| Transcript | Gene symbol | Prediction | Tree vote | Model | Prediction problem | Splice site change | Known ClinVar disease mutation | Potential ClinVar disease mutation | Amino acid changes | Variant type | dbSNP ID | Protein length | Features at a glance |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MUC16 | Benign | 7|93 | simple_ | No | Single base exchange | Normal |
| ||||||
| MUC16 | Benign | 7|93 | simple_ | No | Single base exchange | Normal |
| ||||||
| MUC16 | Benign | 7|93 | simple_ | No | Single base exchange | Normal |
| ||||||
| MUC16 | Benign | 38|62 | simple_ | No | Single base exchange | Normal |
|
| Analysed issue | Analysis result | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | Chr19:8964541T>A (GRCh38) | |||||||||||||
| Gene symbol | MUC16 | |||||||||||||
| Gene constraints | no data | |||||||||||||
| Ensembl transcript ID | ENST00000711672.1 | |||||||||||||
| Genbank transcript ID | NM_001414686 (by similarity) | |||||||||||||
| UniProt / AlphaMissense peptide | N/A | |||||||||||||
| Variant type | Single base exchange | |||||||||||||
| Gene region | CDS | |||||||||||||
| DNA changes | c.12349A>T g.45850A>T | |||||||||||||
| AA changes |
| |||||||||||||
| Frameshift | No | |||||||||||||
| Length of protein | Normal | |||||||||||||
| Pathogenic variant (ClinVar) | Variant not listed in ClinVar as (likely) pathogenic. | |||||||||||||
| Variant DBs |
| |||||||||||||
| Protein conservation | ||||||||||||||
| Protein features | N/A | |||||||||||||
| Phylogenetic conservation |
| |||||||||||||
| Splice sites | No abrogation of potential splice sites predicted by MaxEntScan. | |||||||||||||
| Distance from splice site | N/A | |||||||||||||
| Kozak consensus sequence altered? | No | |||||||||||||
| poly(A) signal | N/A | |||||||||||||
| AA sequence altered | Yes | |||||||||||||
| Chromosome | 19 | |||||||||||||
| Strand | -1 | |||||||||||||
| Original gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Original cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Wildtype AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSTPMTSM FSPRPLVSVS PTPSATGYNR RYWTPATSTP VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS ATAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTTAGPL LMPFTLNFTI TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTSSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL TLLRSEKDGA ATGVDAICTH RLDPKSPGVD REQLYWELSQ LTNGIKELGP YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTTAGPLL VPFTLNFTIT NLKYEEDMHC PGSRKFNTTE RVLQSLLGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMHHPGSR KFNTTERVLQ GLLGPMFKNT SVGLLYSGCR LTLLRPEKNG AATGMDAICS HRLDPKSPGL NREQLYWELS QLTHGIKELG PYTLDRNSLY VNGFTHRSSV APTSTPGTST VDLGTSGTPS SLPSPTTAVP LLVPFTLNFT ITNLQYGEDM RHPGSRKFNT TERVLQGLLG PLFKNSSVGP LYSGCRLISL RSEKDGAATG VDAICTHHLN PQSPGLDREQ LYWQLSQMTN GIKELGPYTL DRNSLYVNGF THRSSGLTTS TPWTSTVDLG TSGTPSPVPS PTTTGPLLVP FTLNFTITNL QYEENMGHPG SRKFNITESV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK DGVATRVDAI CTHRPDPKIP GLDRQQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSTPGT FTVQPETSET PSSLPGPTAT GPVLLPFTLN FTITNLQYEE DMRRPGSRKF NTTERVLQGL LMPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLDR ERLYWKLSQL THGITELGPY TLDRHSLYVN GFTHQSSMTT TRTPDTSTMH LATSRTPASL SGPMTASPLL VLFTINFTIT NLRYEENMHH PGSRKFNTTE RVLQGLLRPV FKNTSVGPLY SGCRLTLLRP KKDGAATKVD AICTYRPDPK SPGLDREQLY WELSQLTHSI TELGPYTLDR DSLYVNGFTQ RSSVPTTSIP GTPTVDLGTS GTPVSKPGPS AASPLLVLFT LNFTITNLRY EENMQHPGSR KFNTTERVLQ GLLRSLFKST SVGPLYSGCR LTLLRPEKDG TATGVDAICT HHPDPKSPRL DREQLYWELS QLTHNITELG PYALDNDSLF VNGFTHRSSV STTSTPGTPT VYLGASKTPA SIFGPSAASH LLILFTLNFT ITNLRYEENM WPGSRKFNTT ERVLQGLLRP LFKNTSVGPL YSGCRLTLLR PEKDGEATGV DAICTHRPDP TGPGLDREQL YLELSQLTHS ITELGPYTLD RDSLYVNGFT HRSSVPTTST GVVSEEPFTL NFTINNLRYM ADMGQPGSLK FNITDNVMQH LLSPLFQRSS LGARYTGCRV IALRSVKNGA ETRVDLLCTY LQPLSGPGLP IKQVFHELSQ QTHGITRLGP YSLDKDSLYL NGYNEPGPDE PPTTPKPATT FLPPLSEATT AMGYHLKTLT LNFTISNLQY SPDMGKGSAT FNSTEGVLQH LLRPLFQKSS MGPFYLGCQL ISLRPEKDGA ATGVDTTCTY HPDPVGPGLD IQQLYWELSQ LTHGVTQLGF YVLDRDSLFI NGYAPQNLSI RGEYQINFHI VNWNLSNPDP TSSEYITLLR DIQDKVTTLY KGSQLHDTFR FCLVTNLTMD SVLVTVKALF SSNLDPSLVE QVFLDKTLNA SFHWLGSTYQ LVDIHVTEME SSVYQPTSSS STQHFYLNFT ITNLPYSQDK AQPGTTNYQR NKRNIEDALN QLFRNSSIKS YFSDCQVSTF RSVPNRHHTG VDSLCNFSPL ARRVDRVAIY EEFLRMTRNG TQLQNFTLDR SSVLVDGYSP NRNEPLTGNS DLPFWAVILI GLAGLLGVIT CLICGVLVTT RRRKKEGEYN VQQQCPGYYQ SHLDLEDLQ* | |||||||||||||
