFRVTGVNKY GVGEPLESVA IKALDPFTVP SPPTSLEITS VTKESMTLCW SRPESDGGSE
ISGYIIERRE KNSLRWVRVN KKPVYDLRVK STGLREGCEY EYRVYAENAA GLSLPSETSP
LIRAEDPVFL PSPPSKPKIV DSGKTTITIA WVKPLFDGGA PITGYTVEYK KSDDTDWKTS
IQSLRGTEYT ISGLTTGAEY VFRVKSVNKV GASDPSDSSD PQIAKEREEE PLFDIDSEMR
KTLIVKAGAS FTMTVPFRGR PVPNVLWSKP DTDLRTRAYV DTTDSRTSLT IENANRNDSG
KYTLTIQNVL SAASLTLVVK VLDTPGPPTN ITVQDVTKES AVLSWDVPEN DGGAPVKNYH
IEKREASKKA WVSVTNNCNR LSYKVTNLQE GAIYYFRVSG ENEFGVGIPA ETKEGVKITE
KPSPPEKLGV TSISKDSVSL TWLKPEHDGG SRIVHYVVEA LEKGQKNWVK CAVAKSTHHV
VSGLRENSEY FFRVFAENQA GLSDPRELLL PVLIKEQLEP PEIDMKNFPS HTVYVRAGSN
LKVDIPISGK PLPKVTLSRD GVPLKATMRF NTEITAENLT INLKESVTAD AGRYEITAAN
SSGTTKAFIN IVVLDRPGPP TGPVVISDIT EESVTLKWEP PKYDGGSQVT NYILLKRETS
TAVWTEVSAT VARTMMKVMK LTTGEEYQFR IKAENRFGIS DHIDSACVTV KLPYTTPGPP
STPWVTNVTR ESITVGWHEP VSNGGSAVVG YHLEMKDRNS ILWQKANKLV IRTTHFKVTT
ISAGLIYEFR VYAENAAGVG KPSHPSEPVL AIDACEPPRN VRITDISKNS VSLSWQQPAF
DGGSKITGYI VERRDLPDGR WTKASFTNVT ETQFIISGLT QNSQYEFRVF ARNAVGSISN
PSEVVGPITC IDSYGGPVID LPLEYTEVVK YRAGTSVKLR AGISGKPAPT IEWYKDDKEL
QTNALVCVEN TTDLASILIK DADRLNSGCY ELKLRNAMGS ASATIRVQIL DKPGPPGGPI
EFKTVTAEKI TLLWRPPADD GGAKITHYIV EKRETSRVVW SMVSEHLEEC IITTTKIIKG
NEYIFRVRAV NKYGIGEPLE SDSVVAKNAF VTPGPPGIPE VTKITKNSMT VVWSRPIADG
GSDISGYFLE KRDKKSLGWF KVLKETIRDT RQKVTGLTEN SDYQYRVCAV NAAGQGPFSE
PSEFYKAADP IDPPGPPAKI RIADSTKSSI TLGWSKPVYD GGSAVTGYVV EIRQGEEEEW
TTVSTKGEVR TTEYVVSNLK PGVNYYFRVS AVNCAGQGEP IEMNEPVQAK DILEAPEIDL
DVALRTSVIA KAGEDVQVLI PFKGRPPPTV TWRKDEKNLG SDARYSIENT DSSSLLTIPQ
VTRNDTGKYI LTIENGVGEP KSSTVSVKVL DTPAACQKLQ VKHVSRGTVT LLWDPPLIDG
GSPIINYVIE KRDATKRTWS VVSHKCSSTS FKLIDLSEKT PFFFRVLAEN EIGIGEPCET
TEPVKAAEVP APIRDLSMKD STKTSVILSW TKPDFDGGSV ITEYVVERKG KGEQTWSHAG
ISKTCEIEVS QLKEQSVLEF RVFAKNEKGL SDPVTIGPIT VKELIITPEV DLSDIPGAQV
TVRIGHNVHL ELPYKGKPKP SISWLKDGLP LKESEFVRFS KTENKITLSI KNAKKEHGGK
YTVILDNAVC RIAVPITVIT LGPPSKPKGP IRFDEIKADS VILSWDVPED NGGGEITCYS
IEKRETSQTN WKMVCSSVAR TTFKVPNLVK DAEYQFRVRA ENRYGVSQPL VSSIIVAKHQ
FRIPGPPGKP VIYNVTSDGM SLTWDAPVYD GGSEVTGFHV EKKERNSILW QKVNTSPISG
REYRATGLVE GLDYQFRVYA ENSAGLSSPS DPSKFTLAVS PVDPPGTPDY IDVTRETITL
KWNPPLRDGG SKIVGYSIEK RQGNERWVRC NFTDVSECQY TVTGLSPGDR YEFRIIARNA
VGTISPPSQS SGIIMTRDEN VPPIVEFGPE YFDGLIIKSG ESLRIKALVQ GRPVPRVTWF
KDGVEIEKRM NMEITDVLGS TSLFVRDATR DHRGVYTVEA KNASGSAKAE IKVKVQDTPG
KVVGPIRFTN ITGEKMTLWW DAPLNDGCAP ITHYIIEKRE TSRLAWALIE DKCEAQSYTA
IKLINGNEYQ FRVSAVNKFG VGRPLDSDPV VAQIQYTVPD APGIPEPSNI TGNSITLTWA
RPESDGGSEI QQYILERREK KSTRWVKVIS KRPISETRFK VTGLTEGNEY EFHVMAENAA
GVGPASGISR LIKCREPVNP PGPPTVVKVT DTSKTTVSLE WSKPVFDGGM EIIGYIIEMC
KADLGDWHKV NAEACVKTRY TVTDLQAGEE YKFRVSAING AGKGDSCEVT GTIKAVDRLT
APELDIDANF KQTHVVRAGA SIRLFIAYQG RPTPTAVWSK PDSNLSLRAD IHTTDSFSTL
TVENCNRNDA GKYTLTVENN SGSKSITFTV KVLDTPGPPG PITFKDVTRG SATLMWDAPL
LDGGARIHHY VVEKREASRR SWQVISEKCT RQIFKVNDLA EGVPYYFRVS AVNEYGVGEP
YEMPEPIVAT EQPAPPRRLD VVDTSKSSAV LAWLKPDHDG GSRITGYLLE MRQKGSDFWV
EAGHTKQLTF TVERLVEKTE YEFRVKAKND AGYSEPREAF SSVIIKEPQI EPTADLTGIT
NQLITCKAGS PFTIDVPISG RPAPKVTWKL EEMRLKETDR VSITTTKDRT TLTVKDSMRG
DSGRYFLTLE NTAGVKTFSV TVVVIGRPGP VTGPIEVSSV SAESCVLSWG EPKDGGGTEI
TNYIVEKRES GTTAWQLVNS SVKRTQIKVT HLTKYMEYSF RVSSENRFGV SKPLESAPII
AEHPFVPPSA PTRPEVYHVS ANAMSIRWEE PYHDGGSKII GYWVEKKERN TILWVKENKV
PCLECNYKVT GLVEGLEYQF RTYALNAAGV SKASEASRPI MAQNPVDAPG RPEVTDVTRS
TVSLIWSAPA YDGGSKVVGY IIERKPVSEV GDGRWLKCNY TIVSDNFFTV TALSEGDTYE
FRVLAKNAAG VISKGSESTG PVTCRDEYAP PKAELDARLH GDLVTIRAGS DLVLDAAVGG
KPEPKIIWTK GDKELDLCEK VSLQYTGKRA TAVIKFCDRS DSGKYTLTVK NASGTKAVSV
MVKVLDSPGP CGKLTVSRVT QEKCTLAWSL PQEDGGAEIT HYIVERRETS RLNWVIVEGE
CPTLSYVVTR LIKNNEYIFR VRAVNKYGPG VPVESEPIVA RNSFTIPSPP GIPEEVGTGK
EHIIIQWTKP ESDGGNEISN YLVDKREKKS LRWTRVNKDY VVYDTRLKVT SLMEGCDYQF
RVTAVNAAGN SEPSEASNFI SCREPSYTPG PPSAPRVVDT TKHSISLAWT KPMYDGGTDI
VGYVLEMQEK DTDQWYRVHT NATIRNTEFT VPDLKMGQKY SFRVAAVNVK GMSEYSESIA
EIEPVERIEI PDLELADDLK KTVTIRAGAS LRLMVSVSGR PPPVITWSKQ GIDLASRAII
DTTESYSLLI VDKVNRYDAG KYTIEAENQS GKKSATVLVK VYDTPGPCPS VKVKEVSRDS
VTITWEIPTI DGGAPVNNYI VEKREAAMRA FKTVTTKCSK TLYRISGLVE GTMYYFRVLP
ENIYGIGEPC ETSDAVLVSE VPLVPAKLEV VDVTKSTVTL AWEKPLYDGG SRLTGYVLEA
CKAGTERWMK VVTLKPTVLE HTVTSLNEGE QYLFRIRAQN EKGVSEPRET VTAVTVQDLR
VLPTIDLSTM PQKTIHVPAG RPVELVIPIA GRPPPAASWF FAGSKLRESE RVTVETHTKV
AKLTIRETTI RDTGEYTLEL KNVTGTTSET IKVIILDKPG PPTGPIKIDE IDATSITISW
EPPELDGGAP LSGYVVEQRD AHRPGWLPVS ESVTRSTFKF TRLTEGNEYV FRVAATNRFG
IGSYLQSEVI ECRSSIRIPG PPETLQIFDV SRDGMTLTWY PPEDDGGSQV TGYIVERKEV
RADRWVRVNK VPVTMTRYRS TGLTEGLEYE HRVTAINARG SGKPSRPSKP IVAMDPIAPP
GKPQNPRVTD TTRTSVSLAW SVPEDEGGSK VTGYLIEMQK VDQHEWTKCN TTPTKIREYT
LTHLPQGAEY RFRVLACNAG GPGEPAEVPG TVKVTEMLEY PDYELDERYQ EGIFVRQGGV
IRLTIPIKGK PFPICKWTKE GQDISKRAMI ATSETHTELV IKEADRGDSG TYDLVLENKC
GKKAVYIKVR VIGSPNSPEG PLEYDDIQVR SVRVSWRPPA DDGGADILGY ILERREVPKA
AWYTIDSRVR GTSLVVKGLK ENVEYHFRVS AENQFGISKP LKSEEPVTPK TPLNPPEPPS
NPPEVLDVTK SSVSLSWSRP KDDGGSRVTG YYIERKETST DKWVRHNKTQ ITTTMYTVTG
LVPDAEYQFR IIAQNDVGLS ETSPASEPVV CKDPFDKPSQ PGELEILSIS KDSVTLQWEK
PECDGGKEIL GYWVEYRQSG DSAWKKSNKE RIKDKQFTIG GLLEATEYEF RVFAENETGL
SRPRRTAMSI KTKLTSGEAP GIRKEMKDVT TKLGEAAQLS CQIVGRPLPD IKWYRFGKEL
IQSRKYKMSS DGRTHTLTVM TEEQEDEGVY TCIATNEVGE VETSSKLLLQ ATPQFHPGYP
LKEKYYGAVG STLRLHVMYI GRPVPAMTWF HGQKLLQNSE NITIENTEHY THLVMKNVQR
KTHAGKYKVQ LSNVFGTVDA ILDVEIQDKP DKPTGPIVIE ALLKNSAVIS WKPPADDGGS
WITNYVVEKC EAKEGAEWQL VSSAISVTTC RIVNLTENAG YYFRVSAQNT FGISDPLEVS
SVVIIKSPFE KPGAPGKPTI TAVTKDSCVV AWKPPASDGG AKIRNYYLEK REKKQNKWIS
VTTEEIRETV FSVKNLIEGL EYEFRVKCEN LGGESEWSEI SEPITPKSDV PIQAPHFKEE
LRNLNVRYQS NATLVCKVTG HPKPIVKWYR QGKEIIADGL KYRIQEFKGG YHQLIIASVT
DDDATVYQVR ATNQGGSVSG TASLEVEVPA KIHLPKTLEG MGAVHALRGE VVSIKIPFSG
KPDPVITWQK GQDLIDNNGH YQVIVTRSFT SLVFPNGVER KDAGFYVVCA KNRFGIDQKT
VELDVADVPD PPRGVKVSDV SRDSVNLTWT EPASDGGSKI TNYIVEKCAT TAERWLRVGQ
ARETRYTVIN LFGKTSYQFR VIAENKFGLS KPSEPSEPTI TKEDKTRAMN YDEEVDETRE
VSMTKASHSS TKELYEKYMI AEDLGRGEFG IVHRCVETSS KKTYMAKFVK VKGTDQVLVK
KEISILNIAR HRNILHLHES FESMEELVMI FEFISGLDIF ERINTSAFEL NEREIVSYVH
QVCEALQFLH SHNIGHFDIR PENIIYQTRR SSTIKIIEFG QARQLKPGDN FRLLFTAPEY
YAPEVHQHDV VSTATDMWSL GTLVYVLLSG INPFLAETNQ QIIENIMNAE YTFDEEAFKE
ISIEAMDFVD RLLVKERKSR MTASEALQHP WLKQKIERVS TKVIRTLKHR RYYHTLIKKD
LNMVVSAARI SCGGAIRSQK GVSVAKVKVA SIEIGPVSGQ IMHAVGEEGG HVKYVCKIEN
YDQSTQVTWY FGVRQLENSE KYEITYEDGV AILYVKDITK LDDGTYRCKV VNDYGEDSSY
AELFVKGVRE VYDYYCRRTM KKIKRRTDTM RLLERPPEFT LPLYNKTAYV GENVRFGVTI
TVHPEPHVTW YKSGQKIKPG DNDKKYTFES DKGLYQLTIN SVTTDDDAEY TVVARNKYGE
DSCKAKLTVT LHPPPTDSTL RPMFKRLLAN AECQEGQSVC FEIRVSGIPP PTLKWEKDGQ
PLSLGPNIEI IHEGLDYYAL HIRDTLPEDT GYYRVTATNT AGSTSCQAHL QVERLRYKKQ
EFKSKEEHER HVQKQIDKTL RMAEILSGTE SVPLTQVAKE ALREAAVLYK PAVSTKTVKG
EFRLEIEEKK EERKLRMPYD VPEPRKYKQT TIEEDQRIKQ FVPMSDMKWY KKIRDQYEMP
GKLDRVVQKR PKRIRLSRWE QFYVMPLPRI TDQYRPKWRI PKLSQDDLEI VRPARRRTPS
PDYDFYYRPR RRSLGDISDE ELLLPIDDYL AMKRTEEERL RLEEELELGF SASPPSRSPP
HFELSSLRYS SPQAHVKVEE TRKDFRYSTY HIPTKAEAST SYAELRERHA QAAYRQPKQR
QRIMAEREDE ELLRPVTTTQ HLSEYKSELD FMSKEEKSRK KSRRQREVTE ITEIEEEYEI
SKHAQRESSS SASRLLRRRR SLSPTYIELM RPVSELIRSR PQPAEEYEDD TERRSPTPER
TRPRSPSPVS SERSLSRFER SARFDIFSRY ESMKAALKTQ KTSERKYEVL SQQPFTLDHA
PRITLRMRSH RVPCGQNTRF ILNVQSKPTA EVKWYHNGVE LQESSKIHYT NTSGVLTLEI
LDCHTDDSGT YRAVCTNYKG EASDYATLDV TGGDYTTYAS QRRDEEVPRS VFPELTRTEA
YAVSSFKKTS EMEASSSVRE VKSQMTETRE SLSSYEHSAS AEMKSAALEE KSLEEKSTTR
KIKTTLAARI LTKPRSMTVY EGESARFSCD TDGEPVPTVT WLRKGQVLST SARHQVTTTK
YKSTFEISSV QASDEGNYSV VVENSEGKQE AEFTLTIQKA RVTEKAVTSP PRVKSPEPRV
KSPEAVKSPK RVKSPEPSHP KAVSPTETKP TPTEKVQHLP VSAPPKITQF LKAEASKEIA
KLTCVVESSV LRAKEVTWYK DGKKLKENGH FQFHYSADGT YELKINNLTE SDQGEYVCEI
SGEGGTSKTN LQFMGQAFKS IHEKVSKISE TKKSDQKTTE STVTRKTEPK APEPISSKPV
IVTGLQDTTV SSDSVAKFAV KATGEPRPTA IWTKDGKAIT QGGKYKLSED KGGFFLEIHK
TDTSDSGLYT CTVKNSAGSV SSSCKLTIKA IKDTEAQKVS TQKTSEITPQ KKAVVQEEIS
QKALRSEEIK MSEAKSQEKL ALKEEASKVL ISEEVKKSAA TSLEKSIVHE EITKTSQASE
EVRTHAEIKA FSTQMSINEG QRLVLKANIA GATDVKWVLN GVELTNSEEY RYGVSGSDQT
LTIKQASHRD EGILTCISKT KEGIVKCQYD LTLSKELSDA PAFISQPRSQ NINEGQNVLF
TCEISGEPSP EIEWFKNNLP ISISSNVSIS RSRNVYSLEI RNASVSDSGK YTIKAKNFRG
QCSATASLMV LPLVEEPSRE VVLRTSGDTS LQGSFSSQSV QMSASKQEAS FSSFSSSSAS
SMTEMKFASM SAQSMSSMQE SFVEMSSSSF MGISNMTQLE SSTSKMLKAG IRGIPPKIEA
LPSDISIDEG KVLTVACAFT GEPTPEVTWS CGGRKIHSQE QGRFHIENTD DLTTLIIMDV
QKQDGGLYTL SLGNEFGSDS ATVNIHIRSI *