| Mutated AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAISRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSTPMTSM FSPRPLVSVS PTPSATGYNR RYWTPATSTP VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS ATAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTTAGPL LMPFTLNFTI TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTSSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL TLLRSEKDGA ATGVDAICTH RLDPKSPGVD REQLYWELSQ LTNGIKELGP YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTTAGPLL VPFTLNFTIT NLKYEEDMHC PGSRKFNTTE RVLQSLLGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMHHPGSR KFNTTERVLQ GLLGPMFKNT SVGLLYSGCR LTLLRPEKNG AATGMDAICS HRLDPKSPGL NREQLYWELS QLTHGIKELG PYTLDRNSLY VNGFTHRSSV APTSTPGTST VDLGTSGTPS SLPSPTTAVP LLVPFTLNFT ITNLQYGEDM RHPGSRKFNT TERVLQGLLG PLFKNSSVGP LYSGCRLISL RSEKDGAATG VDAICTHHLN PQSPGLDREQ LYWQLSQMTN GIKELGPYTL DRNSLYVNGF THRSSGLTTS TPWTSTVDLG TSGTPSPVPS PTTTGPLLVP FTLNFTITNL QYEENMGHPG SRKFNITESV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK DGVATRVDAI CTHRPDPKIP GLDRQQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSTPGT FTVQPETSET PSSLPGPTAT GPVLLPFTLN FTITNLQYEE DMRRPGSRKF NTTERVLQGL LMPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLDR ERLYWKLSQL THGITELGPY TLDRHSLYVN GFTHQSSMTT TRTPDTSTMH LATSRTPASL SGPMTASPLL VLFTINFTIT NLRYEENMHH PGSRKFNTTE RVLQGLLRPV FKNTSVGPLY SGCRLTLLRP KKDGAATKVD AICTYRPDPK SPGLDREQLY WELSQLTHSI TELGPYTLDR DSLYVNGFTQ RSSVPTTSIP GTPTVDLGTS GTPVSKPGPS AASPLLVLFT LNFTITNLRY EENMQHPGSR KFNTTERVLQ GLLRSLFKST SVGPLYSGCR LTLLRPEKDG TATGVDAICT HHPDPKSPRL DREQLYWELS QLTHNITELG PYALDNDSLF VNGFTHRSSV STTSTPGTPT VYLGASKTPA SIFGPSAASH LLILFTLNFT ITNLRYEENM WPGSRKFNTT ERVLQGLLRP LFKNTSVGPL YSGCRLTLLR PEKDGEATGV DAICTHRPDP TGPGLDREQL YLELSQLTHS ITELGPYTLD RDSLYVNGFT HRSSVPTTST GVVSEEPFTL NFTINNLRYM ADMGQPGSLK FNITDNVMQH LLSPLFQRSS LGARYTGCRV IALRSVKNGA ETRVDLLCTY LQPLSGPGLP IKQVFHELSQ QTHGITRLGP YSLDKDSLYL NGYNEPGPDE PPTTPKPATT FLPPLSEATT AMGYHLKTLT LNFTISNLQY SPDMGKGSAT FNSTEGVLQH LLRPLFQKSS MGPFYLGCQL ISLRPEKDGA ATGVDTTCTY HPDPVGPGLD IQQLYWELSQ LTHGVTQLGF YVLDRDSLFI NGYAPQNLSI RGEYQINFHI VNWNLSNPDP TSSEYITLLR DIQDKVTTLY KGSQLHDTFR FCLVTNLTMD SVLVTVKALF SSNLDPSLVE QVFLDKTLNA SFHWLGSTYQ LVDIHVTEME SSVYQPTSSS STQHFYLNFT ITNLPYSQDK AQPGTTNYQR NKRNIEDALN QLFRNSSIKS YFSDCQVSTF RSVPNRHHTG VDSLCNFSPL ARRVDRVAIY EEFLRMTRNG TQLQNFTLDR SSVLVDGYSP NRNEPLTGNS DLPFWAVILI GLAGLLGVIT CLICGVLVTT RRRKKEGEYN VQQQCPGYYQ SHLDLEDLQ* | |||||||||||||
| Position of stopcodon in wt / mu CDS | 43710 / 43710 | |||||||||||||
| Position (AA) of stopcodon in wt / mu AA sequence | 14570 / 14570 | |||||||||||||
| Position of stopcodon in wt / mu cDNA | 43744 / 43744 | |||||||||||||
| Position of start ATG in wt / mu cDNA | 35 / 35 | |||||||||||||
| Last intron/exon boundary | 43645 | |||||||||||||
| Theoretical NMD boundary in CDS | 43560 | |||||||||||||
| Length of CDS | 43710 | |||||||||||||
| Coding sequence (CDS) position | 12349 | |||||||||||||
| cDNA position | 12383 | |||||||||||||
| gDNA position | 45850 | |||||||||||||
| Chromosomal position | 8964541 | |||||||||||||
| Speed | 0.16 s | |||||||||||||
All positions are in basepairs (bp) if not explicitly stated differently. cDNA/gDNA/chromosomal position: Ins/del are shown as 'last normal base / first normal base'.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
| Analysed issue | Analysis result | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | Chr19:8964541T>A (GRCh38) | |||||||||||||
| Gene symbol | MUC16 | |||||||||||||
| Gene constraints | no data | |||||||||||||
| Ensembl transcript ID | ENST00000710610.1 | |||||||||||||
| Genbank transcript ID | ||||||||||||||
| UniProt / AlphaMissense peptide | N/A | |||||||||||||
| Variant type | Single base exchange | |||||||||||||
| Gene region | CDS | |||||||||||||
| DNA changes | c.3055A>T g.45850A>T | |||||||||||||
| AA changes |
| |||||||||||||
| Frameshift | No | |||||||||||||
| Length of protein | Normal | |||||||||||||
| Pathogenic variant (ClinVar) | Variant not listed in ClinVar as (likely) pathogenic. | |||||||||||||
| Variant DBs |
| |||||||||||||
| Protein conservation | ||||||||||||||
| Protein features | N/A | |||||||||||||
| Phylogenetic conservation |
| |||||||||||||
| Splice sites | No abrogation of potential splice sites predicted by MaxEntScan. | |||||||||||||
| Distance from splice site | N/A | |||||||||||||
| Kozak consensus sequence altered? | No | |||||||||||||
| poly(A) signal | N/A | |||||||||||||
| AA sequence altered | Yes | |||||||||||||
| Chromosome | 19 | |||||||||||||
| Strand | -1 | |||||||||||||
| Original gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Original cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Wildtype AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA ATDGTLVTTI KMSSQAAQGN STWPAPAEET GSSPAGTSPG SPEMSTTLKI MSSKEPSISP EIRSTVRNSP WKTPETTVPM ETTVEPVTLQ STALGSGSTS ISHLPTGTTS PTKSPTENML ATERVSLSPS PPEAWTNLYS GTPGGTRQSL ATMSSVSLES PTARSITGTG QQSSPELVSK TTGMEFSMWH GSTGGTTGDT HVSLSTSSNI LEDPVTSPNS VSSLTDKSKH KTETWVSTTA IPSTVLNNKI MAAEQQTSRS VDEAYSSTSS WSDQTSGSDI TLGASPDVTN TLYITSTAQT TSLVSLPSGD QGITSLTNPS GGKTSSASSV TSPSIGLETL RANVSAVKSD IAPTAGHLSQ TSSPAEVSIL DVTTAPTPGI STTITTMGTN SISTTTPNPE VGMSTMDSTP ATERRTTSTE HPSTWSSTAA SDSWTVTDMT SNLKVARSPG TISTMHTTSF LASSTELDSM STPHGRITVI GTSLVTPSSD ASAVKTETST SERTLSPSDT TASTPISTFS RVQRMSISVP DILSTSWTPS STEAEDVPVS MVSTDHASTK TDPNTPLSTF LFDSLSTLDW DTGRSLSSAT ATTSAPQGAT TPQELTLETM ISPATSQLPF SIGHITSAVT PAAMARSSGV TFSRPDPTSK KAEQTSTQLP TTTSAHPGQV PRSAATTLDV IPHTAKTPDA TFQRQGQTAL TTEARATSDS WNEKEKSTPS APWITEMMNS VSEDTIKEVT SSSSVLRTLN TLDINLESGT TSSPSWKSSP YERIAPSEST TDKEAIHPST NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR TEITSSKRIS SSFLAQSMRS SDSPSEAITR LSNFPAMTES GGMILAMQTS PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VSWTSPPSVA ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPEPVTSSPP NLSSPTQERL TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS INTAVANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE MESTFSLAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT SPEPTTSSPP NLSSTSHEIL TTDEDTTAIE AMHPSTSTAA TNVETTSSGH GSQSSVLADS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSSGHESPSS ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL SAMISPSPVS STLPASSHSS SASVTSLLTP GQVKTTEVLD ASAEPETSSP PSLSSTSVEI LATSEVTTDT EKIHPFSNTA VTKVGTSSSG HESPSSVLPD SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT ESAEITMNTH TSPLGATTQG TSTLDTSSTT SLTMTHSTIS QGFSHSQMST LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS LLNPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP WPSLPSVEEA SSVSSSLSSP AMTSTSFFST LPESISSSPH PVTALLTLGP VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP DQSTMSQDIS TEVITRLSTS PIKTESTEMT ITTQTGSPGA TSRGTLTLDT STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS SPPNLSSTSA EILAITEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE SLAASKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST ETSTVLYKMP SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL YGVPTSATTE VSMTEIMSSN RIHIPDSDQS TMSPDIITEV ITRLSSSSMM SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT LMSRSPENPS WKSSLFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSSPILD TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV YTPTLGTLTP LNASMQMAST IPTEMMITTP YVFPDVPETT SSLATSLGAE TSTALPRTTP SVFNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET NTMVPRTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS LVPSSGTDTS TTFPTLSETP YEPETTATWL THPAETSTTV SGTIPNFSHR GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTETSKTFPA STVFPQVSET TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS ATAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTTAGPL LMPFTLNFTI TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTSSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL TLLRSEKDGA ATGVDAICTH RLDPKSPGVD REQLYWELSQ LTNGIKELGP YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTTAGPLL VPFTLNFTIT NLKYEEDMHC PGSRKFNTTE RVLQSLLGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMHHPGSR KFNTTERVLQ GLLGPMFKNT SVGLLYSGCR LTLLRPEKNG AATGMDAICS HRLDPKSPGL NREQLYWELS QLTHGIKELG PYTLDRNSLY VNGFTHRSSV APTSTPGTST VDLGTSGTPS SLPSPTTAVP LLVPFTLNFT ITNLQYGEDM