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

102982

Theoretical NMD boundary in CDS

102706

Length of CDS

103053

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

Back to summary table

Variant:

2:178745884C>A_4_ENST00000342992

Back to summary table

Prediction:

BenignPermalink

Summary:

Model: without_aae
Tree vote: 96|104 (del | benign) ?

Analysed issue

Analysis result

Variant

Chr2:178745884C>A (GRCh38)

Gene symbol

TTN

Gene constraints

LOEUF: 0.46, LOF (oe): 0.44, misssense (oe): 0.90, synonymous (oe): 0.89 ? (gnomAD)

Ensembl transcript ID

ENST00000342992.11

Genbank transcript ID

NM_133378 (by similarity), NM_001256850 (by similarity)

UniProt / AlphaMissense peptide

N/A

Variant type

Single base exchange

Gene region

intron

DNA changes

c.10360+7240G>T
g.84919G>T

AA changes

N/A

Frameshift

Length of protein

N/A

Pathogenic variant (ClinVar)

Variant not listed in ClinVar as (likely) pathogenic.

Variant DBs

dbSNP ID	rs148430495
gnomAD	homozygous (A/A)	heterozygous	allele carriers
	1	133	134

Protein conservation

N/A

Protein features

N/A

Phylogenetic conservation

	PhyloP	PhastCons
(flanking)	5.945	1
	5.11	1
(flanking)	2.793	1

Splice sites

No abrogation of potential splice sites predicted by MaxEntScan.

Distance from splice site

N/A

Kozak consensus sequence altered?