RHPGSRKFNT TERVLQGLLG PLFKNSSVGP LYSGCRLISL RSEKDGAATG VDAICTHHLN PQSPGLDREQ LYWQLSQMTN GIKELGPYTL DRNSLYVNGF THRSSGLTTS TPWTSTVDLG TSGTPSPVPS PTTTGPLLVP FTLNFTITNL QYEENMGHPG SRKFNITESV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK DGVATRVDAI CTHRPDPKIP GLDRQQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSTPGT FTVQPETSET PSSLPGPTAT GPVLLPFTLN FTITNLQYEE DMRRPGSRKF NTTERVLQGL LMPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLDR ERLYWKLSQL THGITELGPY TLDRHSLYVN GFTHQSSMTT TRTPDTSTMH LATSRTPASL SGPMTASPLL VLFTINFTIT NLRYEENMHH PGSRKFNTTE RVLQGLLRPV FKNTSVGPLY SGCRLTLLRP KKDGAATKVD AICTYRPDPK SPGLDREQLY WELSQLTHSI TELGPYTLDR DSLYVNGFTQ RSSVPTTSIP GTPTVDLGTS GTPVSKPGPS AASPLLVLFT LNFTITNLRY EENMQHPGSR KFNTTERVLQ GLLRSLFKST SVGPLYSGCR LTLLRPEKDG TATGVDAICT HHPDPKSPRL DREQLYWELS QLTHNITELG PYALDNDSLF VNGFTHRSSV STTSTPGTPT VYLGASKTPA SIFGPSAASH LLILFTLNFT ITNLRYEENM WPGSRKFNTT ERVLQGLLRP LFKNTSVGPL YSGCRLTLLR PEKDGEATGV DAICTHRPDP TGPGLDREQL YLELSQLTHS ITELGPYTLD RDSLYVNGFT HRSSVPTTST GVVSEEPFTL NFTINNLRYM ADMGQPGSLK FNITDNVMQH LLSPLFQRSS LGARYTGCRV IALRSVKNGA ETRVDLLCTY LQPLSGPGLP IKQVFHELSQ QTHGITRLGP YSLDKDSLYL NGYNEPGPDE PPTTPKPATT FLPPLSEATT AMGYHLKTLT LNFTISNLQY SPDMGKGSAT FNSTEGVLQH LLRPLFQKSS MGPFYLGCQL ISLRPEKDGA ATGVDTTCTY HPDPVGPGLD IQQLYWELSQ LTHGVTQLGF YVLDRDSLFI NGYAPQNLSI RGEYQINFHI VNWNLSNPDP TSSEYITLLR DIQDKVTTLY KGSQLHDTFR FCLVTNLTMD SVLVTVKALF SSNLDPSLVE QVFLDKTLNA SFHWLGSTYQ LVDIHVTEME SSVYQPTSSS STQHFYLNFT ITNLPYSQDK AQPGTTNYQR NKRNIEDALN QLFRNSSIKS YFSDCQVSTF RSVPNRHHTG VDSLCNFSPL ARRVDRVAIY EEFLRMTRNG TQLQNFTLDR SSVLVDGYSP NRNEPLTGNS DLPFWAVILI GLAGLLGVIT CLICGVLVTT RRRKKEGEYN VQQQCPGYYQ SHLDLEDLQ* | |||||||||||||
| Mutated AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA ATDGTLVTTI KMSSQAAQGN STWPAPAEET GSSPAGTSPG SPEMSTTLKI MSSKEPSISP EIRSTVRNSP WKTPETTVPM ETTVEPVTLQ STALGSGSTS ISHLPTGTTS PTKSPTENML ATERVSLSPS PPEAWTNLYS GTPGGTRQSL ATMSSVSLES PTARSITGTG QQSSPELVSK TTGMEFSMWH GSTGGTTGDT HVSLSTSSNI LEDPVTSPNS VSSLTDKSKH KTETWVSTTA IPSTVLNNKI MAAEQQTSRS VDEAYSSTSS WSDQTSGSDI TLGASPDVTN TLYITSTAQT TSLVSLPSGD QGITSLTNPS GGKTSSASSV TSPSIGLETL RANVSAVKSD IAPTAGHLSQ TSSPAEVSIL DVTTAPTPGI STTITTMGTN SISTTTPNPE VGMSTMDSTP ATERRTTSTE HPSTWSSTAA SDSWTVTDMT SNLKVARSPG TISTMHTTSF LASSTELDSM STPHGRITVI GTSLVTPSSD ASAVKTETST SERTLSPSDT TASTPISTFS RVQRMSISVP DILSTSWTPS STEAEDVPVS MVSTDHASTK TDPNTPLSTF LFDSLSTLDW DTGRSLSSAT ATTSAPQGAT TPQELTLETM ISPATSQLPF SIGHITSAVT PAAMARSSGV TFSRPDPTSK KAEQTSTQLP TTTSAHPGQV PRSAATTLDV IPHTAKTPDA TFQRQGQTAL TTEARATSDS WNEKEKSTPS APWITEMMNS VSEDTIKEVT SSSSVLRTLN TLDINLESGT TSSPSWKSSP YERIAPSEST TDKEAIHPST NTVETTGWVT SSEHASHSTI PAHSASSKLT SPVVTTSTRE QAIVSMSTTT WPESTRARTE PNSFLTIELR DVSPYMDTSS TTQTSIISSP GSTAITKGPR TEITSSKRIS SSFLAQSMRS SDSPSEAISR LSNFPAMTES GGMILAMQTS PPGATSLSAP TLDTSATASW TGTPLATTQR FTYSEKTTLF SKGPEDTSQP SPPSVEETSS SSSLVPIHAT TSPSNILLTS QGHSPSSTPP VTSVFLSETS GLGKTTDMSR ISLEPGTSLP PNLSSTAGEA LSTYEASRDT KAIHHSADTA VTNMEATSSE YSPIPGHTKP SKATSPLVTS HIMGDITSST SVFGSSETTE IETVSSVNQG LQERSTSQVA SSATETSTVI THVSSGDATT HVTKTQATFS SGTSISSPHQ FITSTNTFTD VSTNPSTSLI MTESSGVTIT TQTGPTGAAT QGPYLLDTST MPYLTETPLA VTPDFMQSEK TTLISKGPKD VSWTSPPSVA ETSYPSSLTP FLVTTIPPAT STLQGQHTSS PVSATSVLTS GLVKTTDMLN TSMEPVTNSP QNLNNPSNEI LATLAATTDI ETIHPSINKA VTNMGTASSA HVLHSTLPVS SEPSTATSPM VPASSMGDAL ASISIPGSET TDIEGEPTSS LTAGRKENST LQEMNSTTES NIILSNVSVG AITEATKMEV PSFDATFIPT PAQSTKFPDI FSVASSRLSN SPPMTISTHM TTTQTGSSGA TSKIPLALDT STLETSAGTP SVVTEGFAHS KITTAMNNDV KDVSQTNPPF QDEASSPSSQ APVLVTTLPS SVAFTPQWHS TSSPVSMSSV LTSSLVKTAG KVDTSLETVT SSPQSMSNTL DDISVTSAAT TDIETTHPSI NTVVTNVGTT GSAFESHSTV SAYPEPSKVT SPNVTTSTME DTTISRSIPK SSKTTRTETE TTSSLTPKLR ETSISQEITS STETSTVPYK ELTGATTEVS RTDVTSSSST SFPGPDQSTV SLDISTETNT RLSTSPIMTE SAEITITTQT GPHGATSQDT FTMDPSNTTP QAGIHSAMTH GFSQLDVTTL MSRIPQDVSW TSPPSVDKTS SPSSFLSSPA MTTPSLISST LPEDKLSSPM TSLLTSGLVK ITDILRTRLE PVTSSLPNFS STSDKILATS KDSKDTKEIF PSINTEETNV KANNSGHESH SPALADSETP KATTQMVITT TVGDPAPSTS MPVHGSSETT NIKREPTYFL TPRLRETSTS QESSFPTDTS FLLSKVPTGT ITEVSSTGVN SSSKISTPDH DKSTVPPDTF TGEIPRVFTS SIKTKSAEMT ITTQASPPES ASHSTLPLDT STTLSQGGTH STVTQGFPYS EVTTLMGMGP GNVSWMTTPP VEETSSVSSL MSSPAMTSPS PVSSTSPQSI PSSPLPVTAL PTSVLVTTTD VLGTTSPESV TSSPPNLSSI THERPATYKD TAHTEAAMHH STNTAVTNVG TSGSGHKSQS SVLADSETSK ATPLMSTTST LGDTSVSTST PNISQTNQIQ TEPTASLSPR LRESSTSEKT SSTTETNTAF SYVPTGAITQ ASRTEISSSR TSISDLDRPT IAPDISTGMI TRLFTSPIMT KSAEMTVTTQ TTTPGATSQG ILPWDTSTTL FQGGTHSTVS QGFPHSEITT LRSRTPGDVS WMTTPPVEET SSGFSLMSPS MTSPSPVSST SPESIPSSPL PVTALLTSVL VTTTNVLGTT SPEPVTSSPP NLSSPTQERL TTYKDTAHTE AMHASMHTNT AVANVGTSIS GHESQSSVPA DSHTSKATSP MGITFAMGDT SVSTSTPAFF ETRIQTESTS SLIPGLRDTR TSEEINTVTE TSTVLSEVPT TTTTEVSRTE VITSSRTTIS GPDHSKMSPY ISTETITRLS TFPFVTGSTE MAITNQTGPI GTISQATLTL DTSSTASWEG THSPVTQRFP HSEETTTMSR STKGVSWQSP PSVEETSSPS SPVPLPAITS HSSLYSAVSG SSPTSALPVT SLLTSGRRKT IDMLDTHSEL VTSSLPSASS FSGEILTSEA STNTETIHFS ENTAETNMGT TNSMHKLHSS VSIHSQPSGH TPPKVTGSMM EDAIVSTSTP GSPETKNVDR DSTSPLTPEL KEDSTALVMN STTESNTVFS SVSLDAATEV SRAEVTYYDP TFMPASAQST KSPDISPEAS SSHSNSPPLT ISTHKTIATQ TGPSGVTSLG QLTLDTSTIA TSAGTPSART QDFVDSETTS VMNNDLNDVL KTSPFSAEEA NSLSSQAPLL VTTSPSPVTS TLQEHSTSSL VSVTSVPTPT LAKITDMDTN LEPVTRSPQN LRNTLATSEA TTDTHTMHPS INTAVANVGT TSSPNEFYFT VSPDSDPYKA TSAVVITSTS GDSIVSTSMP RSSAMKKIES ETTFSLIFRL RETSTSQKIG SSSDTSTVFD KAFTAATTEV SRTELTSSSR TSIQGTEKPT MSPDTSTRSV TMLSTFAGLT KSEERTIATQ TGPHRATSQG TLTWDTSITT SQAGTHSAMT HGFSQLDLST LTSRVPEYIS GTSPPSVEKT SSSSSLLSLP AITSPSPVPT TLPESRPSSP VHLTSLPTSG LVKTTDMLAS VASLPPNLGS TSHKIPTTSE DIKDTEKMYP STNIAVTNVG TTTSEKESYS SVPAYSEPPK VTSPMVTSFN IRDTIVSTSM PGSSEITRIE MESTFSLAHG LKGTSTSQDP IVSTEKSAVL HKLTTGATET SRTEVASSRR TSIPGPDHST ESPDISTEVI PSLPISLGIT ESSNMTIITR TGPPLGSTSQ GTFTLDTPTT SSRAGTHSMA TQEFPHSEMT TVMNKDPEIL SWTIPPSIEK TSFSSSLMPS PAMTSPPVSS TLPKTIHTTP SPMTSLLTPS LVMTTDTLGT SPEPTTSSPP NLSSTSHEIL TTDEDTTAIE AMHPSTSTAA TNVETTSSGH GSQSSVLADS EKTKATAPMD TTSTMGHTTV STSMSVSSET TKIKRESTYS LTPGLRETSI SQNASFSTDT SIVLSEVPTG TTAEVSRTEV TSSGRTSIPG PSQSTVLPEI STRTMTRLFA SPTMTESAEM TIPTQTGPSG STSQDTLTLD TSTTKSQAKT HSTLTQRFPH SEMTTLMSRG PGDMSWQSSP SLENPSSLPS LLSLPATTSP PPISSTLPVT ISSSPLPVTS LLTSSPVTTT DMLHTSPELV TSSPPKLSHT SDERLTTGKD TTNTEAVHPS TNTAASNVEI PSSGHESPSS ALADSETSKA TSPMFITSTQ EDTTVAISTP HFLETSRIQK ESISSLSPKL RETGSSVETS SAIETSAVLS EVSIGATTEI SRTEVTSSSR TSISGSAEST MLPEISTTRK IIKFPTSPIL AESSEMTIKT QTSPPGSTSE STFTLDTSTT PSLVITHSTM TQRLPHSEIT TLVSRGAGDV PRPSSLPVEE TSPPSSQLSL SAMISPSPVS STLPASSHSS SASVTSLLTP GQVKTTEVLD ASAEPETSSP PSLSSTSVEI LATSEVTTDT EKIHPFSNTA VTKVGTSSSG HESPSSVLPD SETTKATSAM GTISIMGDTS VSTLTPALSN TRKIQSEPAS SLTTRLRETS TSEETSLATE ANTVLSKVST GATTEVSRTE AISFSRTSMS GPEQSTMSQD ISIGTIPRIS ASSVLTESAK MTITTQTGPS ESTLESTLNL NTATTPSWVE THSIVIQGFP HPEMTTSMGR GPGGVSWPSP PFVKETSPPS SPLSLPAVTS PHPVSTTFLA HIPPSPLPVT SLLTSGPATT TDILGTSTEP GTSSSSSLST TSHERLTTYK DTAHTEAVHP STNTGGTNVA TTSSGYKSQS SVLADSSPMC TTSTMGDTSV LTSTPAFLET RRIQTELASS LTPGLRESSG SEGTSSGTKM STVLSKVPTG ATTEISKEDV TSIPGPAQST ISPDISTRTV SWFSTSPVMT ESAEITMNTH TSPLGATTQG TSTLDTSSTT SLTMTHSTIS QGFSHSQMST LMRRGPEDVS WMSPPLLEKT RPSFSLMSSP ATTSPSPVSS TLPESISSSP LPVTSLLTSG LAKTTDMLHK SSEPVTNSPA NLSSTSVEIL ATSEVTTDTE KTHPSSNRTV TDVGTSSSGH ESTSFVLADS QTSKVTSPMV ITSTMEDTSV STSTPGFFET SRIQTEPTSS LTLGLRKTSS SEGTSLATEM STVLSGVPTG ATAEVSRTEV TSSSRTSISG FAQLTVSPET STETITRLPT SSIMTESAEM MIKTQTDPPG STPESTHTVD ISTTPNWVET HSTVTQRFSH SEMTTLVSRS PGDMLWPSQS SVEETSSASS LLSLPATTSP SPVSSTLVED FPSASLPVTS LLNPGLVITT DRMGISREPG TSSTSNLSST SHERLTTLED TVDTEDMQPS THTAVTNVRT SISGHESQSS VLSDSETPKA TSPMGTTYTM GETSVSISTS DFFETSRIQI EPTSSLTSGL RETSSSERIS SATEGSTVLS EVPSGATTEV SRTEVISSRG TSMSGPDQFT ISPDISTEAI TRLSTSPIMT ESAESAITIE TGSPGATSEG TLTLDTSTTT FWSGTHSTAS PGFSHSEMTT LMSRTPGDVP WPSLPSVEEA SSVSSSLSSP AMTSTSFFST LPESISSSPH PVTALLTLGP VKTTDMLRTS SEPETSSPPN LSSTSAEILA TSEVTKDREK IHPSSNTPVV NVGTVIYKHL SPSSVLADLV TTKPTSPMAT TSTLGNTSVS TSTPAFPETM MTQPTSSLTS GLREISTSQE TSSATERSAS LSGMPTGATT KVSRTEALSL GRTSTPGPAQ STISPEISTE TITRISTPLT TTGSAEMTIT PKTGHSGASS QGTFTLDTSS RASWPGTHSA ATHRSPHSGM TTPMSRGPED VSWPSRPSVE KTSPPSSLVS LSAVTSPSPL YSTPSESSHS SPLRVTSLFT PVMMKTTDML DTSLEPVTTS PPSMNITSDE SLATSKATME TEAIQLSENT AVTQMGTISA RQEFYSSYPG LPEPSKVTSP VVTSSTIKDI VSTTIPASSE ITRIEMESTS TLTPTPRETS TSQEIHSATK PSTVPYKALT SATIEDSMTQ VMSSSRGPSP DQSTMSQDIS TEVITRLSTS PIKTESTEMT ITTQTGSPGA TSRGTLTLDT STTFMSGTHS TASQGFSHSQ MTALMSRTPG DVPWLSHPSV EEASSASFSL SSPVMTSSSP VSSTLPDSIH SSSLPVTSLL TSGLVKTTEL LGTSSEPETS SPPNLSSTSA EILAITEVTT DTEKLEMTNV VTSGYTHESP