N/A

poly(A) signal

N/A

AA sequence altered

N/A

Chromosome

Strand

-1

Original gDNA sequence snippet

ACTACACAGACAGTTTTTTTGAATTTCAGGTGGTGGAAGGG

Altered gDNA sequence snippet

ACTACACAGACAGTTTTTTTTAATTTCAGGTGGTGGAAGGG

Original cDNA sequence snippet

N/A

Altered cDNA sequence snippet

N/A

Wildtype AA sequence

MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEAPESIL HERIEQEIEM EMKAAPVIKR KIEPLEVALG HLAKFTCEIQ
SAPNVRFQWF KAGREIYESD KCSIRSSKYI SSLEILRTQV VDCGEYTCKA SNEYGSVSCT
ATLTVTEAYP PTFLSRPKSL TTFVGKAAKF ICTVTGTPVI ETIWQKDGAA LSPSPNWRIS
DAENKHILEL SNLTIQDRGV YSCKASNKFG ADICQAELII IDKPHFIKEL EPVQSAINKK
VHLECQVDED RKVTVTWSKD GQKLPPGKDY KICFEDKIAT LEIPLAKLKD SGTYVCTASN
EAGSSSCSAT VTVREPPSFV KKVDPSYLML PGESARLHCK LKGSPVIQVT WFKNNKELSE
SNTVRMYFVN SEAILDITDV KVEDSGSYSC EAVNDVGSDS CSTEIVIKEP PSFIKTLEPA
DIVRGTNALL QCEVSGTGPF EISWFKDKKQ IRSSKKYRLF SQKSLVCLEI FSFNSADVGE
YECVVANEVG KCGCMATHLL KEPPTFVKKV DDLIALGGQT VTLQAAVRGS EPISVTWMKG
QEVIREDGKI KMSFSNGVAV LIIPDVQISF GGKYTCLAEN EAGSQTSVGE LIVKEPAKII
ERAELIQVTA GDPATLEYTV AGTPELKPKW YKDGRPLVAS KKYRISFKNN VAQLKFYSAE
LHDSGQYTFE ISNEVGSSSC ETTFTVLDRD IAPFFTKPLR NVDSVVNGTC RLDCKIAGSL
PMRVSWFKDG KEIAASDRYR IAFVEGTASL EIIRVDMNDA GNFTCRATNS VGSKDSSGAL
IVQEPPSFVT KPGSKDVLPG SAVCLKSTFQ GSTPLTIRWF KGNKELVSGG SCYITKEALE
SSLELYLVKT SDSGTYTCKV SNVAGGVECS ANLFVKEPAT FVEKLEPSQL LKKGDATQLA
CKVTGTPPIK ITWFANDREI KESSKHRMSF VESTAVLRLT DVGIEDSGEY MCEAQNEAGS
DHCSSIVIVK ESPYFTKEFK PIEVLKEYDV MLLAEVAGTP PFEITWFKDN TILRSGRKYK
TFIQDHLVSL QILKFVAADA GEYQCRVTNE VGSSICSARV TLREPPSFIK KIESTSSLRG
GTAAFQATLK GSLPITVTWL KDSDEITEDD NIRMTFENNV ASLYLSGIEV KHDGKYVCQA
KNDAGIQRCS ALLSVKEPAT ITEEAVSIDV TQGDPATLQV KFSGTKEITA KWFKDGQELT
LGSKYKISVT DTVSILKIIS TEKKDSGEYT FEVQNDVGRS SCKARINVLD LIIPPSFTKK
LKKMDSIKGS FIDLECIVAG SHPISIQWFK DDQEISASEK YKFSFHDNTA FLEISQLEGT
DSGTYTCSAT NKAGHNQCSG HLTVKEPPYF VEKPQSQDVN PNTRVQLKAL VGGTAPMTIK
WFKDNKELHS GAARSVWKDD TSTSLELFAA KATDSGTYIC QLSNDVGTAT SKATLFVKEP
PQFIKKPSPV LVLRNGQSTT FECQITGTPK IRVSWYLDGN EITAIQKHGI SFIDGLATFQ
ISGARVENSG TYVCEARNDA GTASCSIELK VKEPPTFIRE LKPVEVVKYS DVELECEVTG
TPPFEVTWLK NNREIRSSKK YTLTDRVSVF NLHITKCDPS DTGEYQCIVS NEGGSCSCST
RVALKEPPSF IKKIENTTTV LKSSATFQST VAGSPPISIT WLKDDQILDE DDNVYISFVD
SVATLQIRSV DNGHSGRYTC QAKNESGVER CYAFLLVQEP AQIVEKAKSV DVTEKDPMTL
ECVVAGTPEL KVKWLKDGKQ IVPSRYFSMS FENNVASFRI QSVMKQDSGQ YTFKVENDFG
SSSCDAYLRV LDQNIPPSFT KKLTKMDKVL GSSIHMECKV SGSLPISAQW FKDGKEISTS
AKYRLVCHER SVSLEVNNLE LEDTANYTCK VSNVAGDDAC SGILTVKEPP SFLVKPGRQQ
AIPDSTVEFK AILKGTPPFK IKWFKDDVEL VSGPKCFIGL EGSTSFLNLY SVDASKTGQY
TCHVTNDVGS DSCTTMLLVT EPPKFVKKLE ASKIVKAGDS SRLECKIAGS PEIRVVWFRN
EHELPASDKY RMTFIDSVAV IQMNNLSTED SGDFICEAQN PAGSTSCSTK VIVKEPPVFS
SFPPIVETLK NAEVSLECEL SGTPPFEVVW YKDKRQLRSS KKYKIASKNF HTSIHILNVD
TSDIGEYHCK AQNEVGSDTC VCTVKLKEPP RFVSKLNSLT VVAGEPAELQ ASIEGAQPIF
VQWLKEKEEV IRESENIRIT FVENVATLQF AKAEPANAGK YICQIKNDGG MRENMATLMV
LEPAVIVEKA GPMTVTVGET CTLECKVAGT PELSVEWYKD GKLLTSSQKH KFSFYNKISS
LRILSVERQD AGTYTFQVQN NVGKSSCTAV VDVSDRAVPP SFTRRLKNTG GVLGASCILE
CKVAGSSPIS VAWFHEKTKI VSGAKYQTTF SDNVCTLQLN SLDSSDMGNY TCVAANVAGS
DECRAVLTVQ EPPSFVKEPE PLEVLPGKNV TFTSVIRGTP PFKVNWFRGA RELVKGDRCN
IYFEDTVAEL ELFNIDISQS GEYTCVVSNN AGQASCTTRL FVKEPAAFLK RLSDHSVEPG
KSIILESTYT GTLPISVTWK KDGFNITTSE KCNIVTTEKT CILEILNSTK RDAGQYSCEI
ENEAGRDVCG ALVSTLEPPY FVTELEPLEA AVGDSVSLQC QVAGTPEITV SWYKGDTKLR
PTPEYRTYFT NNVATLVFNK VNINDSGEYT CKAENSIGTA SSKTVFRIQE RQLPPSFARQ
LKDIEQTVGL PVTLTCRLNG SAPIQVCWYR DGVLLRDDEN LQTSFVDNVA TLKILQTDLS
HSGQYSCSAS NPLGTASSSA RLTAREPKKS PFFDIKPVSI DVIAGESADF ECHVTGAQPM
RITWSKDNKE IRPGGNYTIT CVGNTPHLRI LKVGKGDSGQ YTCQATNDVG KDMCSAQLSV
KEPPKFVKKL EASKVAKQGE SIQLECKISG SPEIKVSWFR NDSELHESWK YNMSFINSVA
LLTINEASAE DSGDYICEAH NGVGDASCST ALTVKAPPVF TQKPSPVGAL KGSDVILQCE
ISGTPPFEVV WVKDRKQVRN SKKFKITSKH FDTSLHILNL EASDVGEYHC KATNEVGSDT
CSCSVKFKEP PRFVKKLSDT STLIGDAVEL RAIVEGFQPI SVVWLKDRGE VIRESENTRI
SFIDNIATLQ LGSPEASNSG KYICQIKNDA GMRECSAVLT VLEPARIIEK PEPMTVTTGN
PFALECVVTG TPELSAKWFK DGRELSADSK HHITFINKVA SLKIPCAEMS DKGLYSFEVK
NSVGKSNCTV SVHVSDRIVP PSFIRKLKDV NAILGASVVL ECRVSGSAPI SVGWFQDGNE
IVSGPKCQSS FSENVCTLNL SLLEPSDTGI YTCVAANVAG SDECSAVLTV QEPPSFEQTP
DSVEVLPGMS LTFTSVIRGT PPFKVKWFKG SRELVPGESC NISLEDFVTE LELFEVQPLE
SGDYSCLVTN DAGSASCTTH LFVKEPATFV KRLADFSVET GSPIVLEATY TGTPPISVSW
IKDEYLISQS ERCSITMTEK STILEILEST IEDYAQYSCL IENEAGQDIC EALVSVLEPP
YFIEPLEHVE AVIGEPATLQ CKVDGTPEIR ISWYKEHTKL RSAPAYKMQF KNNVASLVIN
KVDHSDVGEY SCKADNSVGA VASSAVLVIK ARKLPPFFAR KLKDVHETLG FPVAFECRIN
GSEPLQVSWY KDGVLLKDDA NLQTSFVHNV ATLQILQTDQ SHIGQYNCSA SNPLGTASSS
AKLILSEHEV PPFFDLKPVS VDLALGESGT FKCHVTGTAP IKITWAKDNR EIRPGGNYKM
TLVENTATLT VLKVGKGDAG QYTCYASNIA GKDSCSAQLG VQEPPRFIKK LEPSRIVKQD
EFTRYECKIG GSPEIKVLWY KDETEIQESS KFRMSFVDSV AVLEMHNLSV EDSGDYTCEA
HNAAGSASSS TSLKVKEPPI FRKKPHPIET LKGADVHLEC ELQGTPPFHV SWYKDKRELR
SGKKYKIMSE NFLTSIHILN VDAADIGEYQ CKATNDVGSD TCVGSIALKA PPRFVKKLSD
ISTVVGKEVQ LQTTIEGAEP ISVVWFKDKG EIVRESDNIW ISYSENIATL QFSRVEPANA
GKYTCQIKND AGMQECFATL SVLEPATIVE KPESIKVTTG DTCTLECTVA GTPELSTKWF
KDGKELTSDN KYKISFFNKV SGLKIINVAP SDSGVYSFEV QNPVGKDSCT ASLQVSDRTV
PPSFTRKLKE TNGLSGSSVV MECKVYGSPP ISVSWFHEGN EISSGRKYQT TLTDNTCALT
VNMLEESDSG DYTCIATNMA GSDECSAPLT VREPPSFVQK PDPMDVLTGT NVTFTSIVKG
TPPFSVSWFK GSSELVPGDR CNVSLEDSVA ELELFDVDTS QSGEYTCIVS NEAGKASCTT
HLYIKAPAKF VKRLNDYSIE KGKPLILEGT FTGTPPISVT WKKNGINVTP SQRCNITTTE
KSAILEIPSS TVEDAGQYNC YIENASGKDS CSAQILILEP PYFVKQLEPV KVSVGDSASL
QCQLAGTPEI GVSWYKGDTK LRPTTTYKMH FRNNVATLVF NQVDINDSGE YICKAENSVG
EVSASTFLTV QEQKLPPSFS RQLRDVQETV GLPVVFDCAI SGSEPISVSW YKDGKPLKDS
PNVQTSFLDN TATLNIFKTD RSLAGQYSCT ATNPIGSASS SARLILTEGK NPPFFDIRLA
PVDAVVGESA DFECHVTGTQ PIKVSWAKDS REIRSGGKYQ ISYLENSAHL TVLKVDKGDS
GQYTCYAVNE VGKDSCTAQL NIKERLIPPS FTKRLSETVE ETEGNSFKLE GRVAGSQPIT
VAWYKNNIEI QPTSNCEITF KNNTLVLQVR KAGMNDAGLY TCKVSNDAGS ALCTSSIVIK
EPKKPPVFDQ HLTPVTVSEG EYVQLSCHVQ GSEPIRIQWL KAGREIKPSD RCSFSFASGT