SSVLADSVTT KATSSMGITY PTGDTNVLTS TPAFSDTSRI QTKSKLSLTP GLMETSISEE TSSATEKSTV LSSVPTGATT EVSRTEAISS SRTSIPGPAQ STMSSDTSME TITRISTPLT RKESTDMAIT PKTGPSGATS QGTFTLDSSS TASWPGTHSA TTQRFPQSVV TTPMSRGPED VSWPSPLSVE KNSPPSSLVS SSSVTSPSPL YSTPSGSSHS SPVPVTSLFT SIMMKATDML DASLEPETTS APNMNITSDE SLAASKATTE TEAIHVFENT AASHVETTSA TEELYSSSPG FSEPTKVISP VVTSSSIRDN MVSTTMPGSS GITRIEIESM SSLTPGLRET RTSQDITSST ETSTVLYKMP SGATPEVSRT EVMPSSRTSI PGPAQSTMSL DISDEVVTRL STSPIMTESA EITITTQTGY SLATSQVTLP LGTSMTFLSG THSTMSQGLS HSEMTNLMSR GPESLSWTSP RFVETTRSSS SLTSLPLTTS LSPVSSTLLD SSPSSPLPVT SLILPGLVKT TEVLDTSSEP KTSSSPNLSS TSVEIPATSE IMTDTEKIHP SSNTAVAKVR TSSSVHESHS SVLADSETTI TIPSMGITSA VDDTTVFTSN PAFSETRRIP TEPTFSLTPG FRETSTSEET TSITETSAVL YGVPTSATTE VSMTEIMSSN RIHIPDSDQS TMSPDIITEV ITRLSSSSMM SESTQMTITT QKSSPGATAQ STLTLATTTA PLARTHSTVP PRFLHSEMTT LMSRSPENPS WKSSLFVEKT SSSSSLLSLP VTTSPSVSST LPQSIPSSSF SVTSLLTPGM VKTTDTSTEP GTSLSPNLSG TSVEILAASE VTTDTEKIHP SSSMAVTNVG TTSSGHELYS SVSIHSEPSK ATYPVGTPSS MAETSISTSM PANFETTGFE AEPFSHLTSG FRKTNMSLDT SSVTPTNTPS SPGSTHLLQS SKTDFTSSAK TSSPDWPPAS QYTEIPVDII TPFNASPSIT ESTGITSFPE SRFTMSVTES THHLSTDLLP SAETISTGTV MPSLSEAMTS FATTGVPRAI SGSGSPFSRT ESGPGDATLS TIAESLPSST PVPFSSSTFT TTDSSTIPAL HEITSSSATP YRVDTSLGTE SSTTEGRLVM VSTLDTSSQP GRTSSSPILD TRMTESVELG TVTSAYQVPS LSTRLTRTDG IMEHITKIPN EAAHRGTIRP VKGPQTSTSP ASPKGLHTGG TKRMETTTTA LKTTTTALKT TSRATLTTSV YTPTLGTLTP LNASMQMAST IPTEMMITTP YVFPDVPETT SSLATSLGAE TSTALPRTTP SVFNRESETT ASLVSRSGAE RSPVIQTLDV SSSEPDTTAS WVIHPAETIP TVSKTTPNFF HSELDTVSST ATSHGADVSS AIPTNISPSE LDALTPLVTI SGTDTSTTFP TLTKSPHETE TRTTWLTHPA ETSSTIPRTI PNFSHHESDA TPSIATSPGA ETSSAIPIMT VSPGAEDLVT SQVTSSGTDR NMTIPTLTLS PGEPKTIASL VTHPEAQTSS AIPTSTISPA VSRLVTSMVT SLAAKTSTTN RALTNSPGEP ATTVSLVTHP AQTSPTVPWT TSIFFHSKSD TTPSMTTSHG AESSSAVPTP TVSTEVPGVV TPLVTSSRAV ISTTIPILTL SPGEPETTPS MATSHGEEAS SAIPTPTVSP GVPGVVTSLV TSSRAVTSTT IPILTFSLGE PETTPSMATS HGTEAGSAVP TVLPEVPGMV TSLVASSRAV TSTTLPTLTL SPGEPETTPS MATSHGAEAS STVPTVSPEV PGVVTSLVTS SSGVNSTSIP TLILSPGELE TTPSMATSHG AEASSAVPTP TVSPGVSGVV TPLVTSSRAV TSTTIPILTL SSSEPETTPS MATSHGVEAS SAVLTVSPEV PGMVTSLVTS SRAVTSTTIP TLTISSDEPE TTTSLVTHSE AKMISAIPTL AVSPTVQGLV TSLVTSSGSE TSAFSNLTVA SSQPETIDSW VAHPGTEASS VVPTLTVSTG EPFTNISLVT HPAESSSTLP RTTSRFSHSE LDTMPSTVTS PEAESSSAIS TTISPGIPGV LTSLVTSSGR DISATFPTVP ESPHESEATA SWVTHPAVTS TTVPRTTPNY SHSEPDTTPS IATSPGAEAT SDFPTITVSP DVPDMVTSQV TSSGTDTSIT IPTLTLSSGE PETTTSFITY SETHTSSAIP TLPVSPGASK MLTSLVISSG TDSTTTFPTL TETPYEPETT AIQLIHPAET NTMVPRTTPK FSHSKSDTTL PVAITSPGPE ASSAVSTTTI SPDMSDLVTS LVPSSGTDTS TTFPTLSETP YEPETTATWL THPAETSTTV SGTIPNFSHR GSDTAPSMVT SPGVDTRSGV PTTTIPPSIP GVVTSQVTSS ATDTSTAIPT LTPSPGEPET TASSATHPGT QTGFTVPIRT VPSSEPDTMA SWVTHPPQTS TPVSRTTSSF SHSSPDATPV MATSPRTEAS SAVLTTISPG APEMVTSQIT SSGAATSTTV PTLTHSPGMP ETTALLSTHP RTETSKTFPA STVFPQVSET TASLTIRPGA ETSTALPTQT TSSLFTLLVT GTSRVDLSPT ASPGVSAKTA PLSTHPGTET STMIPTSTLS LGLLETTGLL ATSSSAETST STLTLTVSPA VSGLSSASIT TDKPQTVTSW NTETSPSVTS VGPPEFSRTV TGTTMTLIPS EMPTPPKTSH GEGVSPTTIL RTTMVEATNL ATTGSSPTVA KTTTTFNTLA GSLFTPLTTP GMSTLASESV TSRTSYNHRS WISTTSSYNR RYWTPATSTP VTSTFSPGIS TSSIPSSTAA TVPFMVPFTL NFTITNLQYE EDMRHPGSRK FNATERELQG LLKPLFRNSS LEYLYSGCRL ASLRPEKDSS ATAVDAICTH RPDPEDLGLD RERLYWELSN LTNGIQELGP YTLDRNSLYV NGFTHRSSMP TTSTPGTSTV DVGTSGTPSS SPSPTTAGPL LMPFTLNFTI TNLQYEEDMR RTGSRKFNTM ESVLQGLLKP LFKNTSVGPL YSGCRLTLLR PEKDGAATGV DAICTHRLDP KSPGLNREQL YWELSKLTND IEELGPYTLD RNSLYVNGFT HQSSVSTTST PGTSTVDLRT SGTPSSLSSP TIMAAGPLLV PFTLNFTITN LQYGEDMGHP GSRKFNTTER VLQGLLGPIF KNTSVGPLYS GCRLTSLRSE KDGAATGVDA ICIHHLDPKS PGLNRERLYW ELSQLTNGIK ELGPYTLDRN SLYVNGFTHR TSVPTSSTPG TSTVDLGTSG TPFSLPSPAT AGPLLVLFTL NFTITNLKYE EDMHRPGSRK FNTTERVLQT LLGPMFKNTS VGLLYSGCRL TLLRSEKDGA ATGVDAICTH RLDPKSPGVD REQLYWELSQ LTNGIKELGP YTLDRNSLYV NGFTHWIPVP TSSTPGTSTV DLGSGTPSSL PSPTTAGPLL VPFTLNFTIT NLKYEEDMHC PGSRKFNTTE RVLQSLLGPM FKNTSVGPLY SGCRLTLLRS EKDGAATGVD AICTHRLDPK SPGVDREQLY WELSQLTNGI KELGPYTLDR NSLYVNGFTH QTSAPNTSTP GTSTVDLGTS GTPSSLPSPT SAGPLLVPFT LNFTITNLQY EEDMHHPGSR KFNTTERVLQ GLLGPMFKNT SVGLLYSGCR LTLLRPEKNG AATGMDAICS HRLDPKSPGL NREQLYWELS QLTHGIKELG PYTLDRNSLY VNGFTHRSSV APTSTPGTST VDLGTSGTPS SLPSPTTAVP LLVPFTLNFT ITNLQYGEDM RHPGSRKFNT TERVLQGLLG PLFKNSSVGP LYSGCRLISL RSEKDGAATG