AVLELRDVAK ADSGDYVCKA SNVAGSDTTK SKVTIKDKPA VAPATKKAAV DGRLFFVSEP
QSIRVVEKTT ATFIAKVGGD PIPNVKWTKG KWRQLNQGGR VFIHQKGDEA KLEIRDTTKT
DSGLYRCVAF NEHGEIESNV NLQVDERKKQ EKIEGDLRAM LKKTPILKKG AGEEEEIDIM
ELLKNVDPKE YEKYARMYGI TDFRGLLQAF ELLKQSQEEE THRLEIEEIE RSERDEKEFE
ELVSFIQQRL SQTEPVTLIK DIENQTVLKD NDAVFEIDIK INYPEIKLSW YKGTEKLEPS
DKFEISIDGD RHTLRVKNCQ LKDQGNYRLV CGPHIASAKL TVIEPAWERH LQDVTLKEGQ
TCTMTCQFSV PNVKSEWFRN GRILKPQGRH KTEVEHKVHK LTIADVRAED QGQYTCKYED
LETSAELRIE AEPIQFTKRI QNIVVSEHQS ATFECEVSFD DAIVTWYKGP TELTESQKYN
FRNDGRCHYM TIHNVTPDDE GVYSVIARLE PRGEARSTAE LYLTTKEIKL ELKPPDIPDS
RVPIPTMPIR AVPPEEIPPV VAPPIPLLLP TPEEKKPPPK RIEVTKKAVK KDAKKVVAKP
KEMTPREEIV KKPPPPTTLI PAKAPEIIDV SSKAEEVKIM TITRKKEVQK EKEAVYEKKQ
AVHKEKRVFI ESFEEPYDEL EVEPYTEPFE QPYYEEPDED YEEIKVEAKK EVHEEWEEDF
EEGQEYYERE EGYDEGEEEW EEAYQEREVI QVQKEVYEES HERKVPAKVP EKKAPPPPKV
IKKPVIEKIE KTSRRMEEEK VQVTKVPEVS KKIVPQKPSR TPVQEEVIEV KVPAVHTKKM
VISEEKMFFA SHTEEEVSVT VPEVQKEIVT EEKIHVAISK RVEPPPKVPE LPEKPAPEEV
APVPIPKKVE PPAPKVPEVP KKPVPEEKKP VPVPKKEPAA PPKVPEVPKK PVPEEKIPVP
VAKKKEAPPA KVPEVQKGVV TEEKITIVTQ REESPPPAVP EIPKKKVPEE RKPVPRKEEE
VPPPPKVPAL PKKPVPEEKV AVPVPVAKKA PPPRAEVSKK TVVEEKRFVA EEKLSFAVPQ
RVEVTRHEVS AEEEWSYSEE EEGVSISVYR EEEREEEEEA EVTEYEVMEE PEEYVVEEKL
HIISKRVEAE PAEVTERQEK KIVLKPKIPA KIEEPPPAKV PEAPKKIVPE KKVPAPVPKK
EKVPPPKVPE EPKKPVPEKK VPPKVIKMEE PLPAKVTERH MQITQEEKVL VAVTKKEAPP
KARVPEEPKR AVPEEKVLKL KPKREEEPPA KVTEFRKRVV KEEKVSIEAP KREPQPIKEV
TIMEEKERAY TLEEEAVSVQ REEEYEEYEE YDYKEFEEYE PTEEYDQYEE YEEREYERYE
EHEEYITEPE KPIPVKPVPE EPVPTKPKAP PAKVLKKAVP EEKVPVPIPK KLKPPPPKVP
EEPKKVFEEK IRISITKREK EQVTEPAAKV PMKPKRVVAE EKVPVPRKEV APPVRVPEVP
KELEPEEVAF EEEVVTHVEE YLVEEEEEYI HEEEEFITEE EVVPVIPVKV PEVPRKPVPE
EKKPVPVPKK KEAPPAKVPE VPKKPEEKVP VLIPKKEKPP PAKVPEVPKK PVPEEKVPVP
VPKKVEAPPA KVPEVPKKPV PEKKVPVPAP KKVEAPPAKV PEVPKKLIPE EKKPTPVPKK
VEAPPPKVPK KREPVPVPVA LPQEEEVLFE EEIVPEEEVL PEEEEVLPEE EEVLPEEEEV
LPEEEEIPPE EEEVPPEEEY VPEEEEFVPE EEVLPEVKPK VPVPAPVPEI KKKVTEKKVV
IPKKEEAPPA KVPEVPKKVE EKRIILPKEE EVLPVEVTEE PEEEPISEEE IPEEPPSIEE
VEEVAPPRVP EVIKKAVPEA PTPVPKKVEA PPAKVSKKIP EEKVPVPVQK KEAPPAKVPE
VPKKVPEKKV LVPKKEAVPP AKGRTVLEEK VSVAFRQEVV VKERLELEVV EAEVEEIPEE
EEFHEVEEYF EEGEFHEVEE FIKLEQHRVE EEHRVEKVHR VIEVFEAEEV EVFEKPKAPP
KGPEISEKII PPKKPPTKVV PRKEPPAKVP EVPKKIVVEE KVRVPEEPRV PPTKVPEVLP
PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVPEKKVPV PPPKKPEVPP TKVPEVPKAA
VPEKKVPEAI PPKPESPPPE VPEAPKEVVP EKKVPAAPPK KPEVTPVKVP EAPKEVVPEK
KVPVPPPKKP EVPPTKVPEV PKVAVPEKKV PEAIPPKPES PPPEVFEEPE EVALEEPPAE
VVEEPEPAAP PQVTVPPKKP VPEKKAPAVV AKKPELPPVK VPEVPKEVVP EKKVPLVVPK
KPEAPPAKVP EVPKEVVPEK KVAVPKKPEV PPAKVPEVPK KPVLEEKPAV PVPERAESPP
PEVYEEPEEI APEEEIAPEE EKPVPVAEEE EPEVPPPAVP EEPKKIIPEK KVPVIKKPEA
PPPKEPEPEK VIEKPKLKPR PPPPPPAPPK EDVKEKIFQL KAIPKKKVPE KPQVPEKVEL
TPLKVPGGEK KVRKLLPERK PEPKEEVVLK SVLRKRPEEE EPKVEPKKLE KVKKPAVPEP
PPPKPVEEVE VPTVTKRERK IPEPTKVPEI KPAIPLPAPE PKPKPEAEVK TIKPPPVEPE
PTPIAAPVTV PVVGKKAEAK APKEEAAKPK GPIKGVPKKT PSPIEAERRK LRPGSGGEKP
PDEAPFTYQL KAVPLKFVKE IKDIILTESE FVGSSAIFEC LVSPSTAITT WMKDGSNIRE
SPKHRFIADG KDRKLHIIDV QLSDAGEYTC VLRLGNKEKT STAKLVVEEL PVRFVKTLEE
EVTVVKGQPL YLSCELNKER DVVWRKDGKI VVEKPGRIVP GVIGLMRALT INDADDTDAG
TYTVTVENAN NLECSSCVKV VEVIRDWLVK PIRDQHVKPK GTAIFACDIA KDTPNIKWFK
GYDEIPAEPN DKTEILRDGN HLYLKIKNAM PEDIAEYAVE IEGKRYPAKL TLGEREVELL
KPIEDVTIYE KESASFDAEI SEADIPGQWK LKGELLRPSP TCEIKAEGGK RFLTLHKVKL
DQAGEVLYQA LNAITTAILT VKEIELDFAV PLKDVTVPER RQARFECVLT REANVIWSKG
PDIIKSSDKF DIIADGKKHI LVINDSQFDD EGVYTAEVEG KKTSARLFVT GIRLKFMSPL
EDQTVKEGET ATFVCELSHE KMHVVWFKND AKLHTSRTVL ISSEGKTHKL EMKEVTLDDI
SQIKAQVKEL SSTAQLKVLE ADPYFTVKLH DKTAVEKDEI TLKCEVSKDV PVKWFKDGEE
IVPSPKYSIK ADGLRRILKI KKADLKDKGE YVCDCGTDKT KANVTVEARL IKVEKPLYGV
EVFVGETAHF EIELSEPDVH GQWKLKGQPL TASPDCEIIE DGKKHILILH NCQLGMTGEV
SFQAANAKSA ANLKVKELPL IFITPLSDVK VFEKDEAKFE CEVSREPKTF RWLKGTQEIT
GDDRFELIKD GTKHSMVIKS AAFEDEAKYM FEAEDKHTSG KLIIEGIRLK FLTPLKDVTA
KEKESAVFTV ELSHDNIRVK WFKNDQRLHT TRSVSMQDEG KTHSITFKDL SIDDTSQIRV
EAMGMSSEAK LTVLEGDPYF TGKLQDYTGV EKDEVILQCE ISKADAPVKW FKDGKEIKPS
KNAVIKADGK KRMLILKKAL KSDIGQYTCD CGTDKTSGKL DIEDREIKLV RPLHSVEVME
TETARFETEI SEDDIHANWK LKGEALLQTP DCEIKEEGKI HSLVLHNCRL DQTGGVDFQA
ANVKSSAHLR VKPRVIGLLR PLKDVTVTAG ETATFDCELS YEDIPVEWYL KGKKLEPSDK
VVPRSEGKVH TLTLRDVKLE DAGEVQLTAK DFKTHANLFV KEPPVEFTKP LEDQTVEEGA
TAVLECEVSR ENAKVKWFKN GTEILKSKKY EIVADGRVRK LVIHDCTPED IKTYTCDAKD
FKTSCNLNVV PPHVEFLRPL TDLQVREKEM ARFECELSRE NAKVKWFKDG AEIKKGKKYD
IISKGAVRIL VINKCLLDDE AEYSCEVRTA RTSGMLTVLE EEAVFTKNLA NIEVSETDTI
KLVCEVSKPG AEVIWYKGDE EIIETGRYEI LTEGRKRILV IQNAHLEDAG NYNCRLPSSR
TDGKVKVHEL AAEFISKPQN LEILEGEKAE FVCSISKESF PVQWKRDDKT LESGDKYDVI
ADGKKRVLVV KDATLQDMGT YVVMVGAARA AAHLTVIEKL RIVVPLKDTR VKEQQEVVFN
CEVNTEGAKA KWFRNEEAIF DSSKYIILQK DLVYTLRIRD AHLDDQANYN VSLTNHRGEN
VKSAANLIVE EEDLRIVEPL KDIETMEKKS VTFWCKVNRL NVTLKWTKNG EEVPFDNRVS
YRVDKYKHML TIKDCGFPDE GEYIVTAGQD KSVAELLIIE APTEFVEHLE DQTVTEFDDA
VFSCQLSREK ANVKWYRNGR EIKEGKKYKF EKDGSIHRLI IKDCRLDDEC EYACGVEDRK
SRARLFVEEI PVEIIRPPQD ILEAPGADVV FLAELNKDKV EVQWLRNNMV VVQGDKHQMM
SEGKIHRLQI CDIKPRDQGE YRFIAKDKEA RAKLELAAAP KIKTADQDLV VDVGKPLTMV
VPYDAYPKAE AEWFKENEPL STKTIDTTAE QTSFRILEAK KGDKGRYKIV LQNKHGKAEG
FINLKVIDVP GPVRNLEVTE TFDGEVSLAW EEPLTDGGSK IIGYVVERRD IKRKTWVLAT
DRAESCEFTV TGLQKGGVEY LFRVSARNRV GTGEPVETDN PVEARSKYDV PGPPLNVTIT
DVNRFGVSLT WEPPEYDGGA EITNYVIELR DKTSIRWDTA MTVRAEDLSA TVTDVVEGQE
YSFRVRAQNR IGVGKPSAAT PFVKVADPIE RPSPPVNLTS SDQTQSSVQL KWEPPLKDGG
SPILGYIIER CEEGKDNWIR CNMKLVPELT YKVTGLEKGN KYLYRVSAEN KAGVSDPSEI
LGPLTADDAF VEPTMDLSAF KDGLEVIVPN PITILVPSTG YPRPTATWCF GDKVLETGDR
VKMKTLSAYA ELVISPSERS DKGIYTLKLE NRVKTISGEI DVNVIARPSA PKELKFGDIT
KDSVHLTWEP PDDDGGSPLT GYVVEKREVS RKTWTKVMDF VTDLEFTVPD LVQGKEYLFK
VCARNKCGPG EPAYVDEPVN MSTPATVPDP PENVKWRDRT ANSIFLTWDP PKNDGGSRIK