VDAICTHHLN PQSPGLDREQ LYWQLSQMTN GIKELGPYTL DRNSLYVNGF THRSSGLTTS TPWTSTVDLG TSGTPSPVPS PTTTGPLLVP FTLNFTITNL QYEENMGHPG SRKFNITESV LQGLLKPLFK STSVGPLYSG CRLTLLRPEK DGVATRVDAI CTHRPDPKIP GLDRQQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSTPGT FTVQPETSET PSSLPGPTAT GPVLLPFTLN FTITNLQYEE DMRRPGSRKF NTTERVLQGL LMPLFKNTSV SSLYSGCRLT LLRPEKDGAA TRVDAVCTHR PDPKSPGLDR ERLYWKLSQL THGITELGPY TLDRHSLYVN GFTHQSSMTT TRTPDTSTMH LATSRTPASL SGPMTASPLL VLFTINFTIT NLRYEENMHH PGSRKFNTTE RVLQGLLRPV FKNTSVGPLY SGCRLTLLRP KKDGAATKVD AICTYRPDPK SPGLDREQLY WELSQLTHSI TELGPYTLDR DSLYVNGFTQ RSSVPTTSIP GTPTVDLGTS GTPVSKPGPS AASPLLVLFT LNFTITNLRY EENMQHPGSR KFNTTERVLQ GLLRSLFKST SVGPLYSGCR LTLLRPEKDG TATGVDAICT HHPDPKSPRL DREQLYWELS QLTHNITELG PYALDNDSLF VNGFTHRSSV STTSTPGTPT VYLGASKTPA SIFGPSAASH LLILFTLNFT ITNLRYEENM WPGSRKFNTT ERVLQGLLRP LFKNTSVGPL YSGCRLTLLR PEKDGEATGV DAICTHRPDP TGPGLDREQL YLELSQLTHS ITELGPYTLD RDSLYVNGFT HRSSVPTTST GVVSEEPFTL NFTINNLRYM ADMGQPGSLK FNITDNVMQH LLSPLFQRSS LGARYTGCRV IALRSVKNGA ETRVDLLCTY LQPLSGPGLP IKQVFHELSQ QTHGITRLGP YSLDKDSLYL NGYNEPGPDE PPTTPKPATT FLPPLSEATT AMGYHLKTLT LNFTISNLQY SPDMGKGSAT FNSTEGVLQH LLRPLFQKSS MGPFYLGCQL ISLRPEKDGA ATGVDTTCTY HPDPVGPGLD IQQLYWELSQ LTHGVTQLGF YVLDRDSLFI NGYAPQNLSI RGEYQINFHI VNWNLSNPDP TSSEYITLLR DIQDKVTTLY KGSQLHDTFR FCLVTNLTMD SVLVTVKALF SSNLDPSLVE QVFLDKTLNA SFHWLGSTYQ LVDIHVTEME SSVYQPTSSS STQHFYLNFT ITNLPYSQDK AQPGTTNYQR NKRNIEDALN QLFRNSSIKS YFSDCQVSTF RSVPNRHHTG VDSLCNFSPL ARRVDRVAIY EEFLRMTRNG TQLQNFTLDR SSVLVDGYSP NRNEPLTGNS DLPFWAVILI GLAGLLGVIT CLICGVLVTT RRRKKEGEYN VQQQCPGYYQ SHLDLEDLQ* | |||||||||||||
| Position of stopcodon in wt / mu CDS | 34350 / 34350 | |||||||||||||
| Position (AA) of stopcodon in wt / mu AA sequence | 11450 / 11450 | |||||||||||||
| Position of stopcodon in wt / mu cDNA | 34384 / 34384 | |||||||||||||
| Position of start ATG in wt / mu cDNA | 35 / 35 | |||||||||||||
| Last intron/exon boundary | 34285 | |||||||||||||
| Theoretical NMD boundary in CDS | 34200 | |||||||||||||
| Length of CDS | 34350 | |||||||||||||
| Coding sequence (CDS) position | 3055 | |||||||||||||
| cDNA position | 3089 | |||||||||||||
| gDNA position | 45850 | |||||||||||||
| Chromosomal position | 8964541 | |||||||||||||
| Speed | 0.12 s | |||||||||||||
All positions are in basepairs (bp) if not explicitly stated differently. cDNA/gDNA/chromosomal position: Ins/del are shown as 'last normal base / first normal base'.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
| Analysed issue | Analysis result | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | Chr19:8964541T>A (GRCh38) | |||||||||||||
| Gene symbol | MUC16 | |||||||||||||
| Gene constraints | no data | |||||||||||||
| Ensembl transcript ID | ENST00000710609.1 | |||||||||||||
| Genbank transcript ID | ||||||||||||||
| UniProt / AlphaMissense peptide | N/A | |||||||||||||
| Variant type | Single base exchange | |||||||||||||
| Gene region | CDS | |||||||||||||
| DNA changes | c.12349A>T g.45850A>T | |||||||||||||
| AA changes |
| |||||||||||||
| Frameshift | No | |||||||||||||
| Length of protein | Normal | |||||||||||||
| Pathogenic variant (ClinVar) | Variant not listed in ClinVar as (likely) pathogenic. | |||||||||||||
| Variant DBs |
| |||||||||||||
| Protein conservation | ||||||||||||||
| Protein features | N/A | |||||||||||||
| Phylogenetic conservation |
| |||||||||||||
| Splice sites | No abrogation of potential splice sites predicted by MaxEntScan. | |||||||||||||
| Distance from splice site | N/A | |||||||||||||
| Kozak consensus sequence altered? | No | |||||||||||||
| poly(A) signal | N/A | |||||||||||||
| AA sequence altered | Yes | |||||||||||||
| Chromosome | 19 | |||||||||||||
| Strand | -1 | |||||||||||||
| Original gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Original cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | |||||||||||||
| Altered cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | |||||||||||||
| Wildtype AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ* | |||||||||||||
| Mutated AA sequence | MGREGPAHPG HRRRPLLALA VSLLLTCWPG LPFDAVVFAQ TTDQGTLGAT RQLTHDPSSP ASLISSVGTH EPGENSSSPH GTSVWPTGSP LVEKSTISPA DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAISRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ* | |||||||||||||