GYIVERCPRG SDKWVACGEP VAETKMEVTG LEEGKWYAYR VKALNRQGAS KPSRPTEEIQ
AVDTQEAPEI FLDVKLLAGL TVKAGTKIEL PATVTGKPEP KITWTKADMI LKQDKRITIE
NVPKKSTVTI VDSKRSDTGT YIIEAVNVCG RATAVVEVNV LDKPGPPAAF DITDVTNESC
LLTWNPPRDD GGSKITNYVV ERRATDSEVW HKLSSTVKDT NFKATKLIPN KEYIFRVAAE
NMYGVGEPVQ ASPITAKYQF DPPGPPTRLE PSDITKDAVT LTWCEPDDDG GSPITGYWVE
RLDPDTDKWV RCNKMPVKDT TYRVKGLTNK KKYRFRVLAE NLAGPGKPSK STEPILIKDP
IDPPWPPGKP TVKDVGKTSV RLNWTKPEHD GGAKIESYVI EMLKTGTDEW VRVAEGVPTT
QHLLPGLMEG QEYSFRVRAV NKAGESEPSE PSDPVLCREK LYPPSPPRWL EVINITKNTA
DLKWTVPEKD GGSPITNYIV EKRDVRRKGW QTVDTTVKDT KCTVTPLTEG SLYVFRVAAE
NAIGQSDYTE IEDSVLAKDT FTTPGPPYAL AVVDVTKRHV DLKWEPPKND GGRPIQRYVI
EKKERLGTRW VKAGKTAGPD CNFRVTDVIE GTEVQFQVRA ENEAGVGHPS EPTEILSIED
PTSPPSPPLD LHVTDAGRKH IAIAWKPPEK NGGSPIIGYH VEMCPVGTEK WMRVNSRPIK
DLKFKVEEGV VPDKEYVLRV RAVNAIGVSE PSEISENVVA KDPDCKPTID LETHDIIVIE
GEKLSIPVPF RAVPVPTVSW HKDGKEVKAS DRLTMKNDHI SAHLEVPKSV RADAGIYTIT
LENKLGSATA SINVKVIGLP GPCKDIKASD ITKSSCKLTW EPPEFDGGTP ILHYVLERRE
AGRRTYIPVM SGENKLSWTV KDLIPNGEYF FRVKAVNKVG GGEYIELKNP VIAQDPKQPP
DPPVDVEVHN PTAEAMTITW KPPLYDGGSK IMGYIIEKIA KGEERWKRCN EHLVPILTYT
AKGLEEGKEY QFRVRAENAA GISEPSRATP PTKAVDPIDA PKVILRTSLE VKRGDEIALD
ASISGSPYPT ITWIKDENVI VPEEIKKRAA PLVRRRKGEV QEEEPFVLPL TQRLSIDNSK
KGESQLRVRD SLRPDHGLYM IKVENDHGIA KAPCTVSVLD TPGPPINFVF EDIRKTSVLC
KWEPPLDDGG SEIINYTLEK KDKTKPDSEW IVVTSTLRHC KYSVTKLIEG KEYLFRVRAE
NRFGPGPPCV SKPLVAKDPF GPPDAPDKPI VEDVTSNSML VKWNEPKDNG SPILGYWLEK
REVNSTHWSR VNKSLLNALK ANVDGLLEGL TYVFRVCAEN AAGPGKFSPP SDPKTAHDPI
SPPGPPIPRV TDTSSTTIEL EWEPPAFNGG GEIVGYFVDK QLVGTNEWSR CTEKMIKVRQ
YTVKEIREGA DYKLRVSAVN AAGEGPPGET QPVTVAEPQE PPAVELDVSV KGGIQIMAGK
TLRIPAVVTG RPVPTKVWTK EEGELDKDRV VIDNVGTKSE LIIKDALRKD HGRYVITATN
SCGSKFAAAR VEVFDVPGPV LDLKPVVTNR KMCLLNWSDP EDDGGSEITG FIIERKDAKM
HTWRQPIETE RSKCDITGLL EGQEYKFRVI AKNKFGCGPP VEIGPILAVD PLGPPTSPER
LTYTERTKST ITLDWKEPRS NGGSPIQGYI IEKRRHDKPD FERVNKRLCP TTSFLVENLD
EHQMYEFRVK AVNEIGESEP SLPLNVVIQD DEVPPTIKLR LSVRGDTIKV KAGEPVHIPA
DVTGLPMPKI EWSKNETVIE KPTDALQITK EEVSRSEAKT ELSIPKAVRE DKGTYTVTAS
NRLGSVFRNV HVEVYDRPSP PRNLAVTDIK AESCYLTWDA PLDNGGSEIT HYVIDKRDAS
RKKAEWEEVT NTAVEKRYGI WKLIPNGQYE FRVRAVNKYG ISDECKSDKV VIQDPYRLPG
PPGKPKVLAR TKGSMLVSWT PPLDNGGSPI TGYWLEKREE GSPYWSRVSR APITKVGLKG
VEFNVPRLLE GVKYQFRAMA INAAGIGPPS EPSDPEVAGD PIFPPGPPSC PEVKDKTKSS
ISLGWKPPAK DGGSPIKGYI VEMQEEGTTD WKRVNEPDKL ITTCECVVPN LKELRKYRFR
VKAVNEAGES EPSDTTGEIP ATDIQEEPEV FIDIGAQDCL VCKAGSQIRI PAVIKGRPTP
KSSWEFDGKA KKAMKDGVHD IPEDAQLETA ENSSVIIIPE CKRSHTGKYS ITAKNKAGQK
TANCRVKVMD VPGPPKDLKV SDITRGSCRL SWKMPDDDGG DRIKGYVIEK RTIDGKAWTK
VNPDCGSTTF VVPDLLSEQQ YFFRVRAENR FGIGPPVETI QRTTARDPIY PPDPPIKLKI
GLITKNTVHL SWKPPKNDGG SPVTHYIVEC LAWDPTGTKK EAWRQCNKRD VEELQFTVED
LVEGGEYEFR VKAVNAAGVS KPSATVGPVT VKDQTCPPSI DLKEFMEVEE GTNVNIVAKI
KGVPFPTLTW FKAPPKKPDN KEPVLYDTHV NKLVVDDTCT LVIPQSRRSD TGLYTITAVN
NLGTASKEMR LNVLGRPGPP VGPIKFESVS ADQMTLSWFP PKDDGGSKIT NYVIEKREAN
RKTWVHVSSE PKECTYTIPK LLEGHEYVFR IMAQNKYGIG EPLDSEPETA RNLFSVPGAP
DKPTVSSVTR NSMTVNWEEP EYDGGSPVTG YWLEMKDTTS KRWKRVNRDP IKAMTLGVSY
KVTGLIEGSD YQFRVYAINA AGVGPASLPS DPATARDPIA PPGPPFPKVT DWTKSSADLE
WSPPLKDGGS KVTGYIVEYK EEGKEEWEKG KDKEVRGTKL VVTGLKEGAF YKFRVRAVNI
AGIGEPGEVT DVIEMKDRLV SPDLQLDASV RDRIVVHAGG VIRIIAYVSG KPPPTVTWNM
NERTLPQEAT IETTAISSSM VIKNCQRSHQ GVYSLLAKNE AGERKKTIIV DVLDVPGPVG
TPFLAHNLTN ESCKLTWFSP EDDGGSPITN YVIEKRESDR RAWTPVTYTV TRQNATVQGL
IQGKAYFFRI AAENSIGMGP FVETSEALVI REPITVPERP EDLEVKEVTK NTVTLTWNPP
KYDGGSEIIN YVLESRLIGT EKFHKVTNDN LLSRKYTVKG LKEGDTYEYR VSAVNIVGQG
KPSFCTKPIT CKDELAPPTL HLDFRDKLTI RVGEAFALTG RYSGKPKPKV SWFKDEADVL
EDDRTHIKTT PATLALEKIK AKRSDSGKYC VVVENSTGSR KGFCQVNVVD RPGPPVGPVS
FDEVTKDYMV ISWKPPLDDG GSKITNYIIE KKEVGKDVWM PVTSASAKTT CKVSKLLEGK
DYIFRIHAEN LYGISDPLVS DSMKAKDRFR VPDAPDQPIV TEVTKDSALV TWNKPHDGGK
PITNYILEKR ETMSKRWARV TKDPIHPYTK FRVPDLLEGC QYEFRVSAEN EIGIGDPSPP
SKPVFAKDPI AKPSPPVNPE AIDTTCNSVD LTWQPPRHDG GSKILGYIVE YQKVGDEEWR
RANHTPESCP ETKYKVTGLR DGQTYKFRVL AVNAAGESDP AHVPEPVLVK DRLEPPELIL
DANMAREQHI KVGDTLRLSA IIKGVPFPKV TWKKEDRDAP TKARIDVTPV GSKLEIRNAA
HEDGGIYSLT VENPAGSKTV SVKVLVLDKP GPPRDLEVSE IRKDSCYLTW KEPLDDGGSV
ITNYVVERRD VASAQWSPLS ATSKKKSHFA KHLNEGNQYL FRVAAENQYG RGPFVETPKP
IKALDPLHPP GPPKDLHHVD VDKTEVSLVW NKPDRDGGSP ITGYLVEYQE EGTQDWIKFK
TVTNLECVVT GLQQGKTYRF RVKAENIVGL GLPDTTIPIE CQEKLVPPSV ELDVKLIEGL
VVKAGTTVRF PAIIRGVPVP TAKWTTDGSE IKTDEHYTVE TDNFSSVLTI KNCLRRDTGE
YQITVSNAAG SKTVAVHLTV LDVPGPPTGP INILDVTPEH MTISWQPPKD DGGSPVINYI
VEKQDTRKDT WGVVSSGSSK TKLKIPHLQK GCEYVFRVRA ENKIGVGPPL DSTPTVAKHK
FSPPSPPGKP VVTDITENAA TVSWTLPKSD GGSPITGYYM ERREVTGKWV RVNKTPIADL
KFRVTGLYEG NTYEFRVFAE NLAGLSKPSP SSDPIKACRP IKPPGPPINP KLKDKSRETA
DLVWTKPLSD GGSPILGYVV ECQKPGTAQW NRINKDELIR QCAFRVPGLI EGNEYRFRIK
AANIVGEGEP RELAESVIAK DILHPPEVEL DVTCRDVITV RVGQTIRILA RVKGRPEPDI
TWTKEGKVLV REKRVDLIQD LPRVELQIKE AVRADHGKYI ISAKNSSGHA QGSAIVNVLD
RPGPCQNLKV TNVTKENCTI SWENPLDNGG SEITNFIVEY RKPNQKGWSI VASDVTKRLI
KANLLANNEY YFRVCAENKV GVGPTIETKT PILAINPIDR PGEPENLHIA DKGKTFVYLK
WRRPDYDGGS PNLSYHVERR LKGSDDWERV HKGSIKETHY MVDRCVENQI YEFRVQTKNE
GGESDWVKTE EVVVKEDLQK PVLDLKLSGV LTVKAGDTIR LEAGVRGKPF PEVAWTKDKD
ATDLTRSPRV KIDTRADSSK FSLTKAKRSD GGKYVVTATN TAGSFVAYAT VNVLDKPGPV
RNLKIVDVSS DRCTVCWDPP EDDGGCEIQN YILEKCETKR MVWSTYSATV LTPGTTVTRL
IEGNEYIFRV RAENKIGTGP PTESKPVIAK TKYDKPGRPD PPEVTKVSKE EMTVVWNPPE
YDGGKSITGY FLEKKEKHST RWVPVNKSAI PERRMKVQNL LPDHEYQFRV KAENEIGIGE
PSLPSRPVVA KDPIEPPGPP TNFRVVDTTK HSITLGWGKP VYDGGAPIIG YVVEMRPKIA
DASPDEGWKR CNAAAQLVRK EFTVTSLDEN QEYEFRVCAQ NQVGIGRPAE LKEAIKPKEI
LEPPEIDLDA SMRKLVIVRA GCPIRLFAIV RGRPAPKVTW RKVGIDNVVR KGQVDLVDTM
AFLVIPNSTR DDSGKYSLTL VNPAGEKAVF VNVRVLDTPG PVSDLKVSDV TKTSCHVSWA
PPENDGGSQV THYIVEKREA DRKTWSTVTP EVKKTSFHVT NLVPGNEYYF RVTAVNEYGP
GVPTDVPKPV LASDPLSEPD PPRKLEVTEM TKNSATLAWL PPLRDGGAKI DGYITSYREE
EQPADRWTEY SVVKDLSLVV TGLKEGKKYK FRVAARNAVG VSLPREAEGV YEAKEQLLPP
KILMPEQITI KAGKKLRIEA HVYGKPHPTC KWKKGEDEVV TSSHLAVHKA DSSSILIIKD
VTRKDSGYYS LTAENSSGTD TQKIKVVVMD APGPPQPPFD ISDIDADACS LSWHIPLEDG
GSNITNYIVE KCDVSRGDWV TALASVTKTS CRVGKLIPGQ EYIFRVRAEN RFGISEPLTS
PKMVAQFPFG VPSEPKNARV TKVNKDCIFV AWDRPDSDGG SPIIGYLIER KERNSLLWVK
ANDTLVRSTE YPCAGLVEGL EYSFRIYALN KAGSSPPSKP TEYVTARMPV DPPGKPEVID
VTKSTVSLIW ARPKHDGGSK IIGYFVEACK LPGDKWVRCN TAPHQIPQEE YTATGLEEKA
QYQFRAIART AVNISPPSEP SDPVTILAEN VPPRIDLSVA MKSLLTVKAG TNVCLDATVF
GKPMPTVSWK KDGTLLKPAE GIKMAMQRNL CTLELFSVNR KDSGDYTITA ENSSGSKSAT
IKLKVLDKPG PPASVKINKM YSDRAMLSWE PPLEDGGSEI TNYIVDKRET SRPNWAQVSA
TVPITSCSVE KLIEGHEYQF RICAENKYGV GDPVFTEPAI AKNPYDPPGR CDPPVISNIT
KDHMTVSWKP PADDGGSPIT GYLLEKRETQ AVNWTKVNRK PIIERTLKAT GLQEGTEYEF
RVTAINKAGP GKPSDASKAA YARDPQYPPG PPAFPKVYDT TRSSVSLSWG KPAYDGGSPI
IGYLVEVKRA DSDNWVRCNL PQNLQKTRFE VTGLMEDTQY QFRVYAVNKI GYSDPSDVPD
KHYPKDILIP PEGELDADLR KTLILRAGVT MRLYVPVKGR PPPKITWSKP NVNLRDRIGL
DIKSTDFDTF LRCENVNKYD AGKYILTLEN SCGKKEYTIV VKVLDTPGPP VNVTVKEISK
DSAYVTWEPP IIDGGSPIIN YVVQKRDAER KSWSTVTTEC SKTSFRVANL EEGKSYFFRV
FAENEYGIGD PGETRDAVKA SQTPGPVVDL KVRSVSKSSC SIGWKKPHSD GGSRIIGYVV
DFLTEENKWQ RVMKSLSLQY SAKDLTEGKE YTFRVSAENE NGEGTPSEIT VVARDDVVAP
DLDLKGLPDL CYLAKENSNF RLKIPIKGKP APSVSWKKGE DPLATDTRVS VESSAVNTTL
IVYDCQKSDA GKYTITLKNV AGTKEGTISI KVVGKPGIPT GPIKFDEVTA EAMTLKWAPP
KDDGGSEITN YILEKRDSVN NKWVTCASAV QKTTFRVTRL HEGMEYTFRV SAENKYGVGE
GLKSEPIVAR HPFDVPDAPP PPNIVDVRHD SVSLTWTDPK KTGGSPITGY HLEFKERNSL
LWKRANKTPI RMRDFKVTGL TEGLEYEFRV MAINLAGVGK PSLPSEPVVA LDPIDPPGKP
EVINITRNSV TLIWTEPKYD GGHKLTGYIV EKRDLPSKSW MKANHVNVPE CAFTVTDLVE
GGKYEFRIRA KNTAGAISAP SESTETIICK DEYEAPTIVL DPTIKDGLTI KAGDTIVLNA
ISILGKPLPK SSWSKAGKDI RPSDITQITS TPTSSMLTIK YATRKDAGEY TITATNPFGT
KVEHVKVTVL DVPGPPGPVE ISNVSAEKAT LTWTPPLEDG GSPIKSYILE KRETSRLLWT
VVSEDIQSCR HVATKLIQGN EYIFRVSAVN HYGKGEPVQS EPVKMVDRFG PPGPPEKPEV
SNVTKNTATV SWKRPVDDGG SEITGYHVER REKKSLRWVR AIKTPVSDLR CKVTGLQEGS
TYEFRVSAEN RAGIGPPSEA SDSVLMKDAA YPPGPPSNPH VTDTTKKSAS LAWGKPHYDG
GLEITGYVVE HQKVGDEAWI KDTTGTALRI TQFVVPDLQT KEKYNFRISA INDAGVGEPA
VIPDVEIVER EMAPDFELDA ELRRTLVVRA GLSIRIFVPI KGRPAPEVTW TKDNINLKNR
ANIENTESFT LLIIPECNRY DTGKFVMTIE NPAGKKSGFV NVRVLDTPGP VLNLRPTDIT
KDSVTLHWDL PLIDGGSRIT NYIVEKREAT RKSYSTATTK CHKCTYKVTG LSEGCEYFFR
VMAENEYGIG EPTETTEPVK ASEAPSPPDS LNIMDITKST VSLAWPKPKH DGGSKITGYV
IEAQRKGSDQ WTHITTVKGL ECVVRNLTEG EEYTFQVMAV NSAGRSAPRE SRPVIVKEQT
MLPELDLRGI YQKLVIAKAG DNIKVEIPVL GRPKPTVTWK KGDQILKQTQ RVNFETTATS
TILNINECVR SDSGPYPLTA RNIVGEVGDV ITIQVHDIPG PPTGPIKFDE VSSDFVTFSW
DPPENDGGVP ISNYVVEMRQ TDSTTWVELA TTVIRTTYKA TRLTTGLEYQ FRVKAQNRYG
VGPGITSACI VANYPFKVPG PPGTPQVTAV TKDSMTISWH EPLSDGGSPI LGYHVERKER
NGILWQTVSK ALVPGNIFKS SGLTDGIAYE FRVIAENMAG KSKPSKPSEP MLALDPIDPP
GKPVPLNITR HTVTLKWAKP EYTGGFKITS YIVEKRDLPN GRWLKANFSN ILENEFTVSG
LTEDAAYEFR VIAKNAAGAI SPPSEPSDAI TCRDDVEAPK IKVDVKFKDT VILKAGEAFR
LEADVSGRPP PTMEWSKDGK ELEGTAKLEI KIADFSTNLV NKDSTRRDSG AYTLTATNPG
GFAKHIFNVK VLDRPGPPEG PLAVTEVTSE KCVLSWFPPL DDGGAKIDHY IVQKRETSRL
AWTNVASEVQ VTKLKVTKLL KGNEYIFRVM AVNKYGVGEP LESEPVLAVN PYGPPDPPKN
PEVTTITKDS MVVCWGHPDS DGGSEIINYI VERRDKAGQR WIKCNKKTLT DLRYKVSGLT
EGHEYEFRIM AENAAGISAP SPTSPFYKAC DTVFKPGPPG NPRVLDTSRS SISIAWNKPI
YDGGSEITGY MVEIALPEED EWQIVTPPAG LKATSYTITG LTENQEYKIR IYAMNSEGLG
EPALVPGTPK AEDRMLPPEI ELDADLRKVV TIRACCTLRL FVPIKGRPAP EVKWARDHGE
SLDKASIEST SSYTLLIVGN VNRFDSGKYI LTVENSSGSK SAFVNVRVLD TPGPPQDLKV
KEVTKTSVTL TWDPPLLDGG SKIKNYIVEK RESTRKAYST VATNCHKTSW KVDQLQEGCS
YYFRVLAENE YGIGLPAETA ESVKASERPL PPGKITLMDV TRNSVSLSWE KPEHDGGSRI
LGYIVEMQTK GSDKWATCAT VKVTEATITG LIQGEEYSFR VSAQNEKGIS DPRQLSVPVI
AKDLVIPPAF KLLFNTFTVL AGEDLKVDVP FIGRPTPAVT WHKDNVPLKQ TTRVNAESTE
NNSLLTIKDA CREDVGHYVV KLTNSAGEAI ETLNVIVLDK PGPPTGPVKM DEVTADSITL
SWGPPKYDGG SSINNYIVEK RDTSTTTWQI VSATVARTTI KACRLKTGCE YQFRIAAENR
YGKSTYLNSE PTVAQYPFKV PGPPGTPVVT LSSRDSMEVQ WNEPISDGGS RVIGYHLERK
ERNSILWVKL NKTPIPQTKF KTTGLEEGVE YEFRVSAENI VGIGKPSKVS ECYVARDPCD
PPGRPEAIIV TRNSVTLQWK KPTYDGGSKI TGYIVEKKEL PEGRWMKASF TNIIDTHFEV
TGLVEDHRYE FRVIARNAAG VFSEPSESTG AITARDEVDP PRISMDPKYK DTIVVHAGES
FKVDADIYGK PIPTIQWIKG DQELSNTARL EIKSTDFATS LSVKDAVRVD SGNYILKAKN
VAGERSVTVN VKVLDRPGPP EGPVVISGVT AEKCTLAWKP PLQDGGSDII NYIVERRETS
RLVWTVVDAN VQTLSCKVTK LLEGNEYTFR IMAVNKYGVG EPLESEPVVA KNPFVVPDAP
KAPEVTTVTK DSMIVVWERP ASDGGSEILG YVLEKRDKEG IRWTRCHKRL IGELRLRVTG
LIENHDYEFR VSAENAAGLS EPSPPSAYQK ACDPIYKPGP PNNPKVIDIT RSSVFLSWSK
PIYDGGCEIQ GYIVEKCDVS VGEWTMCTPP TGINKTNIEV EKLLEKHEYN FRICAINKAG
VGEHADVPGP IIVEEKLEAP DIDLDLELRK IINIRAGGSL RLFVPIKGRP TPEVKWGKVD
GEIRDAAIID VTSSFTSLVL DNVNRYDSGK YTLTLENSSG TKSAFVTVRV LDTPSPPVNL
KVTEITKDSV SITWEPPLLD GGSKIKNYIV EKREATRKSY AAVVTNCHKN SWKIDQLQEG
CSYYFRVTAE NEYGIGLPAQ TADPIKVAEV PQPPGKITVD DVTRNSVSLS WTKPEHDGGS
KIIQYIVEMQ AKHSEKWSEC ARVKSLQAVI TNLTQGEEYL FRVVAVNEKG RSDPRSLAVP
IVAKDLVIEP DVKPAFSSYS VQVGQDLKIE VPISGRPKPT ITWTKDGLPL KQTTRINVTD
SLDLTTLSIK ETHKDDGGQY GITVANVVGQ KTASIEIVTL DKPDPPKGPV KFDDVSAESI
TLSWNPPLYT GGCQITNYIV QKRDTTTTVW DVVSATVART TLKVTKLKTG TEYQFRIFAE
NRYGQSFALE SDPIVAQYPY KEPGPPGTPF ATAISKDSMV IQWHEPVNNG GSPVIGYHLE
RKERNSILWT KVNKTIIHDT QFKAQNLEEG IEYEFRVYAE NIVGVGKASK NSECYVARDP
CDPPGTPEPI MVKRNEITLQ WTKPVYDGGS MITGYIVEKR DLPDGRWMKA SFTNVIETQF
TVSGLTEDQR YEFRVIAKNA AGAISKPSDS TGPITAKDEV ELPRISMDPK FRDTIVVNAG
ETFRLEADVH GKPLPTIEWL RGDKEIEESA RCEIKNTDFK ALLIVKDAIR IDGGQYILRA
SNVAGSKSFP VNVKVLDRPG PPEGPVQVTG VTSEKCSLTW SPPLQDGGSD ISHYVVEKRE
TSRLAWTVVA SEVVTNSLKV TKLLEGNEYV FRIMAVNKYG VGEPLESAPV LMKNPFVLPG
PPKSLEVTNI AKDSMTVCWN RPDSDGGSEI IGYIVEKRDR SGIRWIKCNK RRITDLRLRV
TGLTEDHEYE FRVSAENAAG VGEPSPATVY YKACDPVFKP GPPTNAHIVD TTKNSITLAW
GKPIYDGGSE ILGYVVEICK ADEEEWQIVT PQTGLRVTRF EISKLTEHQE YKIRVCALNK
VGLGEATSVP GTVKPEDKLE APELDLDSEL RKGIVVRAGG SARIHIPFKG RPTPEITWSR
EEGEFTDKVQ IEKGVNYTQL SIDNCDRNDA GKYILKLENS SGSKSAFVTV KVLDTPGPPQ
NLAVKEVRKD SAFLVWEPPI IDGGAKVKNY VIDKRESTRK AYANVSSKCS KTSFKVENLT