| Position of stopcodon in wt / mu CDS | 43644 / 43644 | |||||||||||||
| Position (AA) of stopcodon in wt / mu AA sequence | 14548 / 14548 | |||||||||||||
| Position of stopcodon in wt / mu cDNA | 43678 / 43678 | |||||||||||||
| Position of start ATG in wt / mu cDNA | 35 / 35 | |||||||||||||
| Last intron/exon boundary | 43579 | |||||||||||||
| Theoretical NMD boundary in CDS | 43494 | |||||||||||||
| Length of CDS | 43644 | |||||||||||||
| Coding sequence (CDS) position | 12349 | |||||||||||||
| cDNA position | 12383 | |||||||||||||
| gDNA position | 45850 | |||||||||||||
| Chromosomal position | 8964541 | |||||||||||||
| Speed | 0.14 s | |||||||||||||
All positions are in basepairs (bp) if not explicitly stated differently. cDNA/gDNA/chromosomal position: Ins/del are shown as 'last normal base / first normal base'.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project
| Analysed issue | Analysis result | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | Chr19:8964541T>A (GRCh38) | ||||||||||||||||
| Gene symbol | MUC16 | ||||||||||||||||
| Gene constraints | LOEUF: 0.79, LOF (oe): 0.74, misssense (oe): 1.10, synonymous (oe): 1.07 (gnomAD) | ||||||||||||||||
| Ensembl transcript ID | ENST00000397910.8 | ||||||||||||||||
| Genbank transcript ID | NM_001414687 (by similarity), NM_024690 (by similarity) | ||||||||||||||||
| UniProt / AlphaMissense peptide | MUC16_HUMAN | AlphaMissense: transcript, gene | ||||||||||||||||
| Variant type | Single base exchange | ||||||||||||||||
| Gene region | CDS | ||||||||||||||||
| DNA changes | c.12229A>T g.45850A>T | ||||||||||||||||
| AA changes |
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| Frameshift | No | ||||||||||||||||
| Length of protein | Normal | ||||||||||||||||
| Pathogenic variant (ClinVar) | Variant not listed in ClinVar as (likely) pathogenic. | ||||||||||||||||
| Variant DBs |
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| Protein conservation | |||||||||||||||||
| Protein features |
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| Phylogenetic conservation |
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| Splice sites | No abrogation of potential splice sites predicted by MaxEntScan. | ||||||||||||||||
| Distance from splice site | N/A | ||||||||||||||||
| Kozak consensus sequence altered? | No | ||||||||||||||||
| poly(A) signal | N/A | ||||||||||||||||
| AA sequence altered | Yes | ||||||||||||||||
| Chromosome | 19 | ||||||||||||||||
| Strand | -1 | ||||||||||||||||
| Original gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | ||||||||||||||||
| Altered gDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | ||||||||||||||||
| Original cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCACCAGGCTGTCTAACTTTCCT | ||||||||||||||||
| Altered cDNA sequence snippet | ACAGCCCCTCAGAAGCCATCTCCAGGCTGTCTAACTTTCCT | ||||||||||||||||
| Wildtype AA sequence | MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ* | ||||||||||||||||
| Mutated AA sequence | MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAISRLS NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ* | ||||||||||||||||
| Position of stopcodon in wt / mu CDS | 43524 / 43524 | ||||||||||||||||
| Position (AA) of stopcodon in wt / mu AA sequence | 14508 / 14508 | ||||||||||||||||
| Position of stopcodon in wt / mu cDNA | 43728 / 43728 | ||||||||||||||||
| Position of start ATG in wt / mu cDNA | 205 / 205 | ||||||||||||||||
| Last intron/exon boundary | 43629 | ||||||||||||||||
| Theoretical NMD boundary in CDS | 43374 | ||||||||||||||||
| Length of CDS | 43524 | ||||||||||||||||
| Coding sequence (CDS) position | 12229 | ||||||||||||||||
| cDNA position | 12433 | ||||||||||||||||
| gDNA position | 45850 | ||||||||||||||||
| Chromosomal position | 8964541 | ||||||||||||||||
| Speed | 0.17 s | ||||||||||||||||
All positions are in basepairs (bp) if not explicitly stated differently. cDNA/gDNA/chromosomal position: Ins/del are shown as 'last normal base / first normal base'.
AA/aa: amino acid; CDS: coding sequence; mu: mutated; NMD: nonsense-mediated mRNA decay; nt: nucleotide; wt: wildtype; TGP: 1000 Genomes Project