EGAIYYFRVM AENEFGVGVP VETVDAVKAA EPPSPPGKVT LTDVSQTSAS LMWEKPEHDG
GSRVLGYVVE MQPKGTEKWS IVAESKVCNA VVTGLSSGQE YQFRVKAYNE KGKSDPRVLG
VPVIAKDLTI QPSLKLPFNT YSIQAGEDLK IEIPVIGRPR PNISWVKDGE PLKQTTRVNV
EETATSTVLH IKEGNKDDFG KYTVTATNSA GTATENLSVI VLEKPGPPVG PVRFDEVSAD
FVVISWEPPA YTGGCQISNY IVEKRDTTTT TWHMVSATVA RTTIKITKLK TGTEYQFRIF
AENRYGKSAP LDSKAVIVQY PFKEPGPPGT PFVTSISKDQ MLVQWHEPVN DGGTKIIGYH
LEQKEKNSIL WVKLNKTPIQ DTKFKTTGLD EGLEYEFKVS AENIVGIGKP SKVSECFVAR
DPCDPPGRPE AIVITRNNVT LKWKKPAYDG GSKITGYIVE KKDLPDGRWM KASFTNVLET
EFTVSGLVED QRYEFRVIAR NAAGNFSEPS DSSGAITARD EIDAPNASLD PKYKDVIVVH
AGETFVLEAD IRGKPIPDVV WSKDGKELEE TAARMEIKST IQKTTLVVKD CIRTDGGQYI
LKLSNVGGTK SIPITVKVLD RPGPPEGPLK VTGVTAEKCY LAWNPPLQDG GANISHYIIE
KRETSRLSWT QVSTEVQALN YKVTKLLPGN EYIFRVMAVN KYGIGEPLES GPVTACNPYK
PPGPPSTPEV SAITKDSMVV TWARPVDDGG TEIEGYILEK RDKEGVRWTK CNKKTLTDLR
LRVTGLTEGH SYEFRVAAEN AAGVGEPSEP SVFYRACDAL YPPGPPSNPK VTDTSRSSVS
LAWSKPIYDG GAPVKGYVVE VKEAAADEWT TCTPPTGLQG KQFTVTKLKE NTEYNFRICA
INSEGVGEPA TLPGSVVAQE RIEPPEIELD ADLRKVVVLR ASATLRLFVT IKGRPEPEVK
WEKAEGILTD RAQIEVTSSF TMLVIDNVTR FDSGRYNLTL ENNSGSKTAF VNVRVLDSPS
APVNLTIREV KKDSVTLSWE PPLIDGGAKI TNYIVEKRET TRKAYATITN NCTKTTFRIE
NLQEGCSYYF RVLASNEYGI GLPAETTEPV KVSEPPLPPG RVTLVDVTRN TATIKWEKPE
SDGGSKITGY VVEMQTKGSE KWSTCTQVKT LEATISGLTA GEEYVFRVAA VNEKGRSDPR
QLGVPVIARD IEIKPSVELP FHTFNVKARE QLKIDVPFKG RPQATVNWRK DGQTLKETTR
VNVSSSKTVT SLSIKEASKE DVGTYELCVS NSAGSITVPI TIIVLDRPGP PGPIRIDEVS
CDSITISWNP PEYDGGCQIS NYIVEKKETT STTWHIVSQA VARTSIKIVR LTTGSEYQFR
VCAENRYGKS SYSESSAVVA EYPFSPPGPP GTPKVVHATK STMLVTWQVP VNDGGSRVIG
YHLEYKERSS ILWSKANKIL IADTQMKVSG LDEGLMYEYR VYAENIAGIG KCSKSCEPVP
ARDPCDPPGQ PEVTNITRKS VSLKWSKPHY DGGAKITGYI VERRELPDGR WLKCNYTNIQ
ETYFEVTELT EDQRYEFRVF ARNAADSVSE PSESTGPIIV KDDVEPPRVM MDVKFRDVIV
VKAGEVLKIN ADIAGRPLPV ISWAKDGIEI EERARTEIIS TDNHTLLTVK DCIRRDTGQY
VLTLKNVAGT RSVAVNCKVL DKPGPPAGPL EINGLTAEKC SLSWGRPQED GGADIDYYIV
EKRETSHLAW TICEGELQMT SCKVTKLLKG NEYIFRVTGV NKYGVGEPLE SVAIKALDPF
TVPSPPTSLE ITSVTKESMT LCWSRPESDG GSEISGYIIE RREKNSLRWV RVNKKPVYDL
RVKSTGLREG CEYEYRVYAE NAAGLSLPSE TSPLIRAEDP VFLPSPPSKP KIVDSGKTTI
TIAWVKPLFD GGAPITGYTV EYKKSDDTDW KTSIQSLRGT EYTISGLTTG AEYVFRVKSV
NKVGASDPSD SSDPQIAKER EEEPLFDIDS EMRKTLIVKA GASFTMTVPF RGRPVPNVLW
SKPDTDLRTR AYVDTTDSRT SLTIENANRN DSGKYTLTIQ NVLSAASLTL VVKVLDTPGP
PTNITVQDVT KESAVLSWDV PENDGGAPVK NYHIEKREAS KKAWVSVTNN CNRLSYKVTN
LQEGAIYYFR VSGENEFGVG IPAETKEGVK ITEKPSPPEK LGVTSISKDS VSLTWLKPEH
DGGSRIVHYV VEALEKGQKN WVKCAVAKST HHVVSGLREN SEYFFRVFAE NQAGLSDPRE
LLLPVLIKEQ LEPPEIDMKN FPSHTVYVRA GSNLKVDIPI SGKPLPKVTL SRDGVPLKAT
MRFNTEITAE NLTINLKESV TADAGRYEIT AANSSGTTKA FINIVVLDRP GPPTGPVVIS
DITEESVTLK WEPPKYDGGS QVTNYILLKR ETSTAVWTEV SATVARTMMK VMKLTTGEEY
QFRIKAENRF GISDHIDSAC VTVKLPYTTP GPPSTPWVTN VTRESITVGW HEPVSNGGSA
VVGYHLEMKD RNSILWQKAN KLVIRTTHFK VTTISAGLIY EFRVYAENAA GVGKPSHPSE
PVLAIDACEP PRNVRITDIS KNSVSLSWQQ PAFDGGSKIT GYIVERRDLP DGRWTKASFT
NVTETQFIIS GLTQNSQYEF RVFARNAVGS ISNPSEVVGP ITCIDSYGGP VIDLPLEYTE
VVKYRAGTSV KLRAGISGKP APTIEWYKDD KELQTNALVC VENTTDLASI LIKDADRLNS
GCYELKLRNA MGSASATIRV QILDKPGPPG GPIEFKTVTA EKITLLWRPP ADDGGAKITH
YIVEKRETSR VVWSMVSEHL EECIITTTKI IKGNEYIFRV RAVNKYGIGE PLESDSVVAK
NAFVTPGPPG IPEVTKITKN SMTVVWSRPI ADGGSDISGY FLEKRDKKSL GWFKVLKETI
RDTRQKVTGL TENSDYQYRV CAVNAAGQGP FSEPSEFYKA ADPIDPPGPP AKIRIADSTK
SSITLGWSKP VYDGGSAVTG YVVEIRQGEE EEWTTVSTKG EVRTTEYVVS NLKPGVNYYF
RVSAVNCAGQ GEPIEMNEPV QAKDILEAPE IDLDVALRTS VIAKAGEDVQ VLIPFKGRPP
PTVTWRKDEK NLGSDARYSI ENTDSSSLLT IPQVTRNDTG KYILTIENGV GEPKSSTVSV
KVLDTPAACQ KLQVKHVSRG TVTLLWDPPL IDGGSPIINY VIEKRDATKR TWSVVSHKCS
STSFKLIDLS EKTPFFFRVL AENEIGIGEP CETTEPVKAA EVPAPIRDLS MKDSTKTSVI
LSWTKPDFDG GSVITEYVVE RKGKGEQTWS HAGISKTCEI EVSQLKEQSV LEFRVFAKNE
KGLSDPVTIG PITVKELIIT PEVDLSDIPG AQVTVRIGHN VHLELPYKGK PKPSISWLKD
GLPLKESEFV RFSKTENKIT LSIKNAKKEH GGKYTVILDN AVCRIAVPIT VITLGPPSKP
KGPIRFDEIK ADSVILSWDV PEDNGGGEIT CYSIEKRETS QTNWKMVCSS VARTTFKVPN
LVKDAEYQFR VRAENRYGVS QPLVSSIIVA KHQFRIPGPP GKPVIYNVTS DGMSLTWDAP
VYDGGSEVTG FHVEKKERNS ILWQKVNTSP ISGREYRATG LVEGLDYQFR VYAENSAGLS
SPSDPSKFTL AVSPVDPPGT PDYIDVTRET ITLKWNPPLR DGGSKIVGYS IEKRQGNERW
VRCNFTDVSE CQYTVTGLSP GDRYEFRIIA RNAVGTISPP SQSSGIIMTR DENVPPIVEF
GPEYFDGLII KSGESLRIKA LVQGRPVPRV TWFKDGVEIE KRMNMEITDV LGSTSLFVRD
ATRDHRGVYT VEAKNASGSA KAEIKVKVQD TPGKVVGPIR FTNITGEKMT LWWDAPLNDG
CAPITHYIIE KRETSRLAWA LIEDKCEAQS YTAIKLINGN EYQFRVSAVN KFGVGRPLDS
DPVVAQIQYT VPDAPGIPEP SNITGNSITL TWARPESDGG SEIQQYILER REKKSTRWVK
VISKRPISET RFKVTGLTEG NEYEFHVMAE NAAGVGPASG ISRLIKCREP VNPPGPPTVV
KVTDTSKTTV SLEWSKPVFD GGMEIIGYII EMCKADLGDW HKVNAEACVK TRYTVTDLQA
GEEYKFRVSA INGAGKGDSC EVTGTIKAVD RLTAPELDID ANFKQTHVVR AGASIRLFIA
YQGRPTPTAV WSKPDSNLSL RADIHTTDSF STLTVENCNR NDAGKYTLTV ENNSGSKSIT
FTVKVLDTPG PPGPITFKDV TRGSATLMWD APLLDGGARI HHYVVEKREA SRRSWQVISE
KCTRQIFKVN DLAEGVPYYF RVSAVNEYGV GEPYEMPEPI VATEQPAPPR RLDVVDTSKS
SAVLAWLKPD HDGGSRITGY LLEMRQKGSD FWVEAGHTKQ LTFTVERLVE KTEYEFRVKA
KNDAGYSEPR EAFSSVIIKE PQIEPTADLT GITNQLITCK AGSPFTIDVP ISGRPAPKVT
WKLEEMRLKE TDRVSITTTK DRTTLTVKDS MRGDSGRYFL TLENTAGVKT FSVTVVVIGR
PGPVTGPIEV SSVSAESCVL SWGEPKDGGG TEITNYIVEK RESGTTAWQL VNSSVKRTQI
KVTHLTKYME YSFRVSSENR FGVSKPLESA PIIAEHPFVP PSAPTRPEVY HVSANAMSIR
WEEPYHDGGS KIIGYWVEKK ERNTILWVKE NKVPCLECNY KVTGLVEGLE YQFRTYALNA
AGVSKASEAS RPIMAQNPVD APGRPEVTDV TRSTVSLIWS APAYDGGSKV VGYIIERKPV
SEVGDGRWLK CNYTIVSDNF FTVTALSEGD TYEFRVLAKN AAGVISKGSE STGPVTCRDE
YAPPKAELDA RLHGDLVTIR AGSDLVLDAA VGGKPEPKII WTKGDKELDL CEKVSLQYTG
KRATAVIKFC DRSDSGKYTL TVKNASGTKA VSVMVKVLDS PGPCGKLTVS RVTQEKCTLA
WSLPQEDGGA EITHYIVERR ETSRLNWVIV EGECPTLSYV VTRLIKNNEY IFRVRAVNKY
GPGVPVESEP IVARNSFTIP SPPGIPEEVG TGKEHIIIQW TKPESDGGNE ISNYLVDKRE
KKSLRWTRVN KDYVVYDTRL KVTSLMEGCD YQFRVTAVNA AGNSEPSEAS NFISCREPSY
TPGPPSAPRV VDTTKHSISL AWTKPMYDGG TDIVGYVLEM QEKDTDQWYR VHTNATIRNT
EFTVPDLKMG QKYSFRVAAV NVKGMSEYSE SIAEIEPVER IEIPDLELAD DLKKTVTIRA
GASLRLMVSV SGRPPPVITW SKQGIDLASR AIIDTTESYS LLIVDKVNRY DAGKYTIEAE
NQSGKKSATV LVKVYDTPGP CPSVKVKEVS RDSVTITWEI PTIDGGAPVN NYIVEKREAA
MRAFKTVTTK CSKTLYRISG LVEGTMYYFR VLPENIYGIG EPCETSDAVL VSEVPLVPAK
LEVVDVTKST VTLAWEKPLY DGGSRLTGYV LEACKAGTER WMKVVTLKPT VLEHTVTSLN
EGEQYLFRIR AQNEKGVSEP RETVTAVTVQ DLRVLPTIDL STMPQKTIHV PAGRPVELVI
PIAGRPPPAA SWFFAGSKLR ESERVTVETH TKVAKLTIRE TTIRDTGEYT LELKNVTGTT
SETIKVIILD KPGPPTGPIK IDEIDATSIT ISWEPPELDG GAPLSGYVVE QRDAHRPGWL
PVSESVTRST FKFTRLTEGN EYVFRVAATN RFGIGSYLQS EVIECRSSIR IPGPPETLQI
FDVSRDGMTL TWYPPEDDGG SQVTGYIVER KEVRADRWVR VNKVPVTMTR YRSTGLTEGL
EYEHRVTAIN ARGSGKPSRP SKPIVAMDPI APPGKPQNPR VTDTTRTSVS LAWSVPEDEG
GSKVTGYLIE MQKVDQHEWT KCNTTPTKIR EYTLTHLPQG AEYRFRVLAC NAGGPGEPAE
VPGTVKVTEM LEYPDYELDE RYQEGIFVRQ GGVIRLTIPI KGKPFPICKW TKEGQDISKR
AMIATSETHT ELVIKEADRG DSGTYDLVLE NKCGKKAVYI KVRVIGSPNS PEGPLEYDDI
QVRSVRVSWR PPADDGGADI LGYILERREV PKAAWYTIDS RVRGTSLVVK GLKENVEYHF
RVSAENQFGI SKPLKSEEPV TPKTPLNPPE PPSNPPEVLD VTKSSVSLSW SRPKDDGGSR
VTGYYIERKE TSTDKWVRHN KTQITTTMYT VTGLVPDAEY QFRIIAQNDV GLSETSPASE
PVVCKDPFDK PSQPGELEIL SISKDSVTLQ WEKPECDGGK EILGYWVEYR QSGDSAWKKS
NKERIKDKQF TIGGLLEATE YEFRVFAENE TGLSRPRRTA MSIKTKLTSG EAPGIRKEMK
DVTTKLGEAA QLSCQIVGRP LPDIKWYRFG KELIQSRKYK MSSDGRTHTL TVMTEEQEDE
GVYTCIATNE VGEVETSSKL LLQATPQFHP GYPLKEKYYG AVGSTLRLHV MYIGRPVPAM
TWFHGQKLLQ NSENITIENT EHYTHLVMKN VQRKTHAGKY KVQLSNVFGT VDAILDVEIQ
DKPDKPTGPI VIEALLKNSA VISWKPPADD GGSWITNYVV EKCEAKEGAE WQLVSSAISV
TTCRIVNLTE NAGYYFRVSA QNTFGISDPL EVSSVVIIKS PFEKPGAPGK PTITAVTKDS
CVVAWKPPAS DGGAKIRNYY LEKREKKQNK WISVTTEEIR ETVFSVKNLI EGLEYEFRVK
CENLGGESEW SEISEPITPK SDVPIQAPHF KEELRNLNVR YQSNATLVCK VTGHPKPIVK
WYRQGKEIIA DGLKYRIQEF KGGYHQLIIA SVTDDDATVY QVRATNQGGS VSGTASLEVE
VPAKIHLPKT LEGMGAVHAL RGEVVSIKIP FSGKPDPVIT WQKGQDLIDN NGHYQVIVTR
SFTSLVFPNG VERKDAGFYV VCAKNRFGID QKTVELDVAD VPDPPRGVKV SDVSRDSVNL
TWTEPASDGG SKITNYIVEK CATTAERWLR VGQARETRYT VINLFGKTSY QFRVIAENKF
GLSKPSEPSE PTITKEDKTR AMNYDEEVDE TREVSMTKAS HSSTKELYEK YMIAEDLGRG
EFGIVHRCVE TSSKKTYMAK FVKVKGTDQV LVKKEISILN IARHRNILHL HESFESMEEL
VMIFEFISGL DIFERINTSA FELNEREIVS YVHQVCEALQ FLHSHNIGHF DIRPENIIYQ
TRRSSTIKII EFGQARQLKP GDNFRLLFTA PEYYAPEVHQ HDVVSTATDM WSLGTLVYVL
LSGINPFLAE TNQQIIENIM NAEYTFDEEA FKEISIEAMD FVDRLLVKER KSRMTASEAL
QHPWLKQKIE RVSTKVIRTL KHRRYYHTLI KKDLNMVVSA ARISCGGAIR SQKGVSVAKV
KVASIEIGPV SGQIMHAVGE EGGHVKYVCK IENYDQSTQV TWYFGVRQLE NSEKYEITYE
DGVAILYVKD ITKLDDGTYR CKVVNDYGED SSYAELFVKG VREVYDYYCR RTMKKIKRRT
DTMRLLERPP EFTLPLYNKT AYVGENVRFG VTITVHPEPH VTWYKSGQKI KPGDNDKKYT
FESDKGLYQL TINSVTTDDD AEYTVVARNK YGEDSCKAKL TVTLHPPPTD STLRPMFKRL
LANAECQEGQ SVCFEIRVSG IPPPTLKWEK DGQPLSLGPN IEIIHEGLDY YALHIRDTLP
EDTGYYRVTA TNTAGSTSCQ AHLQVERLRY KKQEFKSKEE HERHVQKQID KTLRMAEILS
GTESVPLTQV AKEALREAAV LYKPAVSTKT VKGEFRLEIE EKKEERKLRM PYDVPEPRKY
KQTTIEEDQR IKQFVPMSDM KWYKKIRDQY EMPGKLDRVV QKRPKRIRLS RWEQFYVMPL
PRITDQYRPK WRIPKLSQDD LEIVRPARRR TPSPDYDFYY RPRRRSLGDI SDEELLLPID
DYLAMKRTEE ERLRLEEELE LGFSASPPSR SPPHFELSSL RYSSPQAHVK VEETRKDFRY
STYHIPTKAE ASTSYAELRE RHAQAAYRQP KQRQRIMAER EDEELLRPVT TTQHLSEYKS
ELDFMSKEEK SRKKSRRQRE VTEITEIEEE YEISKHAQRE SSSSASRLLR RRRSLSPTYI
ELMRPVSELI RSRPQPAEEY EDDTERRSPT PERTRPRSPS PVSSERSLSR FERSARFDIF
SRYESMKAAL KTQKTSERKY EVLSQQPFTL DHAPRITLRM RSHRVPCGQN TRFILNVQSK
PTAEVKWYHN GVELQESSKI HYTNTSGVLT LEILDCHTDD SGTYRAVCTN YKGEASDYAT
LDVTGGDYTT YASQRRDEEV PRSVFPELTR TEAYAVSSFK KTSEMEASSS VREVKSQMTE
TRESLSSYEH SASAEMKSAA LEEKSLEEKS TTRKIKTTLA ARILTKPRSM TVYEGESARF
SCDTDGEPVP TVTWLRKGQV LSTSARHQVT TTKYKSTFEI SSVQASDEGN YSVVVENSEG
KQEAEFTLTI QKARVTEKAV TSPPRVKSPE PRVKSPEAVK SPKRVKSPEP SHPKAVSPTE
TKPTPTEKVQ HLPVSAPPKI TQFLKAEASK EIAKLTCVVE SSVLRAKEVT WYKDGKKLKE
NGHFQFHYSA DGTYELKINN LTESDQGEYV CEISGEGGTS KTNLQFMGQA FKSIHEKVSK
ISETKKSDQK TTESTVTRKT EPKAPEPISS KPVIVTGLQD TTVSSDSVAK FAVKATGEPR
PTAIWTKDGK AITQGGKYKL SEDKGGFFLE IHKTDTSDSG LYTCTVKNSA GSVSSSCKLT
IKAIKDTEAQ KVSTQKTSEI TPQKKAVVQE EISQKALRSE EIKMSEAKSQ EKLALKEEAS
KVLISEEVKK SAATSLEKSI VHEEITKTSQ ASEEVRTHAE IKAFSTQMSI NEGQRLVLKA
NIAGATDVKW VLNGVELTNS EEYRYGVSGS DQTLTIKQAS HRDEGILTCI SKTKEGIVKC
QYDLTLSKEL SDAPAFISQP RSQNINEGQN VLFTCEISGE PSPEIEWFKN NLPISISSNV
SISRSRNVYS LEIRNASVSD SGKYTIKAKN FRGQCSATAS LMVLPLVEEP SREVVLRTSG
DTSLQGSFSS QSVQMSASKQ EASFSSFSSS SASSMTEMKF ASMSAQSMSS MQESFVEMSS
SSFMGISNMT QLESSTSKML KAGIRGIPPK IEALPSDISI DEGKVLTVAC AFTGEPTPEV
TWSCGGRKIH SQEQGRFHIE NTDDLTTLII MDVQKQDGGL YTLSLGNEFG SDSATVNIHI
RSI*

Mutated AA sequence

Position of stopcodon in wt / mu CDS

N/A

Position (AA) of stopcodon in wt / mu AA sequence

N/A

Position of stopcodon in wt / mu cDNA

N/A

Position of start ATG in wt / mu cDNA

226 / 226

Last intron/exon boundary

100201

Theoretical NMD boundary in CDS

99925

Length of CDS

100272

Coding sequence (CDS) position

N/A

cDNA position

N/A

gDNA position

84919

Chromosomal position

178745884

Speed

0.06 s

MutationT@ster 2025

Transcript summary:

MutationT@ster 2025

Variant:

2:178745884C>A_12_ENST00000360870

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_6_ENST00000426232

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_7_ENST00000436599

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_8_ENST00000446966

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_5_ENST00000425332

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_11_ENST00000412264

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_9_ENST00000460472

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_1_ENST00000342175

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_2_ENST00000359218

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_3_ENST00000715174

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_10_ENST00000589042

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_13_ENST00000591111

Prediction:

Summary:

MutationT@ster 2025

Variant:

2:178745884C>A_4_ENST00000342992

Prediction:

Summary: